• Journal of the Korean Society for Geothermal and Hydrothermal Energy
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• v.4 no.1
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• pp.11-19
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• 2008

Groundwater flow in confined aquifer and heat transport in underground geologic media are using same governing equation(line source) like well fuction. Therefore the conventional slope method using only later data obtained from in-situ thermal response test to determine the thermal conductivity of vertical geothermal heat exchanger(GHEX) is basically identical with one of Theis straight line method of aquifer test under artesian condition. In case that the pumping rate(Q, $m^3$/d) and drawdown(s,m) which are used for input data of existing hydrogeologic computer programs for aquifer test are replaced and converted to supplying heat energy per unit length of bore hole(Q/L,w/m or Kcal/h.m) and temperatures (T,$^{\circ}C$)measured at in and out-let of GHEX as in put data respectively, thermal conductivity around geothermal heat exchanger can be easily estimated without any special modification of the existing hydrogeologic computer program. Two numbers of time series temperature variation data obtained from in situ geothermal response test are analized using Theismethods(standard curve and straight line method) by using existing aquifer test program and conventional Slope method proposed by ASHRAE. The results show that thermal conductivity values estimated by two straight methods are identical and the difference of estimated values between standard curve methods and Slope method are also within acceptable ranges. In general,the thermal conductivity estimated from Theis straight linemethod gives more accurate value than the one of Slope method due to that Slope method uses only visual matching otherwise Theis method uses automatic curve matching estimation with reducing RSS.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.37 no.1
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• pp.1-8
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• 2001

This study deals with the experimental and numerical investigations to design the high performance otter board. Experiment was carried out to determine the most effective slot size of single-slot cambered otter board in the circulation water channel of BAEK KYUNG IND. Co. LTD. Numerical analysis was done by the commercial CFD code, FLUENT, to provide some valuable physical interpretations and finally to design the otter board section by numerical method. The major results are as follows ; 1. In experiment, the maximum lift and drag coefficients of simple cambered type otterboard were 1.41, 0.55, respectively, at the angle of attack $28^\circ$, while those of slot one with slot size 0.02C (C denotes the chord length) were 1.72, 0.42 at the angle of attack $24^\circ$. 2. The hydrodynamic characteristics depending upon slot size shows the greatest at 0.02C of the slot size. 3. Numerical results well visualized the streamlines, pressure fields, and speed vectors of a simple cambered and slot cambered otter board with slot size 0.02C. The slot cambered one with slot size 0.02C was shown that pressure field was distributed moderately on front and back side of otter board. And, the delay and decrease of separation were favorably achieved by flow through slot. 4. Computed result on the pattern of hydrodynamic field and the values of $C_L$ and $C_D$ by the commercial CFD code, FLUENT, show almost the same as those of the experimental result.

• Korean Journal of Pharmacognosy
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• v.45 no.4
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• pp.288-293
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• 2014

The present study was conducted to evaluate the hair growth-promoting effect of Clitocybin A from mushroom Clitocybe aurantiaca with dermal papilla cells (DPCs), which play important roles in the regulation of hair cycle. Clitocybin A significantly increased the proliferation of immortalized rat vibrissa DPCs. Flow cytometry analysis revealed that Clitocybin A promoted cell-cycle progression through G0/G1 to S phase in immortalized rat vibrissa DPCs. In addition, Clitocybin A increased the level of cell cycle proteins such as cyclin D1, phospho-pRB, and phospho-CDK2. To elucidate the molecular mechanisms of Clitocybin A on the proliferation of DPCs, we examined the activation of wnt/${\beta}$-catenin signaling which is known to regulate hair follicle development, differentiation and hair growth. Clitocybin A activated wnt/${\beta}$-catenin signaling via the increase of phospho(ser552)-${\beta}$-catenin, phospho(ser675)-${\beta}$-catenin and phospho(ser9)-$GSK3{\beta}$. Furthermore, Clitocybin A markedly increased the activation of extracellular signal-regulated kinase (ERK). These results suggest that the Clitocybin A may induce hair growth by proliferation of DPCs via cell-cycle progression as well as the activation of Wnt/${\beta}$-catenin signaling and ERK pathway.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.7
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• pp.535-543
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• 2014

