• KSBB Journal
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• v.9 no.2
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• pp.211-223
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• 1994

In fermentations with a 4-liter stirred tank bioreactor, a better than two-fold enhancement of the gas-liquid mass transfer coefficient$(k_La)$ in the celite-immobilized fungal cultures of Tolypocladium in flatum over the parallel conventional free-cell was observed at identical biomass concentrations, despite the higher specific oxygen uptake rate of the immobilized fungi during exponential growth. As a result oxygen sufficient conditions, i. e., dissolve oxygen(D.O.) concentrations exceeding 75% air saturation, could be maintained throughout exponential growth period of the immobilized culture, in contrast to the suspended fungal culture, whose D.O. levels fell below 50% air saturation. A linear monotonic dependence of $k_La$ upon impeller agitaion rate was found for both immobilized and conventional cultivation modes over a range of 250 to 550rpm, the slope being a function of biomass concentration for the free but not for the immobilized cell system In contrasts oxygen transfer rate was a much weaker function of aeration rate up to about 2.5 vvm for both culture configurations. Above this level, aeration rate had no further effect on the mass transfer. In addition, the immobilized cultures sustained good morphological and physiological states, leading to almost two times higher cyclosporln A (CyA) productivity overt the parallel free cell system. These experiments suggest that the celite-immobilized fungal system in a stirred tank reactor has considerable promise for scaling up cyclosporin A production in terms of high-density cultivation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.12
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• pp.1261-1266
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• 2014

Smart shipyard, all of the business of shipyard by using a mobile application, and the rapid spread of smart equipment, the overload of infrastructure due to a variety of mobile services is expected. Because macrocell and femtecell to reduce the overloading of existing infrastructure, additional core network devices have a problem, in this paper, the efficiency of resources than the communication over the existing infrastructure smart shipyard network to improve, to apply the D2D communication technology that can reduce the load on the infrastructure. The proposed routing path plan in accordance with the transfer method and the traffic type of network configuration and D2D equipment navigation and data for applying a smart shipyard. Whether to execute the function to overload traffic in the core network can send to the optimized path was confirmed by using the state transition diagram. Smart shipyard, by applying D2D communication allow efficient traffic handling than conventional communication method.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.8
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• pp.1528-1535
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• 1994

In this paper, a filtered-X LMS algorithm by new error path identification method is proposed for active noise control system. The proposed algorithm identifies accurately the error path transfer function using three microphones and the control of error signal through double loop scheme with on-line. In the computer simulation using the sinusoidal and the practical duct noise, the proposed algorithm reduces noise level about 29.1dB and 10.4dB, respectively. We can observe the improvement of about 0.5dB and 2.5dB in noise level compared with that obtained using the filtered-X LMS algorithm of Eriksson model.

• 한국전산유체공학회:학술대회논문집
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• 2003.08a
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• pp.158-163
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• 2003

This paper assesses the two-equation turbulence models available in a commercial code, FLUENT, for heat transfer in a turbulent heated pipe flow. In case of flow under $Re_D=10,000$, Standard $\kappa-\epsilon$ and Realizable $\kappa-\epsilon$ models overpredict the Nusselt number about $20\%$ compared with the experimental correlation, and RNG $\kappa-\epsilon$ model overpredicts about $30\%$ when the two-layer zonal method is employed. When wall function method is adopted, all $\kappa-\epsilon$ models show better predictions. Standard $\kappa-\omega$ and SST $\kappa-\omega$ models have the dependency on the first grid point ($0.3). As Reynolds number becomes high, the predictions of all $\kappa-\epsilon$ and $\kappa-\omega$ models are in a good agreement with the experimental correlation.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05b
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• pp.227-232
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• 1996

The one-third calibrating relation by steady solution can cause large error when applied to an unsteady flow with large amplitude waves. Extended calibrating method, which can treat the normal convective contribution, is developed. The normal mass convective term is included into the 2-D mass transport equation by means of rms value and random function. The unknown shear rate is numerically determined by solving the 2-D mass transport equation inversely. This recovery method which predicts the unknown shear rate is constructed. It is found that it works very well without distortion. The inclusion of the normal convective term has a negligible effect on the mass transfer coefficient.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.43.1-43.1
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• 2017

A three-dimensional (3D) $Ly{\alpha}$ radiative transfer code is developed to study the Wouthuysen-Field effect, which couples the 21 cm spin temperature of neutral hydrogen and the $Ly{\alpha}$ radiation field, and the escape fraction of $Ly{\alpha}$ from galaxies. The Monte Carlo code is capable of treating arbitrary 3D distributions of $Ly{\alpha}$ source, neutral hydrogen and dust densities, gas temperature, and velocity field. It is demonstrated that the resonance-line profile at the center approaches to the Boltzmann distribution with the gas temperature. A plane-parallel ISM model, which is appropriate for the neutral ISM of our Galaxy, is used to calculate the $Ly{\alpha}$ radiation field strength as a function of height above the galactic plane. We also use a two-phase, clumpy medium model which is composed of the cold and warm neutral media (WNM). It is found that the $Ly{\alpha}$ radiation field is strong enough to thermalize the 21 cm spin temperature in the WNM to the gas kinetic temperature. The escape fraction of $Ly{\alpha}$ is found to be a few percent, which is consistent with the $Ly{\alpha}$ observations of our Galaxy and external galaxies.

