• BMB Reports
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• v.56 no.11
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• pp.594-599
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• 2023

A number of therapeutic drugs have been developed from functional chemicals found in plants. Knowledge of plants used for medicinal purposes has historically been transmitted by word of mouth or through literature. The aim of the present study is to provide a systemic platform for the development of lead compounds against breast cancer based on a traditional medical text. To verify our systematic approach, integrating processes consisted of text mining of traditional medical texts, 3-D virtual docking screening, and in vitro and in vivo experimental validations were demonstrated. Our text analysis system identified rutin as a specific phytochemical traditionally used for cancer treatment. 3-D virtual screening predicted that rutin could block EGFR signaling. Thus, we validated significant anti-cancer effects of rutin against breast cancer cells through blockade of EGFR signaling pathway in vitro. We also demonstrated in vivo anti-cancer effects of rutin using the breast cancer recurrence in vivo models. In summary, our innovative approach might be proper for discovering new phytochemical lead compounds designing for blockade of malignant neoplasm including breast cancer.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.1
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• pp.122-129
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• 2005

On the cluster system, the parallel code of rigid-plastic FEM has been developed. The cluster system, Simforge, has 15 processors and the total memory is 4.5GBytes. In the developed parallel code, the distributed data of the column-wise partitioned stiffness are stored as the compressed row storage and the diagonal preconditioned conjugate gradient solver is applied. The analysis of block upsetting is performed with the parallel code on Simforge cluster system. In this paper, the analysis results are compared and discussed.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.31 no.3 s.258
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• pp.217-224
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• 2007

A numerical analysis for a silencer with three baffles of 120mm tank gun has been performed. The Reynolds-Averaged Wavier-Stokes equations with Baldwin-Lomax turbulence model were employed to compute unsteady, compressible flow inside the tank gun and the silencer. An axisymmetric computational domain was constructed by using 12 multi block chimera grids. The resolution of flow field is observed by depicting calculated pressure and muzzle brake force. The peak blast pressure and noise through the silencer reduced approximately 99% and 41dB in comparison to the tank gun without the silencer at near filed.

• The Journal of Engineering Geology
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• v.28 no.3
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• pp.455-463
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• 2018

This study developed a method to quantitatively measure the size of cracks in concrete using X-ray CT images. We prepared samples with a diameter of 50 mm and a length of 100 mm by coring cracked concrete block that was obtained by chipping. We used a micro-focus X-ray CT, then applied the 3DMA method (3 Dimensional Medial axis Analysis) to the 3D CT images to find effective parameters for damage assessment. Finally, we quantitatively assessed the damage based on sample locations, using the damage assessment parameter. Results clearly show that the area near the chipping surface was damaged to a depth of 3 cm. Furthermore, X-ray methods can be used to evaluate the porosity index, burn number, and medial axis, which are used to estimate the damage to the area near the chipping surface.

• Journal of Environmental Impact Assessment
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• v.14 no.5
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• pp.247-254
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• 2005

Road traffic noise has increasing broader effects on urban areas as well as rural areas because of rapidly increasing traffic volume and newly-constructed roads. 10 sites in building development areas were selected and the noise level were measured by the apartment floors and by the various block plans of apartment complex. Analysis result, about correction factor, in the case of right angle arrangement, apply - 2.5dB(A). In the case of apartment house correlation of each floor apply 1st floors 0dB(A), 2st floors 1.2dB(A), 3st floors 2.1dB(A), 4st floors 2.6dB(A), 5st floors 2.7dB(A), 6st floors 2.7dB(A), 7st floors 2.4dB(A), 8st floors 2.0dB(A), 9st floors 1.6dB(A), 10st floors 1.1dB(A), 13st floors 0.2dB(A), 15st floors 0.5dB(A). The level of road traffic noise in the arrangement construction of right angle was about 3.0dB(A) at N-4 point and 2.1dB(A) at N-6 point lower than that of a plan figure, respectively. The results suggested that application of correction coefficient obtained by the apartment floor and by the arrangement construction can be improved in road traffic noise. The results suggested that application of correction coefficient obtained by the apartment floor and by the arrangement construction can be improved in road traffic noise.

• Journal of KIISE:Computing Practices and Letters
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• v.15 no.3
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• pp.211-215
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• 2009

As Programmable Logic Controllers (PLCs) are increasingly used to implement safety critical systems such as nuclear instrumentation & control system, formal verification for PLC based programs is becoming essential. This paper proposes a formal verification technique for PLC program implemented with function block diagram (FBD). In order to verify an FBD program, we translate an FBD program into a Verilog model and perform model checking using SMV model checker We developed a tool, FBD Verifier, which translates FBD programs into Verilog models automatically and supports efficient and intuitive visual analysis of a counterexample. With the proposed approach and the tool, we verified large FBD programs implementing reactor protection system of Korea Nuclear Instrumentation and Control System R&D Center (KNICS) successfully.

