• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2011년도 추계학술대회 초록집
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• pp.159.2-159.2
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• 2011

Hyundai Heavy Industries has developed a tidal current energy converter utilizing the accumulated technology as the world largest constructor for ship and offshore structures. The model has two sets of turbines in both ends in order to utilize the bi-directional current flows in flood and ebb tide. The torque produced by turbine in tidal current is directly delivered to generator along the horizontal axis, in which the turbine, gear, generator, gear and turbine are connected successively. The manufactured model for field test has the turbine diameter of 5 meters to produce the maximum power of 500kW at maximum current speed of 5m/s. The technical verification of tidal power converter was performed by means of small scale model test in towing tank as well as field test at the Strait of Uldolmok located in Jindo of Jeollanamdo province. Field test was performed by mounting the tidal current converter on the SEP(Self Elevating Platform) which could lower the 4 vertical legs on the seabed and could elevate platform over the water surface using the hydraulic power for itself. The field test performed for a month shows that power output is similar or larger compared with the expected one in design stage. This paper presents the development of tidal current energy converter and real sea field test by Hyundai Heavy Industries. This project has finished successfully and provided the technical advance toward commercial services for tidal current power generation in the south-west region in Korea.

• Journal of Microbiology and Biotechnology
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• 제33권12호
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• pp.1576-1586
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• 2023

Vaccination is the most effective method for preventing the spread of the influenza virus. Cell-based influenza vaccines have been developed to overcome the disadvantages of egg-based vaccines and their production efficiency has been previously discussed. In this study, we investigated whether treatment with forskolin (FSK), an adenylyl cyclase activator, affected the output of a cell-based influenza vaccine. We found that FSK increased the propagation of three influenza virus subtypes (A/H1N1/California/4/09, A/H3N2/Mississippi/1/85, and B/Shandong/7/97) in Madin-Darby canine kidney (MDCK) cells. Interestingly, FSK suppressed the growth of MDCK cells. This effect could be a result of protein kinase A (PKA)-Src axis activation, which downregulates extracellular signal-regulated kinase (ERK)1/2 activity and delays cell cycle progression from G1 to S. This delay in cell growth might benefit the binding and entry of the influenza virus in the early stages of viral replication. In contrast, FSK dramatically upregulated ERK1/2 activity via the cAMP-PKA-Raf-1 axis at a late stage of viral replication. Thus, increased ERK1/2 activity might contribute to increased viral ribonucleoprotein export and influenza virus propagation. The increase in viral titer induced by FSK could be explained by the action of cAMP in assisting the entry and binding of the influenza virus. Therefore, FSK addition to cell culture systems could help increase the production efficiency of cell-based vaccines against the influenza virus.

• 한국과학교육학회지
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• 제16권3호
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• pp.314-328
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• 1996

This study investigated the literature about science process skills' evaluation to analyse transition of evaluation objectives before and after a Scholastic Ability Test for College Entrance. In the literature survey the researcher established a 3 dimensional science assessment framework with X axis as science concept, Y axis as science process skills and Z axis as problem context. In order to analysis and compare each items the researcher selected 210 items from the 1st to the 7th trials and 138 items from the 1st to 4th Scholastic Ability Test for College Entrance and sampled 2873 science achievement test items from 10 high schools. In accordance with this taxonomy the researcher analysed and compared science process skills item forms. The following results were drawn : The items were evenly distributed in all the four areas(Earth Science, Biology, Physics and Chemistry) of the science concept domain, but they were heavily concentrated on data analysis and drawing a conclusion in science process domain. In the domain of problem context school context was the majority. In spite of distribution like this the ratio on science process skills measurement items and science achievement test items was increased after the Scholastic Ability Test for College Entrance was given. Also the ratio on item expression type was increased. Item form was almost 5 options selection type in the national level test. Although there were 4 options selection type, 5 options selection type, short answer type, essay type in school level test, rising from 33.1% to 65.5% on 5 options selection type is exhibited. This study showed that the school level item form was better various than the nation level. This point like this is the evidence for the improvement toward the science process skills test and influenced by Scholastic Ability Test for College Entrance. The ratio on the item which joined with the 3 axes had a mean of 99.3% in nation level test and mean 44.9% in school achievement test level. But the ratio in the school achievement test level increased after the Scholastic Ability Test for College Entrance was given. In view of this study we must furthermore study the item types which can evaluate valjdately science process skill's five stage each and evaluation method by the high school students' problem solving patterns and features in scientific inquiry on all science process skills elements.

