• Toxicological Research
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• 제32권3호
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• pp.245-250
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• 2016

3-Methylpentane ($C_6H_{14}$, CAS No. 96-14-0), isomer of hexane, is a colorless liquid originating naturally from petroleum or natural gas liquids. 3-Methylpentane has been used as a solvent in organic synthesis, as a lubricant, and as a raw material for producing carbon black. There is limited information available on the inhalation toxicity of 3-methylpentane, and the aim of this study was to determine its subacute inhalation toxicity. According to OECD Test Guideline 412 (subacute inhalation toxicity: 28-day study), Sprague Dawley rats were exposed to 0, 284, 1,135, and 4,540 ppm of 3-methylpentane for 6 hr/day, 5 days/week for 4 weeks via whole-body inhalation. Mortality, clinical signs, body weights, food consumption, hematology, serum chemistry, organ weights, and gross and histopathological findings were compared between control and all exposure groups. No mortality or remarkable clinical signs were observed during the study. No gross or histopathological lesions, or adverse effects on body weight, food consumption, hematology, serum chemistry, and organ weights were observed in any male or female rats in all exposure groups, although some statistically significant changes were observed in food consumption, serum chemistry, and organ weights. In conclusion, the results of this study indicate that no observable adverse effect level (NOAEL) for 3-methylpentane above 4,540 ppm/6 hr/day, 5 days/week for rats.

• 한국가스학회지
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• 제21권1호
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• pp.6-17
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• 2017

본 연구는 3-methylpentane에 대한 흡입유해성을 평가하여 국제연합에서 정하는 화학물질의 분류 및 표지에 관한 세계조화시스템(Globally harmonized system, GHS)지침 및 고용노동부고시 제2013-37호에 따른 3-methylpentane의 화학물질 분류 표시 자료를 생산하기 위하여 OECD 화학물질 시험가이드라인 아급성흡입독성시험 TG 412(Subacute inhalation toxicity) 시험법에 따라 수행하였다. 본 연구를 위하여 6주령의 랫드(Rat)를 도입하여 1주간 순화시킨 후 암수 각각 대조군 5마리, 저농도군(284 ppm) 5마리, 중농도군(1,135 ppm) 5마리, 고농도군(4,540 ppm) 5마리 등으로 군을 구성하여 일일 6시간, 주 5일, 4주 동안 시험물질을 랫드에 전신으로 노출시켰다. 시험물질 노출을 종료하고 2주 후 시험동물을 희생하여 시험물질에 의한 시험동물의 영향을 평가하였다. 사료섭취량 변화, 체중 변화, 임상관찰, 혈액검사, 부검 소견, 장기무게 측정, 조직병리검사 등 모든 시험결과에서 시험물질에 의한 영향은 나타나지 않아 3-methylpentane의 무유해영향농도는 암수 모두 4,540 ppm이상으로 판단되어 세계조화시스템(GHS) 지침 및 고용노동부고시 제2013-37호(화학물질의 분류 표시 및 물질안전보건에 관한 기준)의 특정표적장기독성(반복노출) 구분 표시 물질에 해당하지 않은 물질로 판단되었다.

• 분석과학
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• 제6권1호
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• pp.21-27
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• 1993

54% 순도의 공업용 n-헥산을 HPLC급으로 분리, 정제하였다. 분별증류법으로 분리하기 어려운 methylcyclopentane, 2-methylpentane, 그리고 3-methylpentane 등은 molecular aieve 5A를 이용한 액체-고체 크로마토그래피법으로 분리하였다. HPLC 용매로서 엄격히 규제받는 UV와 형광불순물은 알루미나와 실리카겔을 이용한 흡착법으로 정제하였다. 이와 같은 방법으로 n-헥산을 정제함으로써 수분, 색도(APHA), 산도, 증발잔류물, 황 및 thiophene 등의 불순물 항목을 모두 HPLC급의 규격까지 낮출 수 있었다.

