• 핵의학기술
• /
• 제14권1호
• /
• pp.18-23
• /
• 2010

최근 PET/CT영상의 발달로 종양의 진단 및 평가를 통해 임상에 많은 도움을 주고 있다. 특히 PET와 CT를 융합한 Fusion PET/CT영상이나 2차원 PET영상을 3차원 영상으로 재구성한 최대강도영상(Maximum Intensity Projection)은 전체적인 병변을 한눈에 시각화하는 데 유용하게 쓰이고 있다. 하지만 Fusion & MIP 3D 재구성 영상에서 $^{18}F$-FDG의 생리적 배출로 소변이나 요루주머니에 의한 열소가 나타나 병변이 겹쳐져 육안적으로 병변을 구별하는 데 어려움이 있다. 본 연구에서는 소변에 의해 나타나는 열소 부위를 제거하여 병변의 분별력을 향상하고자 한다. 2008년 9월부터 2009년 3월까지 내원한 환자 중 PET/CT 검사에서 자궁, 방광, 직장 부위의 질환으로 잔존하는 소변량이 많은 환자들을 대상으로 하였다. 분석장비는 GE사의 Advantage Workstation AW4.3 05 버전 Volume Viewer 프로그램을 사용하였다. 분석 방법은 2D PET axial volume 영상에서 제거하고자 하는 region에 ROI를 설정하여 Cut Outside를 선택한 후 coronal volume 영상도 동일한 방법을 적용한다. 다음으로 3D Tools의 threshold 값을 지정하고, Advanced Processing에서 Subtraction을 선택하여 차집합 방식으로 소변 영상만을 소거한다. 이렇게 Region Cut Subtraction이 된 2D PET영상과 CT영상으로 Fusion영상과 MIP영상을 만들어 Region Cut Subtraction하지 않은 영상과 비교한다. Fusion & MIP 3D 재구성 영상에서 Advantage Workstation AW4.3 05버전의 Region Cut Subtraction으로 환자의 소변이나 요루주머니에 의한 열소 부위를 제거할 수 있었다. Region Cut Definition을 사용한 영상에서 그렇지 않은 영상보다 소변 섭취 때문에 구별이 어렵던 병변과의 경계가 보다 명확하게 재구성되었다. 영상을 재구성하는 과정에서 Region Cut Subtraction을 사용하여 열소 부위를 제거한다면 기존에 사용하던 단순 역치범위 설정에 의한 영상 소거법보다 우수한 진단적 정보를 제공할 것이다. 특히 방광, 자궁, 직장 부위 질환의 경우, 판독의와 임상의에게 판독에 보다 유용한 영상 정보를 제공하고, 영상의 질적 향상에 도움이 될 것이라 판단된다.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제10권3호
• /
• pp.1159-1181
• /
• 2016

This study introduces an image-based 2D-to-3D conversion system that provides significant stereoscopic visual effects for humans. The linear and atmospheric perspective cues that compensate each other are employed to estimate depth information. Rather than retrieving a precise depth value for pixels from the depth cues, a direction angle of the image is estimated and then the depth gradient, in accordance with the direction angle, is integrated with superpixels to obtain the depth map. However, stereoscopic effects of synthesized views obtained from this depth map are limited and dissatisfy viewers. To obtain impressive visual effects, the viewer's main focus is considered, and thus salient object detection is performed to explore the significance region for visual attention. Then, the depth map is refined by locally modifying the depth values within the significance region. The refinement process not only maintains global depth consistency by correcting non-uniform depth values but also enhances the visual stereoscopic effect. Experimental results show that in subjective evaluation, the subjectively evaluated degree of satisfaction with the proposed method is approximately 7% greater than both existing commercial conversion software and state-of-the-art approach.

• 한국미생물·생명공학회지
• /
• 제32권2호
• /
• pp.190-194
• /
• 2004

The gene product of dctD (DctD) activates transcription from the dctA promoter regulatory region by the $\sigma^{54}$ -holoenzyme form ofRNA polymerase ($E\sigma^{54}$ ) in Rhizobium meliloti and R. leguminosarum. The Escherichia coli integration host factor (IHF) stimulated DctD-mediated activation from the dctA promoter regulatory region of R. leguminosarum but not R. meliloti. In the absence of UAS, IHF inhibited DctD-mediated activation from both of these promoter regulatory regions. IHF also inhibited activation from R. leguminosarum dctA by nitrogen regulatory protein C (NtrC), another activator of $E\sigma^{54}$ but not by one which lacks a specific binding site in this promoter regulatory region. IHF, however, stimulated NtrC-mediated activation from the R. meliloti dctA promoter. Upon removal of the UAS, IHF inhibited NtrC-mediated transcription activation from the R. meliloti dctA promoter regulatory region. These data suggest that IHF likely faciliates productive contacts between the activators NtrC or DctD and $E\sigma^{54}$ to stimulate activation from dctA promoter.

