• Asian-Australasian Journal of Animal Sciences
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• 제32권3호
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• pp.413-420
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• 2019

Objective: This study investigated the effects of dry radish leaf and root on the quality of pork patties during refrigeration storage. Methods: The patties were divided into the following three groups: the control containing 0% dry radish leaf root powder, RL1 containing 0.5% dry radish leaf root powder, and RL2 and RL3 containing 1% and 2% dry radish leaf root powder, respectively. Proximate composition, pH, cooking loss, microbial analysis, lipid oxidation analysis, color, texture profile analysis and sensory test were performed. Results: Moisture, crude protein, and crude ash contents in RL2 and RL3 were significantly higher than those in other groups (p<0.05), whereas crude fat contents in RL2 and RL3 were significantly lower than other groups (p<0.05). Lightness was significantly lower in RL2 and RL3 than in CON (p<0.05). Cooking loss for RL2 and RL3 were significantly lower than those for the other groups (p<0.05). The pH, thiobarbituric acid levels, and total plate counts of RL2 and RL3 were significantly lower than those of CON at days 7 and 14 (p<0.05). Hardness values of RL2 and RL3 were significantly lower than those of CON, whereas chewiness values were higher than those of CON (p<0.05). In addition, the juiciness of RL2 were significantly greater (p<0.05) than those of the other groups. Conclusion: Dried radish leaves and roots improved the proximate composition and quality characteristics of pork patties, providing a basis to produce high-quality patties with extended expiration dates. Thus, dried radish leaves and roots are effective ingredients for health or functional foods.

• 분석과학
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• 제17권3호
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• pp.282-288
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• 2004

Inclusion selectivities of the cyanocadmate host complexes with ammonium oniums, $[Cd_x(CN)_{2x}][onium{\cdot}zG]$ (onium = $NMe_3Et^+$, $NMeEt{_3}^+$ and $NEt{_4}^+$, G = guest), have been investigated for $C_6H_6$ (B), PhMe (T), PhEt (E), ortho (O), meta (M), and para (P) isomers of $C_6H_4Me_2$ as the aromatic guest molecules. From the binary, ternary, quaternary and quinary mixed guests of B, T, E, O, M and P, the order of preference in the $NMe_3Et+$-host is $B{\gg}$T>P${\fallingdotseq}O{\fallingdotseq}M$ and E>O${\gg}P{\fallingdotseq}M$; in the $NMeEt{_3}^+$-host is T>B>P${\gg}O{\fallingdotseq}M$ and E>P${\gg}$M>O; in the $NEt{_4}^+$-host is $B{\gg}T{\fallingdotseq}O{\fallingdotseq}M{\fallingdotseq}P$. However, the $NEt{_4}^+$-host complexes of E, O, M and P mixed-guests were not obtained. These inclusion selectivities were compared to our previous results of the $NMe{_4}^+$-host; T>B>P${\gg}$M>O and E>P${\gg}$M>O.

• 한국전산구조공학회논문집
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• 제19권4호
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• pp.347-356
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• 2006

본 논문에서는 단면상의 화이버 요소를 사용하여 3차원 강구조물의 점진적인 소성화를 고려하는 실용적인 비선형 비탄성 해석방법을 개발하였다. 부재의 p-$\delta$, p-$\Delta$ 등의 기하비선형은 안정함수로 고려하였다. 잔류응력은 단면상에 있는 화이버 요소에 초기응력을 가하여 고려하였다. 각 하중 단계에서 탄성상태인 단면을 계산하여 축강성과 휨강성을 직접 결정함으로서 점진적인 소성화를 고려하였다. 각 화이버 요소의 응력 변화를 계산하여 변형률 반전효과를 고려하였다. 제안된 해석 방법은 3차원 강구조물의 실용적인 해석 및 설계에 유용하게 사용될 것이라 판단한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4759-4768
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• 2015