• 월간산업보건
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• 통권341호
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• pp.42-45
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• 2016

• Korean Chemical Engineering Research
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• 제53권3호
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• pp.302-308
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• 2015

본 연구에서는 3-Methylpentane을 포함하는 Ethylene glycol monopropyl ether ($C_3E_1$) 및 Ethylene glycol isopropyl ether ($iC_3E_1$) 계면활성제 혼합물에 대한 2성분계 기-액 상 평형을 서로 다른 온도 조건(303.15, 318.15, 333.15K)에서 측정 및 비교하였다. $C_3E_1$은 분자 내 수소결합과 분자 간 수소결합이 동시에 나타나는 자가 회합 성 물질이므로 상 평형 예측을 어렵게 하는 경향이 있다. 본 연구의 목적은 $C_3E_1$ 혼합물과 그 이성질체인 $iC_3E_1$ 혼합물의 상 평형을 각각 측정 및 비교함으로써, 자가 회합 성 물질의 이성질체가 상 평형에 어떠한 영향을 미치는지 알아보는 것이다. 측정된 시스템은 PR-WS-NRTL, PR-WS-UNIQUAC, 그리고 PR-WS-WILSON 모델을 이용하여 각각 계산하고 각 모델의 성능을 비교하였다. 계산에 사용된 모델은 대부분 좋은 결과를 보여주었으며, 특히 PR-WS-NRTL 모델이 가장 좋은 결과를 나타냈다. 또한 측정 시스템 간의 상 평형 차이가 크게 발생하지 않은 것으로 보아 자가 회합 성 물질의 이성질체가 상 평형에 끼치는 영향은 크지 않음을 알 수 있었다.

• Environmental Engineering Research
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• 제13권1호
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• pp.14-18
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• 2008

Photocatalytic oxidations of benzene gas using the closed system (batch reactor) were induced to determine its by-products and investigate the effect of humidity and oxygen concentration on their generation. The study was able to identify 11 gaseous by-products: 2-methylpropene, acetaldehyde, acetone, pentane, methylcyclobutane, methylcyclopentane, cyclohexane, 2,3-dimethylbutane, 2-methylpentane, 3-methylpentane, and hexane. All the by-products were saturated hydrocarbons, which are less toxic than benzene and were probably formed through hydrogenation reaction on the photocatalytic surface. The photocatalytic oxidation of benzene under higher humidity produced less by-products. However, the amount of acetone released increased with higher humidity and oxygen concentration.

• Bulletin of the Korean Chemical Society
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• 제23권3호
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• pp.459-468
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• 2002

Literature data measured by the author have been processed to report on the effect of solute structure on gas liquid partition coefficients of eleven normal, branched and cyclic alkanes ranging in carbon number from five to nine in sixty nine low molecular weight liquids. The alkane solutes are n-pentane(p), n-hexane(hx), n-heptane(hp), n-octane(o), n-nonane(n), 2-methylpentane(mp), 2,5-dimethylpentane(dp), 2,5-dimethylhexane(dh), 2,3,4-trimethylpentane(tp), cyclohexane(ch), and ethylcyclohexane(ec). The solvent set encompasses most of those studied by Rohrschneider as well as three homologous series of solvents (n-alkanes, 1-alcohols and 1-nitriles) and several perfluorinated alkanes and highly fluorinated alcohols. An excellent linear relationship was observed between lnK and the carbon number of n-alkanes. The effective carbon numbers of branched and cyclic alkanes were determined in a similar fashion to the method of Kovats index. We found that the logarithm of solute vapor pressure multiplied by solute molar volume was a perfect descriptor for the linear relationship with the median effective carbon number.

• Bulletin of the Korean Chemical Society
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• 제19권10호
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• pp.1059-1063
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• 1998

Regiospecific total syntheses of (±)-11-deoxy-4-methoxy-10-oxo-βrhodomycinone (21a) and (±)-11-deoxy-1-methoxy-10-oxo-β-rbodomycinone (21b) are described. 2-(2-Bromoethyl)-1,3-dioxane (6) was transformed to naphthalenone 12, which was condensed with (phenylsulfonyl)-isobenzofuranone 13 to afford 7,8-dihydro-9-ethyl-6-hydroxy-4-methoxynaphthacen-5,12-dione (15). Epoxide 16 prepared from olefinic compound 15, reacted with HF/Pyr (7:3) to give 17. Dihydroxylation of 17 with t-BuOK/P(OMe)3/O2, selective cis-diol protection of mixed compounds 18 with phenylboronic acid in toluene, separation of cis-boronate 19 and trans-diol 20 by column chromatography on silica gel, and cleavage of the boronate group of 19 with 2-methylpentane-2,4-diol in acetic acid completed the construction of 21.