• Journal of Convergence for Information Technology
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• v.11 no.2
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• pp.31-40
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• 2021

Blockchain technology is also actively studied in the real estate transaction field, and real estate transactions have various ways. In this paper, we propose a model that simplifies the authentication procedure of auction systems using Ethereum's Ether to solve the problem of offline court auctions. The proposed model is written in Ethereum's Solidity language, the court registers the sale date and the sale date with the DApp browser, and the bidder accesses the address of the individual's wallet created through Metamask's private key. The bidder then selects the desired sale and enters the bid price amount to participate in the auction. The bidder's record of the highest bid price for the sale he wants is written on the Ethereum test network as a smart contract. and creates a block. Finally, smart contracts written on the network are distributed by the court auction manager to all nodes in the blockchain network, and each node in the blockchain network can be viewed and contract verified. As a result of analyzing the smart contracts of the proposed model and the performance of the system, there are fees incurred due to the creation and use of Ether on platforms using Ethereum, and participation. Ether's changes in value affect the price of the sale, resulting in inconsistent fees in smart contracts each time. However, in future work, we issue our own tokens to solve the market volatility problem and commission problem with the value change of Ether, and refine complex court auction systems.

• Journal of Convergence for Information Technology
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• v.12 no.5
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• pp.71-82
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• 2022

This study aimed to identify the effects of death education programs among Korean aged on death anxiety and attitudes toward death in the convergence era. The searched kew words were included aged, death education program, death anxiety, and attitudes to death in the research papers published in Korea. Finally, 11 studies were selected and the effect size was calculated. Death anxiety and death attitude were selected as dependent variables, and publication type, total duration of intervention, and frequency of intervention were selected as moderator variables. The total of 11 papers were selected to estimate the effect sizes of interventions. As a result, the overall effect size of the death education program for the aged was 1.07. The overall effect size showed death education program was able to lower death anxiety (Hedges' g=1.30, 95% Cl=0.80~1.80, p<.01) and improve attitudes to death (Hedges' g=0.93, 95% Cl=0.49~1.37, p<.01) compared with the no intervention group. In the moderator analysis to identify the cause of heterogeneity, significant results were found in the frequency of intervention. We propose a study that repeatedly verifies the effect of related studies in the future by providing the theoretical basis and basic data for the development of the death education program.

• Korean Journal of Radiology
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• v.21 no.4
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• pp.471-482
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• 2020

Objective: We aimed to determine the optimized image-based surrogate endpoints (IBSEs) in targeted therapies for glioblastoma through a systematic review and meta-analysis of phase III randomized controlled trials (RCTs). Materials and Methods: A systematic search of OVID-MEDLINE and EMBASE for phase III RCTs on glioblastoma was performed in December 2017. Data on overall survival (OS) and IBSEs, including progression-free survival (PFS), 6-month PFS (6moPFS), 12-month PFS (12moPFS), median PFS, and objective response rate (ORR) were extracted. Weighted linear regression analysis for the hazard ratio for OS and the hazard ratios or odds ratios for IBSEs was performed. The associations between IBSEs and OS were evaluated. Subgroup analyses according to disease stage (newly diagnosed glioblastoma versus recurrent glioblastoma), types of test treatment, and types of response assessment criteria were performed. Results: Twenty-three phase III RCTs published between 2000 and 2017, including 8387 patients, met the inclusion criteria. OS showed strong correlations with PFS (standardized β coefficient [R] = 0.719), 6moPFS (R = 0.647), and 12moPFS (R = 0.638). OS showed no correlations with median PFS and ORR. In subgroup analysis according to types of therapies, PFS showed the highest correlations with OS in targeted therapies for cell cycle pathways (R = 0.913) and growth factor receptors and their downstream pathways (R = 0.962). 12moPFS showed the highest correlation with OS in antiangiogenic therapy (R = 0.821). The response assessment in neuro-oncology criteria provided higher correlation coefficients between OS and IBSEs than the Macdonald criteria. Conclusion: Overall, PFS is an optimized IBSE in targeted therapies for glioblastoma; however, 12moPFS is optimal in antiangiogenic therapy.