• 한국방사선학회논문지
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• 제18권2호
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• pp.127-133
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• 2024

팔꿉관절은 3개의 뼈대가 조합하여 관절을 이루고 있으며 신체적 활동 및 외력에 의한 이상 시 X-선 등, 방사선 검사로 영상진단을 한다. 팔꿉 관절 선행연구에 의하면 전완부(forearm)의 Z축 거상에 의한 기울기 자세에서 영상평가 기준에 부합하는 새로운 검사법이 발표되어 이에 최적화된 기구를 설계하고 다른 상지 검사에서도 활용 가능한 보조기구를 개발하고자 하였다. 2D 도면 및 3D 모델링 설계로 디자인 후 4부분의 파트로 구분 된 디자인을 ABS 소재의 3D 프린팅 방법으로 출력 후 조립 단계를 거쳐 제품을 완성하였다. 개발된 보조기구는 Z축 거상 기울기 4단계 각도(0, 5, 10, 15도) 기능과 1도 단위로 360도 회전되어 고정하는 기능으로 구성하였다. 개발된 보조기구는 사용 빈도의 누적 및 신체적 활용에 의한 하중 문제에 대해 구조해석을 통하여 최대 등가응력(equivalent stress) 56.107 Pa, 변위(displacement) 1.6548e-5 mm 의 안전한 물성치 범위로 개발되었다. 또한 개발된 보조기구는 팔꿉관절의 X-선 검사뿐만 아니라 위팔뼈 회전에 의한 어깨 기능검사에서도 활용할 수 있으며 비금속 소재로 MRI, CT 검사에서도 적용이 가능하도록 개발되었다. 개발된 보조기구는 향후 다양한 장치 및 의료영상 검사의 임상 적용을 통하여 검사의 정확성 및 효율화에 기여하리라 판단한다.

• Structural Engineering and Mechanics
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• 제40권4호
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• pp.563-581
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• 2011

Many novel materials, developed in recent years, have obvious properties with different modulus of elasticity in tension and compression. The ratio of their tensile modulus to compressive modulus is as high as five times. Nowadays, it has become a new trend to study the mechanical properties of these bimodular materials. At the present stage, there are extensive studies related to the strength analysis of bimodular structures, but the investigation of the buckling stability problem of bimodular rods seems to cover new ground. In this article, a semi-analytical method is proposed to acquire the buckling critical load of bimodular slender rod. By introducing non-dimensional parameters, the position of neutral axis of the bimodular rod in the critical state can be determined. Then by combining the phased integration method, the deflection differential equation of bimodular pin-ended slender rod is deduced. In addition, the buckling critical load is obtained by solving this equation. An example, which is conducted by comparing the calculation results between the three of the methods including the laboratory tests, numerical simulation method and the method we developed here, shows that the method proposed in the present work is reliable to use. Furthermore, the influence of bimodular characteristics on the stability is discussed and analyzed.

• Journal of Welding and Joining
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• 제35권2호
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• pp.6-12
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• 2017

Ti-alloys have high specific strength and are widely used for the filed of space aeronautics plant. However, it is difficult to process Ti-Alloys due to its high yield strength and it cannot raise the machining speed because it has a possibility of catching fire while processing. In order to reduce the number of processes for the Ti-alloys, the researches related to Additive Manufacturing(AM) have been actively carried out at the moment. As for the initial stage of AM market related to Ti-alloys, it started to use the raw material of powder metal, and it is currently being developed based on welding. In this study, Interpass peening reduced the size of the primary ${\beta}$ grain in the z-axis direction, increased the nucleation site of ${\alpha}-colony$, and decreased the length and width of ${\alpha}$ laths as though interpass rolling. Interpass peening leads to an increase in yield/ultimate tensile strength without decrease elongation, resulting decrease in anisotropy of the material.

• 한국산림과학회지
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• 제102권2호
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• pp.305-308
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• 2013

참나무시들음병 매개충인 광릉긴나무좀 미성숙충태인 알, 유충, 번데기의 외부 형태와 유충 두폭을 활용한 령기구분, 지역 개체군 간 균낭수 변이를 조사하였다. 광릉긴나무좀의 알은 광택을 띠는 타원형이며 크기는 장경 $0.67{\pm}0.051$ mm, 단경 $0.41{\pm}0.053$ mm 이었다. 유충은 5령기를 거치며, 각 령기는 두폭의 크기 차이로 명확하게 구분되었다. 1령유충의 두폭은 $0.35{\pm}0.004$ mm, 2령유충은 $0.45{\pm}0.010$ mm, 3령유충은 $0.67{\pm}0.039$ mm, 4령유충은 $0.94{\pm}0.069$ mm, 5령유충은 $1.12{\pm}0.007$ mm 였다. 5령유충 체색은 유백색의 광택을 띠며, 큰턱이 잘 발달되었다. 번데기는 연한 황색이며, 체장은 $4.64{\pm}0.042$ mm 이었다. 개체당 균낭수는 변이가 있어 적은 개체는 5개, 많은 개체는 12개까지 관찰되었으며 83%의 개체들이 6-8개의 균낭을 가지고 있었다. 남양주지역과 홍천지역의 개체군간 개체당 균낭수 차이는 없었다.

