• Composites Research
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• 제15권1호
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• pp.1-8
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• 2002

본 연구에서는 실제 구조형상의 사각형 상자형 날개와 전투기 날개에 대하여 구조재를 표피(skin)부분은 복합재료로 대체하고, 나머지 스파(spar)와 리브(rib)는 알루미늄으로 하여 플러터 해석을 수행하였다. MS/PATRAN을 이용하여 실제 날개 구조에 근사한 3차인 유한 요소 모델이 구축되었고, MSC/NASTRAN을 이용하여 고유진동 해석이 수행되었다. 유한 요소는 멤브레인(membrane)요소, 1차원 막대(rod)요소, 전단패널(shear panel)요소를 사용하였다. 복합재료의 적층은 실제적인 적층각을 이용하여 다양하게 변화시켜 해석하였다. 아음속 영역에서 비정상 공력 해석을 위하여 주파수 영역에서의 선형 공기력 이론인 DLM코드가 적용되었고, 주파수 영역 공탄성 지배방정식의 해법으로 V-g방법 및 p-k방법이 적응되었다.

• Advances in Computational Design
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• 제6권1호
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• pp.15-30
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• 2021

With improvement in innovative manufacturing technologies, it became possible to fabricate any complex shaped structural design for practical applications. This allows for the fabrication of curvilinearly stiffened pressure vessels and pipes. Compared to straight stiffeners, curvilinear stiffeners have shown to have better structural performance and weight savings under certain loading conditions. In this paper, an optimization framework for designing curvilinearly stiffened composite pressure vessels and pipes is presented. NURBS are utilized to define curvilinear stiffeners over the surface of the pipe. An integrated tool using Python, Rhinoceros 3D, MSC.PATRAN and MSC.NASTRAN is implemented for performing the optimization. Rhinoceros 3D is used for creating the geometry, which later is exported to MSC.PATRAN for finite element model generation. Finally, MSC.NASTRAN is used for structural analysis. A Bi-Level Programming (BLP) optimization technique, consisting of Particle Swarm Optimization (PSO) and Gradient-Based Optimization (GBO), is used to find optimal locations of stiffeners, geometric dimensions for stiffener cross-sections and layer thickness for the composite skin. A cylindrical pipe stiffened by orthogonal and curvilinear stiffeners under torsional and bending load cases is studied. It is seen that curvilinear stiffeners can lead to a potential 10.8% weight saving in the structure as compared to the case of using straight stiffeners.

• JSTS:Journal of Semiconductor Technology and Science
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• 제10권4호
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• pp.300-308
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• 2010

This paper describes the development of a low-power electrocardiogram (ECG) touch sensor intended for the use with two dry metal electrodes. An equivalent ECG extraction circuit model encountered in a ground-free two-electrode configuration is investigated for an optimal sensor read-out circuit design criteria. From the equivalent circuit model, (1) maximum sensor resolution is derived based on the electrode's background thermal noise, which originates from high electrode-skin contact impedance, together with the input referred noise of instrumentation amplifier (IA), (2) 60 Hz electrostatic coupling from mains and motion artifact are also considered to determine minimum requirement of common mode rejection ratio (CMRR) and input impedance of IA. A dedicated ECG read-out front end incorporating chopping scheme is introduced to provide an input referred circuit noise of 1.3 ${\mu}V_{rms}$ over 0.5 Hz ~ 200 Hz, CMRR of IA > 100 dB, sensor resolution of 7 bits, and dissipating only 36 ${\mu}W$. Together with 8 bits synchronous successive approximation register (SAR) ADC, the sensor IC chip is implemented in 0.18 ${\mu}m$ CMOS technology and integrated on a 5 cm $\times$ 8 cm PCB with two copper patterned electrodes. With the help of proposed touch sensor, ECG signal containing QRS complex and P, T waves are successfully extracted by simply touching the electrodes with two thumbs.

• 패션비즈니스
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• 제21권6호
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• pp.47-65
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• 2017

This study is intended to compare an actual wedding dress being made completely through 3D software, and compare it with an actual dress of a real model by using collective tools for comparative analysis. The method of the study was conducted via a literature review along with the production of the dresses. In the production, two wedding dresses for the small wedding ceremony were designed. Each of the design was made into both 3D and an actual garment. The results are as follows. First, the 3D whole body scanner reflects the measure of the exact human body size, however there were some difficulties in matching what the customer wanted, because the difference of the skin color and the hair style. Second, the pattern of the dress is much more easily altered than it was in the real production. Third, the silhouette of the virtual and the actual person with the dress was nearly the same. Fourth, textile tool was much more convenient because of the use of real-time rendering on the virtual dresses. Lastly, the lace and biz decoration were flat, and the luster was duller than in reality. Prospectively, the consumer will decide their own design of variety through the use of the avatar without wearing the actual dresses, and they would demand what the another one desired, different from the presented ones by making the corrections by themselves. Through this process, the consumer would be actively participating in the design, a step which would finally lead to the two way designing rather than the one way design of present times.

