• Journal of Life Science
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• v.24 no.5
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• pp.485-490
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• 2014

Poria cocas has been reported to be effective in skin whitening. However, the direct effect of P. cocas ethanol extracts (PCEE) on melanin synthesis has not been scientifically studied. To elucidate the direct effect of PCEE on melanogenesis, a 3,4-dihydroxyindole-2-carboxylic acid (DOPA) synthesis assay, tyrosinase activity assay, and Western blotting for melanogenic proteins, including tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 were performed in mouse B16F1 cells. The results revealed that PGEE inhibited melanin production in a dose-dependent manner by blocking the synthesis of DOPA. Although the activation of tyrosinase was not affected, the expression levels of TRP-1 and TRP-2 were controlled. These results suggest that PCEE has a whitening effect, indicating that it may be a useful agent in the development of whitening cosmetics.

• Clinical and Experimental Pediatrics
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• v.58 no.1
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• pp.20-27
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• 2015

Purpose: We investigated the molecular types of uropathogenic Escherichia coli (UPEC) by using conventional phylogrouping, multilocus sequence typing (MLST), and fimH genotyping. Methods: Samples of patients younger than 18 years of age were collected from the Chung-Ang University Hospital over 2 years. Conventional phylogenetic grouping for UPEC strains was performed by polymerase chain reaction (PCR). Bacterial strain sequence types (STs) were classified on the basis of the results of partial sequencing of seven housekeeping genes. In addition, we analyzed nucleotide variations in a 424-base pair fragment of fimH, a major virulence factor in UPEC. Results: Sixty-four UPEC isolates were analyzed in this study. Phylogenetic grouping revealed that group B2 was the most common type (n=54, 84%). We identified 16 distinctive STs using MLST. The most common STs were ST95 (35.9%), ST73 (15.6%), ST131 (12.5%), ST69 (7.8%), and ST14 (6.3%). Fourteen fimH allele types were identified, of which 11 had been previously reported, and the remaining three were identified in this study. f1 (n=28, 45.2%) was found to be the most common allele type, followed by f6 and f9 (n=7, 11.3% each). Comparative analysis of the results from the three different molecular typing techniques revealed that both MLST and fimH typing generated more discriminatory UPEC types than did PCR-based phylogrouping. Conclusion: We characterized UPEC molecular types isolated from Korean children by MLST and fimH genotyping. fimH genotyping might serve as a useful molecular test for large epidemiologic studies of UPEC isolates.

• Journal of the Korean Society for Library and Information Science
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• v.47 no.3
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• pp.343-361
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• 2013

We proposed and evaluated a tag semantic analysis method in which original tags are expanded and the semantic relations between original or expanded tags are used to extract key sentences from lecture speech transcripts. To do that, we first investigated how useful Flickr tag clusters and WordNet synonyms are for expanding tags and for detecting the semantic relations between tags. Then, to evaluate our proposed method, we compared it with a latent semantic analysis (LSA) method. As a result, we found that Flick tag clusters are more effective than WordNet synonyms and that the F measure mean (0.27) of the tag semantic analysis method is higher than that of LSA method (0.22).

• Journal of the Korean Society for information Management
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• v.36 no.4
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• pp.83-105
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• 2019

This study aims to suggest an effective method for the automatic classification of keywords with similar patterns by calculating pattern similarity of temporal data. For this, large scale news on the Web were collected and time series data composed of 120 time segments were built. To make training data set for the performance test of the proposed model, 440 representative keywords were manually classified according to 8 types of trend. This study introduces a Dynamic Time Warping(DTW) method which have been commonly used in the field of time series analytics, and proposes an application model, MA-DTW based on a Moving Average(MA) method which gives a good explanation on a tendency of trend curve. As a result of the automatic classification by a k-Nearest Neighbor(kNN) algorithm, Euclidean Distance(ED) and DTW showed 48.2% and 66.6% of maximum micro-averaged F1 score respectively, whereas the proposed model represented 74.3% of the best micro-averaged F1 score. In all respect of the comprehensive experiments, the suggested model outperformed the methods of ED and DTW.

