• Korean Journal of Pharmacognosy
• /
• v.48 no.1
• /
• pp.31-37
• /
• 2017

Glutamate-induced oxidative stress results in neuro-degenerative disorders in many central nervous system (CNS) such as Alzheimer's disease, ischemia, Huntington's disease, and Parkinson's disease. Our study was performed to investigate neuroprotective effects of Allium hookeri extracts (leaf, root, and whole) on glutamate-induced HT22 cells. In this study, ethanol extract of A. hookeri showed the outstanding neuroprotective effect in HT22 cells. In addition, we found that ethanol extract of A. hookeri root increased heme oxygenase (HO)-1 in HT22 cells. Moreover, ethanol extract of A. hookeri root also upregulated nuclear accumulation of nuclear factor E2-related factor 2 (Nrf2) in HT22 cells. These results demonstrate that ethanol extract of A. hookeri root contributes neuroprotective effects against glutamate-induced oxidative stress in HT22 cells, via Nrf2-mediated HO-1 expression. Our study suggests that ethanol extract of A. hookeri root could be the potential agent for the treatment of many neuro-degenerative diseases.

• Clinical and Experimental Pediatrics
• /
• v.45 no.6
• /
• pp.804-808
• /
• 2002

We report a case of trisomy 22 in a liveborn male infant which was confirmed by fluorescence in situ hybridization(FISH), macrocultures and GTG-banding, and RHA-banding procedures of peripheral white blood cells. The infant showed lung hypoplasia, which is a unique presentation, with other clinical manifestations of previously reported cases of trisomy 22, such as intrauterine growth retardation, cleft palate, micrognathia, large atrial septal defect, limb anomalies, imperforate anus, and hypospadias. Our report gives weight to the previously reported observation that pulmonary hypoplasia may be associated in trisomy 22.

• Microbiology and Biotechnology Letters
• /
• v.32 no.1
• /
• pp.22-28
• /
• 2004

A new moderate thermophilic bacterial strain DG-22 which produces thermostable xylanase was isolated from a timber yard soil in Kyungju, Korea. On the basis of morphological, biochemical and phylogenetic studies the new isolate was identified as a Paenibacillus species. Production of xylanase in this strain was strongly induced by adding xylan to the growth medium and repressed by glucose or xylose. No cellulase activity was detected. The temperature and pH for optimum activity were 8$0^{\circ}C$ and 5.0-5.5, respectively. The crude xylanase was stable at $60^{\circ}C$ and retained 60% of initial activity after 2h at $70^{\circ}C$. Zymogram analysis of the culture supernatant showed two xylanase active bands with molecular masses of 22 and 30 kDa.

• Clinical and Experimental Pediatrics
• /
• v.58 no.8
• /
• pp.313-316
• /
• 2015

Interstitial deletions involving the chromosome band 15q22q24 are very rare and only nine cases have been previously reported. Here, we report on a 12-day-old patient with a de novo 15q22q23 interstitial deletion. He was born by elective cesarean section with a birth weight of 3,120 g at 41.3-week gestation. He presented with hypotonia, sensory and neural hearing loss, dysmorphism with frontal bossing, flat nasal bridge, microretrognathia with normal palate and uvula, thin upper lip in an inverted V-shape, a midline sacral dimple, severe calcanovalgus at admission, and severe global developmental delay at 18 months of age. Fluorescence in situ hybridization findings confirmed that the deleted regions contained at least 15q22. The chromosome analysis revealed a karyotype of 46,XY,del(15) (q22q23). Parental chromosome analysis was performed and results were normal. After reviewing the limited literature on interstitial 15q deletions, we believe that the presented case is the first description of mapping of an interstitial deletion involving the chromosome 15q22q23 segment in Korea. This report adds to the knowledge of the clinical phenotype associated with the 15q22q23 deletion.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.10 no.2
• /
• pp.69-75
• /
• 2010

In this paper, we analyze an effect co-existence between digital television (DTV) and 802.22 wireless regional area network (WRAN) systems. We set DTV as an interfering system and 802.22 WRAN as a victim system. When they share the same spectrum, we calculate the minimum separation distance. In analysis, we compare a minimum coupling loss (MCL) with a transmission loss (TL) for determining whether there exists the potential interference or not. The minimum separation distance is determined when the TL is larger than the MCL. In this case, the DTV system does not affect any harmful effect to 802.22 WRAN.

