• Molecules and Cells
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• v.41 no.9
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• pp.830-841
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• 2018

Recent studies have indicated that microRNAs (miRNAs) play an important role in hepatocellular carcinoma (HCC) progression. In this study, we showed that miR-766-3p was decreased in approximately 72% of HCC tissues and cell lines, and its low expression level was significantly correlated with tumour size, TNM stage, metastasis, and poor prognosis in HCC. Ectopic miR-766-3p expression inhibited HCC cell proliferation, colony formation, migration and invasion. In addition, we showed that miR-766-3p repressed Wnt3a expression. A luciferase reporter assay revealed that Wnt3a was a direct target of miR-766-3p, and an inverse correlation between miR-766-3p and Wnt3a expression was observed. Moreover, Wnt3a up-regulation reversed the effects of miR766-3p on HCC progression. In addition, our study showed that miR-766-3p up-regulation decreased the nuclear ${\beta}-catenin$ level and expression of Wnt targets (TCF1 and Survivin) and reduced the level of MAP protein regulator of cytokinesis 1 (PRC1). However, these effects of miR-766-3p were reversed by Wnt3a up-regulation. In addition, PRC1 upregulation increased the nuclear ${\beta}-catenin$ level and protein expression of TCF1 and Survivin. iCRT3, which disrupts the ${\beta}-catenin-TCF4$ interaction, repressed the TCF1, Survivin and PRC1 protein levels. Taken together, our results suggest that miR-766-3p down-regulation promotes HCC cell progression, probably by targeting the Wnt3a/PRC1 pathway, and miR-766-3p may serve as a potential therapeutic target in HCC.

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.3
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• pp.495-501
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• 2003

Impaction is defined as the cessation of the eruption of the tooth caused by a clinically or radiographically detectable physical barrier in the eruption path or by the ectopic position of tooth germ. Besides the third molars and the maxillary canines, the most common impacted tooth is the second premolar. The overall frequency of premolar impaction has been reported to be 0.5%. In some cases, orthodontic traction and surgical repositioning may be indicated. When impacted second premolar is involved with prolonged retained second primary molar, extraction of primary molar and space maintenance lead to eruption of second premolar. In these cases, all patients visited to department of pediatric dentistry of Kyungpook National University Hospital for the chief complaint of unerupted second premolar. Extraction of prolonged retained second primary molar and space management are tried for spontaneous eruption of impacted second premolar tooth. The results were as follows: 1. When impacted second premolar is involved with prolonged retained second primary molar, minimal treatment via elimination of primary molar leads to successful results. 2. Proper space management and periodic radiographic examination are required before eruption of second premolar. 3. Sufficient time must be allowed for confirm of tooth movement before orthodontic traction or surgical repositioning. 4. The result is more successful in incomplete root development.

• Journal of the korean academy of Pediatric Dentistry
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• v.47 no.4
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• pp.368-376
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• 2020

The primary maxillary second molars usually have three roots. However, an additional root located mesiopalatally is occasionally observed. This study aimed to determine the relationship between a mesiopalatal root of primary maxillary second molars and an abnormal eruption pattern of maxillary second premolars. The study was performed on cone beam computed tomography images taken from 916 children who visited the Dental Hospital of Kyung Hee University from 2010 to 2018. 744 serial cross-sectional cone beam computed tomography images were evaluated. The overall incidence of the mesiopalatal root of primary maxillary second molars was 3.2% (n = 24) and the abnormal eruption pattern of maxillary second premolars was 19.2% (n = 143). Especially, patients with the mesiopalatal root of primary maxillary second molars were significantly more likely to have the abnormal eruption pattern on maxillary second premolars (p = 0.000). The odds of the abnormal eruption pattern of maxillary second premolars with the mesiopalatal root of primary maxillary second molars was about 13 times higher than those without. The eruption pattern of the permanent successor should be carefully observed and treated if the mesiopalatal root of primary maxillary second molar is existent.

• Kyungpook Mathematical Journal
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• v.47 no.3
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• pp.341-345
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• 2007

In this paper we show that the second order mock theta function, given by Hikami, is bounded and satisfies the second condition for the mock theta functions.

• The korean journal of orthodontics
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• v.20 no.1
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• pp.123-133
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• 1990

The work was undertaken to evaluate the calcification of the second and the third molars in skeletal Class II and III malocclusions. The differences in the calcification stages between skeletal Class II and III malocclusion were evaluated and statistically analysed from panoramic radiographs of 202 males and females ranging in age from 11 to 15 years old. The results were as follows, 1. The calcification stages of the second and the third molars were not different between the skeletal Class II and III malocclusions in each age groups of both sexes. 2. The calcification stages of lower second and third molars of the skeletal Class III malocclusion are more advanced than those of the skeletal Class II malocclusion in male. 3. The clacification stages of upper second and third molars are more advanced than those of lower second and third molars in skeletal Class II malocclusion. 4. The calcification stages of lower second and third molars are more advanced than those of upper second and third molars in skeletal Class III malocclusion.

