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Double Domination in the Cartesian and Tensor Products of Graphs

  • CUIVILLAS, ARNEL MARINO;CANOY, SERGIO R. JR.
    • Kyungpook Mathematical Journal
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    • v.55 no.2
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    • pp.279-287
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    • 2015
  • A subset S of V (G), where G is a graph without isolated vertices, is a double dominating set of G if for each $x{{\in}}V(G)$, ${\mid}N_G[x]{\cap}S{\mid}{\geq}2$. This paper, shows that any positive integers a, b and n with $2{\leq}a<b$, $b{\geq}2a$ and $n{\geq}b+2a-2$, can be realized as domination number, double domination number and order, respectively. It also characterize the double dominating sets in the Cartesian and tensor products of two graphs and determine sharp bounds for the double domination numbers of these graphs. In particular, it show that if G and H are any connected non-trivial graphs of orders n and m respectively, then ${\gamma}_{{\times}2}(G{\square}H){\leq}min\{m{\gamma}_2(G),n{\gamma}_2(H)\}$, where ${\gamma}_2$, is the 2-domination parameter.

Bit-rate Scalable Video Coder Using a $2{\times}2{\times}2$ DCT for Progressive Transmission

  • Woo, Seock-Hoon;Park, Jin-Hyung;Won, Chee-Sun
    • Proceedings of the IEEK Conference
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    • 2000.07a
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    • pp.66-69
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    • 2000
  • In this paper, we propose a progressive transmission of a video using a 2$\times$2$\times$2 DCT First of all, the video data is transformed into multiresolution represented video data using a 2$\times$2$\times$2 DCT. Then. it is represented by a 3-D EZT(Embedded Zero Tree) coding fur the progressive transmission with a bit-rate scalability. The proposed progressive transmission algorithm needs much less computations and buffer memories than the higher-order convolution based wavelet filter. Also, since the 2$\times$2$\times$2 DCT requires independent local computations, parallel processing can be applied.

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Overexpression of Phospholipase A2 Group IIA in Esophageal Squamous Cell Carcinoma and Association with Cyclooxygenase-2 Expression

  • Zhai, Yan-Chun;Dong, Bin;Wei, Wen-Qiang;He, Yan;Li, Xin-Qing;Cormier, Robert T.;Wang, Wei;Liu, Fen
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.21
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    • pp.9417-9421
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    • 2014
  • Background: Esophageal cancer is one of the most frequently occurring malignancies and the seventh leading cause of cancer-related deaths in the world. The esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer worldwide. Materials and Methods: Our goal in this study was to detect phospholipase A2 Group IIA (PLA2G2A) and cyclooxygenase-2 (COX-2) immuno-expression in ESCC in a high-risk population in China. Results: Positive expression of PLA2G2A protein was observed in 57.2% (166/290) of the cases, while COX-2 was found in 257 of 290 samples (88.6%), both PLA2G2A and COX-2 being expressed in 153 cases (52.8%), with a significant agreement (Kappa=0.091, p=0.031).Overexpression of PLA2G2A was significantly correlated with the depth of invasion (p=0.001). Co-expression of PLA2G2A and COX-2 not only significantly correlated with the depth of invasion (p=0.004) but also with TNM stage (p=0.04). Conclusions: Our results showed that in patients with ESCC, PLA2G2A overexpression and PLA2G2A co-expression with COX-2 is significantly correlated with advanced stage. The biological role and pathophysiologic regulation of PLA2G2A and COX-2 overexpression in ESCC deserve further investigation.

