• Archives of Pharmacal Research
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• 제27권10호
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• pp.1043-1047
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• 2004

Thirteen compounds were isolated from the $CH_2Cl_2$ fraction of Machilus thunbergii as phospholipase $C{\Upsilon}1\;(PLC{\Upsilon}1)$ inhibitors. These compounds were identified as nine lignans, two neolignans, and two flavans by spectroscopic analysis. Of these, 5,7-di-O-methyl-3',4'-methylenated (-)-epicatechin (12) and 5,7,3'-tri-O-methyl (-)-epicatechin (13) have not been reported previously in this plant. In addition, seven compounds, machilin A (1), (-)-sesamin (3), machilin G (5), (+)-galbacin (9), licarin A (10), (-)-acuminatin (11) and compound 12 showed dose-dependent potent inhibitory activities against $PLC{\Upsilon}1$ in vitro with $IC_{50}$ values ranging from 8.8 to 26.0 ${\mu}M$. These lignans, neolignans, and flavans are presented as a new class of $PLC{\Upsilon}1$ inhibitors. The brief study of the structure activity relationship of these compounds suggested that the benzene ring with the methylene dioxy group is responsible for the expression of inhibitory activities against $PLC{\Upsilon}1$. Moreover, it is suggested that inhibition of $PLC{\Upsilon}1$ may be an important mechanism for an antiproliferative effect on the human cancer cells. Therefore, these inhibitors may be utilized as cancer chemotherapeutic and chemopreventive agents.

• 약학회지
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• 제18권1호
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• pp.11-19
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• 1974

A new dammarane-type triterpenoid, betulafolianediol, $C_{30}$H$_{52}$O$_{3}$, mp $165^{\circ}$[${\alpha}$]$_D$^{20}=+$20^{\circ}$, was isolated form the unsaponifiable fraction of leves of Betula latifalia $K_{OMAROV}$ (Betulaceae). From the spectral data of the betulafolianediol and its derivatives, betulafolianediol monoacetate (II) and betulafolianediol monoketone, the structure of betulafolianediol was provide to be 3${\alpha}$, 25-dioxy-dammarane-20[S]->24 [S]-epoxide.

• Bulletin of the Korean Chemical Society
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• 제29권6호
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• pp.1250-1252
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• 2008

• Biotechnology and Bioprocess Engineering:BBE
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• 제4권1호
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• pp.17-20
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• 1999

Facile synthetic methods of 2',5'-dideoxy-, 2',3'-dideoxy- and 3'-deoxy-1, N6-ethenoadenosine nucleosides by either an enzymatic dideoxyribosyl transfer reaction or a simple chemical reaction were proposed. The synthesis products were isolated and purified by preparative HPLC and their structures were confirmed by 1H NMR (500 MHz) and FAB-MS including high resolution mass measurement. These modified nucleoside analogs have not been reported yet. Therefore, these modified nucleoside analogs are of potential value to be studied further for biological activity such as anticancer or antiviral.

• 한국응용과학기술학회지
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• 제15권1호
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• pp.17-23
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• 1998

To prepare a O/W type nonionic durable softner(ANSA), synthesized 1, 3-dihexadanoyl-2, 7-dioxy-6, 8-di(2-hexadecanoyloxyethyl)-1, 3, 6, 8-tetraazacyclodecane as the main component of softner, was blended with beef tallow, anhydrous lanolin, polyoxyethylene(20) oleyl ether, sorbitan sesquioleate, and polyoxyethylene(7) stearyl ether in various compositions. Emulsion stability of ANSA was good, and the mixed HLB value was 9.8. After the treatment of ANSA to all cotton fabrics, the physical properties such as tear strength, crease recovery, and flexing abrasion resistance were measured, respectively. As a result of the measurement, ANSA was proved to be durable softner with good softness.

• Archives of Pharmacal Research
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• 제25권3호
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• pp.240-249
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• 2002

Dibenzyl-g-butyrolactone and 1,2,3,4-tetrahydro-2-naphthoic acid $\gamma$-lactone (TNL) derivatives were synthesized and evaluated for cytotoxic activity against some cancer cell lines. It was found that TNL derivatives with a shorter distance between C-4 in ring A and C'-2 in ring C were more cytotoxic, while dibenzyl-${\gamma}$-butyrolactones with a longer one were nearly inactive. In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity.

• 한국응용과학기술학회지
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• 제7권1호
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• pp.87-91
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• 1990

1,3-Di(2-octadecanoyl)-2,7-dioxy-l,3,6,8-tetra aza cyclodecane [DDTC] was synthesized by reacting octadecanoic acid, 2,2'-di-aminodiethyl amine with urea. O/W type softner (STA) was prepared by blending DDTC and pentaerithritol monostearate with polyoxysthylene (20) oleyl ether, polyoxyethylene (10) castor oil, and PEG #1000-lauric acid ester. Treating STA to all cotton fabrics, the physical properties, such as tear strength, crease recovery, flexing abrasion resistance, and so on were measured. Resulting the measurements, STA was found to be durable softner with softness.

• 한국응용과학기술학회지
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• 제12권2호
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• pp.75-83
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• 1995

1, 3-Di(2-dodecanoylaminoethyl)-2, 7-dioxy-1, 3, 6, 8-tetraazacyclodecane[DDTD] and sorbitan monostearate(SMS) were synthesized as a main component for softner. O/W type softner(DSA) was prepared by blending of DSA, SMS, polyoxyethylene(10) castor oil, glyceryl monooleate, and polyoxyethylene(7) stearyl ether. After treatment of DSA to all cotton fabrics, the physical properties such as tear strength, crease recovery, and flexing abrasion resistance were measured. As a result of the measurement, DSA was found to be durable softner with good softness.

• 한국응용과학기술학회지
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• 제12권2호
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• pp.65-73
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• 1995

1, 3-Di(dodecanoyl)-2, 7-dioxy-6, 8-di(2-hydroxyethyl)-1, 3, 6, 8-tetraazacyclodecane(DDDT) and pentaerythritol monostearate(PMS) were synthesized as a main component for softner. O/W type softner(DPSA) was prepared by blending DDDT and PMS with polyoxyethylene(10) castor oil, polyoxyethylene(20) oleyl ether, and polyoxyethylene(10) monolaurate. After treatment of DPSA to all cotton fabrics, the physical properties such as tear strength, crease recovery, and flexing abrasion resistance were measured. As a result of the measurement, DPSA was proved to be durable softner with good softness.

• 대한화학회지
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• 제13권4호
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• pp.297-302
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• 1969

The activation parameters for the nucleophilic addition reactions of n-propyl-, n-butyl-, n-amyl-and n-hexyl-mercaptan to 3, 4-methylene-dioxy-${\beta}$-nitrostyrene were determined at pH 5.8 and pH 2.0, and also the isokinetic temperature of the reactions at pH 5.8 was obtained numerically 262${\circ}$K, and at pH 2.0, 17.1${\circ}$K. From the values obtained above, the fact that the mercaptan having the longer carbon chain has the greater nucleophilicity of it in the addition reactions has been discussed by the extrathermodynamic analysis of ${\Delta}H^{\neq}$and ${\Delta}S^{\neq}$.