Browse > Article
http://dx.doi.org/10.7742/jksr.2022.16.7.843

A Study on the Probability of Secondary Carcinogenesis during Gamma Knife Radiosurgery  

Joo-Ah, Lee (Department of Radiation Oncology, Catholic University, Incheon St.Mary's Hospital)
Gi-Hong, Kim (Yonsei University Health System, Severance Hospital Gamma Knife Center)
Publication Information
Journal of the Korean Society of Radiology / v.16, no.7, 2022 , pp. 843-849 More about this Journal
Abstract
In this study, the probability of secondary carcinogenesis was analyzed by measuring the exposure dose of surrounding normal organs during radiosurgery using a gamma knife. A pediatric phantom (Model 706-G, CIRS, USA) composed of human tissue-equivalent material was set to four tumor volumes of 0.25 cm3, 0.51 cm3, 1.01 cm3, and 2.03 cm3, and the average dose was 18.4 ± 3.4 Gy. After installing the Rando phantom on the table of the gamma knife surgical equipment, the OSLD nanoDot dosimeters were placed in the right eye, left eye, thyroid, thymus gland, right lung, and left lung to measure each exposure dose. The probability of cancer occurrence due to radiation exposure of surrounding normal organs during gamma knife radiosurgery for acoustic schwannoma disease was 4.08 cancers per 100,000 at a tumor volume of 2.03 cm3. This study is expected to be used as useful data in relation to stochastic effects in the future by studying the risk of secondary radiation exposure that can occur during stereotactic radiosurgery.
Keywords
Gamma Knife; OSLD nanoDot; Radiosurgery; Organs at risk; Target volume;
Citations & Related Records
Times Cited By KSCI : 7  (Citation Analysis)
연도 인용수 순위
1 J. A. Lee, S. R. Kim, S. H. Yoon, J. S. Kim, H. J. Yang, G. H. Kim, "Evaluation and analysis of radiation exposure to normal tissues during gamma knife radiosurgery for vestibular schwannoma", International Journal of Radiation Research, Vol. 20, No. 3, pp. 571-578, 2022. http://dx.doi.org/10.52547/ijrr.20.3.8   DOI
2 S. J. Jin, J. Y. Je, C. W. Park, "Clinical Analysis of Inverse Planning for Radiosurgery ; Gamma Knife Treatment Plan Study", Journal of the Korean Society of Radiology, Vol. 9, No. 6, pp. 343-348, 2015. https://doi.org/10.7742/jksr.2015.9.6.343   DOI
3 B. I. Hur, "Analyses of the indispensible Indices in Evaluating Gamma Knife Radiosurgery Treatment Plans", Journal of the Korean Society of Radiology, Vol. 11, No. 5, pp. 303-312, 2017. https://doi.org/10.7742/jksr.2017.11.5.303   DOI
4 J. Y. Je, "Evaluation of Depth Dose and Surface Dose According to Treatment Room Wall Distance", Journal of the Korean Society of Radiology, Vol. 5, No. 3, pp. 121-125, 2011. http://dx.doi.org/10.7742/jksr.2011.5.3.121   DOI
5 H. S. Won, J. W. Hong, S. Y. Kim, J. H. Choi, J. H. Cho, H. J. Yang, J. Lee, S. Y. Lee, C. S. Park, "Evaluation of Metal Artifact Reduction for Orthopedic Implants (O-MAR)", Journal of the Korean Society of Radiology, Vol. 8, No. 5, pp. 217-223, 2014. https://doi.org/10.7742/jksr.2014.8.5.217   DOI
6 Miljanic S. Hrsak H, Knezevic Z, MaJer M, Heinrich Z, "Peripheral doses in children undergoing Gamma Knife radiosurgery and second cancer risk", Radiation Measurements, Vol. 55, pp. 38-42, 2013. https://doi.org/10.1016/j.radmeas.2012.09.013   DOI
7 S. Y. Lee, Y. H. Seoung, "Evaluation of Effective Dose with National Diagnostic Reference Level using Monte-Carlo Simulation", Journal of the Korean Society of Radiology, Vol. 15, No. 7, pp. 1041-1047, 2021. http://dx.doi.org/10.7742/jksr.2021.15.7.1041   DOI
8 ICRP Publication 103, The 2007 Recommendations of the International Commission on Radiological Protection ICRP Publication 103, Ann. ICRP 37, Vol. 2-4, 2007.
