• Journal of the Korean Society of Radiology
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• v.17 no.2
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• pp.243-248
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• 2023

This study aims to analyze the secondary carcinogenesis rate caused by exposure of organs at risk of damage using a glass dosimeter during radiosurgery in vestibular schwannoma disease. Using a pediatric phantom of human tissue equivalent material, the volume of the tumor was set to a total of three volumes: 0.506 cm³, 1.008 cm³, and 2.032 cm³, and a radiosurgery plan was established with an average dose of 18.4 ± 3.4 Gy. After mounting the human body phantom on the table of surgical equipment, glass dosimeters were placed on the right eye, left eye, thyroid gland, thymus, right lung, and left lung to measure the exposure dose, respectively. In this study, the incidence of secondary cancer due to exposure to damaged organs during gamma knife radiosurgery in vestibular schwannoma disease with the largest tumor volume of 2.032 cm³ was measured with a glass dosimeter. This study studies the risk of secondary radiation exposure dose that can occur during stereotactic radiosurgery, and it is considered that it will be used as basic data in the field of radiation damage related to the stochastic effect of radiation in the future.

• Nuclear industry
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• v.36 no.12
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• pp.2-10
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• 2016

원자력안전위원회는 12월 8일 제62회 원자력안전위원회를 개최하고, '제2차('17~'21년) 원자력안전종합계획안'에 대한 심의를 거쳐 동 계획을 확정하였다. 제2차 종합계획은 '국민이 공감하는 원자력 안전, 방사선 위험으로부터 안전한 사회'를 비전으로 원자력, 방사선 및 핵안보 등 분야별 안전 강화를 위한 7대 전략 21개 중점 추진 과제를 포함하고 있다. 주요 내용은 ${\triangle}$정상 운전부터 중대사고까지 원전의 안전 관리 강화, ${\triangle}$정보 공개 소통을 통한 투명성 제고, ${\triangle}$해체 사용후핵연료 등 원자력산업의 후행주기 안전 관리 체계 구축, ${\triangle}$지진 등 재난대비 및 방사능 비상 대응 체계의 실효성 제고, ${\triangle}$핵안보 핵비확산체제의 국제사회 선도, ${\triangle}$환경 변화에 대응한 선제적 방사선 안전 관리, ${\triangle}$R&D, 인력 양성, 국제 협력 인프라 확충 등이다. 원자력안전종합계획은 "원자력안전법"에 근거하여 5년 단위로 수립되는 원자력 및 방사선 안전 관련 최상위 국가 계획이다.

• Journal of the Korean Applied Science and Technology
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• v.37 no.4
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• pp.830-838
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• 2020

The present study aimed to evaluate the effect of radiation mutant Perilla frutescens var. crispa on bone metabolism and the inflammatory response in a monosodium iodoacetateinduced rat model of osteoarthritis. radiation mutant Perilla frutescens var. crispa was administered orally at doses of 25, 50 or 100 mg/kg/day for 2 weeks before direct injection of monosodium iodoacetate (3 mg/50 μl of 0.9% saline) into the intra-articular space of the rats' right knees. The rats subsequently received the same doses of oral radiation mutant Perilla frutescens var. crispa for another 4 weeks. It was evaluated that the treatment effects based on serum biomarkers, and morphological and histopathological analysis of the knee joints. Compared with those in control rats, the radiation mutant Perilla frutescens var. crispa treatments significantly reduced the serum levels of inflammation, bone metabolism markers (i.e., COX-2, LTB4, MMP-3, and COMP), and the amount of fibrous tissue. Otherwise, it was significantly increased the concentration of TIMP-1 and calcitonin. In addition, the radiation mutant Perilla frutescens var. crispa treatments effectively preserved the knee cartilage and synovial membrane. As a result, it indicates that radiation mutant Perilla frutescens var. crispa prevented and alleviated osteoarthritis symptoms. Thus, radiation mutant Perilla frutescens var. crispa can be used in food and drug material for the management of osteoarthritis.

• Radiation Oncology Journal
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• v.24 no.2
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• pp.149-155
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• 2006