• 한국지반환경공학회 논문집
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• 제24권1호
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• pp.5-14
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• 2023

본 연구에서는 설계 대상인 현장타설말뚝기초에 대하여 상사율을 고려한 하중전이 대형토조 모형시험과 3차원 수치해석을 수행함으로써 현장타설말뚝 선단부와 주면부의 하중전이 특성을 분석하고 하중분담율을 산정하였다. 대형토조 모형시험 및 3차원 수치해석 결과에서 나타난 현장타설말뚝의 선형적 거동으로부터, 본 연구의 설계 조건에 대한 주면하중전이곡선은 Baquelin 등의 제안식, 선단하중전이곡선은 Baquelin 등의 제안식, 수평하중전이곡선은 Reese 등의 제안식이 적정한 것으로 확인되었다. 암반근입부에서 축하중은 시험값이 수치해석값보다 약간 크게 측정되었지만 암반 근입부에서 하중분담율은 연직하중이 증가함에 따라 평균적으로 약 27.8%의 분담율을 나타내었다. 연직재하 시에 말뚝두부의 침하량은 해석값이 시험값보다 약간 작게 평가되었으며, 모형시험 및 해석 최대 연직하중에서 말뚝두부의 최대 침하량은 시험치 10.6mm, 해석치 10.0mm 이고, 말뚝선단에서 최대 침하량은 시험치 2.0mm, 해석치 1.9mm로 나타났다. 수평재하 시에 기둥 두부(지표)와 말뚝 두부에서 수평변위는 시험값과 해석값이 비교적 잘 일치하는 것으로 나타났고, 모형토조시험 결과 최대 수평변위 38.0mm에서 측정된 수평하중은 24,713kN, 수치해석에서의 수평하중은 26,073kN으로 평가되었다.

• 한국항공우주학회지
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• 제45권3호
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• pp.202-211
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• 2017

본 연구에서는 KFLOW에서 사용하고 있는 ${\gamma}-Re_{\theta}$ 천이 모델을 사용하여 KARI-11-180 익형의 공력특성을 수치적으로 예측하고 그 결과를 실험 결과 및 XFOIL과 MSES의 결과와 비교하였다. 완전 난류모델은 천이모델에 비해 마찰항력을 크게 예측하기 때문에 전체적으로 높은 항력을 예측하는 등 천이모델과 완전 난류모델간의 차이를 확인하였다. KFLOW의 ${\gamma}-Re_{\theta}$ 모델을 사용한 결과는 실험을 통해 확인된 천이 유동 실험 결과의 특성을 잘 예측하고 있었으며 XFoil이나 MSES의 결과와도 잘 일치하고 있음을 확인하였다. 본 연구를 통해 drag-bucket현상이 익형 표면의 천이점의 급격한 변화로 인해 발생함을 확인하였다.

• Journal of Advanced Marine Engineering and Technology
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• 제29권6호
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• pp.637-644
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• 2005

This paper describes the numerical simulation of the interaction between longitudinal vortices ("common flow up") and a 3-D turbulent boundary layer over a flat plate To analyze the common flow up Produced from vortex generators. the flow field behind the vortex generators Is modeled by the information that is available from studies on a half-delta winglet. Also. the Reynolds-averaged Navier-Stokes equation for three-dimensional turbulent flows. together with a two-layer turbulence model to resolve the near-wall flow, is solved by the method of AF-ADI. The computational results predict that the boundary layer is thinned in the regions where the secondary flow is directed toward the wall and thickened where it is directed away from the wall Also. the numerical results. such as Reynolds stresses. turbulent kinetic energy and skin friction characteristics generated from the vortex generators . are reasonably close to the experimental data.

