• Structural Engineering and Mechanics
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• 제38권6호
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• pp.803-823
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• 2011

In this paper, the three dimensional Parallel Realistic Failure Process Analysis ($RFPA^{3D}$-Parallel) code based on micromechanical model is employed to investigate the bonding behavior in FRP sheet bonded to concrete in single shear test. In the model, the heterogeneity of brittle disordered material at a meso-scale was taken into consideration in order to realistically demonstrate the mechanical characteristics of FRP-to-concrete. Modified Mohr-coulomb strength criterion with tension cut-off, where a stressed element can damage in shear or in tension, was adopted and a stiffness degradation approach was used to simulate the initiation, propagation and growth of microcracks in the model. In addition, a Master-Slave parallel operation control technique was adopted to implement the parallel computation of a large numerical model. Parallel computational results of debonding of FRP-concrete visually reproduce the spatial and temporal debonding failure progression of microcracks in FRP sheet bonded to concrete, which agrees well with the existing testing results in laboratory. The numerical approach in this study provides a useful tool for enhancing our understanding of cracking and debonding failure process and mechanism of FRP-concrete and our ability to predict mechanical performance and reliability of these FRP sheet bonded to concrete structures.

• Journal of Ginseng Research
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• 제41권4호
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• pp.556-565
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• 2017

Background: Recent studies have revealed that the properties Traditional Chinese Medicine is mostly associated with are substance and energy metabolism. Our study aimed to compare the effect of red ginseng (RG) (warm property) and ginseng leaves (GL; cold property) on the substance and energy metabolism of rats with hypothyroidism. Materials and methods: Rats were administered propylthiouracil intraperitoneally for 20 d to cause hypothyroidism. The reference group was orally administered Aconiti Lateralis Radix Praeparaia [FZ (Fuzi in Chinese)], while both the RG and GL groups were orally administrated crude drugs. The rectal, tail, toe, and axilla temperature of the rats were assayed every 3 d. Oxygen consumption, carbon dioxide production, heat production, and energy expenditure were measured via TSE phenoMaster/LabMaster animal monitoring system. Adenosine monophosphate-activated protein kinase, $Na^+-K^+$-ATPase, fumarase, pyruvic acid and cyclic adenosine monophosphate/cyclic guanosine monophosphate were determined. Results: The lower levels of triiodothyronine, tetraiodothyronine, and thyrotropin-releasing hormone and the higher level of thyroid stimulating hormone revealed the successful establishment of a hypothyroidism model. Oxygen consumption, carbon dioxide production, heat production, and energy expenditure in the FZ and RG groups were obviously increased. The activity of $Na^+-K^+$-ATPase and fumarase in the FZ and RG groups was significantly increased. The cyclic adenosine monophosphate/cyclic guanosine monophosphate level in the FZ and RG groups was increased, while the GL group showed the opposite. Conclusion: Our research provides a new way to explore the efficiency of Chinese medicine on the basis of the relationship between drug property and effects on substance and energy metabolism.

• 대한치과보철학회지
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• 제34권2호
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• pp.373-383
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• 1996

In order to compare the accuracy of impression method using addition silicone putty impression material, metal master die was fabricated with 4 cylindrical abutments that were similar in shape to mandibular arch. Among the 4 abutments, two(A, D) with 8mm width and 7mm height were formed in the 2nd molar regions and the other two(B, C) with 6mm width and 7mm height were on the canine regions. Impressions were taken using one-step putty wash impression technique and two-step putty wash impression technique by three different types of impression materials(Perfect, Express, Exaflex). Upon measuring the distance between the abutments on the model by three dimensional measuring machine, the percent of devitaion of the materials were obtained, rendering the following results. The results obtained are as follows : 1. There was no significant difference in accuracy in regard with the impression method between one-step putty wash impression technique and two-step putty wash impression technique using addition silicone putty impression material. 2. There were no difference in accuracy among with three different addition silicone putty impression materials. 3. All the distances between abutments on improved stone models increased in comparison with those on the metal master model.

