• Nuclear Medicine and Molecular Imaging
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• v.40 no.3
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• pp.155-162
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• 2006

Purpose: Diabetes mellitus (DM) is a critical disease with higher rates of cardiovascular morbidity and mortality due to myocardial ischemia and infarction. There is glowing interest in how to determine high-risk patients who are candidates for screening testing. This study was performed to evaluate the incidence of coronary artery disease (CAD) in diabetic patients detected by Tc-99m MIBI myocardial perfusion SPECT (MPS) and to assess risk factors of CAD and cardiac hard events. Subjects and Methods: 203 diabetic patients (64 male, mean age $64.1{\pm}9.0$ years) who underwent MPS were included between Jan 2000 and July 2004. Cardiac death and nonfatal myocardial infarction (MI) were considered as hard events, and coronary angioplasty and bypass surgery >60 days after testing were considered as soft events. The mean follow-up period was $36{\pm}18$ months. Patients underwent exercise (n=6) or adenosine stress (n=197) myocardial perfusion SPECT. Results: Perfusion defects on MPS were detected in 28.6% (58/203) of the patients. There was no cardiac death but 11 hard events were observed. The annual cardiac hard event rate was 1.1%. In univariate analysis of clinical factors, typical anginal pain, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were significantly associated with the ocurrence of hard events. Anginal pain, peripheral vascular disease, and resting ECG abnormality remained independent predictors of nonfatal MIs with multivariate analysis. Abnormal SPECT results were significantly associated with high prevalence of hard events but not independent predictors on uni- and multivariate analyses. Conclusion: Patients who were male, had longer diabetes duration (especially over 20 years), peripheral vascular disease, peripheral polyneuropathy, or resting ECG abnormality had higher incidence of CAD. Among clinical factors in diabetic patients, typical angina, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were strong predictors of hard events.

• Journal of mucopolysaccharidosis and rare diseases
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• v.2 no.2
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• pp.50-51
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• 2016

Combining basal insulin therapy with a glucagon-like peptide-1 receptor agonist (GLP-1 RA) has clear clinical advantages, and is supported by the latest EASD/ADA position statement (1). IDegLira is a once-daily combination of the basal insulin, degludec, and the GLP-1RA, liraglutide, in one pen. The DUAL phase 3 clinical trial program provides important evidence about the efficacy and safety of IDegLira in three different populations of patients with type 2 diabetes (T2D): insulin naïve subjects uncontrolled on oral antidiabetic drugs (OADs), subjects uncontrolled on OAD(s) and a GLP-1 RA, and subjects uncontrolled on OAD(s) and basal insulin. Treatment with IDegLira reduced mean HbA1c to below the EASD/ADA treatment target of 7.0% in all five trials. The mean reduction of HbA1c from baseline ranged from 1.3% and 1.9%. IDegLira resulted in weight loss for subjects uncontrolled on basal insulin, was weight neutral for subjects on OADs and weight gain was minimal (2 kg) for subjects previously treated with a GLP-1 RA. Rates of hypoglycaemia were low across all the trials, particularly considering the level of glycaemic control achieved.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.4
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• pp.347-353
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• 2010

Purpose: An in vitro study was conducted to compare the lipid cleaning efficacy of care solutions on balafilcon A silicone hydrogel (SiHy) lens. Methods: Lipid spoilation was performed by incubating balafilcon A SiHy lenses in phosphate buffered saline (PBS) containing oleic acid, oleic acid methyl ester and cholesterol. Spoiled contact lenses rinsed with PBS were cleaned with surfactant cleaner, alcohol containing cleaner and multipurpose solution (MPS) respectively and repetitive spoilation and cleaning was conducted up to 14 times. To observe the cleaning effect of ultrasonic wave on the lipid deposit, each spoiled lens was ultrasonicated and then compared with non-sonicated lens. Lipids deposit on the contact lenses was extracted by methanol:chloroform (1:1, v/v) solution. High performance liquid chromatography was used to analyze and quantify lipid deposit extracts. Results: The effectiveness of alcohol containing surfactant cleaner on the lipid deposits was better than that of surfactant cleaner and MPS, and the cleaning efficacy was significantly higher in the ultrasonic wave treated group. Lipid deposits were not removed completely by contact lens care solutions so that lipid deposits increased continuously and cumulatively. Conclusions: The cleaning efficacy of contact lens care solutions was not satisfactory to remove lipid deposits on the SiHy lens that new cleaning products specially designed for SiHy lenses are needed to develop.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.1
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• pp.144-151
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• 2019

Objective: Curdlan has been widely used as a gelling agent in various food systems. This study was performed to evaluate the rheological properties of pork myofibrillar protein (MP) with different levels of curdlan (0.5% to 1.5%) and its application to low-fat model sausages (LFS). Methods: MP mixtures were prepared with 0.5%, 1.0%, and 1.5% of curdlan. Cooking loss (%), gel strength (gf), shear stress (Pa), and scanning electron microscopy were measured. Physicochemical and textural properties of LFS containing different levels of curdlan were measured. Results: The shear stress of MP mixtures increased with increasing levels of curdlan. MP gels with increased levels of curdlan decreased cooking loss and increased gel strength (p<0.05). The MPs with 1.0% and 1.5% of curdlan were observed more compact three-dimensional structure than those with 0.5% curdlan. Increased curdlan level in LFS affected redness ($a^{\star}$) and yellowness ($b^{\star}$) values. Although expressible moisture of LFS did not differ among curdlan levels, LFSs with various levels of curdlan decreased cooking loss as compared to control sausages. Hardness values (2,251 to 2,311 gf) of LFS with 0.5% and 1.0% curdlan was increased and differ from those (1,901 gf) of control sausages. Conclusion: The addition of 1.0% curdlan improved the functional and textural properties of LFS.

