• Journal of the Korean Society for Precision Engineering
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• v.15 no.9
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• pp.101-110
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• 1998

In process planning for 3D pocket machining, the critical issues for the optimal process planning are the generation of cutting layers and the tool selection for each cutting layers as well as the other factors such as the determination of machining types, tool path, etc. This paper describes the optimal tool selection on a single cutting layer for 2D pocket machining, the generation of cutting layers for 3D pocket machining, the determination of the thickness of each cutting layers, the determination of the tool combinations for each cutting layers and also the development of an algorithm for determining the machining sequence which reduces the number of tool exchanges, which are based on the backward approach. The branch and bound method is applied to select the optimal tools for each cutting layer, and an algorithmic procedure is developed to determine the machining sequence consisting of the pairs of the cutting layers and cutting tools to be used in the same operation.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2007.11a
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• pp.101-102
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• 2007

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.11 no.3
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• pp.75-81
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• 2011

Protein molecules are combined with another ones which have similar shapes at pocket positions. The pocket positions can be good references to describe the shapes of protein molecules. Harris corner detector is commonly used to detect feature points of 2 or 3D objects. Feature points can be found on the pocket areas and the points which have high derivatives. Generally speaking, the densities of feature points are relatively high at pocket areas because the shapes of pockets are concave. The pocket areas can be decided by the subdivision of voxel cubes which include feature points. The Euclidean distances between feature points and the central coordinate of the decided pocket area are calculated and sorted. The graph of sorted distances describes the shape of a protein molecule and the distribution of feature points. Therefore, it can be used to classify protein molecules by their shapes. Even though the shapes of protein molecules have been distorted with noises, they can be recognized with the accuracy more than 95 %. The accurate shape recognition provides the information to predict the binding properties of protein molecules.

• Korean Journal of Computational Design and Engineering
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• v.10 no.1
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• pp.11-16
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• 2005

CAD/CAM system may have such advantages of cost reduction, production time shortening, and product quality improvement. But current advanced versions of CAD/CAM system for 3-D NC data generation are too much expensive to purchase and too difficult to make full use for small-scale manufacturers whose main products are of 2-D simple shapes. The objective of this paper is to introduce a cost-effective way to 2-D NC data generation with a widely spread CAD software. Using VISUAL LISP in the well-known AUTO-CAD, the contents and steps of an automatic NC data generation program are presented for 2-D machining of contours and pockets. To approve the usefulness of program, a test application to a real part is exhibited also.

• Bulletin of the Korean Chemical Society
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• v.26 no.1
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• pp.151-156
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• 2005

The conformational dynamics of heme pocket, a small vacant site near the binding site of heme proteins -myoglobin (Mb) and hemoglobin (Hb), was investigated after photolysis of carbon monoxide from MbCO and HbCO in D$_2$O solution at 283 K by probing time-resolved vibrational spectra of photolyzed CO. Two absorption bands, arising from CO in the heme pocket, evolve nonexponentially in time. The band at higher energy side blue shifts and broadens with time and the one at lower energy side narrows significantly with a negligible shift. These spectral evolutions are induced by protein conformational changes following photolysis that modify structure and electric field of heme pocket, and ligand dynamics in it. The conformational changes affecting the spectrum of photolyzed CO in heme pocket likely modulates ligand-binding activity.

• Bulletin of the Korean Chemical Society
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• v.27 no.11
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• pp.1825-1831
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• 2006

The influence of solvent viscosity on conformational dynamics of the heme-pocket, a small vacant site near the binding site of myoglobin (Mb) and hemoglobin (Hb), and playing a functionally important role by serving as a station in ligand binding and escape, was studied by probing time-resolved vibrational spectra of CO photodissociated from MbCO and HbCO in $D_2O$, 75 wt% glycerol/$D_2O$, and trehalose at 283 K. Two absorption bands ($B_1$ and $B_2$) of the sample in viscous solvents, arising from CO in the heme pocket, are very similar to those in $D_2O$. Two bands in Mb and Hb under all three solvents exhibit very similar nonexponential spectral evolution ($B_1$ band; blue shifting and broadening, $B_2$ band; narrowing with a negligible shifting), suggesting that in the present experimental time window of 100 ps, the extents of the spectral shift and narrowing is much influenced neither by the viscosity of solvent nor by the quaternary contact of Hb. Spectral evolution can be described by a biexponential function with a fast universal time constant of 0.52 ps and a slow time constant ranging from 13 to 32 ps. For both proteins in all three solvents majority of spectral evolution occurs with the fast universal time constant. The magnitude of the slow rate in the spectral shift of B1 band decreases with increasing solvent viscosity, indicating that it is influenced by global conformational change which is retarded in viscous solvent, thereby serve as a reporter of global conformational change of heme proteins after deligation.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.40 no.2
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• pp.126-131
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• 2004

