• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2453-2459
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• 2013

Bevacizumab has been approved for use in combination with chemotherapy to treat many types of cancer but associated neutropenic events, including febrile neutropenia, have been reported. To estimate the incidence and relative risk of neutropenic events in cancer patients treated with bevacizumab combination therapy, we searched PubMed, EMBASE, and Web of Science literature databases, as well as abstracts presented at the American Society of Clinical Oncology conferences, to identify relevant studies published from January 1966 to December 2011. Studies that compared bevacizumab plus chemotherapy or biological therapy with chemotherapy or biological therapy alone, and that had adequate safety data profiles, were selected for analysis. Statistical analyses were conducted to calculate the summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) using fixed- or random-effects models. A total of 22 clinical trials involving 15,056 patients were included in the analysis. The summary incidences of high-grade neutropenia (HGN) and high-grade febrile neutropenia (HGFN) in patients receiving bevacizumab was 27.3% (95% CI: 26.4%-28.3%) and 3.91% (95% CI: 3.51%-4.37%), respectively. The risks of HGN (RR=1.10; 95% CI: 1.02-1.19; P=0.02) and HGFN (RR=1.31; 95% CI: 1.08-1.59; P=0.005) were significantly increased in bevacizumab-treated patients, compared to those who did not receive bevacizumab. The RR of bevacizumab-associated HGN, but not HGFN, varied significantly with tumor types (P=0.005). The increased risk of bevacizumab-associated neutropenic events was dose-dependent, as the RR was greater at a dose of 5 mg/kg/week than at 2.5 mg/kg/week. Our findings suggest that bevacizumab addition to cancer therapy significantly increases the risk of serious neutropenic events, and this risk may be dose-dependent.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6393-6398
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• 2013

In this research, we used $GdCl_3$ (gadolinium chloride) to restrain the function of Kupffer cells and assessed effects on hepatocarcinogenesis and metastasis in the Kunming mouse. A 0.25% $GdCl_3$ solution (10 mg/kg b.w.) was infused via the vena caudalis of each mouse 1 week before inoculation of H22 cells and was continued once per three days. Then we observed the follow indexes 3 weeks after injection of H22 cells: tumor weight, histologic characteristics of tumor tissue by light microscopy, ultramicrostructure of Kupffer cells under the electron microscope, distribution and number of Kupffer cells by histochemical staining, and TNF-${\alpha}$ and IFN-${\gamma}$ levels in blood-serum and liver tissue by ELISA and RT-PCR. MMP-2 protein expression was tested by immunohistochemistry. The $GdCl_3$ pretreatment had no effect on the quantity of Kupffer cells, but clearly restrained their functions, with decrease of TNF-${\alpha}$ and IFN-${\gamma}$ levels and elevation of MMP2. Tumor immunity functions were markedly suppressed and tumor growth was accelerated with appearance of metastasis. Furthermore, survival time of trial mice was shortened.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.15 no.1
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• pp.117-126
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• 2002

In this paper, 3-D fame design using second-orders plastic-hinge analysis accounting for lateral torsional buckling is developed. This analysis accounts for material and geometric nonlinearities of the structural system and its component members. Moreover, the problem associated with conventional second-order plastic-hinge analyses, which do not consider the degradation of the flexural strength caused by lateral torsional buckling, is overcome. Efficient ways of assessing steel frame behavior including gradual yielding associated with residual stresses and flexure, second-order effect, and geometric imperfections are presented. In this study, a model consisting of the unbraced length and cross-section shape is used to account for lateral torsional buckling. The proposed analysis is verified by the comparison of the LRFD results. A case studs shows that lateral torsional buckling is a very crucial element to be considered in second-order plastic-hinge analysis. The proposed analysis is shown to be an efficient reliable tool ready to be implemented into design practice.

