• Geomechanics and Engineering
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• v.32 no.4
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• pp.427-443
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• 2023

Across the globe, rapid urbanization demands the construction of basements for car parking and sub way station within the vicinity of high-rise buildings supported on piled raft foundations. As a consequence, ground movements caused by such excavations could interfere with the serviceability of the building and the piled raft as well. Hence, the prediction of the building responses to the adjacent excavations is of utmost importance. This study used three-dimensional numerical modelling to capture the effects of twin excavations (final depth of each excavation, H_e=24 m) on a 20-storey building resting on (4×4) piled raft. Because the considered structure, pile foundation, and soil deposit are three-dimensional in nature, the adopted three-dimensional numerical modelling can provide a more realistic simulation to capture responses of the system. The hypoplastic constitutive model was used to capture soil behaviour. The concrete damaged plasticity (CDP) model was used to capture the cracking behaviour in the concrete beams, columns and piles. The computed results revealed that the first excavation- induced substantial differential settlement (i.e., tilting) in the adjacent high-rise building while second excavation caused the building tilt back with smaller rate. As a result, the building remains tilted towards the first excavation with final value of tilting of 0.28%. Consequently, the most severe tensile cracking damage at the bottom of two middle columns. At the end of twin excavations, the building load resisted by the raft reduced to half of that the load before the excavations. The reduced load transferred to the piles resulting in increment of the axial load along the entire length of piles.

• Journal of the Korean Geophysical Society
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• v.7 no.4
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• pp.283-291
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• 2004

To find out the locus of the Quinling-Dabie-Sulu continental collision’s boundary and to estimate underground structure of the sedimentray basin in the Yellow Sea, three dimensional density modelling is carrid out by using gravity dataset (Free Air Anomaly), which is measured by Tamhae 2, KIGAM in a period between 2000 and 2002. The measured gravity anomaly in the investigations area is mainly responsed by depth and density differences between the sedimentary basin and the basement. The high density model-bodies extend mainly from the southern part of China to the middle-western part of the Korean Peninsula, which might be emplaced along the continental collision’s boundary. The total volume of the very low density model-bodies might be expected at about 20,000 km3 in the model area.

• Geotechnical Engineering
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• v.12 no.6
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• pp.127-138
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• 1996

The in-situ consolidation behavior of drainage system-installed deposits has three dimensional characteristics. Therefore, for an approximate 2-D plane strain consolidation analysis, it is necessary to convert the 3-D spatial flow of actual cases into the laminar flow simulated by the 2-D plane strain model. . In this paper, in order to properly model the effect of three dimensional characteristics, an equivalent and efficient model has been applied in a finite element technique for the analysis of the drainage system-installed soil deposits. The equivalent two dimensional model involves equivalent permeabilities and drainage widths. To validate the equivalent two dimensional model, three dimensional analyses were per formed by using the ABAQUS program and the results of 3-D analyses were compared with those of the 2-D analyses. By using the proposed equivalent model, one may be able to appropriately predict the consolidation behavior of drainage system-installed soft deposits.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1484-1486
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• 2008

Characteristics of pulsatile flow in 3-dimensional elastic vessel wall should be investigated in order to understand the physiological blood flow in human body. In this study, the modelling of the physiological blood flow in the elastic blood vessel is proposed. Variation of the pressure and the velocity wavefroms are obtained using the FSI method

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.4
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• pp.445-452
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• 2009

Through the Airbone LiDAR point, the study for three-dimensional modeling of the city zone has been in progress. So, deciding the Density of Airbone LiDAR point for that is very important to get a result of three-dimensional modeling of the city zone and make efficient use of airbone LiDAR. This study made the standard density to decide the optimum density of Airbone LiDAR point in the city zone. Through each standard density point of DSM and the outline of the buildings, It executed the visual evaluation and the accuracy inspection to decide the optimum density point, and presented the optimum density for the airbone LiDAR point in the city zone.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2009.10a
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• pp.215-216
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• 2009

By growing the capacity of container in the world, main container terminal in countries introduces the automated container equipments and try to improve the productivity for handling the container. ARMC(Automated Rail Mounted Crane) is installed in automated container terminal and expected the high efficiency of productivity by using minimum-time control method. However recently by the GREEN Port policy, high energy efficiency method for container equipments is importance issue in ports. In this paper, the 3-dimensional modelling of AMRC is discussed and the acceleration characteristics for ARMC is analyzed By using the results of this paper, the advanced controller for the crane will be developed in future.

