• Title/Summary/Keyword: 4E-T

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Design, Synthesis and Biological Activity of Certain 3,4-Disubstituted-5-mercapto-1,2,4-triazoles and Their Hydrazino Derivatives

  • Udupi, R.H.;Sudheendra, Sudheendra;Bheemachari, Bheemachari;Srinivasulu, N.;Varnekar, Rajesh;Purushottamachar, Puranik
    • Bulletin of the Korean Chemical Society
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    • v.28 no.12
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    • pp.2235-2240
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    • 2007
  • 3-Aryloxy methyl-4-(N-pyrazin-2'yl carboxamido)-5-mercapto-1,2,4-triazoles (3a1-a14) were prepared starting from potassium dithio carbazinates (2a1-a14). These triazoles were then employed in the synthesis of 3-aryloxy methyl-4-(N-pyrazin-2'yl carboxamido)-5-hydrazino-1,2,4-triazoles (4a1-a14). All the newly synthesized compounds were characterized by analytical, IR, NMR spectral studies. The compounds were screened for their antibacterial, antifungal, anti-inflammatory and analgesic properties. Most of the compounds have shown significant antifungal activity while few have shown excellent anti-inflammatory and analgesic activity. An attempt is made to study the structure activity relationship (SAR).

A study on the change of the views on E.M.T. profession of the E.M.T. college students (일부 전문대 응급구조학생의 응급구조전문직관의 변화에 대한 연구)

  • Kim, Hak-Soo;Choi, Eun-Sook;Kim, Jin-Hue;Shin, Dong-Min;Lee, In-Soo
    • The Korean Journal of Emergency Medical Services
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    • v.1 no.1
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    • pp.28-41
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    • 1997
  • The purpose of this study was to identify the change of perceptions related to E.M.T. profession of E.M.T. student and to provide the basic data for development of curriculum. The subjects of the survey were 216 students from 3 junior college by questionaire from November 25 to November 29, 1996 in Kwang-Ju, Cheong-Ju, and Kong-Ju. The results were analyzed using the SAS and can be summerized as follows : 1. The view on profession was a statistically significant difference inspecial knowledge & skill training (t=-1.686, P<.001), high income (t=-0.753, P<.05) 2. The view on competence as a E.M.T. was a statistically significant differncein sufficient professional knowledge on the E.M.T. (t=-1.144, P<.001), own's health (t=-0.808, P<.001), sincerity and responsibility (t=-1.429, P<.01), satisfaction and effort (t=-1.335, P<.01), boundary of affairs (t=-1.356, P<.01) 3. The view on E.M.T. profession was a statistically significant difference inprotect of pt. life & to relieve the pain (t=-2.388, P<.001) 4. The view on necessary knowledge of E.M.T. was a statistically significant difference in patient assessment (t=-2.168, P<.001), ACLS (t=1.678, P<.001), hemorrhage & shock (t=-3.252, P<.001), trauma (t=-4.284, P<.001), cardiopulmonary disturbance (t=-2.897, P<.001), acute abdomen (t=-4.284, P<.001), neonatal disease (t=-4.032, P<.001), OBGY disease(t=-4.151, P<.001), emergency delivery (t=-2.825, P<.001), infectious disease (t=-2.930, P<.001), environmental emergency (t=-3.123, P<.05), recording(t=2.22, P<.05) 5. The view on ideology of E.M.T. was a statistically significant difference in belief & faith (t=-2.344, P<.001), knowing of own (t=-2.142, P<.01), humanity (t=-2.581, P<.05), knowing of patient (t=-2.079, P<.05).