LOCAL PERMUTATION POLYNOMIALS OVER FINITE FIELDS

  • Lee, Jung-Bok;Ko, Hyoung-June
    • Communications of the Korean Mathematical Society
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    • v.9 no.3
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    • pp.539-545
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    • 1994
  • Let $q = p^r$, where p is a prime. A polynomial $f(x) \in GF(q)[x]$ is called a permutation polynomial (PP) over GF(q) if the numbers f(a) where $a \in GF(Q)$ are a permutation of the a's. In other words, the equation f(x) = a has a unique solution in GF(q) for each $a \in GF(q)$. More generally, $f(x_1, \cdots, x_n)$ is a PP in n variables if $f(x_1,\cdots,x_n) = \alpha$ has exactly $q^{n-1}$ solutions in $GF(q)^n$ for each $\alpha \in GF(q)$. Mullen ([3], [4], [5]) has studied the concepts of local permutation polynomials (LPP's) over finite fields. A polynomial $f(x_i, x_2, \cdots, x_n) \in GF(q)[x_i, \codts,x_n]$ is called a LPP if for each i = 1,\cdots, n, f(a_i,\cdots,x_n]$ is a PP in $x_i$ for all $a_j \in GF(q), j \neq 1$.Mullen ([3],[4]) found a set of necessary and three variables over GF(q) in order that f be a LPP. As examples, there are 12 LPP's over GF(3) in two indeterminates ; $f(x_1, x_2) = a_{10}x_1 + a_{10}x_2 + a_{00}$ where $a_{10} = 1$ or 2, $a_{01} = 1$ or x, $a_{00} = 0,1$, or 2. There are 24 LPP's over GF(3) of three indeterminates ; $F(x_1, x_2, x_3) = ax_1 + bx_2 +cx_3 +d$ where a,b and c = 1 or 2, d = 0,1, or 2.

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Circ_UBE2D2 Attenuates the Progression of Septic Acute Kidney Injury in Rats by Targeting miR-370-3p/NR4A3 Axis

  • Huang, Yanghui;Zheng, Guangyu
    • Journal of Microbiology and Biotechnology
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    • v.32 no.6
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    • pp.740-748
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    • 2022
  • As circ_UBE2D2 has been confirmed to have targeted binding sites with multiple miRNAs involved in septic acute kidney injury (SAKI), efforts in this study are directed to unveiling the specific role and relevant mechanism of circ_UBE2D2 in SAKI. HK-2 cells were treated with lipopolysaccharide (LPS) to construct SAKI model in vitro. After sh-circ_UBE2D2 was transfected into cells, the transfection efficiency was detected by qRT-PCR, cell viability and apoptosis were determined by MTT assay and flow cytometry, and expressions of Bcl-2, Bax and Cleaved-caspase 3 were quantified by western blot. Target genes associated with circ_UBE2D2 were predicted using bioinformatics analysis. After the establishment of SAKI rat model, HE staining and TUNEL staining were exploited to observe the effect of circ_UBE2D2 on tissue damage and cell apoptosis. The expression of circ_UBE2D2 was overtly elevated in LPS-induced HK-2 cells. Sh-circ_UBE2D2 can offset the inhibition of cell viability and the promotion of cell apoptosis induced by LPS. Circ_UBE2D2 and miR-370-3p as well as miR-370-3p and NR4A3 have targeted binding sites. MiR-370-3p inhibitor reversed the promoting effect of circ_UB2D2 silencing on viability of LPS-treated cells, but shNR4A3 neutralized the above inhibitory effect of miR-370-3p inhibitor. MiR-370-3p inhibitor weakened the down-regulation of NR4A3, Bax and Cleaved caspase-3 and the up-regulation of Bcl-2 induced by circ_UB2D2 silencing, but these trends were reversed by shNR4A3. In addition, sh-circ_UBE2D2 could alleviate the damage of rat kidney tissue. Circ_UBE2D2 mitigates the progression of SAKI in rats by targeting miR-370-3p/NR4A3 axis.

