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Association between assisted reproductive technology and autism spectrum disorders in Iran: a case-control study

  • Jenabi, Ensiyeh;Seyedi, Mahdieh;Hamzehei, Ronak;Bashirian, Saeid;Rezaei, Mohammad;Razjouyan, Katayoon;Khazaei, Salman
    • Clinical and Experimental Pediatrics
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    • v.63 no.9
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    • pp.368-372
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    • 2020
  • Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by impairments in social interaction and verbal and nonverbal communication. Purpose: Determine the association between use of assisted reproduction technology (ART) and the risk of ASD among children. Methods: This case-control study included 300 participants (100 cases, 200 controls). The control group included women with a child aged 2-10 years without ASD, while the cases were women with a child aged 2-10 years with ASD. We used a researcher-made questionnaire. Data were analyzed using Stata ver. 14 at the 0.05 significance level. Results: In the univariate analysis, there was significant association between child sex, delivery mode, history of preterm delivery, history of using ART, and maternal age at child's birth and the risk of ASD. After the adjustment for other variables, this association was significant for male sex (2.66; 95% confidence interval [CI], 1.11-4.31; P=0.001) and history of using ART (4.03; 95% CI, 1.76-9.21; P=0.001). Therefore, after the adjustment for confounder variables, there was no significant association between ART and the risk of ASD among children (4.98; 95% CI, 0.91-27.30; P=0.065). Conclusion: After the adjustment for other variables, risk factors for ASD were male sex and history preterm delivery. Thus, there was no significant association between ART and the risk of ASD among children.

Design of a Variable Shortened and Punctured RS Decoder (단축 및 펑처링 기반의 가변형 RS 복호기 설계)

  • Song Moon-Kyou;Kong Min-Han;Lim Myoung-Seob
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.31 no.8C
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    • pp.763-770
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    • 2006
  • In this paper, a variable Reed-Solomon(RS) decoder with erasure decoding functionality is designed based on the modified Euclid's algorithm(MEA). The variability of the decoder is implemented through shortening and puncturing based on the RS(124, 108, 8) code, other than the primitive RS(255, 239, 8) code. This leads to shortening the decoding latency. The decoder performs 4-step pipelined operation, where each step is designed to be clocked by an independent clock. Thus by using a faster clock for the MEA block, the complexity and the decoding latency can be reduced. It can support both continuous- and burst-mode decoding. It has been designed in VHDL and synthesized in an FPGA chip, consuming 3,717 logic cells and 2,048-bit memories. The maximum decoding throughput is 33 MByte/sec.

Monitoring of 7 mycotoxins in pork (돼지고기에서 7종 mycotoxins 잔류실태 조사)

  • Kim, Yoen-Joo;Kim, Mi-Ran;Choi, Tae-Suk;Kim, Young-Seob;Lee, Ju-Hyoung
    • Korean Journal of Veterinary Service
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    • v.36 no.4
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    • pp.303-309
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    • 2013
  • This study was conducted to determine the content of 7 mycotoxins (aflatoxin $B_1$, $B_2$, $G_1$, $G_2$, $M_1$, ochratoxin A and zearalenone) using LC-MS/MS in pork available on the Korean markets. The analysis was carried out using following conditions; C18 column ($2.1{\times}100mm$, $1.7{\mu}m$), mobile phase composed of $H_2O$ (0.1 mM $NH_4Ac$ 0.01% HCOOH) : Methanol (0.1 mM $NH_4Ac$ 0.01% HCOOH), binary pump at a flow rate of 0.5 mL/min and $2{\mu}L$ of injection volume, MS/MS detector with ESI positive and negative mode. The quantication of mycotoxins was based on matrix-matched calibration curves with a correlation coefficient in excess of 0.99 for the 7 mycotoxins. The dectection limits were ranged 0.74~2.13 ng/g, with mean recoveries between 73.10~97.46% except aflatoxin $B_1$ (61.31%). We also monitored mycotoxin residues in 208 pork samples. The test results, mycotoxins were not found except one sample. Ochratoxin A in one sample of the test samples was detected below the quantification limit.

Low Flow Analysis of the Nakdong River Basin by SSARR-8 Model (SSARR-8 모형을 이용한 낙동강 수계의 저수유출 해석)

  • Gang, Ju-Hwan;Lee, Gil-Seong;Kim, Nam-Il
    • Journal of Korea Water Resources Association
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    • v.31 no.1
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    • pp.71-84
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    • 1998
  • The SSARR model adopting IS(integrated snowband) watershed model is applied to the Nakdong River basin for low flow analysis. The IS watershed model is added to new version of the SSARR which has functions of simulating evapotranspiration. infiltration and lower zone routing. It provides annual water budget information as an output file and can be operated by interactive mode. Sensitivity analysis for both cases of high and low flows was carried out, which becomes the knowledge base for model calibration. Model verification was performed using the relative errors of high flows and absolute errors of low flows at the control points. Monthly water budget analysis was done by IS watershed model. and it reveals that runoff coefficient is 52.6%

