• Journal of Animal Science and Technology
• /
• v.56 no.8
• /
• pp.33.1-33.8
• /
• 2014

Background: Sox 9 is a major marker of chondrocyte differentiation. When chondrocytes are cultured in vitro they progressively de-differentiate and this is associated with a decline in Sox 9 expression. The active form of vitamin D, 1, 25 $(OH)_2D_3$ has been shown to be protective of cartilage in both humans and animals. In this study equine articular chondrocytes were grown in culture and the effects of 1, 25 $(OH)_2D_3$ upon Sox 9 expression examined. The expression of the transient receptor potential vanilloid (TRPV) ion channels 5 and 6 in equine chondrocytes in vitro, we have previously shown, is inversely correlated with de-differentiation. The expression of these channels in response to 1, 25 $(OH)_2D_3$ administration was therefore also examined. Results: The active form of vitamin D (1, 25 $(OH)_2D_3$ when administered to cultured equine chondrocytes at two different concentrations significantly increased the expression of Sox 9 at both. In contrast 1, 25 $(OH)_2D_3$ had no significant effect upon the expression of either TRPV 5 or 6 at either the protein or the mRNA level. Conclusions: The increased expression of Sox 9, in equine articular chondrocytes in vitro, in response to the active form of vitamin D suggests that this compound could be utilized to inhibit the progressive de-differentiation that is normally observed in these cells. It is also supportive of previous studies indicating that $1{\alpha}$, 25-dihydroxyvitamin $D_3$ can have a protective effect upon cartilage in animals in vivo. The previously observed correlation between the degree of differentiation and the expression levels of TRPV 5/6 had suggested that these ion channels may have a direct involvement in, or be modulated by, the differentiation process in vitro. The data in the present study do not support this.

• Proceedings of the IEEK Conference
• /
• 2003.11a
• /
• pp.175-178
• /
• 2003

This paper proposes a stereo image insertion technique on DCT coefficients using the embedded method developed in the digital watermarking in due consideration of compatibility with conventional 2D system such JPEG, and MPEG. In conventional transmission method users with conventional digital TV cannot watch the transmitted 3D image sequence as 2D image, because of affectivity of conventional 3D image compression. To give an answer, in this paper, DCT coefficients are changed according to its disparity on YCbCr channels. Our method can insert stereo images into a conventional image compression method based on DCT.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.3
• /
• pp.147-154
• /
• 2018

This paper focuses on the development of a support system that can rapidly generate the design data of a hot-form die with cooling channels, commonly known as hot stamping technology. We propose a new process for designing hot-form dies based on our (automated) system, whose main features are derived from the analysis of the design requirements and design process in the current industry. Our design support system consists of two modules, which allow for the generation of a 3D geometry model and its 2D drawings. The module for 3D modeling automation is implemented as a type of CATIA template model based on CATIA V5 Knowledgeware. This module automatically creates a 3D model of a hot-form die, including the cooling channels, that depends on the shape of the forming surface and the number of STEELs (subsets of die product) and cooling channels. It also allows for both the editing of the positions and orientations of the cooling channels and testing for the purpose of satisfying the constraints on the distance between the forming surface and cooling channels. Another module for the auto-generation of the 2D drawings is being developed as a plug-in using CAA (CATIA SDK) and Visual C++. Our system was evaluated using the S/W test based on a user defined scenario. As a result, it was shown that it can generate a 3D model of a hot form die and its 2D drawings with hole tables about 29 times faster than the conventional manual method without any design errors.

• Proceedings of the KSME Conference
• /
• 2004.04a
• /
• pp.1458-1463
• /
• 2004

By using unique experimental techniques and careful construction of the experimental apparatus, the characteristics of the local heat transfer were investigated using the condensing R134a two-phase flow, in horizontal single mini-channels. The circular channels ($D_h=0.493$, 0.691, and 1.067 mm) and rectangular channels ($D_h=0.494$, 0.658, and 0.972 mm) were tested and compared. Tests were performed for a mass flux of 100, 200, 400, and 600 $kg/m^2s$, a heat flux of 5 to 20 $kW/m^2$, and a saturation temperature of $40^{\circ}C$. In this study, effect of heat flux, mass flux, vapor qualities, hydraulic diameter, and channel geometry on flow condensation were investigated and the experimental local condensation heat transfer coefficients are shown. The experimental data of condensation Nusselt number are compared with existing correlations.