• Magazine of the Korean Society of Agricultural Engineers
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• v.32 no.3
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• pp.56-66
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• 1990

To investigate the status of irrigation water use and the degree of repeated use of irrigation water, observations for water balance analysis were made during the irrigation periods in 1986 and 1987 crop year. The total area of studied site is 1,441 ha. The site is a major portion of Jedaecheon basin which is located in Bubuk-myeon, Miryang-gun, Gyeongnam Province. The studied area was subdivided into six small blocks. The water balance analysis for these subdivided blocks were carried out considering characteristics of each block. Obtained results are as follow: 1.In mountainous sloppy paddy area(less than 7% slope), the surface inflow was 5A mm/day in average that is one third of the surface inflow into plain paddy area ; 16.7 mm/day. 2.The surface inflows at the vegetative stage and the ripening stage were 15.5 mm/day and 10.4 mm/day, respectively. Those figures were larger than the actual consumptive use at respective same stages ; 13.3 mm/day and 9.2 mm/day, respectively. Whereas, the surface inflow at generative stage was 12.5 mm/day which was less than 14.0 mm/day ; the actual consumptive use. 3.The range of the variation of water storage term was 1 mm/day. This means that there were no change in depth of ponded water on paddy fields. The relationship between the variation of water storage(AS) and the variation of ground water table(H) could be expressed as follow: : AS=0.14H+0.26 4.The ground water inflow: into the transition region ; paddy fields which are located continuously from the mountainous area to the plain area, was larger than the out flow from this region, in general. Rowever, in the plain region where the ground water utilization was predominant, the ground water outflow from this region was larger than inflow: to this region. The relationship between the ground water flow(G2- G1) and the consumptive use in large paddy area(D1-D2) could be expressed as follow: (G2-G1) =0.95(D1-D2) -3.79

• Genomics & Informatics
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• v.10 no.2
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• pp.110-116
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• 2012

Recent several studies have shown that the genetic variation of SCN5A is related with atrioventricular conduction block (AVB); no study has yet been published in Koreans. Therefore, to determine the AVB-associated genetic variation in Korean patients, we investigated the genetic variation of SCN5A in Korean patients with AVB and compared with normal control subjects. We enrolled 113 patients with AVB and 80 normal controls with no cardiac symptoms. DNA was isolated from the peripheral blood, and all exons (exon 2-exon 28) except the untranslated region and exon-intron boundaries of the SCN5A gene were amplified by multiplex PCR and directly sequenced using an ABI PRISM 3100 Genetic Analyzer. When a variation was discovered in genomic DNA from AVB patients, we confirmed whether the same variation existed in the control genomic DNA. In the present study, a total of 7 genetic variations were detected in 113 AVB patients. Of the 7 variations, 5 (G87A-A29A, intervening sequence 9-3C>A, A1673G-H558R, G3578A-R1193Q, and T5457C-D1819D) have been reported in previous studies, and 2 (C48G-F16L and G3048A-T1016T) were novel variations that have not been reported. The 2 newly discovered variations were not found in the 80 normal controls. In addition, G298S, G514C, P1008S, G1406R, and D1595N, identified in other ethnic populations, were not detected in this study. We found 2 novel genetic variations in the SCN5A gene in Korean patients with AVB. However, further functional study might be needed.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.9
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• pp.1703-1710
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• 2017

This paper propose a 3D point clouds (depth) security technique for digital holographic display service. Image contents encryption is a method to provide only authorized right owners with the original image information by encrypting the entire image or a part of the image. The proposed method detected an edge from a depth and performed quad tree decomposition, and then performed encryption. And encrypts the most significant block among the divided blocks. The encryption effect was evaluated numerically and visually. The experimental results showed that encrypting only 0.43% of the entire data was enough to hide the constants of the original depth. By analyzing the encryption amount and the visual characteristics, we verified a relationship between the threshold for detecting an edge-map. As the threshold for detecting an edge increased, the encryption ratio decreased with respect to the encryption amount.

• Journal of Environmental Science International
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• v.27 no.9
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• pp.803-807
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• 2018

This study evaluated the duck growth performance and the economic benefits on using illite as a feed additive for ducks. Illite powder at three levels (0%, 1%, and 1.5%) was added to commercial duck diets, and fed to 180 one-day-old ducks (Pekin, 3 replicates, 20 ducks per pen) using a randomized block design for 39 days. During the experimental period, there were no significant growth performance differences between treatments (p>0.05), except with the feed conversion ratio (p<0.05), for all periods (8-39 days). In addition, the dietary supplementation of 1% and 1.5% illite did not significantly improve (p>0.05) Feed Intake Cost (FIC), Weight Gain Value (WGV), Meat Production Cost (MPC), Economic Efficiency (EE), Profitability (P), or cost benefit ratio for 8 to 21 d, 22 to 39 d, and 8 to 39 d. However, the differences in meat production cost and profitability between treatments were statistically significant (p<0.05) for all periods (8-39 d). In conclusion, adding 1% and 1.5% illite to duck diets is not beneficial for improving either the duck growth performance or the economic indicators.