• Molecules and Cells
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• v.37 no.11
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• pp.819-826
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• 2014

Protein modifications of recombinant pharmaceuticals have been observed both in vitro and in vivo. These modifications may result in lower efficacy, as well as bioavailability changes and antigenicity among the protein pharmaceuticals. Therefore, the contents of modification should be monitored for the quality and efficacy of protein pharmaceuticals. The interface of EPO and its receptor was visualized, and potential amino acids interacting on the interface were also listed. Two different types of modifications on the interface were identified in the preparation of rHu-EPO BRP. A UPLC/Q-TOF MS method was used to evaluate the modification at those variants. The modification of the oxidized variant was localized on the Met54 and the deamidated variants were localized on the Asn47 and Asn147. The extent of oxidation at Met54 was 3.0% and those of deamidation at Asn47 and Asn147 were 2.9% and 4.8%, respectively.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2010.11a
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• pp.14-17
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• 2010

Following the proliferation of three-dimensional video contents and displays, many terrestrial broadcasting companies prepare for starting stereoscopic 3DTV service. In terrestrial stereoscopic broadcast, it is a difficult task to code and transmit two video sequences while sustaining as high quality as 2DTV broadcast attains due to the limited bandwidth defined by the existing digital TV standards such as ATSC. Thus, a terrestrial 3DTV broadcasting system with heterogeneous video coding systems is considered for terrestrial 3DTV broadcast where the left image and right images are based on MPEG-2 and H.264/AVC, respectively, in order to achieve both high quality broadcasting service and compatibility for the existing 2DTV viewers. Without significant change in the current terrestrial broadcasting systems, we propose a joint rate control scheme for stereoscopic 3DTV service. The proposed joint rate control scheme applies to the MPEG-2 encoder a quadratic rate-quantization model which is adopted in the H.264/AVC. Then the controller is designed for the sum of two bit streams to meet the bandwidth requirement of broadcasting standards while the sum of image distortions is minimized by adjusting quantization parameter computed from the proposed optimization scheme. Besides, we also consider a condition on quality difference between the left and right images in the optimization. Experimental results demonstrate that the proposed bit rate control scheme outperforms the rate control method where each video coding standard uses its own bit rate control algorithm in terms of minimizing the mean image distortion as well as the mean value and the variation of absolute image quality differences.

• Journal of the HCI Society of Korea
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• v.7 no.1
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• pp.1-10
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• 2012

This paper deals with the effects of seat position in the theater on viewers' visual fatigue, presence, and perceived characteristics. As a result of this study, there is a significantly positive effect of Dx(deviation from mean distance from the screen) and viewing angle on visual fatigue. Second, there is no significant effect of seat position on presence. Finally, there is a significantly negative effect of Dx and viewing angle on perceived characteristics. This means, as the author assume, the seat position in the theater during watching a 3D movie is important in case of visual fatigue and perceived characteristics. This paper provides an empirical result related to effect of spatial variable at 3D theater on 3D effect. The results could be helpful to establish spatial standard in 3D theater and 3D contents; furthermore, it could help to establish regulations of visual fatigue induced from 3D effects and indications for 3D efficiency.

• Journal of Broadcast Engineering
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• v.19 no.6
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• pp.896-906
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• 2014

In this paper, a real-time dual-mode temporal synchronization and compensation method based on a new reliability measure in stereoscopic video is proposed. The goal of temporal alignment is to detect the temporal asynchrony and recover synchronization of the two video streams. The accuracy of the temporal synchronization algorithm depends on the 3DTV contents. In order to compensate the temporal synchronization error, it is necessary to judge whether the result of the temporal synchronization is reliable or not. Based on our recently developed temporal synchronization method[1], we define a new reliability measure for the result of the temporal synchronization method. Furthermore, we developed a dual-mode temporal synchronization method, which uses a usual texture matching method and the temporal spatiogram method[1]. The new reliability measure is based on two distinctive features, a dynamic feature for scene change and a matching distinction feature. Various experimental results show the effectiveness of the proposed method. The proposed algorithms are evaluated and verified through an experimental system implemented for 3DTV.

