• Journal of Korean Neurosurgical Society
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• v.64 no.4
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• pp.514-523
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• 2021

Objective : Aneurysm volume quantification (AVQ) using the equation of ellipsoid volume is widely used although it is inaccurate. Furthermore, AVQ with 3-dimensional (3D) rendered data has limitations in general use. A novel universal method for AVQ is introduced for any diagnostic modality and application to any shape of aneurysms. Methods : Relevant AVQ studies published from January 1997 to June 2019 were identified to determine common methods of AVQ. The basic idea is to eliminate the normal artery volume from 3D model with the aneurysm. After Digital Imaging and Communications in Medicine (DICOM) data is converted and exported to stereolithography (STL) file format, the 3D STL model is modified to remove the aneurysm and the volume difference between the 3D model with/without the aneurysm is defined as the aneurysm volume. Fifty randomly selected aneurysms from DICOM database were used to validate the different AVQ methods. Results : We reviewed and categorized AVQ methods in 121 studies. Approximately 60% used the ellipsoid method, while 24% used the 3D model. For 50 randomly selected aneurysms, volumes were measured using 3D Slicer, RadiAnt, and ellipsoid method. Using 3D Slicer as the reference, the ratios of mean difference to mean volume obtained by RadiAnt and ellipsoid method were -1.21±7.46% and 4.04±30.54%, respectively. The deviations between RadiAnt and 3D Slicer were small despite of aneurysm shapes, but those of ellipsoid method and 3D Slicer were large. Conclusion : In spite of inaccuracy, ellipsoid method is still mostly used. We propose a novel universal method for AVQ that is valid, low cost, and easy to use.

• Journal of Electrical Engineering and Technology
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• v.3 no.4
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• pp.584-592
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• 2008

In this paper, we propose a new model of the magnetic control force exerted on the levitation object in magnetic levitation systems. The model assumes that the magnetic force is a function of the voltage applied to an electromagnet and the position of a levitation object. The function is not explicitly expressed but represented through a 2D lookup table constructed from the experimentally measured data. Unlike the conventional model that reveals only local characteristics of the magnetic force, the proposed model shows global characteristics satisfactorily. Specially devised measurement equipment is utilized in order to gather the data required for model construction. An experimental procedure to construct the model is presented. We apply the proposed model to designing a sliding mode controller for a lab-built magnetic system. The validity of the proposed model is illustrated by comparing the performances of the controller adopting the conventional model with that of the controller adopting the proposed model.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.12 no.4
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• pp.622-629
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• 2001

An engineering model VCO with a good phase noise for Ku-band satellite transponder is designed using a nonlinear design methodology. It generates frequencies from 1,745 and 1,755 MHz with control voltages from 0 to 5 V DC. This unit requires 7 mA of current from 5 V DC supply voltage. Phase noise characteristics of the manufactured VCO exhibit -114 dBc/Hz @10 kHz offset and -131 dBc/Hz @100 kHz of offset and its output power is 5 dBm.

• The Journal of the Korea Contents Association
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• v.3 no.4
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• pp.69-76
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• 2003

Recently, in computer graphics, researches on 3D animations have been very active. one of the important research areas in 3D animation is animation of human being. The creation and animation of 3D facial models has depended on animators' manual work frame by frame. Thus, it needs many efforts and time as well as various hardwares and softwares. In this paper, we implements a way to generation 3D human face model easily and quickly just with the front face images. Then, we suggests a methodology for mesh data simplification of 3D generic model.

• International Journal of Ocean System Engineering
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• v.3 no.4
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• pp.225-230
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• 2013

This paper introduces the experimental results of sloshing model tests carried out at Seoul National University. Two 1/50-scale tanks, i.e., 2D and 3D models with the same shape, were manufactured for the comparative study. Particular interest was taken in the differences in impact pressures between the 2D and 3D models. Regular motion tests were conducted for different filling depths. For each filling depth, 500 cycles of regular excitation were imposed at each frequency. To observe the characteristics and severity of sloshing from the acquired pressure data, statistical analyses were performed, not only for the peak pressure, but also for the area-concept indices, which represented the amount of impulse.

• Journal of Technologic Dentistry
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• v.39 no.4
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• pp.227-233
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• 2017

Purpose: The purpose of this study was to evaluate the validity of digital models fabricated by difference optical source of non-contact 3D dental scanner. Methods: A master model with the prepared upper full arch tooth was used. Stone model(N=10) were produced from master model, and on the other hands, digital models were made with the 3D dental scanner(Blue, white, red optical source). The linear distance between the reference points were measured and analyzed on the Delcam $Copycad^{(R)}$ graphic software. The results were statistically analyzed using the one-way ANOVA and Tukey's HSD test(${\alpha}=0.05$). Results: There were considerable differences in mean values between optical source within each color(blue, white, red), and this difference was not statistically significant(p>0.05). Conclusion : Three different color of dental scanner optical source showed clinically acceptable accuracies of full arch digital model produced by them. Besides, these results will have to be confirmed in further clinical studies.