9 S. Y. Choi, S. C. Won, C. J. Lyu, S. H. Oh, C. H. Yang, C. O. Suh, J. U. Choi, B. S. Kim, "Results of treatments for children with primary brain tumors : Long-term follow up results of a single institute", Journal of the Korean Pediatric Society, Vol. 45, No. 8, pp. 1016-1023, 2002.
10 C. P. Yen, S. J. Monteith, J. H. Nguyen, J. Rainey, D. J. Schlesinger, J. P. Sheehan, "Gamma knife surgery for arteriovenous malformations in children", Journal of neurosurgery, Vol 6, No. 5, pp. 426-434, 2010. https://doi.org/10.3171/2010.8.peds10138   DOI
11 E. J. Chung, C. O. Suh, G. E. Kim, C. J. Lyu, B. S. Kim, "Second malignant solid neoplasms in children treated with radiotherapy", Journal of the Korean society for therapeutic radiology and oncology, Vol. 13, No. 3, pp. 267-275, 1995.
12 D. H. Lim, "Radiation therapy for pediatric brain tumors", Journal of the Korean Medical Association, Vol. 55, No. 5, pp. 447-453, 2012. https://doi.org/10.5124/jkma.2012.55.5.447   DOI
13 Y. J. Choi, J. I. Lee, Y. D. Kim, "Gamma Knife radiosurgery for orbital lesions", Journal of the korean ophthalmological society, Vol. 49, No. 4. pp 555-561, 2008. https://doi.org/10.3341/jkos.2008.49.4.555   DOI
14 J. H. Chang, J. W. Chang, Y. G. Park, S. S. Chung, "Gamma Knife Radiosurgery for Juxtasellar Tumors", Journal of Korean Neurosurgical Society, Vol. 29, No. 10, pp. 1345-1351, 2000.
15 J. C. Ganz, E. O. Backlund, F. A. Thorsen, "The results of Gamma Knife surgery of meningiomas, related to size of tumor and dose", Stereotactic and functional neurosurgery, Vol. 61, No. 1, pp. 23-29, 1993. https://doi.org/10.1159/000100656   DOI
16 Y. S. Lee, "Gamma Knife Radiosurgery for Pineal gland tumors", Inje University, Master of Sciences in Medicine, pp. 1-22, 2017.
17 Th. Flannery, H. Kano, J. J. Martin, A. Niranjan, J. C. Flickinger, L. D. Lunsford, D. Kondziolka, "Boost radiosurgery as a strategy after failure of initial management of pediatric primitive neuroectodermal tumors", Journal of Neurosurgery, Vol. 3, No. 3, pp. 205-210, 2009. https://doi.org/10.3171/2008.11.peds08268   DOI
18 Y. G. Kim, "Stereotactic Radiosurgery for Metastatic Brain Tumor", The Ewha Medical Journal, Vol. 44, No. 4, pp. 103-110, 2021. http://dx.doi.org/10.12771/emj.2021.44.4.103   DOI
19 S. M. Kwon, J. S. Kim, "The Evaluation of Eye Dose and Image Quality According to The New Tube Current Modulation and Shielding Techniques in Brain CT", Journal of the Korean Society of Radiology, Vol. 9, No. 5, pp. 279-285, 2015. http://dx.doi.org/10.7742/jksr.2015.9.5.279   DOI
20 J. S. Lee, K. S. Chon, "Reduction of Radiation Exposure Dose of Eyeball and Thyroid for Chest and Abdomen CT Scan", Journal of the Korean Society of Radiology, Vol. 13, No. 2, pp. 147-151, 2019. http://dx.doi.org/10.7742/jksr.2019.13.2.147   DOI
21 M. N. Ha, "Radiation exposure and cancer", Journal of Clinical Otolaryngology Head and Neck Surgery, Vol. 22, No. 2, pp. 275-281, 2011.   DOI