• Archives of Pharmacal Research
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• v.23 no.6
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• pp.620-625
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• 2000

The mechanisms of liver injury from cold storage and reperfusion are not completely under-stood. The aim of the present study was to investigate whether the inactivation of Kupffer cells (KCs) by gadolinium chloride ($GdCl_3$) modulates ischemia-reperfusion injury in the rat liver. Hepatic function was assessed using an isolated perfused rat liver model. In livers subjected to cold storage at $4^{\circ}C$ in University of Wisconsin solution for 24 hrs and to 20 min rewarm-ing ischemia, oxygen uptake was markedly decreased, Kupffer cell phagocytosis was stimulated, releases of purine nucleoside phosphorylase and lactate dehydrogenase were increased as compared with control livers. Pretreatment of rats with $GdCl_3$) , a selective KC toxicant, suppressed kupffer cell activity, and reduced the grade of hepatic injury induced by ischemia-reperfusion. While the initial mixed function oxidation of 7-ethoxycoumarin was not different from that found in the control livers, the subsequent conjugation of its meta-bolite to sulfate and glucuronide esters was suppressed by ischemia-reperfusion, CdCl$_3$restored sulfation and glucuronidation capacities to the level of the control liver. Our findings suggest that Kupffer cells could play an important role in cold/warm ischemia-reperfusion hepatic injury.

• Journal of Ecology and Environment
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• v.32 no.2
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• pp.103-107
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• 2009

We investigated colonization and extinction patterns in a meta population of the gold-spotted pond frog (Rana planeyi ehoseniea) near the Korea National University of Education, Chungbuk, Korea, by surveying the frogs in the nine occupied habitat patches in the study area four times per breeding season for three years (2006$\sim$2008) and recording whether the patches were occupied by frogs as well as how many frogs were calling in the patches. We then developed five a priori year-specific models using the Akaike Information Criterion (AIC). The models predicted that: 1) probabilities of colonization and local extinction of the frogs were better explained by year-dependent models than by constant models, 2) there are high local extinction and low colonization probabilities, 3) approximately 31% number of patches will be occupied at equilibrium, and 4) that considerable variation in occupation rate should occur over a 30-year period, due to demographic stochasticity (in our model, the occupation rate ranged from 0.222 to 0.889). Our results suggest that colonization is important in this metapopulation system, which is governed by mainly stochastic components, and that more constructive conservation effects are needed to increase local colonization rates.

• Korean Journal of Adult Nursing
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• v.23 no.6
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• pp.633-641
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• 2011

Purpose: This study was to examine the trend of qualitative study published by Korean Journal of Adult Nursing from 1989 to 2011, and to suggest future directions through identifying its strength and weakness. Methods: Ninety one published qualitative studies were analyzed focusing on research methodology and research themes using descriptive statistics. Results: During the last 22 years, the number of qualitative studies has rapidly increased and the methodology used to analyze qualitative data has been diversified. The most frequently used analytic method was a phenomenology (48.4%) and the frequency of conducting a content analysis has increased. The prevailing data collection settings were community (61.5%), followed by hospital (35.2%). Especially, many researches showed specific description on researcher's efforts to get validity and reliability of studies in individual studies presented within recent 10 years. However, it was noted that meta study using mixed methodology and secondary analysis of qualitative studies are rarely used and need to be facilitated. Conclusion: Nursing Researchers utilizing qualitative research should continuously make efforts to increase the validity and reliability of their studies and to find knowledges or strategies applicable to practice through using mixed methods or secondary analysis of individual studies.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3411-3417
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• 2013

