• Journal of Electrochemical Science and Technology
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• 제10권1호
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• pp.69-81
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• 2019

The corrosion inhibiting mechanism of Vietnam orange peel essential oil (OPEO) for mild steel in 1 N HCl solution was investigated elaborately. Corrosion inhibition ability of OPEO was characterized by electrochemical polarization, electrochemical impedance spectroscopy (EIS), and weight loss method. In the corrosive solution, OPEO worked as a mixed inhibitor and the inhibition efficiency of OPEO increased with the increase of its concentration. High inhibition efficiencies over 90% were achieved for the concentration of 3 - 4 g/L OPEO, comparable to that of 3.5 g/L urotropine (URO), a commercial corrosion inhibitor for acid media used in industry. By using adsorption isotherm models (Langmuir, Temkin and Frumkin), thermodynamic parameters of adsorption were calculated. The obtained results indicated physical adsorption mechanism of OPEO on the steel surface. The components responsible for the corrosion inhibition activity of OPEO were not only D-limonene, but also other compounds, which contain C=O, C=C, O-H, C-O-C, -C=CH and C-H bonding groups in the molecules.

• 마이크로전자및패키징학회지
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• 제23권4호
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• pp.69-77
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• 2016

We propose nano-scale Cu direct bonding technology using ultra-high density Cu nano-pillar (CNP) with for high stacking yield exascale 2.5D/3D integration. We clarified the joining mechanism of nano-scale Cu direct bonding using CNP. Nano-scale Cu pillar easily bond with Cu electrode by re-crystallization of CNP due to the solid phase diffusion and by morphology change of CNP to minimize interfacial energy at relatively lower temperature and pressure compared to conventional micro-scale Cu direct bonding. We confirmed for the first time that 4.3 million electrodes per die are successfully connected in series with the joining yield of 100%. The joining resistance of CNP bundle with $80{\mu}m$ height is around 30 m for each pair of $10{\mu}m$ dia. electrode. Capacitance value of CNP bundle with $3{\mu}m$ length and $80{\mu}m$ height is around 0.6fF. Eye-diagram pattern shows no degradation even at 10Gbps data rate after the lamination of anisotropic conductive film.

• Geomechanics and Engineering
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• 제17권6호
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• pp.515-525
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• 2019

The calculation of active earth pressure behind retaining wall is a typical three-dimensional (3D) problem with spatial effects. With the help of limit analysis, this paper firstly deduces the internal energy dissipation power equations and various external forces power equations of the 3D retaining wall under the nonlinear strength condition, such as to establish the work-energy balance equation. The pseudo-static method is used to consider the effect of earthquake on active earth pressure in horizontal state. The failure mode is a 3D curvilinear cone failure mechanism. For the different width of the retaining wall, the plane strain block is inserted in the symmetric plane. By optimizing all parameters, the maximum value of active earth pressure is calculated. In order to verify the validity of the new expressions obtained by the paper, the solutions are compared with previously published solutions. Agreement shows that the new expressions are effective. The results of different parameters are given in the forms of figures to analysis the influence caused by nonlinear strength parameters.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 춘계학술대회
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• pp.119-119
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• 1997

Valacyclovir is a L-valyl ester prodrug of acyclovir which is a highly effective and selective antiviral agent in the treatment of herpes virus diseases. Valacyclovir is rapidly and almost completely converted to acyclovir and increases the oral bioavailability of acyclovir three to five fold. However, the intestinal absorption mechanism of valacyclovir is not clear. If the improved absorption mechanism of valacyclovir is fully understood, it will provide a rationale of designing the amino acid ester prodrugs of polar drugs containing hydroxyl group. The main objective of our present study is to characterize the membrane transport mechanism of valacyclovir. Methods : Intestinal absorption of valacyclovir was investigated by using in-situ rat perfusion study and its wall permeability was estimated by modified boundary layer model. The membrane transport mechanism was also investigated through the uptake study in Caco-2 cells and in CHO-hPepTl cells. Results : In the rat perfusion study, the wall permeability of valacyclovir was ten times higher than acyclovir and showed concentration dependency, Valacyclovir also demonstrated a D,L stereo-selectivity with L-isomer having an approximately five-fold higher permeability than D-isomer. Mixed dipeptides and cephalexin, which are transported by dipeptide carriers, strongly competed with valacyclovir for the intestinal absorption, while L-valine did not show any competition with valacyclovir. This indicated that the intestinal absorption of valacyclovir could be dipeptide carrier-mediated. In addition, the competitive uptake study in Caco-2 cells presented that dipeptides reduced the valacyclovir uptake but valine did not. Also, in IC$\sub$50/ study, valacyclovir showed strong inhibition on the $^3$H-gly-sar uptake in CHO-hPepTl cells over-expressing a human intestinal peptide transporter. Taken together, the result from our present study indicated that valacyclovir utilized the peptide transporter for the intestinal absorption.

• Bulletin of the Korean Chemical Society
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• 제25권5호
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• pp.721-725
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• 2004

Acetohydroxy acid synthase (AHAS) is one of several enzymes that require thiamine diphosphate and a divalent cation as essential cofactors. The active site contains several conserved ionizable groups and all of these appear to be important as judged by the fact that mutation diminishes or abolishes catalytic activity. Recently, we have shown [Yoon, M.-Y., Hwang, J.-H., Choi, M.-K., Baek, D.-K., Kim, J., Kim, Y.-T., Choi, J.-D. FEBS Letters 555 (2003), 185-191] that the activity is pH-dependent due to changes in $V_{max}$ and V/$K_m$. Data were consistent with a mechanism in which substrate was selectively catalyzed by the enzyme with an unprotonated base having a pK 6.48, and a protonated group having a pK of 8.25 for catalysis. Here, we have in detail studied the pH dependence of the kinetic parameters of the cofactors (ThDP, FAD, $Mg^{2+}$) in order to obtain information about the chemical mechanism in the active site. The $V_{max}$ of kinetic parameters for all cofactors was pH-dependent on the basic side. The pK of ThDP, FAD and $Mg^{2+}$ was 9.5, 9.3 and 10.1, respectively. The V/$K_m$ of kinetic parameters for all cofactors was pH-dependent on the acidic and on the basic side. The pK of ThDP, FAD and $Mg^{2+}$ was 6.2-6.4 on the acidic side and 9.0-9.1 on the basic side. The well-conserved histidine mutant (H392) did not affect the pH-dependence of the kinetic parameters. The data are discussed in terms of the acid-base chemical mechanism.

