• Title/Summary/Keyword: 1L-5

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Enviromental Influences on Gentamicin Pharmacokinetics by Using Population Pharmacokinetic Methods (모집단 약물동태학 방법에 의한 겐타마이신 약물동태에 미치는 환경의 영향)

  • Burm, Jin-Pil
    • YAKHAK HOEJI
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    • v.56 no.1
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    • pp.48-54
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    • 2012
  • Enviromental differences in gentamicin pharmacokinetics by using population pharmacokinetic methods were compared with 20 Korean patients and 24 Korean-American appendicitis patients. Two to six blood specimens were collected from all patients at the following times : just before a regularly scheduled infusion and at 0.5 hour after the end of a 0.5 hour infusion. Nonparametric expected maximum (NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constant (K), the slope (KS) of the relationship between K versus creatinine clearance ($C_{cr}$), the apparent volume of distribution (V), the slope (VS) of the relationship between V versus weight, gentamicin clearance (CL) and the slope (CS) of the relationship between CL versus $C_{cr}$ and the V. The output includes two marginal probability density function (PDF), means, medians, modes, variance and CV%. The mean K (KS) were $0.402{\pm}0.129\;h^{-1}(0.00486{\pm}0.00197\;[h{\cdot}ml/min/1.73\;m^2]^{-1})$ and $0.411{\pm}0.135\;h^{-1}(0.00475{\pm}0.00180\;[h{\cdot}ml/min/1.73\;m^2]^{-1})$ for Korean and Korean-American populations, respectively. The mean V (VS) were not different at $14.3{\pm}3.6l(0.241{\pm}0.0511l/kg)$ and $15.1{\pm}3.84l(0.239{\pm}0.0492l/kg)$ for Korean and Korean-American populations, respectively (p>0.2). The mean CL (CS) were $5.68{\pm}1.69l/h(0.0714{\pm}0.0222l/kg[h{\cdot}ml/min/1.73\;m^2])$ and $5.70{\pm}1.77l/h(0.0701{\pm}0.0215l/kg[h{\cdot}ml/min/1.73\;m^2])$ for Korean and Korean-American populations, respectively. There were no enviromental differences in gentamicin pharmacokinetics between Korean and Korean-American appendicitis patients.

Effects of Disinfectant Concentration, pH, Temperature, Ammonia, and Suspended Solids on the Chlorine Disinfection of Combined Sewer Overflow (소독제 농도, pH, 온도, 암모니아 농도, 부유물질이 강우 월류수 염소 소독에 미치는 영향)

  • Kim, Sang-Hyoun
    • Journal of Korean Society of Environmental Engineers
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    • v.36 no.10
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    • pp.685-690
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    • 2014
  • The treatment of combined sewer overflow (CSO) is one of potential concerns in domestic wastewater treatment in Korea due to the pre-announce of CSO regulations. This work investigated the effects of disinfectant (NaOCl) concentration (0.11 to 4.0 mg $Cl_2/L$), pH (6.5 to 8.0), temperature (15 to $25^{\circ}C$), ammonia (10 to 41 mg N/L), and suspended solids (91 to 271 mg SS/L) on the chlorine disinfection of CSO. The effect of NaOCl concentration on the pseudo-$1^{st}$ order reaction rate for total coliform inactivation was described well with a saturation-type model with the half-velocity constant of 1.212 mg/L. The total coliform inactivation reaction rate decreased with SS and pH, and increased with temperature. Ammonia in the examined range did not affect the disinfection kinetics. A chlorine contact tank with the injection chlorine level of 1 mg $Cl_2/L$ and the hydraulic retention time of 1.25 min is estimated to reduce total coliform from $1{\times}10^5MPN/mL$ to 1,000 MPN/mL at 271 mg SS/L, $15^{\circ}C$, and pH 8.0. Chlorine would be a proper option for the disinfection of CSO.

