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2,3-Dibenzylbutyrolactones and 1,2,3,4-Tetrahydro-2-Naphthoic acid ${\gamma}-Lactones$: Structure and Activity Relationship in Cyto-toxic Activity  

Kim, Yong (College of Pharmacy, Chungnam National University)
You, Young-Jae (College of Pharmacy, Chungnam National University)
Nam, Nguyen-Hai (College of Pharmacy, Chungnam National University)
Ahn, Byung-Zun (College of Pharmacy, Chungnam National University)
Publication Information
Archives of Pharmacal Research / v.25, no.3, 2002 , pp. 240-249 More about this Journal
Abstract
Dibenzyl-g-butyrolactone and 1,2,3,4-tetrahydro-2-naphthoic acid $\gamma$-lactone (TNL) derivatives were synthesized and evaluated for cytotoxic activity against some cancer cell lines. It was found that TNL derivatives with a shorter distance between C-4 in ring A and C'-2 in ring C were more cytotoxic, while dibenzyl-${\gamma}$-butyrolactones with a longer one were nearly inactive. In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity.
Keywords
Yatein analogues; Deoxypodophyllotoxin analogues; Cytotoxic activity;
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