• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1992년도 제1회 신약개발 연구발표회 초록집
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• pp.42-42
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• 1992

ras oncogene은 암조직이나 transformed human cell line에서 거의 공통적으로 발견되는 oncogene으로서 그 product인 p2l 단백질은 C-terminal 25개의 아미노산 외에는 거의 동일한 배열을 가지고 있는 매우 conservative한 단백질이며 C-terminal cysteine이 carboxy methylation되어 있고 또한 palmitic acid와 같은 long chain fatty acid도 결합되어 있다. 보고된 바에 의하면 p21 protein의 palmitation은 ras protein의 세포막에 대한 친화력을 유지시키며 이와 같은 친화력은 cell transforming activity의 기본요건으로 알려져 있다. 이와 같은 관점에서 볼때 p21 단백질의 C-terminal processing현상을 new drug target으로, 즉 p2l 단백질의 C-terminal processing을 억제하므로서 cell transforming activity를 저해 할 수 있을 것이므로 생체내에 존재하는 p21 단백질 C-terminal processing 억제제의 identification 및 purification은 항암제 연구와 밀접한 관계가 있다. 구체적으로 farnesyl-protein transferase inhibitor 혹은 carboxyl methyl inhibitor의 identification 및 purification은 이같은 목적을 달성 할 수 있는 가능성이 크다.

• IEIE Transactions on Smart Processing and Computing
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• 제4권2호
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• pp.126-131
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• 2015

When a battery is discharging, the battery's current and terminal voltage must both be measured to estimate its state of charge (SOC). If the SOC can be estimated by using only the current or voltage, hardware costs will decrease. This paper proposes an SOC estimation algorithm that needs to measure only the terminal voltage while a battery is discharging. The battery's SOC can be deduced from its open circuit voltage (OCV) through the relationship between SOC and OCV. But when the battery is discharging, it is not possible to measure the OCV due to the voltage drop in the battery's internal resistance (IRdrop). The proposed algorithm calculates OCV by estimating IRdrop using a dynamic terminal voltage measurement. This paper confirms the results of applying the algorithm in a hardware environment via algorithm binarization. To evaluate the algorithm, a Simulink battery model based on actual values was used.

• 한국산학기술학회논문지
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• 제16권7호
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• pp.4349-4356
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• 2015

본 연구는 현재 우리나라 컨테이너터미널에 적용가능한 친환경 운영기술 요인들을 도출하고, 관련 실무자들을 대상으로 한 실증분석을 통하여 친환경 컨테이너터미널 운영기술들에 대한 항목별 중요도와 만족도의 차이를 Importance-Performance Analysis로 검증함으로써 친환경 컨테이너터미널 운영기술에 대한 향후 방안을 제시하고자 하였다. 본 연구의 결과로 친환경 컨테이너터미널 운영기술 평가항목들 중 '빈이동 최소화'가 가장 중요한 요소로, '전기식 TC'가 가장 만족한 항목으로 분석되었다. 20개의 친환경 컨테이너터미널 운영기술 항목들은 '터미널 안벽시스템', '터미널 야드시스템', '터미널 접안지원 시스템'의 3개 요인으로 도출되었다. 이러한 결과들은 향후 우리나라 친환경 컨테이너터미널에 관련한 운영 정책수립 및 관리지침에 기여할 것으로 기대된다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 추계종합학술대회 논문집(2)
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• pp.5-8
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• 2000

This paper shows the high performance as a photodetector of InGaP/GaAs HPT with 3-terminal caused by its inherent good electrical properties compared with AIGaAs/GaAs HPT. InGaP/GaAs HPT produced the high optical gain of about 61 where HPT is biased at Vc=3V, Iв=2${\mu}\textrm{A}$ with an input optical power of 1.23㎼. This is 2.5 times higher than that of AIGaAs/GaAs HPT. And we examined that the optical gain of HPTs becomes larger when operating in 3-terminal configuration rather than 2-terminal with the floating base. for a given base current of 2${\mu}\textrm{A}$, the optical gain is enhanced about 18% in the InGaP/GaAs HPT and about 27% in the AIGaAs/GaAs HPT over that of the 2-terminal device.

• Journal of Biosystems Engineering
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• 제19권4호
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• pp.343-357
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• 1994

Current commercial dairy feed has various problems in low feed productivity, inadequate formulation and higher feeding cost due to excessive capital investment and non-specialized system for the end product. To solve those problems, 6 TMR terminal models were developed in this study. The developed TMR terminal system consists of TMR terminal, TMR main center and combined system linked TMR terminal and TMR main center. 15 TMR main center models were developed to support 10, 20, 30, 40, 50 TMR terminal(30 ton/day basis) by 3 different types, and evaluated for capital investment and operation cost by the analysis of the newly developed computer program. Optimum model size is analyzed and suggested for each model. Followings are summary of this study : 1. The capital investment costs of TMR main centers were 1,600 to 3,800 million won for type 1, 2,200 to 4,500 million won for type 2 and 2,200 to 4,800 million won for type 3. Also model MACE30 or bigger were justified as the economical models. 2. The feed production costs of TMR main center models were 3,166 to 4,824 won/ton for type 1, 3,816 to 6,182 won/ton for type 2 and 3,990 to 6,263 won/ton for type 3. So feed production cost range was 3,166 to 6,263 won/ton. 3. The bigger production capacity, the less TMR main center production cost. The feed production cost of the biggest model MACE50 was 62~65% of smallest model MACE10.