Background: Several studies have investigated predictive and prognostic biomarkers for patients treated with anti-epidermal growth factor receptor (EGFR) agents in lung cancer. However, the conclusion is controversial. Materials and Methods: A meta-analysis was conducted to evaluate the associations of mutant K-ras, PIK3CA and PTEN deficiency with the efficacy of anti-EGFR agents in lung cancer. The primary endpoint was objective response rate (ORR). The secondary endpoints were overall survival (OS) and progression-free survival (PFS). Results: A total of 61 studies were included in the final meta-analysis. The result showed that K-ras mutation was a good predictor for ORR (RR=0.42, 95%CI, 0.33-0.55, p=0.000) and an effective prognostic marker for OS (HR=1.37, 95%CI, 1.15-1.65, p=0.001) and PFS (HR=1.33, 95%CI, 1.05-1.69, p=0.019). However, PTEN deficiency or PIK3CA mutation did not show any significance predictive value for ORR (PTEN, RR=0.82, 95%CI, 0.56-1.19, p=0.286; PIK3CA, RR=1.08, 95%CI, 0.17-6.66, P=0.938). And PTEN deficiency or expression of PIK3CA did not show significance prognostic value for OS (PTEN, HR=0.88, 95%CI, 0.31-2.46,P=0.805; PIK3CA, HR=0.79, 95%CI: 0.23-2.68, P=0.706). Conclusions: Our meta-analysis showed that K-ras mutation may be an effective predictor in lung cancer patients treated with anti-EGFR agents. Whereas, the predictive and prognostic value of PTEN deficiency and PIK3CA mutation need to be further investigated.

• 대한치과보철학회지
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• 제58권1호
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• pp.7-13
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• 2020

목적: 본 연구의 목적은 절삭 가공법 및 적층 가공법에 의해 제작된 3본 고정성 국소의치의 변연 및 내면 적합도를 비교하는 것이다. 재료 및 방법: 상악 좌측 제2소구치가 상실된 3본 고정성 국소의치 지대치를 제작하고(주모형), 구강 스캐너를 이용해 주모형 스캔 데이터를 얻었다. 3본 고정성 보철물은 다음과 같은 3가지 방법으로 제작하였다: Milled 3-unit fixed dental prostheses (FDP) (MIL군), digital light processing (DLP) 3D printed 3-unit FDP (D3P군), stereolithography apparatus (SLA) 3D printed 3-unit FDP (S3P군). 보철물의 변연 및 내면 적합도와 내면 정밀도 평가하기 위해 각각 triple-scan protocol과 콤비네이션 수식을 사용하여 스캔 데이터를 중첩하였다. 3차원 분석 프로그램(Geomagic control X)을 사용하여 root mean square (RMS) 값과 color difference map 통해 정량 및 정성 분석 시행하였다. Kruskal-Wallis test (α = .05)와 Mann-Whitney U test 및 Bonferroni correction (α = .05/3 = .017)을 이용하여 통계 분석하였다. 결과: S3P군의 변연 적합도는 MIL군과 D3P군에 비해 우수하였으며, MIL군과 D3P군은 비슷한 수준을 보였다. D3P군과 S3P군은 MIL군에 비해 상대적으로 우수한 내면 적합도를 보였으며, D3P군과 S3P군 사이에는 유의한 차이가 없었다. 한편, MIL군, S3P군, 그리고 D3P군 순으로 우수한 정밀도를 보였다. 결론: 본 연구의 한계 내에서 적층 가공법으로 제작된 3본 고정성 보철물은 절삭 가공법으로 제작된 3본 고정성 보철물에 비해 우수한 변연 및 내면 적합도를 보인 반면 정밀도는 떨어지는 것으로 나타났다.

• Macromolecular Research
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• 제13권6호
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• pp.467-476
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• 2005

The main objective of this study was to develop and characterize pH-sensitive biodegradable polymeric materials. For pH-sensitivity, we employed three kinds of moieties: 2-amino-3-(lH-imidazol-4-yl)-propionic acid (H), N-[4-( 4,6-dimethyl-pyrimidin-2ylsulfamoyl)-phenyl]succinamic acid (SM), and 2- {3-[ 4-( 4,6-dimethyl-pyrim­idin- 2-ylsulfamoyl)-phenylcarbamoyl]-propionylamino} -3-(3 H - imidazol-4-yl)-propionic acid (SH). The pH -sensitive diblock copolymers were synthesized by ring opening polymerization and coupling reaction from poly(ethylene glycol) (MPEG), $\varepsilon$-caprolactone (CL), D,L-lactide (LA) and pH-sensitive moieties. The pH-sensitive SH molecule was synthesized in a two-step reaction. The first step involved the synthesis of SHM, a methyl ester derivative of SH, by coupling reaction of SM and L-histidine methyl ester dihydrochloride, whereas the second step involved the hydrolysis of the same. The synthesized SM, SHM and SH molecules were characterized by FTIR, $^{1}H$-NMR and $^{13}C$-NMR spectroscopy, whereas diblock copolymers and pH-sensitive diblock copolymer were characterized by $^{1}H$-NMR and GPC analysis. The critical micelle concentrations were determined at various pH conditions by fluorescence technique using pyrene as a probe. The micellization and demicellization studies of pH-sensitive diblock copolymers were also done at different pH conditions. The pH-sensitivity was further established by acid-based titration and DLS analysis.