A computational simulation for a nonslender BWB UCAV configuration with rounded leading edge and span of 1.0m was performed to analyze its aerodynamic characteristics. The freestream is 50m/s over -4 to 26 degree A.o.A.s. Reynolds number based on the mean chord length is $1.25{\times}10^6$. 3D multi block hexahedral grids are used which allow good grid quality and ease to capture boundary layer. ${\gamma}-Re_{\theta}$ model as well as $k-{\omega}$ SST model is employed to assess the effect of transition for flow behavior. Drag and lift of the UCAV were well predicted while $C_M$ is under predicted at high angle of attacks and influenced by the turbulence models strongly. After assessing pressure distribution, skin friction lines and velocity field around the UCAV configuration, it was found that transition effect should be considered to enhance the prediction of aerodynamic behavior by a vortical flowfield.

• YAKHAK HOEJI
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• v.52 no.1
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• pp.7-11
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• 2008

A high performance liquid chromatographic (HPLC) method for the determination of glycyrrhizic acid was developed for the quality control of traditional herbal medicinal preparation Bu-Zhong-Yi-Qi-Tang (BZYQT), which is well-known herbal medicine used as tonic. RP-HPLC analysis was carried out using Capcell pak $C_{18}$ MG column $(5\;{\mu},\;150{\times}4.6\;mm)$ and a mobile phase consisting of acetonitrile and water containing 0.03% phosphoric acid (pH 2.46) at a flow rate of 1.0 ml/min. The optimum wavelength for the detection of the glycyrrhizic acid was found at 250 nm using diode-array UV/VIS detector. The glycyrrhizic acid in BZYQT shows good linearity $(r^2>0.999)$ in the range of $15\;{\mu}g/ml$ to 500 ${\mu}g/ml$. The limit of detection (LOD) was less than 5 ng and R.S.D for intra-day and inter-day reproducibility was less than 7%. The mean recovery of the glycyrrhizic acid was $97.3{\sim}113.0%$. These results suggest that the developed HPLC method is simple and efficient, and could be contributed for the quality control of commercial BZYQT products.

• Journal of Acupuncture Research
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• v.18 no.1
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• pp.129-145
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• 2001

Objectives : To characterize the antitumorigenic potential of three representative bee venom components, Melittin, Apamin, and Phospholipase A2, their effects on cell proliferation and apotosis of the human melanoma cell line SK-MEL-2 were analyzed using molecular biological approaches. Methodes & Results : To determine the doses of the drugs that do not induce cytotoxic damage to this cell line, cell viability was examined by MTT assay. While SK-MEL-2 cells treated with 0.5 - 2.0㎍/㎖ of each drug showed no recognizable cytotoxic effect, marked reductions of cell viability were detected at concentrations over 5.0㎍/㎖. [3H]thymidine incorporation assay for cell proliferation demonstrated that DNA replication of SK-MEL-2 cells is inhibited by Apamin and Phospholipase A2 in a dose-dependent manner. Consistent with this result, the cells were accumulated at the G1 phase of the cell cycle after treatment with Apamin and Phospholipase A2, whereas no detectable change in cell proliferation was identified by Melittin treatment. In addition, tryphan blue exclusion and flow cytometric analyses showed that all of these drugs can trigger apoptotic cell death of SK-MEL-2, suggesting that Melittin, Apamin, and Phospholipase A2 have antitumorigenic potential through the suppression of cell growth and/or induction of apoptosis. Qantitative RT-PCR analysis revealed that Apamin and Phospholipase A2 inhibit expression of growth-promoting genes such as c-Jun, c-Fos, and Cyciin D1. Furthermore, Phospholipase A2 induced tumor suppressors p53 and p21/Wafl. In addition, all three drugs were found to activate expression of a representative apoptosis-inducing gene Bax while expression of apoptosis-suppressing Bcl-2 and Bcl-XL genes was not changed. Taken together, this study strongly suggests that Metittin, Apamin, and Phosphalipase A2 may have antitumorigenic activities, which are associated with its growth-inhibiting and/or apoptosis-inducing potentials.