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The Effects of Gamichunggumgangwha-tang (Jiaweiqingjinjianghuo-tang) and Gamiyukmigiwhang-tang (Jiaweiliuweidihuang-tang) on Immune Cell & Serum OA-specific IgE in BALF in a Rat Asthma Model (가미청금항화탕 및 가미육미지황탕이 Allergy 천식 모델 흰쥐의 BALF내 면역세포 및 혈청 IgE에 미치는 영향)

  • 조영민;정희재;정승기;이형구
    • The Journal of Korean Medicine
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    • v.24 no.3
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    • pp.1-10
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    • 2003
  • Background : Asthma is a chronic inflammatory disorder under immunological influence. Gamichunggumgangwha-tang (CG, Jiaweiqingjinjianghuo-tang) and Gamiyukmigiwhang-tang (YM, Jiaweiliuweidihuang-tang) are herbal tonics for asthma from traditional herbal medicine. Objective : To evaluate the effect of CG and YM on immune cell & serum OA-specific IgE in broncho-alveolar lavage fluid (BALF) in a rat asthma model. Materials and Methods : Rats were sensitized with OA; at day I sensitized group and CG and YM groups were systemically immunized by subcutaneous injection of 1mg OA and 300mg of Al(OH)3 in a total volume of 2ml. At the same time, 1 ml of 0.9% saline containing $6{\times}10^9$ B. pertussis bacilli was injected by Lp. 14 days after the systemic immunization, rats received local immunization by inhaling 0.9% saline aerosol containing 2% (wt/vol) OA. A day after local immunization, BALF was collected from the rats. Rats were orally administered with each of CG and YM extract for 14 days since the day after local immunization. Lymphocyte, CD4+ T cell and CD8+ T cell counts, CD4+/CD8+ ratio in BALF, change of serum OA-specific IgE level, CD4+ T cell and CD8+ T cell percentages in the peripheral blood were measured and evaluated. Results : CG and YM showed an alleviating effect on asthmatic responses of rats. CG decreased total cell, lymphocyte, CD4+ T cells in BALF, and serum OA-specific IgE level as compared with the control group. YM decreased lymphocytes as compared with the control group. CD4+/CD8+ ratio in BALF from the CG and YM groups and serum OA-specific IgE level from the YM group didn't show any significant variation from the control group. Conclusion : CG alleviated asthmatic hyperreactivity of the immune system through CD4+ T cells and serum IgE. Further the study of this immune system modulating mechanism is expected.

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Energy Levels of Rhodium ions in Phosphate Glasses (Phosphate 유리에 첨가된 Rhodium 이온의 에너지 준위)

  • 권택용
    • Korean Journal of Optics and Photonics
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    • v.4 no.2
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    • pp.220-225
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    • 1993
  • This is the first reported observation of absorption and emission of glasses with a 4d transition metal ion(rhodium). The optical absorption and photoluminescence spectra, and the lifetimes of rhodium ions in phosphate glasses are interpreted on the basis of strong-field scheme of Sugano-Tanabe diagram. We conclude that rhodium ion is present in its divalent form. $^2 E{\rightarrow}^2 T_1$ and $^2 E{\rightarrow}^2 T_2$ transitions are superimposed and observed at 460 nm. Whereas $^2 T_1{\rightarrow}^2 E$ and $^2 T_1{\rightarrow}^2 E$ transitions are observed at 650 nm and 580 nm, respectively.

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OSCILLATION AND NONOSCILLATION THEOREMS FOR NONLINEAR DIFFERENTIAL EQUATIONS OF SECOND ORDER

  • Kim, Rak-Joong;Kim, Dong-Il
    • Journal of the Korean Mathematical Society
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    • v.44 no.6
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    • pp.1453-1467
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    • 2007
  • By means of a Riccati transform some oscillation or nonoscillation criteria are established for nonlinear differential equations of second order $$(E_1)\;[p(t)|x#(t)|^{\alpha}sgn\;x#(t)]#+q(t)|x(\tau(t)|^{\alpha}sgn\;x(\tau(t))=0$$. $$(E_2),\;(E_3)\;and\;(E_4)\;where\;0<{\alpha}$$ and $${\tau}(t){\leq}t,\;{\tau}#(t)>0,\;{\tau}(t){\rightarrow}{\infty}\;as\;t{\rightarrow}{\infty}$$. In this paper we improve some previous results.