• Journal of Embryo Transfer
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• v.15 no.3
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• pp.237-245
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• 2000

This study was carried out to elucidate whether sperm contain a factor inducing second polar body extrusion and to search for an effective collection method of the sperm factor Thus, sperm extract, dialyzed sperm-extract or liquid chromatographic fractions of sperm extract was microinjected into ovulated oocytes. And the microinjected oocytes were incubated for 24 hours to investigate about the extrusion of second polar body. The results obtained were as follows; 1. Sperm extract significantly increased the second polar body extrusion. 2. Sperm extract showed five major fractions at retention volumes (RVs) 1.25, 1.37, 1.84, 2.10 and 2.67ml after separation with Superose 12 column. These sperm extract fractions did not significantly increase the second polar body extrusion. 3. Dialyzed sperm-extract significantly increased the second polar body extrusion 4. Dialyzed sperm-extract showed three maior fractions at RVs 1.88, 2.14 and 2.77ml after separation with Superose 12 column. Of these fractions, the fraction RV2.14 significantly increased the second polar body extrusion. In conclusion, sperm extract contained a factor inducing the second polar body extrusion and the factor was contained largely in fraction RV2.14 after dialysis and liquid chromatographic fractionation of sperm extract.

• Journal of the Korean Society for Nondestructive Testing
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• v.33 no.3
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• pp.257-263
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• 2013

Acoustic nonlinearity of surface waves is an effective method to evaluate the micro damage on the surface of materials. In this method, the $A_1$ (magnitude of the fundamental wave) and $A_2$ (magnitude of the second-order harmonic wave) are measured for evaluation of acoustic nonlinearity. However, if there is another source of second-order harmonic wave other than the material itself, the linear relationship between $A_1{^2}$ and $A_2$ will not be guaranteed. Therefore, the second-order harmonic generation by another source should be fully suppressed. In this paper, we investigated the initial second-order harmonic generation in narrowband surface waves by multi-line laser beams. The spatial profile of laser beam was considered in the cases of Gaussian and square-like. The temporal profile was assumed to be Gaussian. In case of Gaussian spatial profile, the generation of the initial second-order harmonic wave was inevitable. However, when the spatial profile was square-like, the generation of the initial second-order harmonic wave was able to be fully suppressed at specific duty ratio. These results mean that the multi-line laser beams of square-like profile with a proper duty ratio are useful to evaluate the acoustic nonlinearity of the generated surface waves.

• The korean journal of orthodontics
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• v.16 no.2
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• pp.123-133
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• 1986

The purpose of this study was to collect the information of the straight-wire appliance and to determine the amount of second-order bends in clinical orthodontics. The author analysed the study model of 50 individuals with normal occlusion and results were obtained as follows. 1. The crown angulation was 4 degree in upper central incisor, 7 degree in upper lateral incisor, and 0 degree in lower central incisor and lateral incisor. 2. The crown angulation was 8 degree in upper cuspid and 2 degree in lower cuspid. 3. The crown angulations were 4 degree in upper first bicuspid, upper second bicuspid and lower second bicuspid and 1 degree in lower first bicuspid. 4. The crown angulation was 3 degree in upper first molar, 0 degree in upper second molar, 5 degree in lower first molar and 8 degree in lower second molar. 5. The crown angulations in lower arch were progressively increased from first premolar to second molar. 6. In upper arch, as the crown angulation of one tooth was increased, those of adjacent teeth were increased, too. 7. In the case of lower arch, the crown angulation of cuspid was increased as that of lateral incisor was increased, the crown angulation of second premolar was increased as that of first premolar was increased, and similarity the crown angulation of second molar was increased as that of first molar was increased.

• Kyungpook Mathematical Journal
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• v.54 no.3
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• pp.443-452
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• 2014

In the present investigation we consider Fekete-Szeg$\ddot{o}$ problem with complex parameter ${\mu}$ and also find upper bound of the second Hankel determinant ${\mid}a_2a_4-a^2_3{\mid}$ for functions belonging to a new class $S^{\tau}_{\gamma}(A,B)$ using Toeplitz determinants.

• Bulletin of the Korean Chemical Society
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• v.17 no.1
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• pp.61-65
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• 1996

The semiempirical time-dependent Hartree-Fock PM3 calculations have been performed on three polyene systems. In order to study the nonlinear optical properties, we calculated the frequency-dependent first-, second-, and third-order polarizabilities of thiophene-, furan-, pyrrole-nitro polyene systems. The PM3 predicted average and longitudinal polarizabilties increase in the order: thiophene- > pyrrole- > furan-nitro polyene systems. The PM3 predicted limiting average second-order polarizabilities show the order: pyrrole- > furan- > thiophene-nitro polyene systems. The average and longitudinal third-order polarizabilties have the following order: pyrrole- > thiophene- > furan-nitro polyene systems. In these trends, we sugest that pyrrole group is the best donor group among the three polyene systems.