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A Study on Sizes Specifications of Infants' Apparels (유아복(乳兒服)브랜드 치수규격(値數規格) 실태(實態) 조사(調査) 연구(硏究) II)

  • Kim, Jin;Sohn, Hee-Soon
    • Journal of Fashion Business
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    • v.3 no.4
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    • pp.31-39
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    • 1999
  • The purpose of this study is to survey and analyze the general conditions of infants' apparel brands in Korea, review the sizes and specifications of each brand, analyze the differences and correlations among brands, and thereby, present the reasonable sizes and specifications for infants' apparels in consideration of domestic and foreign specifications and infants' health conditions. for this purpose, 13 brands manufacturing the apparels for the infants aged from 0 to 4 were sampled, and their design directors and outside pattern suppliers were surveyed through direct interviews. The collected data were processed for frequencies, mean, median and mode. The results of this study can be summarized as follows; 1. The sample infants' apparel brands were mostly launched as national brands in 1990's, while their target ages were diverse : 0 $\sim$ 72 months, 0 $\sim$ 36 months, 0 $\sim$ 48 months, 0 $\sim$ 60 months, 12 $\sim$ 24 months, etc. 2. More brands were restructuring the pattern suppliers' sizes and specifications rather than developing them directly, which suggests that most of infants' brands depend much on pattern suppliers. 3. Infants' apparel brands were presenting the 'space suites' sized from #60 to #90 because consumers prefer those space suites distinct in their upper and lower parts and convenient for their toddlers aged 36 months or older. The brands were setting the sizes for 6 parts: total length, breast, sleeve length, hip, hip height, leg. 4. The sizes for infants' one-pieces were #70, #75, #80, #85, #90, #95, #100, #110 and #120, while their subsizes were determined for 4 parts: total length, breast, sleeve length, hip.

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Comparisons of Physical Properties of Bacterial Celluloses Produced in Different Culture Conditions Using Saccharified Food Wastes

  • Moon Seung-Hyeon;Park Ji-Min;Chun Hwa-Youn;Kim Seong-Jun
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.11 no.1
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    • pp.26-31
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    • 2006
  • The saccharogenic liquid (SFW) obtained by the enzymatic saccharification of food wastes was used as a medium for production of bacterial cellulose (BC). The enzymatic saccharification of food wastes was carried out by the cultivation supernatant of Trichoderma harziaum FJ1 culture. Acetobacter xylinum KJ1 was employed for the BC production culture. The physical properties, such as polymerization, crystallinity, Young's modulus, and tensile strength, of BCs produced by three culture methods: the static cultures using HS (Hestrin-Schramm) as a reference medium (A) or the SFW medium (B), the shaking culture (C) or the air circulation culture (D) using the SFW medium, were investigated. The degrees of polymerization of BCs produced under the different culture conditions (A-D) showed 11000, 9500, 8500, and 9200, respectively. Young's modulus was 4.15, 5.0, 4.0, and 4.6 GPa, respectively. Tensile strength was 124, 200, 80, and 184 MPa, respectively. All of the BC had a form of cellulose I representing pure cellulose. In the case of the shaking culture, the degree of crystallinity was 51.2%, the lowest degree. Under the other culturing conditions, the trend should remain in the range of 89.7-84%. Overall, the physical properties of BC produced from SFW were similar to those of BC from HS medium, a commercial complex medium, and BC production by the air circulation culture mode brought more favorable results in terms of the physical properties and its ease of scale-up. Therefore, it is expected that a new BC production method, like air circulation culture using SFW, would contribute greatly to BC-related manufacturing.

EXPRESSION OF E-CADHERIN WITH CORRELATION TO CLINICOPATHOLOGIC PARAMETERS IN ORAL SQUAMOUS CELL CARCINOMA (구강 편평세포암종에서 E-cadherin의 발현과 임상병리학적 지표와의 관계)

  • Shin, Jae-Myoung;Kim, Young-Sill;Kim, Chang-Hyen;Pyo, Sung-Woon
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.31 no.1
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    • pp.1-6
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    • 2005
  • It becomes more concerned that the cell adhesion molecule plays an important role in the process of malignant transformation and tumor behaviors including invasive growth and metastasis. It is postulated if the expression of adhesion molecule is reduced in tumor tissue, the tumor cell will be undifferentiated and lose their cell adhesion ability and polarity. So the tumor cells lost the adhesion of cell to cell and to basement membrane that they became more aggressive. Reduced cadherin expression enhances invasiveness through infiltrative growth and metastasis of tumor cells is well known and mostly accepted in many epithelia tumors. We explored the expression of E-cadherin by immunohistochemical staining in 50 oral squamous cell carcinomas and investigated the correlation between the expression of E-cadherin and clinicopathologic parameters and prognosis. The expression of E-cadherin was reduced in 40/50(80%) of primary tumors, and 21/22(95.5%) of lymph nodes. The reduced expression of the E-cadherin was associated with lymph node metastasis(P=0.029), invasive mode(P=0.030) and marginal status(P=0.038). Survival analysis showed that predictive period of E-cadherin reduced group(37 months) was lower than that of E-cadherin preserved group(60 months), but there was no statistical significant difference.