• Journal of mucopolysaccharidosis and rare diseases
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• v.5 no.1
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• pp.1-7
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• 2021

Gaucher disease (GD, OMIM #230800 OMIM#230800) is a rare, autosomal recessive inherited metabolic disorder caused by mutation in GBA1 encoding the lysosomal enzyme, glucocerebrosidase. The deficiency of glucocerebrosidase leads to an accumulation of its substrate, glucosylceramide in macrophages of various tissues. Common clinical manifestations include cytopenia, splenomegaly, hepatomegaly, and bone lesions. The phenotype of GD is classified into three clinical categories: Type 1 (non-neuronopathic) is characterized by involvements on the viscera, whereas types 2 and 3 (neuronopathic) are associated with not only visceral symptoms but also neurological impairment, either severe in type 2 or variable in type 3. A diagnosis of GD can be confirmed by demonstrating the deficiency of acid glucocerebrosidase activity in leukocytes. Mutations in the GBA1 should be identified as they may be of prognostic value in some cases. Biomarkers including Chitotriosidase, CCL18, and glucosylsphingosine (lyso-GL1) are useful in diagnosis and treatment monitoring. Currently available disease-specific treatment in Korea consists of intravenous enzyme replacement therapy and substrate reduction therapy. For enhancing long-term prognosis, the onset of Parkinson's disease and Lewy body dementia, or the occurrence of a blood disease or cancer (hepatocellular carcinoma) should be monitored in older patients. The development of new strategies that can modify the neurological phenotype are expected, especially in Asia including Korea, where the prevalence of neuronopathic GD is relatively higher than that in western countries.

• Journal of computational fluids engineering
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• v.13 no.1
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• pp.28-34
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• 2008

A particle method recognized as one of the gridless methods has been developed to investigate the nonlinear free-surface motions interacting to the structures. The method is more feasible and effective than convectional grid methods for solving the non-linear free-surface motion with complicated boundary shapes. The right-handed side of the governing equations for incompressible fluid, which includes gradient, viscous and external force terms, can be replaced by the particle interaction models. In the present study, the developed method is applied to the dam-broken problem on dried- and wet-floor and its adequacy will be discussed by the comparison with the experimental results.

• Journal of the Korean Operations Research and Management Science Society
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• v.24 no.2
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• pp.1-15
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• 1999

This research involves the development and evaluation of a work flow control model for a type of flexible manufacturing system(FMS) called a flexible flow line(FFL). The control model can be considered as a kind of hybrid intelligent model in that it utilizes both computer simulation and neural network technique. Training data sets were obtained using computer simulation of typical FFL states. And these data sets were used to train the neural network model. The model can easily incorporate particular aspects of a specific FFL such as limited buffer capacity and dispatching rules used. It also dynamically adapts to system uncertainty caused by such factors as machine breakdowns. Performance of the control model is shown to be superior to the random releasing method and the Minimal Part Set(MPS) heuristic in terms of machine utilization and work-in-process inventory level.

• THE HEALTH and ORGANIC FARMING
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• no.242
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• pp.1-12
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• 2007

2007년도 지회장단 연찬회 성료/광주.전남도지부장 이.취임식/'저출산고령화대책연석회의' 의장께 드리는 건의문/2007년도 전국 지회장단 연찬회 이모저모/유기농식품 인증제 이르면 2008년 도입/유기재배 꽃 등장/화훼산업의 친환경인증제도 MPS/전통식품산업의 지연화와 세방화/글로벌시장에 '유기농 에코라벱' 바람/식물영양소 기능과 정식준비/골다공증의 원인과 예방 및 관리법/<암을 이기는 음식>(7) 부추/유기자연농업의 원조를 찾아서/서울시 친환경농산물 지원조례 제정/우리의 산야초-팽나무/사과나무의 적정 시비기술의 실제/지역거점 급식지원센터 운영 및 친환경농산물 급식방안

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2009.05a
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• pp.162-163
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• 2009

마이크로플라즈마 스프레이(Microplasma spray, MPS)를 이용하여 hydroxyapatite(HA) 코팅을 수행하여, HA코팅 층에 대한 밀착력을 측정하였다. 밀착력의 측정은 ASTM C633에 의거하였으며, 실험의 설계는 다꾸치법 (L18($2^{1}3^{7}$))을 이용하였다. 본 실험에서 HA코팅 층과 모재에 대한 밀착력 측정에서 35.8MPa의 밀착력을 얻었으며, SEM을 이용하여, 표면 형상과 밀착력 실험 후의 파단면을 관찰하였다. 또한, 나노 인덴테이션을 사용하여, 탄성계수와 미소경도를 측정하였다.

• Proceedings of the KIPE Conference
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• 2005.07a
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• pp.106-108
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• 2005

High accuracy and stability digital controlled power supply for magnet is developed at PLS. This power supply has three sections. The first section is digital controller including DSP&FPGA and precision ADC, the second section consists of IGBT driver and four quad IGBT switch, and the third section is LC output filter section. AC input voltage of power supply is 3-phase 21V, output current is 0 ${\sim}$ 150 A dc. Switching frequency of four quad IGBT switch is 25 kHz. The output current of power supply has very high accuracy of 100 A step resolution at full range and the stability of +/- 1.5 ppm for short term and +/- 5 ppm for long term. This paper describes characteristics of filter and output current performance improvement after LC output filter at four quad digital power supplies.