• 한국지역지리학회지
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• 제2권2호
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• pp.173-182
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• 1996

본 연구는 경상남도 밀양군에 위치하는 천황산 talus에 대한 수 차례의 현지조사를 통하여 그것의 지형적 특성과 성인을 분석하여 보았으며 주된 결과는 다음과 같다. 첫째, 연구지역의 talus는 한반도에서 흔히 볼 수 있는 talus와는 상이한 지형적 경관을 보여준다. 둘째, 암설의 입경과 talus의 규모 그리고 사면경사는 비교적 큰 편에 해당된다. 셋째, talus 형성의 전제 조건인 금애면은 완전히 평행후퇴하여 지금은 소멸되었다. 넷째, 연구지역의 talus는 지난 빙기의 주빙하적 기후환경하에서 생성된 각력의 암설들이 rock fall 상태로 금애면 아래에 집적되어 형성되었다. 다섯째, 급애면의 완전소멸로 현재는 더 이상 암설의 추가공급이 이루어지지 않고 있을 뿐만 아니라 구성암설의 이동성도 인정되지 않아 지형발달단계상 화석지형화 단계로 파악된다. 결국 이러한 지형적 경관의 특이성은 본 지형의 형성프로세서와 지형적 발달단계를 설명하는데 중요하며, talus의 유형 분류에 큰 도움을 줄 수 있다.

• BMB Reports
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• 제57권4호
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• pp.167-175
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• 2024

Cancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are associated with poor prognosis of various cancers by communicating with cancer cells, immune cells, and peripheral nerves within the TME. Over the past decade, research has been conducted to prevent cancer growth by controlling the activation of neurotrophic factors within tumors, exhibiting a novel attemt in cancer treatment with promising results. More recently, research focusing on controlling cancer growth through regulation of the autonomic nervous system, including the sympathetic and parasympathetic nervous systems, has gained significant attention. Sympathetic signaling predominantly promotes tumor progression, while the role of parasympathetic signaling varies among different cancer types. Neurotransmitters released from these signalings can directly or indirectly affect tumor cells or immune cells within the TME. Additionally, sensory nerve significantly promotes cancer progression. In the advanced stage of cancer, cancer-associated cachexia occurs, characterized by tissue wasting and reduced quality of life. This process involves the pathways via brainstem growth and differentiation factor 15-glial cell line-derived neurotrophic factor receptor alpha-like signaling and hypothalamic proopiomelanocortin neurons. Our review highlights the critical role of neurotrophic factors as well as central nervous system on the progression of cancer, offering promising avenues for targeted therapeutic strategies.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5675-5680
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• 2013

Background: Preexisting type 2 diabetes mellitus (T2DM) affects the prognosis and mortality of patients with some cancers. Insulin like growth factor (IGF) and insulin receptor (IR) signaling axes play important roles in both cancer and diabetes development. We aimed to explore the expression characteristics of proteins in IGF/IR axis in non-small cell lung cancer (NSCLC) cases with preexisting T2DM. Methods: Fifty-five NSCLC patients with preexisting T2DM were retrospectively included and matched by 55 NSCLC without diabetes at a 1:1 ratio. The expression of proteins in IGF/IR axis was detected by immunohistochemical staining. Clinicopathological data were collected to analyze their relationship with the protein expression. Results: Both IGF 1 receptor (IGF-1R) and insulin receptor substrate 2 (IRS-2) showed higher expression in the NSCLC with T2DM group, compared with those without T2DM. The high expression of IGF-1R and IRS-2 were found to be negatively associated with lymph node metastases and T staging in the T2DM group, respectively, and IRS-2 expression was also found more in the subgroup whose T2DM duration was more than 4 years. No difference was detected in the expression of IRS-1, IGF-1, IGF-2, IGFBP3, IR and mTOR between groups with or without T2DM. Conclusion: Our study found higher expression of IGF-1R and IRS-2 proteins in NSCLC patients with preexisting T2DM, and that there was an association with early stage NSCLC, which suggested that IGF signaling may play an important early event in development of NSCLC associated with diabetes.