• Bulletin of the Korean Chemical Society
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• 제35권6호
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• pp.1619-1624
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• 2014

A new series of carbazole based 2,4-disubstituted thiazole derivatives were synthesized. All the synthesized compounds were tested for their cytotoxicity against three different cancer cell lines A549, MCF-7, and HT29. Some of these compounds showed good cytotoxicity. These compounds were also evaluated for antioxidant activity. Compounds 3a, 3b, 3d-f and 3i showed higher antioxidant activity than standard BHT.

• 공업화학
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• 제20권2호
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• pp.134-139
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• 2009

(E)-3-(Aryl)acrylaldehyde 유도체들 (1a~1e)과 thiosemicarbazide 축합반응으로 일련의 알릴리덴치오세미카르바존 화합물 (2a~2e)을 45~85%로 얻었다. 이 화합물들을 2,4'-dibromoacetophenone와 2,3-dichloroquinoxaline로 처리하여 각각 2,4-이치환 티아졸류(3a~3e)와 2-[(E)-3-(aryl)allylidenehydrazone]thiazolo[5,4-b]quinoxaline류 (4a~4e)를 좋은 수율로 합성하였다. 새로이 합성한 모든 화합물들의 구조들은 IR과 $^1H-NMR$ 분광학 자료로 확인하였다.