Production of Tannin from Hairy Root Cultures of Rheum undulatum L. (대황 모상근의 배양에 의한 tannin 생산)

  • Hwang, Sung-Jin;Na, Myoung-Suk;Pyo, Byoung-Sik;Lee, Jong-Bin;Hwang, Baik
    • Korean Journal of Medicinal Crop Science
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    • v.8 no.3
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    • pp.250-258
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    • 2000
  • Hairy root cultures of Rheum undulatum L. induced by a co-culture with Agrobacterium rhizogenes ATCC15834 were established and the production of tannin in hairy roots was investigated. The growth of hairy roots was maximized in WPM liquid medium supplemented with 2 mg/L IAA, and 3% sucrose (pH 5.7). The highest yields of tannin were obtained from WPM medium containing 0.5 mg/L ABA, and 5% sucrose (pH 5.5). The growth and tannin production in hairy root cultures were influenced by the addition of elicitors to the medium. The addition of 50 mg/L chitosan enhanced the production of tannin with about 1.7 fold.

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Design and Manufacture of Triple-Band Antennas with Two Branch Line and a Vertical Line for WLAN/WiMAX system applications (2개 분기선로와 수직 선로를 갖는 WLAN/WiMAX 시스템에 적용 가능한 삼중대역 안테나 설계 및 제작)

  • Choi, Tae-Il;Yoon, Joong-Han
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.23 no.6
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    • pp.740-747
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    • 2019
  • In this paper, an antenna applicable to WLAN and WiMAX frequency bands is designed, fabricated, and measured. The proposed antenna is designed to have two branch strip line in the patch plane and a rectangular slit in the ground plane based on microstrip feeding for triple band characteristics and added a vertical strip in the ground plane to enhance impedance bandwidth characteristics. The proposed antenna is designed on a substrate with a relative permittivity of 4.4, a thickness of 1.0 mm, and has a size of $18.0mm(W1){\times}37.3mm$ (L4+L5+L7). From the fabricated and measured results, impedance bandwidths of 480 MHz (2.32 to 2.80 GHz) for 2.4/2.5 GHz band, 810 MHz (3.22 to 4.03 GHz) for 3.5 GHz band, and 1,820 MHz (5.05 to 6.87 GHz) for 5.0 GHz band were obtained based on the impedance bandwidth. Measured 3D pattern and gains are displayed.

Effects of Growth Regulators on Micropropagation of Peach in vitro (복숭아나무 기내번식에 미치는 생장조절물질의 영향)

  • 전지혜;정경호;강상조;이돈균
    • Korean Journal of Plant Tissue Culture
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    • v.26 no.1
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    • pp.27-30
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    • 1999
  • The most effective cytokinin for shoot multiplication in vitro of Prunus persica cv. Baekmijosaeng, Okubo, and Yumyeong was 2.0 mg/L BA. As the result of combinational treatment of BA and auxin sources (IAA, IBA and NAA), 2.0 mg/L BA with 1.0 mg/L IAA was the most effective for shoot multiplication of cv. Baekmijosaeng. The most effective auxin source for rooting was IAA and the concentration was 5.0 mg/L and 3.0 mg/L for cv. Baekmijosaeng and Okubo, respectively.

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A Survey of the Kumho River Pollution (금호강 오염의 종합적 조사)

