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http://dx.doi.org/10.5012/bkcs.2014.35.6.1619

Synthesis, Anticancer and Antioxidant Activity of Novel 2,4-Disubstituted Thiazoles  

Tran, Nguyen Minh An (Department of Nanomaterial Chemistry, Dongguk University)
Kumar, Mungara Anil (Department of Nanomaterial Chemistry, Dongguk University)
Chang, Seung Hyun (Department of Chemistry, Daegu University)
Kim, Mi Yeong (College of Pharmacy, Yeungnam University)
Kim, Jung-Ae (College of Pharmacy, Yeungnam University)
Lee, Kap Duk (Department of Nanomaterial Chemistry, Dongguk University)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.6, 2014 , pp. 1619-1624 More about this Journal
Abstract
A new series of carbazole based 2,4-disubstituted thiazole derivatives were synthesized. All the synthesized compounds were tested for their cytotoxicity against three different cancer cell lines A549, MCF-7, and HT29. Some of these compounds showed good cytotoxicity. These compounds were also evaluated for antioxidant activity. Compounds 3a, 3b, 3d-f and 3i showed higher antioxidant activity than standard BHT.
Keywords
2,4-Disubstituted thiazole; Carbazole; ${\alpha}$-Bromoketone; Cytotoxicity;
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