Competitive Adsorption of CO2 and H2O Molecules on the BaO (100) Surface: A First-Principle Study

  • Kwon, Soon-Chul;Lee, Wang-Ro;Lee, Han-Na;Kim, J-Hoon;Lee, Han-Lim
    • Bulletin of the Korean Chemical Society
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    • v.32 no.3
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    • pp.988-992
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    • 2011
  • $CO_2$ adsorption on mineral sorbents has a potential to sequester $CO_2$. This study used a density functional theory (DFT) study of $CO_2$ adsorption on barium oxide (BaO) in the presence of $H_2O$ to determine the role of $H_2O$ on the $CO_2$ adsorption properties on the ($2{\times}2$; $11.05\;{\AA}{\times}11.05\;{\AA}$) BaO (100) surface because BaO shows a high reactivity for $CO_2$ adsorption and the gas mixture of power plants generally contains $CO_2$ and $H_2O$. We investigated the adsorption properties (e.g., adsorption energies and geometries) of a single $CO_2$ molecule, a single $H_2O$ molecule on the surface to achieve molecular structures and molecular reaction mechanisms. In order to evaluate the coordinative effect of $H_2O$ molecules, this study also carried out the adsorption of a pair of $H_2O$ molecules, which was strongly bounded to neighboring (-1.91 eV) oxygen sites and distant sites (-1.86 eV), and two molecules ($CO_2$ and $H_2O$), which were also firmly bounded to neighboring sites (-2.32 eV) and distant sites (-2.23 eV). The quantum mechanical calculations show that $H_2O$ molecule does not influence on the chemisorption of $CO_2$ on the BaO surface, producing a stable carbonate due to the strong interaction between the $CO_2$ molecule and the BaO surface, resulting from the high charge transfer (-0.76 e).

The Study on Location and Adsorbate Interaction for Vanadium Species in $VO^{2+}-SAPO-5$ by Electron Spin Resonance and Electron Spin Echo Modulation Spectroscopies

  • Back Gern-Ho;Park Sung-Gun;Lee Chul-Wee
    • Journal of the Korean Magnetic Resonance Society
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    • v.9 no.2
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    • pp.138-154
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    • 2005
  • Vanadium-incorporated aluminophosphate molecular sieve $VO^{2+}-SAPO-5$ was studied by electron spin resonance (ESR) and electron spin echo modulation (ESEM) spectroscopies to determine the vanadium structure and interaction with various adsorbate molecules. It was found that the main species at low concentration of vanadium is a monomeric vanadium units in square pyramidal or distorted octahedral coordination, both in oxidation state (IV) for the calcined hydrated material and in oxidation state (V) for the calcined material. After calcinations in $O_2$ and exposure to moisture, only species A is observed with reduced intensities. It is suggested as a $VO(H_2O)_3^{2+}$ complex coordinated to two framework oxygen bonded aluminum. When calcined, hydrated $VO^{2+}-}SAPO-5$ is dehydrated at elevated temperature, a species loses its water ligands and transforms to $VO^{2+}$ ions coordinated to two framework oxygens (species B). Species B reduces its intensity, significantly after treatment with $O_2\;at\;600^{\circ}C$ for 5 h, thus suggesting oxidation of $V^{4+}\;to\;V^{5+}$. When dehydrated $VO^{2+}-SAPO-5$ contacts with $D_2O$ at room temperature, the EPR signal of species A is observed. Thus species assumed as a $VO^{2+}(O_f)_2(D_2O)_3$, by considering two framework oxygens. Adsorption of deuterated ethanol, propanol on dehydrated $VO^{2+}_{-}SAPO-5$ result in another new vanadium species E and F, respectively, which are identified as a $VO^{2+}-(CH_3CH_2OD)_3,\;VO^{2+}-(CH_3CH_2CH_2OD)_2$ complex. When deuterated benzene is adsorbed on dehydrated $VO^{2+}-SAPO-5$, another new vanadium species G, identified as a $VO^{2+}-(C_6D_6)$ is observed. Possible coordination geometries of these various complexes are discussed.