• Journal of Embryo Transfer
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• v.31 no.3
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• pp.169-177
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• 2016

There is a growing interest in the application of primary hepatocytes for treatment of liver diseases in humans and for drug development. Several studies have focused on long-term survival and di-differentiation blocking of primary hepatocytes in an in vitro culture system. Therefore, the present study also aimed to optimize an in vitro culture system using primary rat hepatocytes. Primary rat hepatocytes from 6-week-old male Crl:CD rats were isolated using a modified two-step collagenase perfusion. Healthy $3.5{\times}10^6$ primary rat hepatocytes were seeded into a 2 dimensional (2D) culture in a 25T culture flask coated with collagen type I or into a 3D culture in a 125-ml spinner flask for 7 days. Production of plasma protein (ALB and TF), apoptosis (BAX and BCL2), and CYP (CYP3A1) related genes were compared between the 2D and 3D culture systems. The 3D culture system had an advantage over the 2D system because of the relatively high expression of ALB and low expression of BAX in the 3D system. However, the level of CYP3A1 did not improve in the 3D culture with and without the presence of a dexamethasone inducer. Therefore, 3D culture has an advantage for albumin production and primary rat hepatocyte survivability, but a low expression of CYP3A1 indicated that primary rat hepatocytes require a high-density culture for stress reduction by continuous flow.

• Korean Journal of Optics and Photonics
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• v.18 no.5
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• pp.337-344
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• 2007

In recent years, there has been rapid progress in different areas of vision science, such as refractive surgical procedures, contact lenses and spectacles, and near vision. This progress requires a highly accurate modeling of optical performance of the human eyes in different accommodation states. A new novel model-eye was designed using the Navarro accommodation-dependent finite model eye. For each of the vergence distances, ocular wavefront error, accommodative response, and visual acuity were calculated. Using the new model eye ocular wavefront error, accommodation dative response, and visual acuity are calculated for six vergence stimuli, -0.17D, 1D, 2D, 3D, 4D and -5D. Also, $3^{rd}\;and\;4^{th}$ order aberrations, modulation transfer function, and visual acuity of the accommodation-dependent model eye were analyzed. These results are well-matched to anatomical, biometric, and optical realities. Our corrected accommodation-dependent model-eye may provide a more accurate way to evaluate optical transfer functions and optical performances of the human eye.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2002.11a
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• pp.328.2-328
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• 2002

General modeling of a resonant shunting damper has been made Iron piezoelectric sensor/actuator equation. It is found that an additional damping, which is augmented to a system, is generated by the shunt damping effect The transfer function of the tuned electrical absorber is derived for both series and parallel shunt circuit. The governing equations and associated boundary conditions are derived using Hamilton's Principle. The shunt voltage equation is also derived from the charge generated in PZT due to beam vibration. The frequency response function of the obtained mathematical model is compared with that of the tuned eledtrical absorber and experimental work. The vibration amplitude is reduced about 15 dB at targeted second mode frequency.

• ETRI Journal
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• v.38 no.2
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• pp.217-226
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• 2016

We propose an architecture that reduces the power consumption and active area of such a modulator through a reduction in the number of active components and a simplification of the topology. The proposed architecture reduces the power consumption and active area by reducing the number of active components and simplifying the modulator topology. A novel second-order loop filter that uses a single operational amplifier resonator reduces the number of active elements and enhances the controllability of the transfer function. A trapezoidal-shape half-delayed return-to-zero feedback DAC eliminates the loop-delay compensation circuitry and improves pulse-delay sensitivity. These simple features of the modulator allow higher frequency operation and more design flexibility. Implemented in a 130 nm CMOS technology, the prototype modulator occupies an active area of $0.098mm^2$ and consumes 5.23 mW power from a 1.2 V supply. It achieves a dynamic range of 62 dB and a peak SNDR of 60.95 dB over a 15 MHz signal bandwidth with a sampling frequency of 780 MHz. The figure-of-merit of the modulator is 191 fJ/conversion-step.