• Korean Journal of Optics and Photonics
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• v.17 no.3
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• pp.268-272
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• 2006

We have demonstrated the selection and the amplification of the components of an optical frequency comb using femto-second laser injection-locking technique. We used a mode-locked Ti:sapphire laser as a master laser and a single-mode diode laser as a slave laser. After passing through the interference filter with the center wavelength 794.7 nm and the transmittance bandwidth 1.5 nm, the optical frequency comb by mode-locked femto-second laser was injected into the slave laser. The injection-locked slave laser had $3{\sim}4$ multi-mode with the mode spacing 100.5 MHz, whichcorrespond to the repetition rate of a mode-locked Ti:sapphire laser. The power of the modes selected by femto-second laser injection-locking technique was amplified to several thousands times

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.2699-2701
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• 2013

The RAS family genes encode small GTP-binding cytoplasmic proteins. Activated KRAS engages multiple effector pathways, notably the RAF-mitogen-activated protein kinase, phosphoinositide-3-kinase (PI3K) and RalGDS pathways. In the clinical field, K-ras oncogene activation is frequently found in human cancers and thus may serve as a potential diagnostic marker for cancer cells in circulation. This mini-review aims to summarise information on Ras-induced oncogenesis and the clinical significance of K-ras.

• Korean Journal of Optics and Photonics
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• v.25 no.5
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• pp.273-278
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• 2014

We present an algorithm for surface reconstruction from the second-derivative data for free-form aspherics, which uses a subaperture scanning system that measures the local surface profile and determines the three second-derivative values at those local sampling points across the free-form surface. The three second-derivative data were integrated to get a map of x- and y-slopes, which went through a second Southwell integration step to reconstruct the surface profile. A synthetic free-form surface 200 mm in diameter was simulated. The simulation results show that the reconstruction error is 19 nm RMS residual difference. Finally, the sensitivity to noise is diagnosed for second-derivative Gaussian random noise with a signal to noise ratio (SNR) of 16, the simulation results proving that the suggested method is robust to noise.

• Restorative Dentistry and Endodontics
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• v.45 no.4
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• pp.46.1-46.8
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• 2020

Objectives: This study aimed to investigate the incidence and location of the second mesiobuccal root (MB2) canal in maxillary molars with the aid of various measuring points and lines using cone-beam computed tomography (CT). Materials and Methods: A total of 205 images of patients who underwent cone-beam CT examinations between 2011 and 2015 as part of their dental diagnosis and treatment were included. There were 76 images of the maxillary first molar and 135 images of the maxillary second molar. Canal orifices were detected at -1 mm from the top of the pulpal floor on cone-beam CT images. Image assessment was performed by 2 observers in reformatted image planes using software. Assessments included measurement of the distance between the MB1 and MB2 canals, and the angles between the lines connecting the MB1-MB2 and distobuccal (DB)-palatal (P) canals. The data were analyzed using the student's t-test. Results: The prevalence of the MB2 canal was 86.8% in the first molar and 28.9% in the second molar. The angle between the lines connecting the MB1-MB2 and DB-P canals was 2.3° ± 5.7° in the first molar and -3.95° ± 7.73° in the second molar. The distance between the MB1 and MB2 canals was 2.1 ± 0.44 mm in the first molar and 1.98 ± 0.42 mm in the second molar. Conclusions: The angles between the lines connecting the MB1-MB2 and DB-P canals was almost parallel. These findings may aid in the prediction of the location of the MB2 canal orifice.

• BMB Reports
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• v.44 no.8
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• pp.547-552
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• 2011

MED19 is a member of the Mediator that plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas. To tested the functional role of MED19 in human prostate cancer, we downregulated MED19 expression in prostate cancer cells (PC-3 and DU145) by lentivirus-mediated short hairpin (shRNA), and analyzed the effect of inhibition of MED19 on prostate cancer cell proliferation and tumorigenesis. The in vitro prostate cancer cell proliferation, colony formation, and in vivo tumor growth in nude mice xenografts was significantly reduced after the downregulation of MED19. Knockdown of MED19 caused S-phase arrest and induced apoptosis via modulation of Bid and Caspase 7. It was suggested that MED19 serves as a novel proliferation regulator that promotes growth of prostate cancer cells.