• Journal of Animal Science and Technology
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• v.57 no.12
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• pp.44.1-44.9
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• 2015

Background: Heat shock proteins play an important role in protection from stress stimuli and metabolic insults in almost all organisms. Methods: In this study, computational tools were used to deeply analyse the physicochemical characteristics and, using homology modelling, reliably predict the tertiary structure of the blunt snout bream (Ma-) Hsp70 and Hsc70 proteins. Derived three-dimensional models were then used to predict the function of the proteins. Results: Previously published predictions regarding the protein length, molecular weight, theoretical isoelectric point and total number of positive and negative residues were corroborated. Among the new findings are: the extinction coefficient (33725/33350 and 35090/34840 - Ma-Hsp70/ Ma-Hsc70, respectively), instability index (33.68/35.56 - both stable), aliphatic index (83.44/80.23 - both very stable), half-life estimates (both relatively stable), grand average of hydropathicity (-0.431/-0.473 - both hydrophilic) and amino acid composition (alanine-lysine-glycine/glycine-lysine-aspartic acid were the most abundant, no disulphide bonds, the N-terminal of both proteins was methionine). Homology modelling was performed by SWISS-MODEL program and the proposed model was evaluated as highly reliable based on PROCHECK's Ramachandran plot, ERRAT, PROVE, Verify 3D, ProQ and ProSA analyses. Conclusions: The research revealed a high structural similarity to Hsp70 and Hsc70 proteins from several taxonomically distant animal species, corroborating a remarkably high level of evolutionary conservation among the members of this protein family. Functional annotation based on structural similarity provides a reliable additional indirect evidence for a high level of functional conservation of these two genes/proteins in blunt snout bream, but it is not sensitive enough to functionally distinguish the two isoforms.

• Proceedings of the KIEE Conference
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• 2006.07b
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• pp.661-662
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• 2006

On the contrary of a conventional motor with very narrow air-gap, it is difficult to calculate the accurate magnetic field distribution and the performance of an air-cored superconducting motor by 2 dimensional analysis, which does not use high permeability material except outer machine shield. This paper aims to do analysis of magnetic field and force distribution from the 3 dimensional modelling of a 1MW class superconducting synchronous motor. Especially, the field coil composed of Bi-2223 high-temperature superconductor and the outer machine shield are modelled by finite element analysis software according to their structures and the self-inductance and Lorentz force are calculated based on the 3 dimensional magnetic field calculation.

• Journal of Institute of Control, Robotics and Systems
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• v.11 no.9
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• pp.768-773
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• 2005

A new approach for human foot modelling and last design based on the cross sectional method is presented in this paper. The proposed last design method utilizes the dynamic trimmed parametric patches for the foot 3D data and last 3D data. The cross section a surface of 3D foot for the 3D last, design modeling of free form geometric last shapes. The proposed last design scheme wraps the 3D last data surrounding the measured 3D foot data with the effect of deforming the last design rule The last design rule of the FFD is constructed on the FFD lattice based on foot-last shape analysis. In addition, the control points of FFD lattice are constructed with cross sectional data interpolation methods from the a finite set of 3D foot data. The deformed 3D last result obtained from the proposed FFD is saved as a 3D dxf foot data. The experimental results demonstrate that the last designed with the proposed scheme has good performance.

• Biomolecules & Therapeutics
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• v.29 no.5
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• pp.506-518
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• 2021

The imprinted tumour suppressor NOEY2 is downregulated in various cancer types, including ovarian cancers. Recent data suggest that NOEY2 plays an essential role in regulating the cell cycle, angiogenesis and autophagy in tumorigenesis. However, its detailed molecular function and mechanisms in ovarian tumours remain unclear. In this report, we initially demonstrated the inhibitory effect of NOEY2 on tumour growth by utilising a xenograft tumour model. NOEY2 attenuated the cell growth approximately fourfold and significantly reduced tumour vascularity. NOEY2 inhibited the phosphorylation of the signalling components downstream of phosphatidylinositol-3'-kinase (PI3K), including phosphoinositide-dependent protein kinase 1 (PDK-1), tuberous sclerosis complex 2 (TSC-2) and p70 ribosomal protein S6 kinase (p70S6K), during ovarian tumour progression via direct binding to vascular endothelial growth factor receptor-2 (VEGFR-2). Particularly, the N-terminal domain of NOEY2 (NOEY2-N) had a potent anti-angiogenic activity and dramatically downregulated VEGF and hypoxia-inducible factor-1α (HIF-1α), key regulators of angiogenesis. Since no X-ray or nuclear magnetic resonance structures is available for NOEY2, we constructed the three-dimensional structure of this protein via molecular modelling methods, such as homology modelling and molecular dynamic simulations. Thereby, Lys15 and Arg16 appeared as key residues in the N-terminal domain. We also found that NOEY2-N acts as a potent inhibitor of tumorigenesis and angiogenesis. These findings provide convincing evidence that NOEY2-N regulates endothelial cell function and angiogenesis by interrupting the VEGFR-2/PDK-1/GSK-3β signal transduction and thus strongly suggest that NOEY2-N might serve as a novel anti-tumour and anti-angiogenic agent against many diseases, including ovarian cancer.