• Proceedings of the KSRS Conference
• /
• 2007.10a
• /
• pp.29-32
• /
• 2007

Tidal channel development is influenced by sediment type, grain size, composition and tidal current. Tidal channels are usually characterized by channel development, density and shape. Quantitative analysis of tidal channels using remotely sensed data have rarely been studied. The objective of this study is to quantify tidal channels in terms of fractal dimension and compare different inter-tidal channel patterns. For the fractal analysis, we used Box counting method which had been successfully applied to streams, coastlines and others linear features. For a study, the southern part of Ganghwado tidal flats was selected where is famous for high dynamics of tidal currents and vast tidal flats. This area has different widths and lengths of tidal channels. IKONOS and Komsat-2 MSC images were used for extracting tidal channels, and the Box counting method was applied to obtain fractal dimensions (D) for each tidal channel. Yeochari area possesses channels with linear pattern and less dense development and accordingly show low D values ranging from 1.037 to 1.038. On other hands, area (near Donggumdo and Yeongjongdo ) of dendrites channel pattern and dense development resulted in high D values from 1.2057 to 1.2667. Also, area possesses channels with linear pattern had low density about $18{\sim}24%$. Area of dendritic channel pattern had high density about $34{\sim}69%$. The difference of fractal dimensions about 0.2 according to channel development in tidal flats is relatively large enough to use as an index for tidal channel classification. Also, area where channels showed linear pattern had low density about $18{\sim}24%$. Area of dendritic channel pattern had high density about $34{\sim}69%$. Using fractal dimension and density, it would be possible to quantify the tidal channel development in association with surface characteristics.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.13 no.4
• /
• pp.1884-1903
• /
• 2019

Device-to-Device (D2D) communications can provide proximity based services in the future 5G cellular networks. It allows short range communication in a limited area with the advantages of power saving, high data rate and traffic offloading. However, D2D communications may reuse the licensed channels with cellular communications and potentially result in critical interferences to nearby devices. To control the interference and improve network throughput in overlaid D2D cellular networks, a novel channel assignment approach is proposed in this paper. First, we characterize the performance of devices by using Poisson point process model. Then, we convert the throughput maximization problem into an optimal spectrum allocation problem with signal to interference plus noise ratio constraints and solve it, i.e., assigning appropriate fractions of channels to cellular communications and D2D communications. In order to mitigate the interferences between D2D devices, a cluster-based multi-channel assignment algorithm is proposed. The algorithm first cluster D2D communications into clusters to reduce the problem scale. After that, a multi-channel assignment algorithm is proposed to mitigate critical interferences among nearby devices for each D2D cluster individually. The simulation analysis conforms that the proposed algorithm can greatly increase system throughput.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.2 no.1
• /
• pp.133-140
• /
• 1998

In this paper, RS coded DTMF modulation for reliable data transmission over mobile fading channels is considered. The circuits of (15,9) RS codec are proposed and synthesized, and the performances are evaluated over fading channels. The codec circuits take about 14000 gates standardized by 2-input NAMD gate. The (15,9) RS coded DTMF signalling provides theoretical coding gain more than 20 dB over fading channels for BER 10.6, the criterion for data transmissions in mobile communications such as IMT-2000. Thus, It is very effective to apply RS codec to DTMF signalling for data transmission in mobile communications over fading channels.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.28 no.11
• /
• pp.1432-1439
• /
• 2004

By using unique experimental techniques and careful construction of the experimental apparatus, the characteristics of the local heat transfer were investigated using the condensing R134a two-phase flow, in horizontal single mini-channels. The circular channels (D$_{h}$=0.493, 0.691, and 1.067 mm) and rectangular channels (Aspect Ratio=1.0, D$_{h}$=0.494, 0.658, and 0.972 mm) were tested and compared. Tests were performed for a mass flux of 100, 200, 400, and 600 kg/$m^2$s, a heat flux of 5 to 20 ㎾/$m^2$, and a saturation temperature of 4$0^{\circ}C$. In this study, effect of heat flux, mass flux, vapor qualities, hydraulic diameter, and channel geometry on flow condensation are investigated and the experimental local condensation heat transfer coefficients are shown. The experimental data of condensation Nusselt number are compared with existing correlations.ons.

• Bulletin of the Korean Chemical Society
• /
• v.30 no.1
• /
• pp.264-266
• /
• 2009

• Proceedings of the Korean Biophysical Society Conference
• /
• 2001.06a
• /
• pp.36-36
• /
• 2001

Small conductance $Ca^{2＋}$-activated $K^{+}$ channels (or S $K_{Ca}$ channels) are a group of $K^{＋}$-selective ion channels activated by sub-micromolar concentrations of intracellular $Ca^{2＋}$ independent of membrane voltage. We expressed a cloned S $K_{Ca}$ channel, rSK2, in Xenopus oocytes and investigated the monovalent cation selectivity of the channels. We have used site-directed mutagenesis and macro-channel recordings to identify amino acid residues influencing the ion selectivity.(omitted)d)