• Restorative Dentistry and Endodontics
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• v.18 no.2
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• pp.341-356
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• 1993

In the prevention of root surface caries, antimicrobial therapy for the control of subgingival and supragingival plaque is seriously considered as a long term suppression of pathogenic microflora. Recently, varnishes containing antimicrobial agents have been developed to control the supragingival microflora. The purpose of this study was to determine the antimicrobial effects of 20% chlorhexidine varnish and 2.6% silane fluoride varnish with sealant. In clinical experiments, 12 subjects were selected from the periodontally treated patient and divided into 3 groups. After a dental prophylaxis, the subjects were treated with single application of placebo varnish (group I), 20% chlorhexidine varnish (group II), and 2.6% silane fluoride varnish (group III). Root surface plaque samples were taken before (baseline) and one, two, four, and 8 weeks after the treatments. Microbiological examinations of root surface plaque were performed with culture study and indirect immunoflorescence (I.I.F.) study, and immunological examination of gingival crevicular fluid antibody titers was performed with ELISA study. The results were as follows: 1. Pathogenic microflora on the root surface including S. mutans, S. sanguis, S. mitis, A. naeslundii, A. viscosus were 24 - 37% on I.I.F. study. 2. S. mutans, S. sanguis, S. mitis, A. naeslundii, A. viscosus of the root surface plaque was significantly reduced from 1 week to 8 weeks after antimicrobial varnish treatment, but showed generally increasing tendency in control group. 3. Gingival crevicular fluid antibody titers were significantly reduced from 1 or 2 weeks to 4 weeks after antimicrobial varnish treatment.

• The Journal of Korean Society for School & Community Health Education
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• v.16 no.1
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• pp.15-25
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• 2015

Objectives: The purpose of this study was to identify the mediated effect of social support in relationship of stress and mental health of woman college students. Methods: Data were collected by distributing self recording type questionnaire to 336 woman students in three universities placed in Gyeonggi-do, who agreed attending to the research, and then were re-collected. The statistical methods used for data analysis were the descriptive statistics, frequency analysis, One-way ANOVA test, Pearson correlation coefficient, hierarchial regression analysis. Results: 1. According to the research, it appeared that social support differed depending on the grade the one is in(F=10.643, p<0.05), and mental health(F=3.446, p<0.05) and social support(F=2.444, p<0.05) differed depending on the family's economical level. 2. As the result of analysis of relationship of objects' mental health, stress, and social support, it appeared that mental health and stress(r=-0.605, p<0.01), mental health and social support(r=0.276, p<0.01) have relationship to each other. 3. As the result of hierarchial regression analysis for verifying the mediated effect of social support in relationship of research objects' stress and mental health, it showed that social support partially mediate in relationship of stress and mental health. Conclusion: The program which can intensify woman college students' social support and decrease stress needs to be developed and provided, in order to arrange solution of promoting woman students' mental health.

• Korean Journal of Plant Resources
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• v.34 no.1
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• pp.89-97
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• 2021

Two unrecorded alien plants, Pilea microphylla (L.) Liebm. (Urticaceae) and Elsholtzia griffithii Hook. f. (Lamiaceae), were found in Korea. P. microphylla was discovered in Seoul-si and Jeju-do. This species is distinguished from other related Korean taxa by leaf characteristics such as spatulate or obovate shape and 2-7 mm long with entire margin. E. griffithii was discovered in Incheon-si. This species is defined by spikes, narrowly lanceolate bract with 3 mm long and relatively shorter corolla length as ca 2.5 mm. Here, we provide Korean name, descriptions of the morphological characteristics, photographs and a key to allied taxa.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.6
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• pp.1154-1162
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• 2016