  • Bae, Zun-Ung;Lee, Sang-Hak;Lee, Sung-Ho
    • Analytical Science and Technology
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    • v.15 no.1
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    • pp.54-66
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    • 2002
  • In order to study systematic survey of Kumho river pollution, water analysis for 24 items was conducted at 16 sites surrounding the Kumho river system for 3 times from May 2000 to February 2001. Analytical items for the study of water quality are as follows; water temperature, pH, BOD, COD, DO, SS, electrical conductivity, oil & grease, ABS, phenol, T-P, ${PO_4}^{3-}-P$, T-N, $NH_3-N$, ${NO_2}^--N$, ${NO_3}^--N$, Cu, Zn, Cr, Cd, Mn, Fe, Pb and As. The mean values obtained for water temperature, pH, BOD, COD, DO, SS, electrical conductivity, oil & grease, ABS, phenol T-P, T-N, Cu, Zn, Fe and Mn showed $17.84^{\circ}C$, 8.04, $2.54{\mu}g/mL$, $5.64{\mu}g/mL$, $7.07{\mu}g/mL$, $8.75{\mu}g/mL$, $600.4{\mu}S/cm$, $0.19{\mu}g/mL$, $0.015{\mu}g/mL$, $0.29{\mu}g/mL$, $0.21{\mu}g/mL$, $5.22{\mu}g/mL$, $0.005{\mu}g/mL$, $0.007{\mu}g/mL$, $0.044{\mu}g/mL$ and $0.001{\mu}g/mL$ respectively. As, Cd, Cr and Pb are not detected. The mean concentration of phenol, $NH_3-N$ and $NO_2-N$ were found to be increased compared to the prior study for 3 years from January 1997 to December 1999, that of BOD, COD, SS, oil & grease and ABS were found to be decreased and the others are nearly constant. The effect of Kumho river to the Nakdong river pollution are as follows. The mean concentration of BOD changed from $1.07{\mu}g/mL$ to $1.42{\mu}g/mL$ before and after of introducing of Kumho river water respectively. The mean concentration of COD, electrical conductivity, oil & grease, ABS, phenol, T-N and T-P changed from $1.99{\mu}g/mL$, $221{\mu}S/cm$, $0.15{\mu}g/mL$, $0.006{\mu}g/mL$, $0.06{\mu}g/mL$, $2.21{\mu}g/mL$ and $0.08{\mu}g/mL$ to $2.44{\mu}g/mL$, $392{\mu}S/cm$, $0.16{\mu}g/mL$, $0.015{\mu}g/mL$, $0.07{\mu}g/mL$, $2.81{\mu}g/mL$ and $0.19{\mu}g/mL$ respectively.

Magnetic Shielding Study using 3-D Field Analysis (3차원 자기장해석을 이용한 자기차폐 연구)

  • Kim, Chan-Uk;Lee, Dong-Chang
    • Korean Journal of Materials Research
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    • v.9 no.3
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    • pp.251-256
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    • 1999
  • 대전력을 사용하는 제강공장의 L/F설비에서 발생되는 강자계를 효율적으로 차폐하기 위하여 L/F주위의 자기장 분포를 유한해석법을 이용한 사용해석도구인 ANSYS 5.3 3차원 자기장해석기를 통해 해석하고 그 결과를 평판형태의 차폐체에 적용시키고자 하였다. 분석결과, L1 및 L2가 각각 2.7 및 2.9m 이려 높이가 3.5m인 2중차폐체(1차측 차폐: 1mmt의 전기강판, 2차측차폐: 1mmt의 Fe-Ni alloy sheet)를 설치하는 거싱 최적의 처폐방안으로 도출되었다.

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Plant Regeneration from the Stem Tissue of Orostachys japonicus A. Berger (바위솔의 줄기조직으로부터 식물체 재분화)

  • 최상욱;남상해;양기종;조무제;양민석
    • Korean Journal of Plant Tissue Culture
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    • v.21 no.2
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    • pp.65-68
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    • 1994
  • Plant regeneration from the stem tissue of Orostachys japonicus A. Beiger was investigated. The calli derived from shoot apex when apex when cultured on Murashige and Skoog (MS) medium supplemented with 4mg/L 2,4-dichlorophenoxyacetic acid (2,4-D)and 2 mg/L benzyl aminopurine (BAP). The calli were developed into shoot to MS medium with 0.5mg/L NAA and 2mg/L and into root with 1mg/L kinetin. The reddish pigment which might be essential for the rootregeneration was observed in the tip of regenerated root.

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