• 대한치과기공학회지
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• 제41권4호
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• pp.287-293
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• 2019

Purpose: To evaluate the accuracy of the 3D printed die models and to investigate its clinical applicability. Methods: Stone die models were fabricated from conventional impressions(stone die model; SDM, n=7). 3D virtual models obtained from the digital impressions were manufactured as a 3D printed die models using a 3D printer(3D printed die models;3DM, n=7). Reference model, stone die models and 3D printed die models were scanned with a reference scanner. All dies model dataset were superimposed with the reference model file by the "Best fit alignment" method using 3D analysis software. Statistical analysis was performed using the independent t-test and 2-way ANOVA (α=.05). Results: The RMS value of the 3D printed die model was significantly larger than the RMS value of the stone die model (P<.001). As a result of 2-way ANOVA, significant differences were found between the model group (P<.001) and the part (P<.001), and their interaction effects (P<.001). Conclusion: The 3D printed die model showed lower accuracy than the stone die model. Therefore, it is necessary to further improve the performance of 3D printer in order to apply the 3D printed model in prosthodontics.

• 음성과학
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• 제8권3호
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• pp.201-208
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• 2001

The purpose of the study was to examine a method most pertinent to measure subglottic air pressure. Subglottic air pressure and loudness analyses were performed on vowels /a/, /i/ and consonant /p/ in 12 normal subjects using. Aerophone II voice function. The experimental contexts were, therefore, /i:pi:pi:/ and /a:pa:pa:/. The subjects produced the intervocalic /p/ in 4 different situations: 1) /i:pi:pi:/ with voiceless /p/, 2) /i:pi:pi:/ with voiced /p/, 3) /a:pa:pa:/ with voiceless /p/, and 4) /a:pa:pa:/ with voiced /p/. A t-test and a correlation analysis revealed the following results. First, when we measured subglottic air pressure by /i:pi:pi:/, voiceless /p/ was significantly different from voiced /p/. Second, when we measured subglottic air pressure by /a:pa:pa:/, voiceless /p/ was significantly different from voiced /p/. Therefore, it was concluded that voiceless /p/ produced more accurate subglottic air pressure and clinicians needed to have patients produce accurate /p/ when measuring subglottic air pressure using Aerophone II.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7111-7115
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• 2015

Background: The aim of the meta-analysis was to derive a more precise assessment of the association between p16 promoter methylation and thyroid cancer risk. Materials and Methods: The PubMed, Web of Science databases and Chinese CNKI were searched for relevant articles. Ultimately, seventeen case-control studies were included with a total of 804 thyroid cancer cases and 487 controls analysis by R Software (R version 3.1.2) including meta. Crude odds ratios with 95% confidence intervals were calculated using the random-effects model which were used to assess the strength of relationship between p16 methylation and lung carcinogenesis. Funnel plots were carried out to evaluate publication bias. Results: The meta-analysis results showed that the frequency of p16 promoter methylation in cancer tissue/blood was significantly higher than that normal tissue/blood (OR=5.46, 95%CI 3.12-9.55, P<0.0001) by random effects model with small heterogeneity. Conclusions: Thus, p16 promoter methylation may be associated with thyroid cancer risk.

• 대한골관절종양학회지
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• 제6권4호
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• pp.143-151
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• 2000

목적 : p53 종양억제 유전자는 사람의 암에서 변형이 가장 많이 발견되는 유전자로 유잉 육종에서 p53 유전자의 변형을 관찰하고자 하였다. 재료 및 방법 : 유잉육종 환자 35례의 파라핀 블록을 사용하였으며, 유전자의 결핍과 p53 유전자의 염기서열의 변형을 관찰하였다. 결과 : 정성적인 중합효소 연쇄반응을 이용한 p53의 4-9번까지의 유전자검사중 2례에서 동일성의 유전자 결핍이 관찰되었으며, exon 5-8의 유전자 중합효소 연쇄반응에서는 3례에서 missense 점돌연변이가 관찰되었다. 결론 : 이상의 결과로 p53은 유전적으로 적은 부분에서 유잉육종에 관여하는 것으로 관찰 되었다.