• 대한치과보철학회지
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• 제43권4호
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• pp.478-486
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• 2005

Statement of problem : Fracture and dimensional change of an acrylic resin denture are a rather common occurrence. Purpose : The purpose of this study was to compare differences in dimensional changes and flexural strength of separate maxillary complete dentures after immediate deflasking by injection molding and conventional compression processing. Material and method: To evaluate dimensional stability, the maxillary dentures were fabricated by using different materials and methods. Lucitone 199(Dentsply Trubyte. york, pennsylvania, USA) and Vertex(Dentimex, zeist, Netherlands) were used as materials. Compression and injection packing methods were used as processing methods. The impression surface of the dentures was measured by 3D Scann-ing System(PERCEPTRON USA) and overlapped original impression surface of the master cast. To evaluate flexural strength, resin specimens were made according to the different materials, powder/liquid ratio and processing methods. Flexural strength of the complete resin specimens (64mm$\times$10mm$\times$3.3mm) were measured by INSTRON 4467. (INSTRON, England) The data was analyzed by ANOVA, t-test and Tukey test. (p<.05 level of significance) Result: The results were as follows 1. There was no significant differences between master model and denture base for each group in overall dimensional changes. 2. Palatal area was more stable than flange or alveolar area in dimensional stability. but. there was no significant differences among each area. 3. Materials and power/liquid ratio had an effect on flexural strength. (P<.05) Especially materials was most effective. (P<.05) 4. Lucitone 199(powder/liquid ratio followed by manufacturer's direction) showed higher flexural strength than Vertex. Conclusion : Dimensional stability or flexural strength are affected by materials rather than packing techniques.

• 터널과지하공간
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• 제29권6호
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• pp.468-479
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• 2019

최근 대두되고 있는 지하공간 활용의 필요성 증대에 따라 지하공간의 안정적인 활용을 위해서는 수리-역학적 복합거동에 대한 이해가 필수적이다. 본 연구에서는 향후 국내 다양한 현장 및 지중 조건을 고려한 연구를 수행하는데 도구가 될 수 있는 수치해석을 위한 시뮬레이터를 개발하였다. 이를 위해 지중의 유체역학과 열역학, 역학을 해석하는 과학 소프트웨어 중 하나인 OpenGeoSys와 지반의 여러 역학적 문제들을 해석하는데 전문성을 지닌 FLAC3D를 연계하기로 하였다. 연동해석 기법에 대한 조사를 통해 OpenGeoSys를 주(master)로, FLAC3D를 종속(slave)으로 하여 연계 해석하는 파일 기반의 순차적 연계 방식으로 알고리즘을 개발하였다. 또한, 개발된 시뮬레이터의 검증을 위해 포화된 상태에서의 단상 유체 거동과 관련한 Terzaghi의 압밀 문제를 벤치마크 모델로 선정하여 비교 검증을 수행하였으며, 해석적 해와 수치해석의 결과가 잘 일치하는 것을 확인하였다.

• 품질경영학회지
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• 제50권3호
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• pp.373-386
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• 2022

Purpose: This study proposes the application of Six Sigma management innovation method for more systematically enhanced execution of Quality by Design (QbD) activities. QbD requires a deeper understanding of the product and process at the design and development stage of the drug, and it is very important to ensure that no fault is fundamentally generated through thorough process control. Methods: Analyzing the background and specific procedures of quality improvement based on the drug design basis, and analyzing the key contents of each step, we have differentated and common points from the 6 Sigma methodology. We propose a new model of Six Sigma management innovation method suitable for pharmaceutical industry. Results: Regulatory agencies are demanding results from statistical analysis as a scientific basis in developing medicines to treat human life through quality improvement activities based on drug design. By utilizing the education system to improve the statistical analysis capacity in the Six Sigma activities and operating the 6 Sigma Belt system in conjunction, it helped systematically strengthen the execution power of quality improvement activities based on pharmaceutical design based on the members of the pharmaceutical industry. Conclusion: By using QbD Six Sigma, which combines quality enhancement based on pharmaceutical design basis and Six Sigma methodology suitable for pharmaceutical industry, it is possible to obtain satisfactory results both by pharmaceutical companies and regulators by using appropriate statistical analysis methods for preparing scientific evidence data required by regulatory.