Tocotrienol and Tocopherol Contents of Rice Bran by Milling Recovery (도정율에 따른 미강의 Tocotrienol과 Tocopherol 함량)

  • Park Kyeong-Yeol;Kang Chang-Sung;Cho Young-Cheol;Lee Yong-Sun;Lee Young-Hyun;Lee Young-Sang
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.49 no.6
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    • pp.468-471
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    • 2004
  • Tocotrienol $(T_3)$ and tocopherol (T) are well-known antioxidant vitamin E isomers that are enriched in rice bran, most of which is removed during polishing process. To verify the polishing-dependent fractional content of tocotrienol and tocopherol, harvested brown rice of 4 cultivars were polished by 4.0, 6.4, 8.0, 9.6, and $12\%$ (w/w) and resultant bran powder and rice were used for $T_3$ and T analysis. Polishing degree affected bran $T_3$ content in that bran polished by $6.4\%$ exhibited highest $T_3$ content compared to other polishing degrees except in cv. Chucheongbyeo which showed similar $T_3$ content from 4.0 to $8.0\%$ polishing. In case of tocopherol, bran polished by $8.0\%$ exhibited highest T content in all tested cultivars. In general, $T_3$ distributed in higher quantity in exterior i.e., in less polished bran, while T showed relatively less decrease with enhanced polishing degree. Consequently, total vitamin E content in bran as calculated by the summation of $T_3$ and T became less dependent on polishing degree in that bran polished between 6.4 to $9.6\%$ exhibited no statistical differences. The rice of cv. Chuchongbyeo, remained after polishing, exhibited similar vitamin E content up to $6.4\%$ polishing, above which significant vit E loss could be observed. These results suggest that polishing less than $6.4\%$ is desirable to minimize the loss of tocotrienols and tocopherols during polishing.

Effects of Feeding Dietary Different Oil and Tocopherol on Physico-Chemical Characteristics of Pork (오일과 토코페롤 급여가 돈육의 이화학적 성질에 미치는 영향)

  • 진상근;김일석;송영민;정기화;이성대;하경희;김회윤;박기훈
    • Food Science of Animal Resources
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    • v.23 no.2
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    • pp.115-121
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    • 2003
  • The pork quality was determined with following treatments. The meat samples were obtained from pigs which had been fed finishing pig diets containing 5% beef tallow(Control), 3% beef tallow and 2% perillar seed oil(T1), 250 ppm vitamin E(a-tocopheryl acetate) in T1(T2), 3% beef tallow and 2% squid viscera oil(T3), 250 ppm vitamin E in T3(T4), 3% beef tallow and 2% CLA(Conjugated linoleic acid, T5). T1 had the lowest sarcomere length, salt solubility and total protein contents among the treatments. Salt solubility and total protein content of T2 and T4 which had been fed diets containing Vit. E were higher than those of T1 and T3 which had not been fed diets without Vit. E. pH and water holding capacity(WHC) values of control were higher than those of T1, T3 and T5, while WHC of T2 and T4 was higher than those of T1, T3 and T5. The hunter L value of meat and a value of fat showed higher in T5 than those in control, T, T3. The adhesiveness of T3 and the springiness of T5 in cooked meat showed higher level than other treatments.

T-786C, G894T, and Intron 4 VNTR (4a/b) Polymorphisms of the Endothelial Nitric Oxide Synthase Gene in Bladder Cancer Cases

  • Polat, Fikriye;Diler, Songul Budak;Azazi, Irfan;Oden, Artun
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.6
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    • pp.2199-2202
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    • 2015
  • The aim of the present study was to determine whether endothelial nitric oxide synthase (eNOS) gene polymorphisms play a role in development of bladder cancer in the Turkish population. The study was performed on 75 patients (64 men, 11 women) with bladder cancer and 143 healthy individuals (107 men, 36 women) with any kind of cancer history. Three eNOS gene polymorphisms (T-786C promoter region, G894T and intron 4 VNTR 4a/b) were determined with polymerase chain reaction and restriction fragment lenght polymorphism methods. In our study, GT and TT genotypes for eNOS G894T polymorphism were found to significantly vary among patients with bladder cancer and control group (OR: 0.185, CI: 0.078-0.439, p=0.0001 and OR: 0.324, CI: 0.106-0.990, p=0.026). Also, the frequency of the 894T allele was significantly higher in patients with bladder cancer (51%). No association was identified for eNOS T-786C and intron 4 VNTR 4a/b polymorphisms between patients with bladder cancer and control groups in our Turkish population.