• Journal of Embryo Transfer
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• v.10 no.1
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• pp.73-82
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• 1995

large scale production of cloned embryos requires the technology of multiple generation nuclear transplantation(NT) using NT embryos as the subsequent donor nuclei. The purposes of this study were producing the second generation cloned rabbit embryos, and also to determine the electrofusion rate and in vitro developmental potential comparatively in the cloned embryos of the first and second NT generation. The embryos of 16-cell stage were collected from the mated does by flushing oviducts with Dulbecco's phosphate buffered saline(D-PBS) containing 10% fetal calf serum(FCS) at 47 hours after hCG injection In the first generation NT, the nuclear donor embryos were synchronized in the phase of Gi /S transition of 32-cell stage. The first generation NT embryos which were developed to 8-cell were synchronized in Gi /S transition phase of the following 16-cell stage and used as donor nuclei for second generation Synchronization of the cell cycle of blastomeres was induced, first, using an inhibitor of microtuble polymerization, colcemid for 10 hours to arrest blastomeres in M phase, and secondly, using a DNA synthesis inhibitor, aphidicolin for 1.5 to 2 hours to arrest them in Gi /S transition boundary. The recipient cytoplasms were obtained by removing the nucleus and the first polar body from the oocytes collected at 14 hours after hCG injection. The separated donor blastomeres were injected into the enucleated recipient oocytes by micromanipulation and were electrofused by electrical stimulation of three pulses for 60 $\mu$sec at 1.25 kV /cm in 0.28 M rnannitol solution The fused oocytes were co-cultured with a monolayer of rabbit oviductal epithelial cells in M-199 solution containing 10% FCS for 120 hours at 39$^{\circ}C$ in a 5% $CO_2$ incubator. Following in vitro culture of the first and second generation cloned embryos to blastocyst stage, they were stained with Hoechst 33342 dye for counting the number of blastomeres by fluorescence microscopy. The results obtained were summarized as follows: 1. The electrofusion rate was found to be similar as 79.4 and 91.5% in the first and second generation NT rabbit embryos, respectively. 2. The in vitro developmental potential to blastocyst stage of the second generation NT embryos (23.3%) was found significantly(p<0.05) lower, compared with that of the first generation NT embryos (56.8%). 3. The mean blastomeres counts of embryos developed to blastosyst stage following in vitro culture for 120 hours and also their daily cell cycles during the culture period were decreased significantly (p<0.05) to 104.3 cells and 1.33 cylces in the second NT generation, compoared with 210.4 cells and 1.54 cycles in the first NT generation, respectively.

• Journal of Information Technology Applications and Management
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• v.22 no.1
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• pp.153-163
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• 2015

The purpose of this study is to investigate the relationship among factors that expand the win-win growth between domestic finished goods-making manufacturers and subcontractors. One-hundred twenty six firms participated for this study and were used for the data analysis. As a result of analysis, first, it was found that the win-win growth between first-tier suppliers and second-tier suppliers has positive effects on the win-win growth made by second-tier suppliers helping the third-tier suppliers. Second, it was found that the win-win growth policies supported by the government for the positive relationship between first-tier suppliers and second-tier suppliers for the finished goods-making manufacturers have positive effects on the win-win growth between second-tier suppliers and third-tier suppliers. Third, the results also showed that the win-win growth between second-tier suppliers and third-tier suppliers has a positive influence both on the financial and on the non-financial performances of the second-tier suppliers. Based on the results of this study, it is recommended to (1) construct infrastructure by sector through partnership between finished goods-making manufacturers and subcontractors, (2) draw in active support through the governmental win-win growth policies, (3) induce increasing productivities through information sharing, manpower support, technical support and educational support, and (4) strengthen and cultivate the culture of the small- and medium-sized companies.