• 스마트미디어저널
• /
• 제5권1호
• /
• pp.49-54
• /
• 2016

Medical image processing is a compulsory process to diagnose many kinds of disease. Therefore, an automatic algorithm for this task is highly demanded as an important part to construct a computer-aided diagnosis system. In this paper, we introduce an automatic method to segment the liver region from 3D abdominal CT images using Otsu method. First, we choose a 2D slice which has most liver information from the whole 3D image. Secondly, on the chosen slice, we enhanced the image based on its intensity using Otsu method with multiple thresholds and use the threshold to enhance the whole 3D image. Then, we apply a liver mask to mark the candidate liver region. After that, we execute the Otsu method again to segment the liver region from the chosen slice and propagate the result to the whole 3D image. Finally, we apply preprocessing on the frontal side of 3D images to crop only the liver region from the image.

• 대한토목학회논문집
• /
• 제32권2B호
• /
• pp.103-111
• /
• 2012

본 연구는 5개의 대설지역을 울릉도(a), 영동북부(b), 서태백산맥(c), 소백산맥북서부(d), 남해안(e)으로 구분하여 30년(1980-2010)동안의 최심신적설자료를 이용하여 시공간적 경향성을 분석하였다. 30년 동안의 적설량과 빈도를 분석한 결과, c와 d의 일부지역에서 감소하는 경향을 나타내었다. 1980년부터 2000년까지의 기간(A)과 1990년부터 2010년까지의 기간(B)으로 구분하여 공간적 경향성을 비교한 결과, A에서 B기간까지 대설경보의 빈도수는 c와 d지역의 일부 지역에서 B기간 동안 감소한 경향을 명확하게 나타내었다. 연평균 적설량은 A기간부터 B기간까지 b지역이 증가하는 동안 d지역은 감소하여 지역간 큰 격차가 나타난 것으로 분석하였다.

• Bulletin of the Korean Chemical Society
• /
• 제28권8호
• /
• pp.1341-1345
• /
• 2007

The surface chemistry of D2O dosed Zircaloy-4 (Zry-4) surface followed by Ar-ion bombardment and annealing was studied by means of X-ray photoelectron spectroscopy (XPS) and Ultraviolet photoelectron spectroscopy (UPS). In the XPS study, Ar-ion bombardment caused decrease of the oxygen on the surface region of Zry-4 and therefore led to change the oxidation states of the zirconium from oxide to metallic form. In addition, oxidation states of zirconium were changed to lower oxidation states of zirconium due to depopulation of oxygen on the surface region by annealing. Up to about 787 K, the bulk oxygen diffused out to the subsurface region and after this temperature, the oxygen on the surface of Zry-4 was depopulated. UPS study showed that the valence band spectrum of the D2O exposed Zry-4 exhibited a dominant peak at around 13 eV and no clear Fermi edge was detected. After stepwise Ar+ sputtering processes, the decrease of the oxygen on the surface of Zry-4 led to suppress the dominant peak around 13 eV, the peak around 9 eV and develop a new peak of the metallic Zr 4d state (20.5-21.0 eV) at the Fermi level.