Tensile strength of bilayered ceramics and corresponding glass veneers

  • Anunmana, Chuchai;Champirat, Tharee;Jirajariyavej, Bundhit
    • The Journal of Advanced Prosthodontics
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    • v.6 no.3
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    • pp.151-156
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    • 2014
  • PURPOSE. To investigate the microtensile bond strength between two all-ceramic systems; lithium disilicate glass ceramic and zirconia core ceramics bonded with their corresponding glass veneers. MATERIALS AND METHODS. Blocks of core ceramics (IPS e.max$^{(R)}$ Press and Lava$^{TM}$ Frame) were fabricated and veneered with their corresponding glass veneers. The bilayered blocks were cut into microbars; 8 mm in length and $1mm^2$ in cross-sectional area (n = 30/group). Additionally, monolithic microbars of these two veneers (IPS e.max$^{(R)}$ Ceram and LavaTM Ceram; n = 30/group) were also prepared. The obtained microbars were tested in tension until fracture, and the fracture surfaces of the microbars were examined with fluorescent black light and scanning electron microscope (SEM) to identify the mode of failure. One-way ANOVA and the Dunnett's T3 test were performed to determine significant differences of the mean microtensile bond strength at a significance level of 0.05. RESULTS. The mean microtensile bond strength of IPS e.max$^{(R)}$ Press/IPS e.max$^{(R)}$ Ceram ($43.40{\pm}5.51$ MPa) was significantly greater than that of Lava$^{TM}$ Frame/Lava$^{TM}$ Ceram ($31.71{\pm}7.03$ MPa)(P<.001). Fluorescent black light and SEM analysis showed that most of the tested microbars failed cohesively in the veneer layer. Furthermore, the bond strength of Lava$^{TM}$ Frame/Lava$^{TM}$ Ceram was comparable to the tensile strength of monolithic glass veneer of Lava$^{TM}$ Ceram, while the bond strength of bilayered IPS e.max$^{(R)}$ Press/IPS e.max$^{(R)}$ Ceram was significantly greater than tensile strength of monolithic IPS e.max$^{(R)}$ Ceram. CONCLUSION. Because fracture site occurred mostly in the glass veneer and most failures were away from the interfacial zone, microtensile bond test may not be a suitable test for bonding integrity. Fracture mechanics approach such as fracture toughness of the interface may be more appropriate to represent the bonding quality between two materials.

Efficient Fast Multiple Reference Frame Selection Technique for H.264/AVC (H.264/AVC에서의 효율적인 고속 다중 참조 프레임 선택 기법)

  • Lee, Hyun-Woo;Ryu, Jong-Min;Jeong, Je-Chang
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.33 no.10C
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    • pp.820-828
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    • 2008
  • In order to achieve high coding efficiency, H.264/AVC video coding standard adopts the techniques such as variable block size coding, motion estimation with quarter-pel precision, multiple reference frames, rate-distortion optimization, and etc. However, these coding methods have a defect to greatly increase the complexity for motion estimation. Particularly, from multiple reference frame motion estimation, the computational burden increases in proportion to the number of the searched reference frames. Therefore, we propose the method to reduce the complexity by controlling the number of the searched reference frames in motion estimation. Proposed algorithm uses the optimal reference frame information in both $P16{\times}16$ mode and the adjacent blocks, thus omits unnecessary searching process in the rest of inter modes. Experimental results show the proposed method can save an average of 57.31% of the coding time with negligible quality and bit-rate difference. This method also can be adopted with any of the existing motion estimation algorithm. Therefore, additional performance improvement can be obtained.

Alterations in the Level of Fibronectin and its Receptors during Chick Myoblast Differentiation (계배 근원세포 분화에 따른 Fibronection의 수준과 그 수용체의 변화)

  • 정창용;강만식
    • The Korean Journal of Zoology
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    • v.31 no.2
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    • pp.95-103
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    • 1988
  • Alterations in the amount of fibronectin during chick myogenesis were investigated. The amount of fibronectin as measured by immunoblotting was found to decrease during the process. As a first step in answering the precise mode of change in the level of ibronedin during myogensis, the interaction of 28,000 dalton(28 kDa) amino terminal fragment of fibronectin as well as 85,000 dalton (85 kDa) fragrxient with myoblasts was examined. The specific binding of 125 l-28 kDa fragment to myoblasts was time-dependent and reached a maximum within 60 min. Unlabelled 28 kDa fragment inhibited the binding of 125 I-28 kDa fragment, whereas 85 kDa fragment containing adhesion promoting activity did not inhibit it. This finding suggests that the 28 kDa fragment interacts with the matrix assembly receptors but not with the cell adhesion receptors. Accordingly, the decrease in the level of fibronectin is likely to correlate with the fall of fibronectin receptors on the myoblasts.

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