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Newly Emerging Human Coronaviruses: Animal Models and Vaccine Research for SARS, MERS, and COVID-19

  • Pureum Lee;Doo-Jin Kim
    • IMMUNE NETWORK
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    • v.20 no.4
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    • pp.28.1-28.25
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    • 2020
  • The recent emergence of the novel coronavirus (CoV) or severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a global threat to human health and economy. As of June 26, 2020, over 9.4 million cases of infection, including 482,730 deaths, had been confirmed across 216 countries. To combat a devastating virus pandemic, numerous studies on vaccine development are urgently being accelerated. In this review article, we take a brief look at the characteristics of SARS-CoV-2 in comparison to SARS and Middle East respiratory syndrome (MERS)-CoVs and discuss recent approaches to coronavirus disease-2019 (COVID-19) vaccine development.

Cytotaxonomic study of Korean Euphorbia L. (Euphorbiaceae) (한국산 대극속(Euphorbia L., Euphorbiaceae)의 세포분류학적 연구)

  • Chung, Gyu Young;Oh, Byoung-Un;Park, Ki-Ryong;Kim, Joo-Hwan;Kim, Mi Suk;Nam, Gi-Heum;Jang, Chang-Gee
    • Korean Journal of Plant Taxonomy
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    • v.33 no.3
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    • pp.279-293
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    • 2003
  • Somatic chromosomes about 13 taxa of Korean Euphorbia L. was investigated to estimate its taxonomic significance. Somatic chromosome numbers of treated taxa were 2n= 12, 20, 22, 28, 40, 42, 56, therefore basic chromosome numbers of those were x=6, 7, 10, 11. The chromosome numbers of E. pallasii Turcz. (2n=20), E. hylonoma Hand.-Mazz (2n=20.), E. fauriei H. L$\acute{e}$v. & Vaniot ex H. L$\acute{e}$v (2n=28) and E. jolkini Boiss. (2n=28) were determined for the first time in this study. The chromosome numbers of four taxa were same as previous ones; E. sieboldiana Moor. & Decne. (2n=20), E. ebracteolata Hayata (2n=20), E. humifusa Willd. ex Schlecht. (2n=22). But those of six taxa were different; E. esula L (2n= 16, 20, 60, 64 vs 2n=20), E. helioscopia L. (2n=12, 42 vs 2n=42), E. lucorum Rupr. (2n=28, 40 vs 2n=56), E. pekinensis Rupr. in Maxim. (2n=24 vs 2n=28, 56), E. maculata L. (2n=28, 42 vs 2n=12), E. supina Raf. (n=7 vs 2n=40). E. ebracteolata, E. pallasii and E. hylonoma were distingushcd from the other taxa by the chromosome numbers, size and satellites, E. maculata, E. humifusa, E. supina had the different basic and somatic chromosome numbers in spite of the similar morphological. anatomical and palynological chracters. The chromosomal character of Korean Euphorbia was supported the Ma and Hu's systems, and as above results, it was found to be a good character in delimiting above sections and estimating relationships for some species.

ULG 및 ELA Poly-Si TFTs의 게이트-바이어스 스트레스에 따른 비교 연구

  • Kim, Ji-Ung;Kim, Tae-Yong;Lee, Jun-Sin
    • Proceedings of the Korean Vacuum Society Conference
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    • 2014.02a
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    • pp.264.1-264.1
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    • 2014
  • 현재 디스플레이에서 가장 널리 이용되는 ELA poly-Si TFT의 표면 거칠기 등으로 인한 대면적 문제를 해결하고자 연구 중인 MIC 방식의 ULG poly-Si TFT를 이용한 게이트-바이어스 스트레스에 따른 전기적 특성을 비교하고자 한다. Positive gate bias의 경우 20V의 게이트 전압과 -0.1V의 드레인 전압에서 10,000초 동안 비교 측정하였으며, 이때 ${\Delta}VTH$는 ELA poly-Si TFT가 143.6 mV, ULG poly-Si TFT가 28.8 mV였다. 또한 negative gate bias의 경우 -20 V의 게이트 전압과 -0.1 V의 드레인 전압에서 10,000초 동안 비교 측정하였으며, 이때 ${\Delta}VTH$는 ELA poly-Si TFT가 154.4 mV, ULG poly-Si TFT가 70.8 mV였다. 이는 게이트 절연막과 채널층 사이의 계면에서 높은 표면 거칠기로 인한 전계의 차이에 의해 더 많은 전하의 트랩에 기인한 것이다.