• 한국농공학회지
• /
• 제32권3호
• /
• pp.56-66
• /
• 1990

To investigate the status of irrigation water use and the degree of repeated use of irrigation water, observations for water balance analysis were made during the irrigation periods in 1986 and 1987 crop year. The total area of studied site is 1,441 ha. The site is a major portion of Jedaecheon basin which is located in Bubuk-myeon, Miryang-gun, Gyeongnam Province. The studied area was subdivided into six small blocks. The water balance analysis for these subdivided blocks were carried out considering characteristics of each block. Obtained results are as follow: 1.In mountainous sloppy paddy area(less than 7% slope), the surface inflow was 5A mm/day in average that is one third of the surface inflow into plain paddy area ; 16.7 mm/day. 2.The surface inflows at the vegetative stage and the ripening stage were 15.5 mm/day and 10.4 mm/day, respectively. Those figures were larger than the actual consumptive use at respective same stages ; 13.3 mm/day and 9.2 mm/day, respectively. Whereas, the surface inflow at generative stage was 12.5 mm/day which was less than 14.0 mm/day ; the actual consumptive use. 3.The range of the variation of water storage term was 1 mm/day. This means that there were no change in depth of ponded water on paddy fields. The relationship between the variation of water storage(AS) and the variation of ground water table(H) could be expressed as follow: : AS=0.14H+0.26 4.The ground water inflow: into the transition region ; paddy fields which are located continuously from the mountainous area to the plain area, was larger than the out flow from this region, in general. Rowever, in the plain region where the ground water utilization was predominant, the ground water outflow from this region was larger than inflow: to this region. The relationship between the ground water flow(G2- G1) and the consumptive use in large paddy area(D1-D2) could be expressed as follow: (G2-G1) =0.95(D1-D2) -3.79

• IMMUNE NETWORK
• /
• 제3권2호
• /
• pp.89-95
• /
• 2003

Background: Unusually high amounts of N region addition and CDR3 length diversity were found in immunoglobulin (Ig) light chain Vk and Jk joins in patients with rheumatoid arthritis (RA). We sought to determine whether this finding is due to excessive activity of the enzyme responsible for N region addition (terminal deoxynucleotidyl transferase [TdT]) in B lineage cells in bone marrow or from positive antigenic selection of B cells with long CDR3 lengths. Methods: We used FACS to isolate $IgM^+/IgD^+$ B cells (predominantly naive) and $IgM^-/IgD^-$ B cells (predominantly class-switched) B cells from peripheral blood of a patient with RA known to have enrichment for long Vk CDR3s and from that of two normal controls. RT-PCR of VkIII transcripts was performed, followed by sequencing of individual cDNA clones. We analyzed the CDR3 lengths and N region additions in 97 clones. Results: There was enrichment for long CDR3 lengths (11 or 12 amino acids) in both $IgM^+/IgD^+$ and $IgM^-/IgD^-$ B cells in RA compared to B cell subsets in the normal controls. The $IgM^+/IgD^+$ B cell subset in RA was markedly enriched for N region addition and was similar to that seen in the $IgM^-/IgD^-$ subset. Conclusion: These data suggest that enrichment for N region addition and long CDR3 lengths in RA may result from unusually high or prolonged activity of TdT in bone marrow.

• The Korean Journal of Physiology and Pharmacology
• /
• 제23권6호
• /
• pp.475-482
• /
• 2019

Glioma is the most common brain tumor with a dismal prognosis. While temozolomide (TMZ) based chemotherapy significantly improves survival in glioma patients, resistance against this compound commonly leads to glioma treatment failure. Overexpression of long-noncoding RNA (LncRNA) FoxD2 adjacent opposite strand RNA 1 (FoxD2-AS1) was identified to promote glioma development, but the role in TMZ resistance remains unclear. In this paper, we found that FoxD2-AS1 was overexpressed in recurrent glioma, high FoxD2-AS1 expression was significantly correlated with poor patient outcome. Methylation of $O^6$-methylguanine-DNA methyltransferase (MGMT) is significantly less frequent in high FoxD2-AS1 expression patients. Knockdown of FoxD2-AS1 decreased the proliferation, metastatic ability of glioma cells and promote the sensitivity to TMZ in glioma cells. Furthermore, knockdown of FoxD2-AS1 induced hypermethylation of the promoter region of MGMT. Our data suggested that FoxD2-AS1 is a clinical relevance LncRNA and mediates TMZ resistance by regulating the methylation status of the MGMT promoter region.

• 대한전기학회논문지:시스템및제어부문D
• /
• 제53권2호
• /
• pp.118-126
• /
• 2004

The modified Wiener filtering method is proposed for effective noise suppression in edge region of images corrupted by additive white gaussian noise. Although the pixels classified as a edge region in the conventional Wiener filter have lots of noise components, the conventional Wiener filter cannot remove noise effectively due to the preserving of edges. To reduce noise well in edge region, we modify filter coefficients of the conventional Wiener filter. The modified filter coefficients increase in noise suppression effect in edge region, while they preserve edges for strong edge region. From simulation (256${\times}$256 size, 256 graylevel images) filtered images by the proposed method show much improved subjective image quality with higher peak signal-to-noise ratio compared to those by the conventional Wiener filtering.