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SERCA2a: a prime target for modulation of cardiac contractility during heart failure

  • Park, Woo Jin;Oh, Jae Gyun
    • BMB Reports
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    • v.46 no.5
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    • pp.237-243
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    • 2013
  • Heart failure is one of the leading causes of sudden death in developed countries. While current therapies are mostly aimed at mitigating associated symptoms, novel therapies targeting the subcellular mechanisms underlying heart failure are emerging. Failing hearts are characterized by reduced contractile properties caused by impaired $Ca^{2+}$ cycling between the sarcoplasm and sarcoplasmic reticulum (SR). Sarcoplasmic/endoplasmic reticulum $Ca^{2+}$ ATPase 2a (SERCA2a) mediates $Ca^{2+}$ reuptake into the SR in cardiomyocytes. Of note, the expression level and/or activity of SERCA2a, translating to the quantity of SR $Ca^{2+}$ uptake, are significantly reduced in failing hearts. Normalization of the SERCA2a expression level by gene delivery has been shown to restore hampered cardiac functions and ameliorate associated symptoms in pre-clinical as well as clinical studies. SERCA2a activity can be regulated at multiple levels of a signaling cascade comprised of phospholamban, protein phosphatase 1, inhibitor-1, and $PKC{\alpha}$. SERCA2 activity is also regulated by post-translational modifications including SUMOylation and acetylation. In this review, we will highlight the molecular mechanisms underlying the regulation of SERCA2a activity and the potential therapeutic modalities for the treatment of heart failure.

Phosphorylation on the PPP2R5D B regulatory subunit modulates the biochemical properties of protein phosphatase 2A

  • Yu, Un-Young;Ahn, Jung-Hyuck
    • BMB Reports
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    • v.43 no.4
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    • pp.263-267
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    • 2010
  • To characterize the biochemical properties of the PP2A regulatory B subunit, PPP2R5D, we analyzed its phosphorylation sites, stoichiometry and effect on holoenzyme activity. PPP2R5D was phosphorylated on Ser-53, Ser-68, Ser-81, and Ser-566 by protein kinase A, and mutations at all four of these sites abolished any significant phosphorylation in vitro. In HEK293 cells, however, the Ser-566 was the major phosphorylation site after PKA activation by forskolin, with marginal phosphorylation on Ser-81. Inhibitory tyrosine phosphorylation on Tyr-307 of the PP2A catalytic C subunit was decreased after forskolin treatment. Kinetic analysis showed that overall PP2A activity was increased with phosphorylation by PPP2R5D phosphorylation. The apparent Km was reduced from $11.25\;{\mu}M$ to $1.175\;{\mu}M$ with PPP2R5D phosphorylation, resulting in an increase in catalytic activity. These data suggest that PKA-mediated activation of PP2A is enabled by PPP2R5D phosphorylation, which modulates the affinity of the PP2A holoenzyme to its physiological substrates.

Glucosylsphingosine Activates Serotonin Receptor 2a and 2b: Implication of a Novel Itch Signaling Pathway

  • Afzal, Ramsha;Shim, Won-Sik
    • Biomolecules & Therapeutics
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    • v.25 no.5
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    • pp.497-503
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    • 2017
  • Recent reports claimed that glucosylsphingosine (GS) is highly accumulated and specifically evoking itch-scratch responses in the skins of atopic dermatitis (AD) patients. However, it was unclear how GS can trigger itch-scratch responses, since there were no known molecular singling pathways revealed yet. In the present study, it was verified for the first time that GS can activate mouse serotonin receptor 2a (mHtr2a) and 2b (mHtr2b), but not 2c (mHtr2c) that are expressed in HEK293T cells. Specifically, effects of GS on all mouse serotonin receptor 2 subfamily were evaluated by calcium imaging techniques. The GS-induced intracellular calcium increase was dose-dependent, and antagonists such as ketanserin (Htr2a antagonist) and RS-127445 (Htr2b antagonist) significantly blocked the GS-induced responses. Moreover, the proposed GS-induced responses appear to be mediated by phospholipase C (PLC), since pretreatment of a PLC inhibitor U-73122 abolished the GS-induced responses. Additionally, the GS-induced calcium influx is probably mediated by endogenous TRPC ion channels in HEK293T cells, since pretreatment of SKF-96365, an inhibitor for TRPC, significantly suppressed GS-induced response. In conclusion, the present study revealed for the first time that GS can stimulate mHtr2a and mHtr2b to induce calcium influx, by utilizing PLC-dependent pathway afterwards. Considering that GS is regarded as a pruritogen in AD, the present study implicates a novel GS-induced itch signaling pathway.