• 한국지반공학회논문집
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• 제37권2호
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• pp.19-31
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• 2021

마이크로파일은 소구경 현장타설말뚝으로 간단한 시공법과 비교적 저렴한 공사비용으로 각종 건축물 및 구조물 기초보강 및 내진보강 등에 활용되고 있다. 말뚝 선단에 단순한 메커니즘의 고정 지압 구조체를 장착하여, 상부하중 작용 시 지압구가 압축·팽창하면서 선단 면적의 확대와 주면으로의 쐐기수평력을 발휘하여 지지력을 증대시키는 "선단 확장형 마이크로파일"이 개발되었으나, 개발된 공법에 대한 정확한 검증이 부족하여 실제 현장에서 활용되지 못하고 있는 실정이다. 이에 본 연구에서는, 선단 확장형 마이크로파일의 지지 메커니즘과 일반 마이크로파일 대비 지지력 증대효과를 검증하고자 3차원 수치해석을 수행하였다. 선단 확장형 마이크로파일을 모델링하고 수치해석을 위한 입력 물성치를 산정하였으며, Lab-scale 수치해석을 통하여 고정 지압 구조체가 압축·팽창되면서 발현되는 수평력에 의한 지지 메커니즘을 확인하였다. 이와 더불어 Field-scale 수치해석을 통해 일반 마이크로파일과의 지지력을 비교·검증한 결과, 압축 및 인발지지력이 각각 20.0%와 38.9% 증대되는 것을 확인하였다.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2007년도 정기총회 및 학술발표대회
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• pp.263-266
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• 2007

In this paper, analysis results on the failure of slope behind a Plant Complex of Gimhae due to typhoon Rusa in 2002 are introduced. The left side of the slope was reinforced by soil nails and the right side of the slope was going to construct slope reinforcement works. In the slope failure, the damage area is about $34,000m^2$, the lower width of slope failure is about 230m, the upper width of slope failure is about 50m, and the height of slope failure is about 120m. The elevation of a bedrock in the right side of the slope was lower than the left side of the slope. Due to the depth of weathered soils and weathered rocks in right side of the slope was thick, it will be expected that the effects of pore-water pressure during the rainfalls are large. For the analysis of the failure mechanism, 3-dimensional numerical analysis was carried out by FLAC-3D.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2011년도 제36회 춘계학술대회논문집
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• pp.253-257
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• 2011

고체로켓에서 발생하는 vortex shedding 현상 중 인히비터로 인해 발생하는 연소실내 와류(vortex)의 특성을 조사하기 위해 Large Eddy Simulation을 수행하였다. 해석의 결과는 기존 연구자들의 결과와 잘 일치하며 정략적 및 정성적 분석을 수행하였다. 인히비터 후방에서 발생하는 vortex는 Flow-acoustic coupling 에 의해 주기적으로 반복되며 생성, 소멸이 이루어지는 것을 확인 할 수 있었으며, 발생 주기는 연소실내 mode 2의 주파수와 일치하는 것을 확인하였다. 3차원 해석결과 인히비터 후방에서 Roll 발생은 비균일한 노즐 유동을 발생시킨다.

• Bulletin of the Korean Chemical Society
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• 제29권7호
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• pp.1335-1343
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• 2008

Theoretical studies on the un-catalyzed and catalyzed aminations of ketene with $NH_3$ and $(NH_3)_2$, respectively, were studied using MP2 and hybrid density functional theory of B3LYP at the 6-31+G(d,p) and 6- 311+G(3df,2p) basis sets in the gas phase and in benzene and acetonitrile solvents. In the gas phase reaction, the un-catalyzed mechanism was the same as those previously reported by others. The catalyzed mechanism, however, was more complicated than expected requiring three transition states for the complete description of the C=O addition pathways. In the un-catalyzed amination, rate determining step was the breakdown of enol amide but in the catalyzed reaction, it was changed to the formation of enol amide, which was contradictory to the previous findings. Starting from the gas-phase structures, all structures were re-optimized using the CPCM method in solvent medium. In a high dielectric medium, acetonitrile, a zwitterions formed from the reaction of $CH_2$=C=O with $(NH_3)_2$, I(d), exists as a genuine minimum but other zwitterions, I(m) in acetonitrile and I(d) in benzene become unstable when ZPE corrected energies are used. Structural and energetic changes induced by solvation were considered in detail. Lowering of the activation energy by introducing additional $NH_3$ molecule amounted to ca. −20 $\sim$ −25 kcal/mol, which made catalyzed reaction more facile than un-catalyzed one.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2006년도 추계공동학술대회
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• pp.437-450
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• 2006

The Contour Crafting(CC) process, which has been developed at the University of Southern California, aims at automated construction of whole houses as well as sub-components. For this purpose, new trowel mechanism is basically needed in order to fabricate the true 3D shape. This paper presents our concepts and initial investigation of 3D free form fabrication using the pivoting side trowel. Specifically, the status of research and development of the processand experiments with ceramics materials, and its potential application areas are detailed.