Meningeal hemangiopericytoma (HPC) is an uncommon dura-based tumor and can recur not only locally but also distantly in the neural axis or extraneural sites. We report our experience of radiation therapy, one preoperative and one elective postoperative, In two patients with meningeal HPC and reviewed the role of radiation therapy. A 41-year-old man (Case 1) presented with a 3-month history of headache and right hemiparesis. The mass was nearly unresectable at the first and second operation and diagnosed as meningeal HPC. Preoperative radiation therapy was given with a total dose of 55.8 Gy/31 fractions to the large residual mass of left frontoparietal area. Follow-up computerized tomography (CT) showed marked regression of tumor after radiation therapy. The third operation was peformed to remove the residual tumor at 6 months after the radiation therapy and a $2{\times}2cm$ sized tumor was encountered. The mass was totally removed. The serial follow-up CT showed no evidence of recurrence and he is alive without distant metastasis for 4 years and 10 months after the first operation. A 45-year-old woman (Case 2) presented with suddenly developed headache and visual impairment. Tumor mass occupying right frontal lobe was removed with the preoperative diagnosis of meningioma. It was totally removed with attached sagittal sinus and diagnosed as meningeal HPC. Elective postoperative radiation therapy was peformed to reduce local recurrence with a total dose of 54 Gy/30 fractions to the involved area of right frontal lobe. She is alive for 5 years maintaining normal activity without local recurrence and distant metastasis.

• Journal of the Korean Society of Radiology
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• v.12 no.3
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• pp.351-357
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• 2018

During radiation therapy, the patient is exposed to secondary radiation by scattered and leakage radiation. For the diagnostic radiation, guidelines for reducing the patient's exposure as the diagnostic reference level are provided. However, in the case of therapeutic radiation, even though the radiation dose by the secondary radiation is considerable, the prescription dose is not limited because of the reason of the therapeutic efficiency. The purpose of this study was to evaluate the secondary radiation that the patient could be received at the peripheral tissue during the radiotherapy using the linear accelerator with the radiophotoluminescent glass dosimeter. In addition, we measured the degree of saturation of the luminescent amount according to the build-up characteristic of the radiophotoluminescent glass dosimeter. As a result of carrying out this study, the exposure dose decreased drastically farther away from the treatment field. When the head was irradiated with 1 Gy, the neck could be exposed to 18.45 mGy. When the same dose was irradiated at the neck, 15.55 mGy of the head and irradiated at the chest, 14.26 mGy of the neck and irradiated at the pelvis, 1.14 mGy of the chest were exposed separately. The degree of saturation of the luminescent intensity could be overestimated by 1.8 ~ 4.8% depending on time interval for 3 days.

• Journal of Radiation Protection and Research
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• v.38 no.4
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• pp.202-207
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• 2013

Bioimpedance involves a lot of information related to living tissue. If there is alteration in bio tissue, its electrical characteristics also change. It is to study electrical characteristics of pork tenderlion in using a HP-4194A Impedance/Gain-phase analyzer instrument and electrical characteristics changes by graded radiation exposure dose. The results were as follow 1. Electrical characteristics of pork tenderlion in repeated measurement had high precision within ${\pm}5$% of coefficiency of variability. 2. During the measurement impedance absolute value and phase alteration did not show statistically significant difference.(p>0.05) 3. While impedance phase of electrical characteristics associated with frequency change was almost stable, impedance absolute value was in inverse proportion to frequency that means high inverse correlation of -0.096(r). 4. Impedance absolute value dropped in radiation exposure dose. The alteration of the value did not show statistically significant difference in 1 Gy, 2 Gy and 4 Gy.(p>0.05) However in radiation exposure dose of 10 Gy, the decrease of impedance absolute value was significantly different.(p<0.05) 5. Impedance phase according to radiation exposure dose change did not show statistically significant difference in 1 Gy, 2 Gy, 4 Gy, and 10 Gy(p>0.05).

• Journal of the Korean Society of Radiology
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• v.16 no.3
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• pp.225-231
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• 2022

Transcendence of space and time, virtual reality, augmented reality, etc. are being realized through the latest technologies in the era of the 4th industrial revolution. In a situation where they are currently experiencing artificial intelligence, augmented reality, big data, etc., the degree of interest in the latest technologies of the 4th industrial revolution for radiology students, the necessary competencies in the 4th industrial revolution era, and the prospect of the radiation field employment environment in the 4th industrial revolution era The purpose of this study was to find out the level of awareness of From February 7th to February 18th, 2022, surveys on awareness were analyzed using questionnaires for 2nd and 3rd year students in the Department of Radiology at S University in Daegu. As a result of the study, the level of interest in 3D modeling was shown to be the highest with an average of 3.34 ± 1.09 points, and interest in big data and artificial intelligence was also shown with an average of 3.27 ± 1.17 and 3.33 ± 1.07 points. In addition, the correlation between the awareness of the necessary competencies in the 4th industrial revolution era and the awareness of the prospects for employment in the radiation field in the 4th industrial revolution era was the highest (r=0.778, p<0.01), and the interest in the latest technologies in the 4th industrial revolution and the 4th industrial revolution It was found that there was also a correlation between the perceptions of the necessary capabilities of the times (r=0.694, p<0.01). In the era of the 4th industrial revolution, it is judged that it is necessary to strengthen professional education that can handle the latest technologies such as 3D printing, artificial intelligence, and big data, and to strengthen employment capabilities related to the latest technologies in the field of radiation medical technology.

