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Synthesis of New 2,4-Disubstituted Thiazoles and 2-(Allylidenehydrazono)-thiazolo[5,4-b]quinoxaline Derivatives  

Kim, Jong-Geun (Department of Chemistry, Kunsan National University)
Bae, Sun Kun (Department of Chemistry, Kunsan National University)
Publication Information
Applied Chemistry for Engineering / v.20, no.2, 2009 , pp. 134-139 More about this Journal
Abstract
A series of allylidenethiosemicarbazone compounds (2a~2e) were obtained in 45~85% by condensing (E)-3-(aryl)acrylaldehyde (1a~1e) with thiosemicarbazide. Theses compounds on treatment of 2,4'-dibromoacetophenone and 2,3-dichloroquinoxaline yielded 2,4-disubstituted thiazoles (3a~3e) and 2-[(E)-3-(aryl)allylidenehydrazono]thiazolo[5,4-b]quinoxaline (4a~4e) in good yield respectively. The structures of all the newly synthesized compounds were identified by IR and $^1H-NMR$ spectral data.
Keywords
thiosemicarbazide; 2,4'-dibromacetophenone; 2,3-dichloroquinoxaline; thiazole;
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