This paper proposes a fast-transient digital LDO(Low dropout) regulator with binary-weighted current control technique. Conventional digital LDO takes a long time to stabilize the output voltage, because it controls the amount of current step by step, thus ringing problem is generated. Binary-weighted current control technique rapidly stabilizes output voltage by removing the ringing problem. When output voltage reliably reaches the target voltage, It added the FRZ mode(Freeze) to stop the operation of digital LDO. The proposed fast response digital LDO is used with a slow response DC-DC converter in the system which rapidly changes output voltage. The proposed digital controller circuit area was reduced by 56% compared to conventional bidirectional shift register, and the ripple voltage was reduced by 87%. A chip was implemented with a $0.18{\mu}F$ CMOS process. The settling time is $3.1{\mu}F$ and the voltage ripple is 6.2mV when $1{\mu}F$ output capacitor is used.

• Journal of Hydrogen and New Energy
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• v.26 no.2
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• pp.170-178
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• 2015

In this study, we carry out a study on how to improve performance of vanadium redox flow battery (VRFB) through promoting reaction rate of rate determining vanadium reaction ($[VO]^{2+}/[VO_2]^+$). In order to do that, three different carbons like Vulcan (XC-72), CMK3 and MSU-F-C are adopted as the catalysts, while their catalytic activity and reaction reversibility are evaluated using half-cell tests. Their topological images are also measured by TEM. For estimation of the VRFB performance, multiple charge-discharge curves of VRFBs including the catalysts are measured by single cell tests. As a result of that, MSU-F-C shows relatively excellent catalytic activity and reaction reversibility as well as large surface area compared to those of Vulcan (XC-72) and CMK3. Also, in terms of the performance of VRFBs including the catalysts, VRFB including MSU-F-C indicates (i) low charging/discharging overpotentials and low internal resistance, (ii) high charge/discharge capacities and (iii) high energy efficiency. These VRFB performance data are well agreed with results on catalytic activity and reaction reversibility. The reason that MSU-F-C induces superior VRFB performances is attributed to (i) its large surface area and (ii) its hydrophilic surface functional groups that mainly consist of hydroxyl bonds that are supposed to play active surface site role for facilitaing $[VO]^{2+}/[VO_2]^+$ redox reaction. Based on the above results, it is found that adoption of MSU-F-C as catalyst for VRFB results in improvement in VRFB performance by promoting the languid $[VO]^{2+}/[VO_2]^+$ redox reaction.

• Journal of Life Science
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• v.24 no.9
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• pp.946-951
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• 2014

Melanin plays a key role in the protection of skin from ultraviolet light that generates reactive oxygen species (ROS), such as superoxide, hydroxyl radical, singlet oxygen and hydrogen peroxide. However, the ROS leading to the oxidation of lipids, proteins and DNA are involved in the overproduction of melanin that is known to cause melasma, age spots and freckles. Among the herb medicines, Ulmus macrocarpa used in this study was reported to contain flavonoids as a main component. The aim of this study is to investigate the whitening and anti-oxidant effects of Ulmus macrocarpa ethanolic extracts (UMEE) in B16F1 cells. UMEE below $3.12{\mu}g/ml$ did not show cytotoxicity. In an anti-oxidant experiment, UMEE showed not only high reducing power and scavenging activity on DPPH, but it was also observed that UMEE exhibit an inhibitory effect on lipid peroxidation. UMEE did not display an inhibitory effect on tyrosinase activity in vitro. However, UMEE inhibited melanin synthesis in B16F1 cells. In addition, UMEE reduced the expression levels of tyrosinase and tyrosinase-related protein-2 (TRP-2), which are key enzymes in melanogenesis. These results indicate that UMEE exert a whitening effect through the inhibition of both tyrosinase and TRP-2 expressions as well as anti-oxidant activity, suggesting that UMEE could have the functional potential for a whitening effect on the skin.