• Journal of Advanced Marine Engineering and Technology
• /
• v.32 no.1
• /
• pp.50-56
• /
• 2008

Experimental results for forced convection condensation of Refrigerant-22 and ternary Refrigerant-407C(HFC-32/125/134a 23/25/52 wt%) which is being considered as a substitute R-22 inside a horizontal micro-fin tube are presented. The test section was horizontal double-tube counterflow condenser with a length 4,000 mm micro-fin tube, having 8.53 mm ID, 0.2 mm fin height and 60 fins. The range of parameters of mass velocity were varied from 102.1 to 301.0 kg/(m2.s) and inlet quality 1.0. At the given experimental conditions. the average heat transfer coefficients for R-407C were lower than that for R-22 at a micro-fin tube. Over the mass velocity range tested. the PF(penalty factor) for R-22, R-407C were lower than the increasing ratio of heat transfer area by fins, and the EF(enhancement factor) for R-22, R-407C were higher than the increasing ratio of heat transfer area by fins.

• Korean Journal of Pharmacognosy
• /
• v.39 no.3
• /
• pp.237-240
• /
• 2008

C-22 is one of health food made in Han Kook Shin Yak. For studying its antitumor activity, the 50% ethanol extract from C-22 was tested on BDF1 mice bearing LLC tumor cell by Teruhiro’s method. The samples were intraperitoneally injected to mice once a day with a daily dose of 50, 100, and 200 mg/kg for 14 consecutive days. Taxol was used as positive control with a dose of 50 mg/kg. As a result, the C-22's extracts dose dependently inhibited the tumor volume with the IRTV values of 28.7, 46.7, 58.9% and the IRTW values of 28.1, 46.0, 57.8% in 50, 100, and 200 mg/kg, respectively, while the Taxol showed antitumor activity with IRTV and IRTW values of 68.5 and 67.3% in 50 mg/kg. No loss of body weight was observed at any samples. This data suggested that the C-22's antitumor activity was enough to use as a cancer chemopreventive agent, and it will be used for preventing cancer as health food.

• Journal of Power System Engineering
• /
• v.12 no.4
• /
• pp.26-31
• /
• 2008

The evaporation heat transfer coefficient and pressure drop of R-22 and R-407C in a small diameter copper tube were investigated experimentally. The main components of the refrigerant loop are a receiver, a compressor, a mass flow mete, a condense and a double pipe type evaporate (test section). The test section consists of a smooth copper tube of 4.3 mm inner diameter. The refrigerant mass fluxes were varied from 100 to $300[kg/m^{2}s]$ and the saturation temperature of evaporator were $5[^{\circ}C]$. The evaporation heat transfer coefficients of R-22 and R-407C increase with the Increase in mass flux and vapor quality. The evaporation heat transfer coefficient of R-22 is about $7.3\sim47.1%$ higher than that of R-407C. The evaporation pressure drop of R-22 and R-407C increase with the increase of mass flux. The pressure drop of R-22 is about $8\sim20%$ higher than that of R-407C.

• Journal of Power System Engineering
• /
• v.9 no.1
• /
• pp.76-81
• /
• 2005

The effect of micro-pulse plasma nitriding temperature and time on the case thickness, hardness and nitride formation in the surface of Fe-12Cr-22Mn-X alloy with 3% Co and 1% Ti alloys elements investigated. External compound layer and internal diffusion layer was constituted in plasma nitride case of Fe-12Cr-22Mn-X alloys and formed nitride phase such as ${\gamma}'-Fe4N\;and\;{\varepsilon}-Fe2-3N$. Case depth increased with increasing the plasma nitriding temperature and time. Surface hardness of nitrided Fe-12Cr-22Mn-X alloys obtained the above value of Hv 1,600 and case depth obtained the above value of $45{\mu}m$ in Fe-12Cr-22Mn-3Co alloy and $60{\mu}m$ in Fe-12Cr-22Mn-1Ti alloy. Wear-resistance increased with increasing plasma nitriding time and showing the higher value in Fe-12Cr-22Mn-1Ti alloy than Fe-12Cr-22Mn-3Co alloy.

• Journal of Advanced Marine Engineering and Technology
• /
• v.32 no.4
• /
• pp.542-549
• /
• 2008

The evaporation heat transfer coefficient and pressure drop of R-22 and R-407C in a horizontal copper tube were investigated experimentally. The main components of the refrigerant loop are a receiver, a compressor, a mass flow meter, a condenser and a double pipe type evaporator (test section). The test section consists of a smooth copper tube of 6.4 mm inner diameter. The refrigerant mass fluxes were varied from 100 to $300\;kg/m^2s$ and the saturation temperature of evaporator were $5^{\circ}C$. The evaporation heat transfer coefficients of R-22 and R-407C increase with the increase of mass flux and vapor quality. The evaporation heat transfer coefficients of R-22 is about $5.68{\times}46.6%$ higher than that of R-407C. The evaporation pressure drop of R-22 and R-407C increase with the increase of mass flux. The pressure drop of R-22 is similar to that of R-407C. In comparison with test results and existing correlations, correlations failed to predict the evaporation heat transfer coefficient of R-22 and R-407C. therefore, it is necessary to develope reliable and accurate predictions determining the evaporation heat transfer coefficient of R-22 and R-407C in a horizontal tube.