• Journal of Broadcast Engineering
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• v.27 no.4
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• pp.569-580
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• 2022

In this study, we investigated the effect of peripheral blur on binocular fusion to resolve binocular fusion failure which is one of the 3D visual fatigues in the perspective of human visual system. With stimulus having discrete disparity change, binocular fusion failure rate for target stimulus having crossed and uncrossed disparity decreased. And target stimulus having continuous disparity also required relatively larger binocular disparity when peripheral blur was presented with target stimulus rather than when peripheral blur was not presented. These results imply that peripheral blur facilitated binocular fusion in the situation of binocular disparity change, and suggest that considering the characteristics of human three-dimensional visual systems, manipulating 3D contents can improve visual discomfort caused by binocular displays at low costs.

• Journal of Broadcast Engineering
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• v.19 no.4
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• pp.478-490
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• 2014

In order to make 3-D display technique a better tool to provide viewers with realistic stereoscopic experience, various researches have been done in the many relevant fields. This psychophysical study was designed to investigate whether there was any difference in the perceptual processing between a dominant and non-dominant eye when a 3-D cue was provided exclusively to only one eye. We measured the reaction time for detecting a depth change by providing the viewer's each eyes with differential 3-D stimuli, which have systematical patterns. We obtained that there was a consistent 3-D perceptual performance when the 3-D cue was provided to the viewers' left eye regardless of their eye dominance. The result suggests that it might be a better technique to arrange the camera for left eye to carry 3-D cues to get the viewer's consistent 3-D perception.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.28 no.6
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• pp.669-676
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• 2010

Visualization requires for effective analysis of the spatial data collected by various sensors. The best way to convey 3D digital spatial information which is modeling of the real world to the users, realistic 3D visualization and display technology. Since most of the display is based on 2D or 2.5D projection to the plane, there is limitation in representing real world in 3D space. In this paper, data from airborne LiDAR for topographic mapping, Flashi-LiDAR as emerging sensor with great potential to 3D data acquisition, and multibeam echo-sounder for underwater measurement, were stereoscopically visualized. 3D monitors are getting popular and could be information media and platform in geoinformatics. Therefore, study on creating 3D stereoscopic contents of spatial information is essential for new technology of stereo viewing systems.

• Journal of Broadcast Engineering
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• v.19 no.5
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• pp.677-686
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• 2014

This paper analyzes the 3D accuracy of stereo images captured from a mobile phone. For 3D accuracy evaluation, we have compared the accuracy result according to the amount of the convergence angle. In order to calculate the 3D model space coordinate of control points, we perform inner orientation, distortion correction and image geometry estimation. And the quantitative 3D accuracy was evaluated by transforming the 3D model space coordinate into the 3D object space coordinate. The result showed that relatively precise 3D information is generated in more than $17^{\circ}$ convergence angle. Consequently, it is necessary to set up stereo model structure consisting adequate convergence angle as an measurement distance and a baseline distance for accurate 3D information generation. It is expected that the result would be used to stereoscopic 3D contents and 3D reconstruction from images captured by a mobile phone camera.

• Journal of Korea Multimedia Society
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• v.19 no.3
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• pp.548-556
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• 2016

Integral imaging is an auto-stereoscopic display method that can produce 3D image of a finite viewing window through an array of micro elemental lenses. Integral imaging requires the pickup part of each elemental images acquisition and display part of reconstruction of the images. The successful reconstructed image depends on various parameters such as distance between lens arrays and display device, focal length of lenses, and a number of the array. In this paper, we present reconstruction emulator for display of Integral imaging in order to adjust parameters for 3D contents reconstruction and to observe the result from different configuration. Especially, we provide the user interface for the emulator to control the distance easily. We have confirmed through various experiments that the emulator adjusted the distance and could check error in the process of creating elemental images.

• Journal of Korea Society of Digital Industry and Information Management
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• v.9 no.2
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• pp.99-109
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• 2013

In this paper, we propose a new system which captures real depth and color information from natural scene and implemented it. Based on it, we produced stereo and multiview images for 3-dimensional stereoscopic contents and introduced the production of a digital hologram which is considered to the next-generation image. The system consists of both a camera system for capturing images which correspond to RGB and depth images and softwares (SWs) for various image processings which consist of pre-processing such as rectification and calibration, 3D warping, and computer generated hologram (CGH). The camera system use a vertical rig with two paris of depth and RGB camera and a specially manufactured cold mirror which has the different transmittance according to wavelength for obtaining images with the same view point. The wavelength of our mirror is about 850nm. Each algorithm was implemented using C and C++ and the implemented system can be operated in real-time.