• Journal of the Korean Society of Radiology
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• v.18 no.4
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• pp.383-389
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• 2024

In this study, we aimed to analyze the probability of secondary cancer occurring in the abdomen, a normal organ, due to photoneutron exposure during intensity-modulated radiotherapy for prostate cancer. The design of the radiation treatment plan for prostate cancer was established as a daily prescription dose of 220 cGy, a total of 35 treatments, and 7700 cGy. The experimental equipment was a True Beam STx (Varian, USA) linear accelerator from Varian. The energy used in the experiment was 15 MV, and the treatment plan was designed so that the photoneutron dose would be generated within the planning target volume (PTV). The radiation treatment plan was an Eclipse System (Varian Ver. 10.0, USA), and the number of irradiation portals was set to 5 to 9. The irradiation angle was designed so that 95% of the prescription dose area was set to 0 to 320°, and the number of beamlets per irradiation portal was set to 100. The optically stimulated luminescence dosimeter used in this study to measure the dose of photoneutrons was designed to measure photoneutron doses by coating ⁶LiCO₃ on a device containing aluminum oxide components. It was studied that there is a minimum of 7.07 to 11 cases per 1,000 people with secondary cancer due to the photoneutron dose to the abdomen during intensity-modulated radiotherapy. In this study, we studied the risk of secondary radiation dose that may occur during intensity-modulated radiotherapy, and we expect that this will be used as meaningful data related to the probabilistic effects of radiation in the future.

• Journal of the Korean Society of Radiology
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• v.16 no.7
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• pp.843-849
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• 2022

In this study, the probability of secondary carcinogenesis was analyzed by measuring the exposure dose of surrounding normal organs during radiosurgery using a gamma knife. A pediatric phantom (Model 706-G, CIRS, USA) composed of human tissue-equivalent material was set to four tumor volumes of 0.25 cm³, 0.51 cm³, 1.01 cm³, and 2.03 cm³, and the average dose was 18.4 ± 3.4 Gy. After installing the Rando phantom on the table of the gamma knife surgical equipment, the OSLD nanoDot dosimeters were placed in the right eye, left eye, thyroid, thymus gland, right lung, and left lung to measure each exposure dose. The probability of cancer occurrence due to radiation exposure of surrounding normal organs during gamma knife radiosurgery for acoustic schwannoma disease was 4.08 cancers per 100,000 at a tumor volume of 2.03 cm³. This study is expected to be used as useful data in relation to stochastic effects in the future by studying the risk of secondary radiation exposure that can occur during stereotactic radiosurgery.

• Radiation Oncology Journal
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• v.16 no.1
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• pp.35-41
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• 1998

Purpose : To investigate the role of adjuvant chemoradiotherapy in adenocarcinoma of the rectum, we retrospectively compared the treatment results between postoperative adjuvant radiotherapy alone and combined chemoradiotherapy. Material and Methods : From October 1989 to May 1994, 141 patients with rectal carcinoma were treated by postoperative adjuvant therapy in Yonsei Cancer Center. Sixty eight patients were treated by radiation therapy alone. Seventy three patients were treated by combined chemoradiotherapy. Radiation therapy was delivered with 10 MV linear accelerator, 180cGy fraction/5 days per week. Total radiation doses were 5400cGy in the postoperative radiotherapy alone group. Three to twelve cycles of Fluorouracil(mean dose $393.9mg/m^2$) with Leucovorin($20mg/m^2$) and 5040cGy of radiation were delivered in the combined chemoradiotherapy group. Third and 4th cycle of chemotherapy were administrated during the radiation treatment in the combined group. The median follow up was 38 months with a range of 3 to 81 months. Results : The 5 year overall survival rate of radiation alone group and combined group were $60.1\%$ and $66.3\%$, respectively. The 5 year disease free survival rate of radiation aione group and combined group were $54.2\%$ and $65.5\%$, respectively There was no significant difference of overall survival and disease free survival between RT alone group and combined group(p<0.05). But the 5 year Local failure free survival rate of combined group was significantly better than radiotherapy alone group($05.8\%\;vs.\;50.3\%.\;p=0.04$). Conclusion : There was no significant difference in overall survival, disease free survival, and distant metastasis free survival between postoperative adjuvant radiotheray alone group and combinded chemoradiotherapy group. Only the Local failure free survival rate was superior in the combined treatment group. These results confirm the radiosensitizing effect of the chemotherapeutic agent in the combined chemoradiotherapy treatment.