• 한국CDE학회논문집
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• 제13권6호
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• pp.429-439
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• 2008

With a remote operated manipulator system, the situation at a remote site can be rendered through remote visualized image to the operator. Then the operator can quickly realize situations and control the slave manipulator by operating a master input device based on the information of the virtual image. In this study, the remote operator visual support system (ROVSS) was developed for viewing support of a remote operator to perform the remote task effectively. A visual support model based on virtual environment was also inserted and used to fulfill the need of this study. The framework for the system was created by Windows API based on PC and the library of 3D graphic simulation tool such as ENVISION. To realize this system, an operation test environment for a limited operating site was constructed by using experimental robot operation. A 3D virtual environment was designed to provide accurate information about the rotation of robot manipulator, the location and distance of operation tool through the real time synchronization. In order to show the efficiency of the visual support, we conducted the experiments by four methods such as the direct view, the camera view, the virtual view and camera view plus virtual view. The experimental results show that the method of camera view plus virtual view has about 30% more efficiency than the method of camera view.

• The Journal of Advanced Prosthodontics
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• 제14권4호
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• pp.250-261
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• 2022

PURPOSE. The purpose of this study was to analyze the marginal fit of three-unit resin prostheses printed with the stereolithography (SLA) method in two build orientations (45°, 60°) and two layer thicknesses (50 ㎛, 100 ㎛). MATERIALS AND METHODS. A master model for a three-unit resin prosthesis was designed with two implant abutments. Forty specimens were printed using an SLA 3D printer. The specimens were printed with two build orientations (45°, 60°), and each orientation was printed with two layer thicknesses (50 ㎛, 100 ㎛). The marginal fit was measured as the marginal gap (MG) and absolute marginal discrepancy (AMD), and MG and AMD measurements were performed at 8 points per abutment, for 16 points per specimen. All statistical analyses were performed using SPSS software. Two-way analysis of variance (ANOVA) was separately performed on the MG and AMD values of the build orientations and layer thicknesses. Moreover, one-way ANOVA was performed for each point within each group. RESULTS. The margins of the area adjacent to the pontic showed significantly high values, and the values were smaller when the build orientation was 45° than when it was 60°. However, the margin did not differ significantly according to the layer thicknesses. CONCLUSION. The marginal fit of the three-unit resin prosthesis fabricated by the SLA 3D method was affected by the pontic. Moreover, the marginal fit was affected by the build orientation. The 45° build orientation is recommended.

• 대한치과보철학회지
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• 제59권1호
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• pp.27-35
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• 2021