• 한방안이비인후피부과학회지
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• 제24권1호
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• pp.121-141
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• 2011

Objective : This Experimental study was done to investigate the Effect of Taklisodok-um and Hwangryunhaedok-tang(TH) on Atopic Dermatitis. Methods : We assessed effects of TH on the IgE, IL-4, IL-5, IL-6, IgM, IgG1, IFN-${\gamma}$ in vivo, on the IL-4, IL-5, CCR3 in the skin tissues of ear and dorsum with NC/Nga mice. And we assessed effects of TH on the COX-2, IL-$1{\beta}$, TNF-${\alpha}$, IL-6 with RAW 264.7 cell. Results and Conclusion : 1. IgE, IL-4, IL-5, IL-6, IgM, IgGl levels in the serum of TH treated NC/Nga mouse group were decreased compared to the untreated control mice. IFN-r showed a increase in the experimental group compared to the untreated control group. The spleen weight of TH treated NC/Nga mice was decreased compared to the untreated control group. 2. mRNA expression levels of IL-4, IL-5 and CCR3 in the skin tissues of TH treated NC/Nga mice were decreased, and expression levels of IL-6 in the skin tissues of TH treated NC/Nga mice were decreased compared to the untreated control group. IFN-${\gamma}$ mRNA expression levels were increased compared to the untreated control group. 3. Judged from that IL-$1{\beta}$, TNF-${\alpha}$, IL-6 express of gene, effect of inflammatory Cytokines revelation were decreased compared to the untreated control group. 4. Depend on the strength of TH, inflammatory RAW 264.7 in the serum of TH were inhibited compared to the untreated control serum that leaded a COX-2 activity model. 5. Histological observation of the ear and skin tissues showed that the extents of inflammation and infiltrated immune cells in the epidermis and dermis of TH treated NC/Nga mice were highly reduced compared to the untreated control group.

• Journal of Veterinary Science
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• 제24권3호
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• pp.44.1-44.17
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• 2023

Background: Antibiotic resistance is a significant public health concern around the globe. Antimicrobial peptides exhibit broad-spectrum and efficient antibacterial activity with an added advantage of low drug resistance. The higher water content and 3D network structure of the hydrogels are beneficial for maintaining antimicrobial peptide activity and help to prevent degradation. The antimicrobial peptide released from hydrogels also hasten the local wound healing by promoting epithelial tissue regeneration and granulation tissue formation. Objective: This study aimed at developing sodium alginate based hydrogel loaded with a novel antimicrobial peptide Chol-37(F34-R) and to investigate the characteristics in vitro and in vivo as an alternative antibacterial wound dressing to treat infectious wounds. Methods: Hydrogels were developed and optimized by varying the concentrations of crosslinkers and subjected to various characterization tests like cross-sectional morphology, swelling index, percent water contents, water retention ratio, drug release and antibacterial activity in vitro, and Pseudomonas aeruginosa infected wound mice model in vivo. Results: The results indicated that the hydrogel C proved superior in terms of cross-sectional morphology having uniformly sized interconnected pores, a good swelling index, with the capacity to retain a higher quantity of water. Furthermore, the optimized hydrogel has been found to exert a significant antimicrobial activity against bacteria and was also found to prevent bacterial infiltration into the wound site due to forming an impermeable barrier between the wound bed and external environment. The optimized hydrogel was found to significantly hasten skin regeneration in animal models when compared to other treatments in addition to strong inhibitory effect on the release of pro-inflammatory cytokines (interleukin-1β and tumor necrosis factor-α). Conclusions: Our results suggest that sodium alginate -based hydrogels loaded with Chol-37(F34-R) hold the potential to be used as an alternative to conventional antibiotics in treating infectious skin wounds.

• IMMUNE NETWORK
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• 제5권3호
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• pp.137-143
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• 2005

Background: Millions of people in the world are suffering from atopic dermatitis (AD), which is a chronic inflammatory skin disease triggered by Th2 immune responses. The NC/Nga mouse is the most extensively studied animal model of AD. Like human AD, NC/Nga mice demonstrate increased levels of IgE, a hallmark of Th2 immune responses. Adaptive immunity cannot be generated without help of innate immunity. Especially natural killer T (NKT) cells and marginal zone B (MZB) cells have been known to play important roles in linking innate immunity to adaptive immunity. Methods: Through flow cytometric analysis and ELISA assay, we investigated whether these lymphocytes might be altered in number in NC/Nga mice. Results: Our data demonstrated that the number of NKT cells was reduced in NC/Nga mice and IFN${\gamma}$ production by NKT cells upon ${\alpha}-GalCer$ stimulation decreased to the levels of CD1d KO mice lacking in NKT cells. However, reduction of NKT cells in NC/Nga mice was not due to CD1d expression, which was normal in the thymus. Interestingly, there was a significant increase of $CD1d^{high}B220^+$ cells in the spleen of NC/Nga mice. Further, we confirmed that $CD1d^{high}B220^+$ cells are B cells, not dendritic cells. These $CD1d^{high}B220^+$ B cells show $IgM^{high}CD21^{high}CD23^{low}$, a characteristic phenotype of MZB cells. Conclusion: We provide the evidence that there are decreased activities of NKT cells and increased number of MZB cells in the NC/Nga mice. Our findings may thus explain why NC/Nga mice are susceptible to AD.