On-machine automatic measuring software from 3-D solid modeler is generally applied to assess the functional performance of a final produce for computer numerical control (CNC) machine. Automatic measuring software may also be performed on individual components of CNC machine in which some functional aspect of the component must be examined and cannot be implicity determined by means of a mechanical inspection. The manufacturing specialist, combined with the appropriate software simulation, can not only create the commands to drive the virtual measuring but also can check for mistakes by viewing the computer graphics simulation of the tool cutting sequence.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.14 no.5
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• pp.120-125
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• 2015

This research aims to increase the reliability and reproducibility of the ambient cycling test by properly making corrections to the test procedure. The vessel (106 L) is initially filled with 70 L of water and horizontally placed on a balance. The pressure range inside the vessel varies from 2.5 to 25.9 MPa at the frequency of 6 cycles per minute. After reviewing the results, there was a temperature difference of approximately $10^{\circ}C$ between the air pocket and the water, and the upper part of the liner faced a repeated temperature change of $40^{\circ}C$. It is possible for the aluminum liner of the composite vessel to be damaged by such a sharp change in temperature. Additionally, as a result, no pass having anything to do with the purpose of the test would occur. Therefore, it is suggested that the air pocket be completely removed.

• Biomolecules & Therapeutics
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• v.29 no.4
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• pp.392-398
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• 2021

In this study, we determined the effect of 24 different synthetic 4-benzylpiperidine carboxamides on the reuptake of serotonin, norepinephrine, and dopamine (DA), and characterized their structure-activity relationship. The compounds with a two-carbon linker inhibited DA reuptake with much higher potency than those with a three-carbon linker. Among the aromatic ring substituents, biphenyl and diphenyl groups played a critical role in determining the selectivity of the 4-benzylpiperidine carboxamides toward the serotonin transporter (SERT) and dopamine transporter (DAT), respectively. Compounds with a 2-naphthyl ring were found to exhibit a higher degree of inhibition on the norepinephrine transporter (NET) and SERT than those with a 1-naphthyl ring. A docking simulation using a triple reuptake inhibitor 8k and a serotonin/norepinephrine reuptake inhibitor 7j showed that the regions spanning transmembrane domain (TM)1, TM3, and TM6 form the ligand binding pocket. The compound 8k bound tightly to the binding pocket of all three monoamine reuptake transporters; however, 7j showed poor docking with DAT. Co-expression of DAT with the dopamine D₂ receptor (D₂R) significantly inhibited DA-induced endocytosis of D₂R probably by reuptaking DA into the cells. Pretreatment of the cells with 8f, which is one of the compounds with good inhibitory activity on DAT, blocked DAT-induced inhibition of D₂R endocytosis. In summary, this study identified critical structural features contributing to the selectivity of a molecule for each of the monoamine transporters, critical residues on the compounds that bound to the transporters, and the functional role of a DA reuptake inhibitor in regulating D₂R function.

• Journal of Preventive Medicine and Public Health
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• v.32 no.4
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• pp.546-555
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• 1999

Objectives : To determine the prevalence, pattern. and out-of-pocket expenditure of complementary and alternative medicine (CAM) utilization in Korean adult population. Methods : We conducted a representative telephone survey of 2,042 persons aged 18 or older. Data about any health problem, details of their use of medical doctors(MDs) offices/hospitals/pharmacies services and CAM during the preceding 12 months were collected with structured questionnaire. Results : The utilization rate of CAM among Korean adults was 29% in one year. A total of 231 kinds of CAM was identified from this survey. Annual out-of-pocket expenditure associated with CAM use in 1998 amounted to ${\xi}{\S}1.88$ billion and was comparable to 40.8% of out-of-pocket expenditure paid for MDs offices/hospitals/pharmacies services. Among those(N=424) who paid for both MDs offices/hospitals/pharmacies services an d CAM, 35.8% paid more for CAM. CAM gave more satisfaction than western medicine to those who had experience of both types of therapy. About half of CAM users were willing to recommend CAM to others. Disclosure rate to physician among CAM users was not high(40.6%). Conclusion : CAM became a popular source of health care in Korea, Korean spent a substantial amount of out-of-pocket money on CAM without any public control. Because CAM use is likely to be increased rapidly through lay referral system, health policy makers and health professionals should pay more attention to CAM for making appropriate utilization of CAM.