• Journal of Microbiology and Biotechnology
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• v.32 no.6
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• pp.740-748
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• 2022

As circ_UBE2D2 has been confirmed to have targeted binding sites with multiple miRNAs involved in septic acute kidney injury (SAKI), efforts in this study are directed to unveiling the specific role and relevant mechanism of circ_UBE2D2 in SAKI. HK-2 cells were treated with lipopolysaccharide (LPS) to construct SAKI model in vitro. After sh-circ_UBE2D2 was transfected into cells, the transfection efficiency was detected by qRT-PCR, cell viability and apoptosis were determined by MTT assay and flow cytometry, and expressions of Bcl-2, Bax and Cleaved-caspase 3 were quantified by western blot. Target genes associated with circ_UBE2D2 were predicted using bioinformatics analysis. After the establishment of SAKI rat model, HE staining and TUNEL staining were exploited to observe the effect of circ_UBE2D2 on tissue damage and cell apoptosis. The expression of circ_UBE2D2 was overtly elevated in LPS-induced HK-2 cells. Sh-circ_UBE2D2 can offset the inhibition of cell viability and the promotion of cell apoptosis induced by LPS. Circ_UBE2D2 and miR-370-3p as well as miR-370-3p and NR4A3 have targeted binding sites. MiR-370-3p inhibitor reversed the promoting effect of circ_UB2D2 silencing on viability of LPS-treated cells, but shNR4A3 neutralized the above inhibitory effect of miR-370-3p inhibitor. MiR-370-3p inhibitor weakened the down-regulation of NR4A3, Bax and Cleaved caspase-3 and the up-regulation of Bcl-2 induced by circ_UB2D2 silencing, but these trends were reversed by shNR4A3. In addition, sh-circ_UBE2D2 could alleviate the damage of rat kidney tissue. Circ_UBE2D2 mitigates the progression of SAKI in rats by targeting miR-370-3p/NR4A3 axis.

• Tribology and Lubricants
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• v.14 no.4
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• pp.44-50
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• 1998

This paper describes the simulation of the levitation force between permanent magnet and high Tc(critical temperature) superconductor(HTSC). Levitation force is evaluated numerically on the basis of the magnetic vector potential method and the critical state model. The superconductor is approximated to 2-D slab model. By performing computations, the following characteristics have been investigated: the process of the generation of hysteresis, the various hysteretic behaviors. The characteristics of hysteresis are important for the application to magnetic bearing, for the damping and the nonlinear stiffness is related to hysteresis.

• Ocean and Polar Research
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• v.30 no.4
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• pp.537-543
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• 2008

The sediment resuspension and diffusion model is an integral part of a sediment transport and morphologic change model. We examined a vertical one-dimensional sediment resuspension and diffusion model using field data collected at about 10-m depth off the Saemangeun $4^{th}$ dike. The field data include waves, currents and suspended sediment concentration near the bed for about a day in May, 2007. The suspended sediment concentration obtained from the 1D model overestimated the observation about two orders of magnitude with single grain size and multiple grain sizes. The incorporation of the bed armoring effect, which adjusts the amount of suspended sediment with the available bed sediment, improved the agreement between the model and observation within a factor of two.

• Bulletin of the Korean Chemical Society
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• v.33 no.4
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• pp.1123-1127
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• 2012

P-gp (P-glycoprotein) is a member of the ATP binding cassette (ABC) family of transporters. It transports many kinds of anticancer drugs out of the cell. It plays a major role as a cause of multidrug resistance (MDR). MDR function may be a cause of the failure of chemotherapy in cancer and influence pharmacokinetic properties of many drugs. Hence classification of candidate drugs as substrates or nonsubstrate of the P-gp is important in drug development. Therefore to identify whether a compound is a P-gp substrate or not, in silico method is promising. Recursive Partitioning (RP) method was explored for prediction of P-gp substrate. A set of 261 compounds, including 146 substrates and 115 nonsubstrates of P-gp, was used to training and validation. Using molecular descriptors that we can interpret their own meaning, we have established two models for prediction of P-gp substrates. In the first model, we chose only 6 descriptors which have simple physical meaning. In the training set, the overall predictability of our model is 78.95%. In case of test set, overall predictability is 69.23%. Second model with 2D and 3D descriptors shows a little better predictability (overall predictability of training set is 79.29%, test set is 79.37%), the second model with 2D and 3D descriptors shows better discriminating power than first model with only 2D descriptors. This approach will be used to reduce the number of compounds required to be run in the P-gp efflux assay.