• Proceedings of the KSME Conference
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• 2000.11b
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• pp.371-376
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• 2000

In this study, the computational method is presented to simulate the hemodynamics of the patients after the Fontan procedure. The short-term feedback control models are implemented to assess the hemodynamic responses of the patients exposed to the stresses such as gravitational effect or hemorrhage. To construct the base line of the Fontan model, we assume an increase in venous tone, in heart rates, and in systemic resistance that are based on the clinical observations. For the verification of the present method we simulate the LBNP (lower body negative pressure) test for the normal and the Fontan model and we compare these with experimental data. Computational results show that the diastolic ABP(arterial blood pressure) increases but the systolic ABP decreases during LBNP. The increase in heart rate is due to the control system activated by the decreased mean ABP and CVP(central venous pressure). In case of the Fontan model, the increased venous tone is the reason of the diminished CVP change during LBNP. We also simulate 20% hemorrhage stress to the patient after the Fontan procedure and these results are compared with the experimental and the existing computational one. Computational results on the hemodynamics of patients after the Fontan procedure show that the mean ABP and cardiac output decrease. Heart rate and systemic resistance increase to compensate for the decrease in ABP. The sensitivity analysis according to the conduit resistance is also presented to delineate the effects of the local blood flow resistance. The cardiac output decreases according to the increase of the conduit resistance. The 50% increase in the conduit resistance causes about 3% decrease of cardiac output.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.24 no.4
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• pp.469-474
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• 2015

In ultrasonic spray pyrolysis deposition, a precursor solution is evaporated by an ultrasonic atomizer, then gas-carried into a furnace where the solute is separated from the water vapor. After condensation, polymerization, and nucleation, the solute oxide forms a thin film. To improve the deposition efficiency, the ultrasonic atomizer was studied to optimize the evaporated gas flow. The vat cover was redesigned, using three versions with different inlet factors being tested through a computational fluid dynamic analysis as well as a water evaporation experiment. The atomization rate with a hemispherical cover with a $30^{\circ}$ inlet was found to be 2.4 times higher than that with the original. This improvement was verified with fluorine-doped tin oxide spray pyrolysis deposition. The film obtained with the modified vat cover was 2.4 times thicker than that obtained with the original vat cover.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.6 no.3
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• pp.302-314
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• 1994

The effects of the inclination of enclosure and partition on natural convective flow and heat transfer were investigated numerically. The enclosure was composed of the lower hot and the upper cold horizontal walls and the adiabatic vertical walls, and a partition was positioned perpendicularly at the mid-height of one vertical insulated wall. The governing equations are solved by using the finite element method with Galerkin method. The computations were performed with the variations of the partition length and Rayleigh number based on the temperature difference between two horizontal walls and the enclosure height with water(Pr=4.95). The effects of the inclination angle of enclosure and partition on the heat transfer within an enclosure were also studied. As the results, the increase of the inclination angle of enclosure rapidly raised the heat transfer rate, while the inclination angle for the maximum Nusselt number was retarded with the increase of the partition length and the decrease of the heat transfer rate became larger in proportion to the increase of the partition length. The Nusselt number obtained by the inclination of partition was smaller than that of the inclination of enclosure. However, the difference of the heat transfer rates was considerably decreased at the longer partition lengths and the trends for the variation of the average Nusselt number were more similar with that of the inclination of enclosure. The upward oriented partition increases the convective heat transfer distinctly in contrast to that of the inclination of enclosure as the partition length increases.

• Journal of the Korean Institute of Gas
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• v.13 no.3
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• pp.49-53
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• 2009

Relief systems can improve the process safety because it has the function for the prevention of overpressure. Flare stacks is necessary to avoid explosion, radiation, or toxicity by waste-gas emitted from relief system. Safe combustion is one of the important factors to improve safety and the quantity and velocity emitted is ruled in the API code 521. Due to the pressure of released gas and mass flow, a flame from flare stack is similar to jet fire. In this study, we have investigated the effect of flame form on complete combustion and heat emission. API code was similar to jet fire model in flame length, the flame had an effect on the ground.