목적: 현재 임상에서 스캔바디를 이용한 임플란트의 디지털 인상이 활용되고 있으나 스캔바디의 형태에 따른 스캔의 정확도에 대한 연구는 부족한 실정이다. 본 연구의 목적은 구내 스캔바디의 형태에 따른 스캔의 정확도를 비교하고, 구강 내 노출 높이에 따른 라이브러리 중첩 정확도를 비교하기 위함이다. 재료 및 방법: 덴티폼 상에서 36번 치아를 삭제 후 모델 스캐너로 스캔하여 3D 프린터로 주모형을 출력하였다. 첫 번째 실험으로 세 종류(A, B, C)의 구내 스캔바디를 준비하여 각 그룹마다 다음과 같은 실험을 하였다: 36번 부위에 임플란트를 이상적인 위치로 식립 후 스캔바디를 15 N으로 체결하였다. 스캔바디가 체결된 주모형을 모델 스캐너로 스캔하여 master reference file (대조군)을 STL (Standard Tessellation Language) file로 생성하였다. 이후 구강 스캐너로 10회의 연속적인 스캔을 시행하여 10개의 STL file (실험군)을 생성하였다. 3D 측정 소프트웨어를 이용하여 대조군과 실험군들의 STL file들을 중첩한 후 좌표계 상에서 다음과 같은 값들을 도출하였다: 1) 스캔바디 상 특정 point의 거리 편차 2) 스캔바디 장축의 각도 편차. 두 번째 실험으로는 스캔바디의 구강내 노출 높이에 따른 라이브러리 중첩 정확도를 비교하기 위해 스캔바디 스캔 데이터를 7, 4.5, 2.5, 1.5, 1.0, 0.5 mm 총 6 가지 높이로 준비하여 라이브러리 파일과 중첩하였다. 전체가 노출된 7 mm 데이터를 대조군으로 하여 거리 편차와 각도 편차를 계산하였다. 결과: 첫번째 실험에서 A, B 스캔바디 간(P = .278), B, C 스캔바디 간(P = .568), C, A 스캔바디 간(P = .711) 스캔 파일의 거리 편차 모두 유의한 차이가 나타나지 않았다. A, B 스캔바디 간(P= .568), B, C 스캔바디 간(P = .546), C, A 스캔바디 간(P = .112) 스캔 파일의 각도 편차 또한 모두 유의한 차이가 나타나지 않았다. 또한 스캔바디는 구강 내 노출 높이가 높은 실험군(GH, Gingival Height = 4.5)의 라이브러리 중첩 정확도가 높이가 낮은 실험군(GH = 0.5)보다 통계적으로 유의하게 높았다 (P < .05). 결론: 스캔바디의 각기 다른 형태에 따른 스캔 정확도는 유의한 차이가 없었으며, 스캔바디의 구강 내 노출 높이에 따라 라이브러리 중첩의 정확도는 증가한다. 추후 in vivo 환경에서 더 다양한 형태의 스캔바디를 이용한 후속연구가 필요할 것이다.

• 구강회복응용과학지
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• 제36권4호
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• pp.254-261
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• 2020

목적: 본 연구의 목적은 서로 다른 제작 방법인 절삭 가공과 적층 가공 기술로 제작된 임시 보철물의 변연 및 내면 적합도를 평가하는 것이다. 연구 재료 및 방법: 상악 우측 제1대구치를 도재 수복을 위한 지대치 모형으로 준비하였다. 석고를 이용하여 총 40개의 실험 모형으로 복제하였고, 각각의 실험 모형을 구강 스캐너를 사용하여 스캔 데이터를 획득하였다. 3종의 3D 프린터(Meg-printer 2; Megagen, Zenith U; Dentis 그리고 Zenith D; Dentis) 및 1종의 밀링 장비(imes-icore 450i; imes-icore GmbH)를 사용하여 각 그룹당 10개의 임시 보철물을 제작하였다. 임시 보철물의 내면에 실리콘을 채우고 모형에 적합하여 중합이 완료된 후, 실리콘으로 내면이 복제되어 있는 실험 모형을 구강 스캐너를 사용하여 스캔 데이터를 획득하였다. 3차원 검사 소프트웨어(Geomagic control X; 3D Systems)를 이용하여 변연 간격, 절대 변연 간격, 섐퍼, 축벽, 교두, 교합 영역의 적합도를 분석하였다. 통계 분석은 제작 방법의 차이를 비교하기 위해서 Kruskal-Wallis test를 사용하여 검증하였으며, 사후 검정을 위해서 Mann-Whitney U-test and Bonferroni correction method을 사용하였다(α = 0.05). 결과: 3종의 3D 프린터와 1종의 밀링 장비에서 제작된 임시 보철물의 절대 변연 간격은 유의한 차이를 보이지 않았다(P = 0.812). 축벽, 교합 간격에서 밀링 장비와 3D 프린터 사이에 유의한 차이를 보였다(P < 0.001). 결론: 3종의 3D 프린터로 제작된 임시 보철물의 변연 적합도는 모두 임상적 허용 범위(< 120 ㎛)에 있었으므로, 적합도 측면에서 본다면 임시 보철물 제작을 위해서 충분히 사용될 수 있다.