A Study on the influence of job transfer in E&T programs characteristics & organizational situational characteristics of the medium and small-sized hospitals (중소병원의 교육훈련 프로그램 특성 및 조직상황적 특성이 직무전이에 미치는 영향에 관한 연구)

  • Kim, Young-Hyuk
    • Korea Journal of Hospital Management
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    • v.16 no.4
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    • pp.131-160
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    • 2011
  • The purpose of this study was 1) to understand the job transfer in education & training(E&T) programs & organizational situational characteristics, and 2) to analyze the effects of the E&T programs & organizational situational characteristic groups on each of the levels of job transfer. There is intimate relationship between E&T programs characteristics & organizational situational characteristics and job transfer, so we can't think of them separately. With this point of view the most frequently discussed problem is how to apply the theory in actual job, but in reality it's true that the improvement of job transfer can't reach the expectations of the E&T programs. In literature view study, the concepts of job transfer in E&T, the general theory on E&T, and the actual condition and points at issue of the existing E&T practices in the medium and small-sized hospitals were defined. As the results from empirical analysis, we could find followings: First, in evaluation of the job transfer, demographic characteristics (seniority, occupational category, position) variables have a significant different. Second, in degree of the job transfer, E&T programs characteristics(contents of E&T, design of E&T, conditions of E&T, teaching ability of lecturer, methods of E&T) variables have a different influence upon each of the evaluation levels of E&T. Third, support of CEO variables have a different influence on the job transfer according to contents, design, conditions of the E&T programs. Fourth, support of co-works variables have a different influence on the job transfer according to design, conditions, method of the E&T programs. Fifty, support of organizational atmosphere variables have a different influence on the job transfer according to contents, design, conditions of the E&T programs.

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Variation of Inclusion Selectivities of the Cadmium Host Complexes with Ammonium Oniums for Aromatic Guest Molecules (암모니움 이온을 가진 카드뮴 호스트 착물의 방향족 게스트 분자에 대한 포접선택성 변화)

  • Kim, Chong-Hyeak;Lee, Sueg-Geun
    • Analytical Science and Technology
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    • v.17 no.3
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    • pp.282-288
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    • 2004
  • Inclusion selectivities of the cyanocadmate host complexes with ammonium oniums, $[Cd_x(CN)_{2x}][onium{\cdot}zG]$ (onium = $NMe_3Et^+$, $NMeEt{_3}^+$ and $NEt{_4}^+$, G = guest), have been investigated for $C_6H_6$ (B), PhMe (T), PhEt (E), ortho (O), meta (M), and para (P) isomers of $C_6H_4Me_2$ as the aromatic guest molecules. From the binary, ternary, quaternary and quinary mixed guests of B, T, E, O, M and P, the order of preference in the $NMe_3Et+$-host is $B{\gg}$T>P${\fallingdotseq}O{\fallingdotseq}M$ and E>O${\gg}P{\fallingdotseq}M$; in the $NMeEt{_3}^+$-host is T>B>P${\gg}O{\fallingdotseq}M$ and E>P${\gg}$M>O; in the $NEt{_4}^+$-host is $B{\gg}T{\fallingdotseq}O{\fallingdotseq}M{\fallingdotseq}P$. However, the $NEt{_4}^+$-host complexes of E, O, M and P mixed-guests were not obtained. These inclusion selectivities were compared to our previous results of the $NMe{_4}^+$-host; T>B>P${\gg}$M>O and E>P${\gg}$M>O.