• 한국응용과학기술학회지
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• 제35권4호
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• pp.1393-1406
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• 2018

본 연구는 3개의 운전변수(압력, 공기량, 운전시간)를 실험 설계하고 마이크로 버블의 종말부상속도(Terminal rise velocity)를 반응 값으로 하여 예측식 모델과 최적 조건을 수립하였다. 다항식 회귀분석을 통해 펌프의 압력($X_1$) 4.5bar, 공기량($X_2$) 3.3L/min 그리고 운전시간($X_3$)이 2.2min에서 종말상승속도(Terminal rise velocity)에 대한 최적값인 5.14 cm/min ($85.7{\mu}m/sec$)을 얻었다. 또한, 레이저 입자계수 측정장치를 이용하여 $2{\sim}5{\mu}m$ 및 $25{\sim}50{\mu}m$ 영역에서의 가장 높은 마이크로버블 직경크기 분포를 확인하였다.

• 종양간호연구
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• 제8권1호
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• pp.32-39
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• 2008

Purpose: This study was to identify the relationship between perceived family support and quality of life in hospitalized patient with terminal cancer. Method: Study subjects were 104 patients with terminal cancer who were hospitalized and treated at K university hospital, in Busan. Perceived family support and quality of life were measured using the Kang's Revised Family Support Scale and Youn's Quality of Life scale for terminal patients. Results: 1) The mean score of perceived family support was $4.23{\pm}0.61$. The mean score of quality of life was $5.83{\pm}1.37$. 2) The perceived family support was significantly different with primary care giver, food type, medical period after diagnosis. 3) The levels of quality of life was significantly different by number of children, effect of religion on the one' life, perceived state of disease and pain. 4) There was moderate positive correlation between perceived family support and quality of life. Conclusions: Increase in perceived family support was associated with increase in quality of life in hospitalized patients with terminal cancer. It is necessary that the development of nursing education program for family which help to support the patient with terminal cancer for increasing the quality of life of patient with terminal cancer.

• 대한의생명과학회지
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• 제9권2호
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• pp.105-110
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• 2003

Ankyrins are a ubiquitously expressed family of intracellular adaptor proteins involved in targeting diverse proteins to specialized membrane domains in both the plasma membrane and the endoplasmic reticulum. Canonical ankyrins are 190-220 kDa proteins expressed in most tissues and cell types and comprise a membrane-binding domain (MBD) of 24 ANK repeats, a spectrin-binding domain, a death domain and a C-terminal domain. Rescue studies with ankyrin-B/G chimeras have identified the C-terminal domain of ankyrin-B as the defining domain in specifying ankyrin-B activity, but the function of C-terminal domain of ankyrin-B is, however, not known. We report here that the C-terminal domain of ankyrin-B is capable of interacting with the C-terminal Region of Hsp40. The Hsps are induced not only by heat shock but also by various other environmental stresses. Hsps are also expressed constitutively at normal growth temperatures and have basic and indispensable functions in the life cycle of proteins as molecular chaperones, as well as playing a role in protecting cells from the deleterious stresses. The binding sites required in the interaction between C-terminal domain of ankyrin-B and C-terminal region of Hsp40 were characterized using the yeast two-hybrid system and GST-pull down assay. The interaction between ankyrin-B and Hsp40 represents the first direct evidence of ankyrin's role as chaperones.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1991년도 추계학술대회 논문집
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• pp.48-51
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• 1991

Short channel Nonvolatile EEPROM memory devices were fabricated to CMOS 1M bit design rule, and reviews the characteristics and applications of SNOSFET. Application of SNOS field effect transistors have been proposed for both logic circuits and nonvolatile memory arrays, and operating characteristics with write and erase were investigated. As a results, memory window size of four terminal devices and two terminal devices was established low conductance stage and high conductance state, which was operated in “1” state and “0”state with write and erase respectively. And the operating characteristics of unit cell in matrix array were investigated with implementing the composition method of four and two terminal nonvolatile memory cells. It was shown that four terminal 2${\times}$2 matrix array was operated bipolar, and two termineal 2${\times}$2 matrix array was operated unipolar.

• 한국식품위생안전성학회:학술대회논문집
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• 한국식품위생안전성학회 2002년도 춘계학술발표대회 및 심포지움
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• pp.215-215
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• 2002

Catalytic subunit of pyruvate dehydrogenase phosphatase (PDPc) has been suggested to have three major funational domains such as dihydrplipoamide adetyltransferase(E2)-binding domain, regulatory subunit of PDP(PDP)r-binding domain, and calcium-binding domain. In order to identify functional domains, recombinant catalytic subunit of pyruvate dehydrogenase phosphatase(rPDPc) was expressed in E. coli JM101 and purified to near homogeneity using the unique property of PDPc: PDPc binds to the inner lipoyl domain (L2) of E2 of ppyruvate dehydrogenase complex (PDC) in the presence of Ca+2, not under EGTA. PDPc was limited-proteolysed by typsin, chymotypsin, Arg-C, and elastase at pH 7.0 and 30C and N-terminal analysis of the fragments was done. Chymotrypsin, trypsin, and elastase made two major fragments: N-terminal large fragment, approx. 50kD and C-terminal small fragment, approx.10 kDa. Arg-C made three major fragments: N-terminal fragment, approx. 35kD, and central fragment, approx. 15 kD, and C-terminal fragment, approx. 10 kD. This study strongly suggest that PDPc consists of three major functional domains. However, further study should be necessary to identify the functional role.