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Effects of Hormones, Oviductal Epithelial Cell and Cumulus Cell during the In-Vitro Culture in Medium on the Survival Rates of Bisected Porcine Embryos (돼지 분할초기배와 호르몬, 난관상피세포 및 난구세포와의 공배양이 생존율에 미치는 영향에 관한 연구)

  • 김상근;이종진
    • Korean Journal of Animal Reproduction
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    • v.19 no.2
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    • pp.135-140
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    • 1995
  • The study was conducted to investigate on the survival rate of bisected porcine embryos co-cultured in 10% FCS(v/v)+TCM-199 media containing hormones, oviductal epithelial cells and cumulus cells 0 to 72 hrs after bisection. In vitro survival rate was defined as development rate on in vitro culture or FDA-test. The results are summarized as follows ; 1. The survival rate of bisected porcine embryos cultrued in 10% FCS+TCM-199 media contaning PMSG, hCG, PMSG+hCG, hCG+$\beta$-estradiol 0 to 20 hrs and 20 to 40 hrs were 37.6% and 37.5%, 28.6% and 28.6%, 35.7% and 28.8%, 30.8% and 23.1%, 38.5% and 30.7%, respectively. The survival rate of bisected embryos co-cultured in TCM-199 media containing hormones, oviductal epithelial cells and cumulus cells was significantly higher than that of non co-culture. 2. The survival rate of bisected porcine embryos co-cultured 10% FCS+TCM-199 media containing oviductal epithelial cells 4 to 5 hrs and 20 to 24 hrs were 42.9% and 38.5%, respectively. 3. The survival rate of bisected porcine embryos co-cultured in 10% FCS+TCM-199 media containing cumulus cells 4 to 5 hrs and 20 to 24 hrs were 40.0% and 35.7%, respectively.

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Characteristics of Site Amplification of the Broad-band Seismic Stations in Korea (국내 광대역 지진관측소의 부지증폭 특성)

  • Kim, Seo-Young;Kim, Sung-Kyun
    • Journal of the Korean earth science society
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    • v.30 no.7
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    • pp.810-823
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    • 2009
  • One of the critical factors in accurate determination of earthquake source parameters, and in prediction of seismic hazards is the detailed information related to the site amplification characteristics. The site amplification characteristics of the broad-band seismic stations in Korea were estimated as a function of frequency in the range of 0.2 to 20 Hz. A total of 1275 seismograms recorded from 43 earthquakes observed from 2003 to 2008 in the southern Korean Peninsula were used. It was found that the site amplification ratios for 28 stations estimated from the inversion of the ground motion model were approximately concordant with those obtained from the horizontal-to-vertical (H/V) spectral ratio except for some stations. The spectral site amplification characteristics obtained in this study did not show any considerable spatial distribution. It revealed to be largely correlated with the degree of weathering rather than the basement rock type. Considering the spectral site amplification ratio, 28 broad-band stations were classified into four groups and the characteristics of each group were described in the text.

A Study on the Machining Characteristics of Ti-6Al-4V Alloy (Ti-6Al-4V 타이타늄 합금의 절삭특성에 관한 연구)

  • 김남용;고준빈;이동주
    • Journal of the Korean Society for Precision Engineering
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    • v.20 no.4
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    • pp.20-28
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    • 2003
  • The machinability of Ti-6Al-4V titanium alloy and tool wear behavior in machining of Ti-6Al-4V titanium alloy was studied to understand the machining characteristics. This material is one of the strong candidate materials in present and future aerospace or medical applications. Recently, their usage has already been broaden to everyday's commercial applications such as golf club heads, finger rings and many decorative items. To anticipate the general use of this material and development of the titanium alloys in domestic facilities, the review and the study of the machining parameters for those alloys are necessary. This study is concentrated to the machining parameters of the Ti-6Al-4V alloy due to their dominant position in the production of titanium alloys.

Isolation and Indentification of Yeast Strains Producing High Concentration of Ethanol with High Viabi-lity. (에탄올 생성능과 생존능이 우수한 효모균주의 분리와 동정)

  • Kang, Tae-Young;Oh, Gui-Hwan;Kim, Keun
    • Microbiology and Biotechnology Letters
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    • v.28 no.6
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    • pp.309-315
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    • 2000
  • To isolate yeast strains producing high concentration of ethanol, 125 strains were subjected to screening. Initially 14 strains able to grow in a medium containing 15%(v/v) ethanol, 7 strains capable of growing in a medium containing 50%(v/v) glucose, 23 strains having relatively fast fermentation rates, 13 strains able to grow at $42^{\circ}C$ were selected. After secondary screening, 11 strains having relatively high ini-tial fermentation rate and producing high concentration of ethanol were selected. After tertiary screening 5 strains producing high concentration of ethanol were selected. These 5 strains were again for their ethanol produc-tion, residual sugar, and viability using fermentation medium containing 25% glucose. The strain producing the highest concentration of ethanol was 20-1 strain which produced 10.56%(v/v) ethanol in 4 days, and the highest viable strain was 11-1 which produced 10.35%(v/v) ethanol(13.1%. v/v) with the viability of 30.44% after 5 days of fermentation. Both of the 20-1 and 11-1 strains were identified as Saccharomyces cerevisiae.