Over the last 10 years, the number of cancer survivors in South Korea has reached nearly one million with a survival rate of 49.4%. However, integrated supportive care for cancer survivors is lagging. One area in which the current cancer control policy needs updating is in the utilization of information and communication technology (ICT). The remarkable progress in the field of ICT over the past 10 years presents exciting new opportunities for health promotion. Recent communication innovations are conducive to the exchange of meta-information, giving rise to a new service area and transforming patients into active medical consumers. Consequently, such innovations encourage active participation in the mutual utilization and sharing of high-quality information. However, these benefits from new ICTs will almost certainly not be equally available to all, leading to so-called communication inequalities where cancer survivors from lower socioeconomic classes will likely have more limited access to the best means of making use of the health information. Therefore, most essentially, emphasis must be placed on helping cancer survivors and their caregivers utilize such advances in ICT to create a more efficient flow of health information, thereby reducing communication inequalities and expanding social support. Once we enhance access to health information and better manage the quality of information, as a matter of fact, we can expect an alleviation of the health inequalities faced by cancer survivors.

• The Transactions of the Korean Institute of Power Electronics
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• v.4 no.5
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• pp.405-412
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• 1999

Meta! Halide Discharge(]\1HD) Iamps have good color rendition, long life and good focusing capability but h have flickers bv acoustic resonances. We have designed the electronic ballast for reducing acoustic resonances in high pressure discharge tube. The ballast consists of main two parts, the first part is a half-bridge inverter to make a square wave form a and the st'Cond part is a flyback converter to combine the low frequency and high frequency component. As a r result of this study, we conclude that MHD lamps of 70 watt 따c very well light(D without acoustic resonance p phenomena by the elestronic ballast.

• Health Policy and Management
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• v.11 no.3
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• pp.71-88
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• 2001

The purpose of this study is to analyze the cost-effectiveness of four medications for treating and preventing osteoporosis -HRT therapy(conjugated equine estrogen 0.625mg for 25 days and medroxyprogesterone acetate 5mg for 01112 days), Alendronate(10mg and 5mg), Active Vitamin D(Calcitriol), and Calcium. Total costs include the direct medical cost -examination fee, consultation fee, prescription fee, fee for preparing medications, and the price of pharmaceuticals- and the indirect cost of patients such as traffic expenses and time cost. In addition, the costs of monitoring in adverse reactions are added. The effects of four medications are expressed as BMD(Bone Mineral Density) percent change measured by DEXA(Dual Energy X-ray Absorptiometry) in lumbar spine(L2-L4) and femoral neck site. A mixed model based on meta analysis provides the estimates of effectiveness, which are then appled to the hypothetical cohort consisting of postmenopausal women at the age of 50-59. HRT therapy is the most cost-effective medication at 172,433.64 won (lumbar spine site) and 546,328.28 won (femoral neck site) per BMD percent change for osteoporosis. Alendronate 10mg is more cost-effective than Alendronate 5mg as 345,971.23 won and 378,441.63 won per lumbar BMD percent change at 0.991ｇ/$cm^2$, respectively. Alendronate 10mg is more cost-effective than Alendronate 5mg as 1,329,257.89 won and 1,467,291.23 won per femoral neck BMD percent change at 0.834ｇ/$cm^2$, respectively.

• The KSFM Journal of Fluid Machinery
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• v.16 no.1
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• pp.24-31
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• 2013

The motion of living organisms such as birds, fishes, and insects, has been analyzed for the purpose of the design of MAV(Micro Air Vehicle) and NAV(Nano Air Vehicle). In this research, natural motion was considered to be applied to the determination of the geometry and motion of AUV(Autonomous Underwater Vehicle). The flapping motion of a number of hydrofoil shapes in AUV was studied, and at the same time, the optimization of the hydrofoil shape and flapping motion was executed that allow the highest thrust and efficiency. The harmonic motion of plunging and pitching of NACA 4 digit series models, was used for the numerical analysis. The meta model was made by using the kriging method in Optimization method and the experimental points of 49 were extracted for the OA(Orthogonal array) in DOE(Design of experiments). Parametric study using this experimental points was conducted and the results were applied to MGA(Micro Genetic Algorithm). The flow simulation model was validated to be an appropriate tool by comparing with experimental data and the optimized shape and motion of AUV was turned out to produce highest thrust and efficiency.