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Getter Properties of Ti80-XZr20VX Alloy Powders (Ti80-XZr20VX 합금분말의 게터 특성)

  • Park, Je-Shin;Kim, Won-Baek;Soh, Chang-Youl;Cho, Sung-Wook
    • Journal of Powder Materials
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    • v.16 no.1
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    • pp.28-32
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    • 2009
  • The activation temperatures and hydrogen sorption rates of $Ti_{80-X}Zr_{20}V_X$ alloys were evaluated at room temperature. The alloy powders were prepared by arc melting and then hydride-dehydride(HDH) process. The alloy powders were apt to activate by increase of vanadium in Ti-Zr-V alloys. The easy activation was explained in terms of surface oxygen content which decreased with increase of vanadium on Ti-Zr-V alloys.

Electro-optical properties of organic EL device (유기 EL 소자의 전기-광학적 특성)

  • Kim, Min-Soo;Park, Lee-Soon;Park, Se-Kwang
    • Journal of Sensor Science and Technology
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    • v.6 no.4
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    • pp.252-257
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    • 1997
  • Organic EL devices, which have the sing3e-layer structure of ITO(indium-tin-oxide) /PPV(poly(p-phenylene vinylene))/cathode and the double-layer structure of ITO/PVK (poly(N- vinylcarbazole)) /PPV/cathode, were fabricated and their electro-optical properties were investigated. Experimental results, in single-layer structure, shown that the increment of temperature for thermal conversion of PPV film from $140^{\circ}C$ to $260^{\circ}C$ decreases the maximum luminance from $118.8\;cd/m^{2}$(20V) to $21.14\;cd/m^{2}$(28V) and shift the maximum peak of EL spectrum from 500nm to 580nm. The lower the work function of cathode is, the more the luminance and injection current of device. In double-layer structure, as the concentration of PVK solution decreases from 0.5 wt% to 0.05 wt%, the luminance of device increases from $70.71\;cd/m^{2}$(32V) to $152.7\;cd/m^{2}$(26V).

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Characteristics of the ( Pb, La ) $TiO_3$ Thin Films with Pb/La Compositions (Pb/La 조성에 따른 ( Pb, La ) $TiO_3$ 박막의 특성 변화)

  • Kang, Seong-Jun;Joung, Yang-Hee;Yoon, Yung-Sup
    • Journal of the Korean Institute of Telematics and Electronics D
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    • v.36D no.1
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    • pp.29-37
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    • 1999
  • In this study, we have prepared PLT thin films having various La concentrations by using sol-gel method and studied on the effect of La concentration on the electrical properties of PLT thin films. As the La concentration increases from 5mol% to 28mol%, the dielectric constant at 10kHz increases from 428 to 761, while the loss tangent decreases from 0.063 to 0.024. Also, the leakage current density at 150kV/cm has a tendency to decrease from 6.96${\mu}A/cm^2$ to 0.79${\mu}A/cm^2$. In the result of hysteresis loops of PLT thin films, the remanent polariation and the coercive field decrease from 9.55${\mu}C/cm^2$ to 1.10${\mu}C/cm^2$ and from 46.4kV/cm to 13.7kV/cm, respectively. With the result of the fatigue test on the PLT thin films, we have found that the fatigue properties are improved remarkably as the La concentration increases from 5 mol% to 28mol%. In particular, the PLT28) has paraelectric phase and its charge storage clensity and leakage current density at 5V are 134fC/${\mu}cm^2$ and 1.01${\mu}A/cm^2$, respectively. The remanent polarization and coercive field of the PLT(10) film are 6.96${\mu}C/cm^2$ and 40.2kV/cm, respectively. After applying of $10^9$ square pulses with ${\pm}5V$, the remanent polarilzation of the PLT(10) film decreases about 20% from the initial state. In the results, we conclude that the 10mol% and the 28mol% La doped PLT thin films are very suitable for the capacitor dielectrics of new generation of DRAM and NVFRAM respecitively.

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