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The Ameliorating Effect of Hoveniae Semen Seu Fructus Extract against Ethanol-induced Psychomotor Alterations in Rats (흰쥐에서 지구자 추출물의 에탄올 유도 숙취 행동 개선 효능)

  • dela Pena, Irene Joy I.;de la Pena, June Bryan;Cheong, Jae Hoon
    • YAKHAK HOEJI
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    • v.58 no.5
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    • pp.300-306
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    • 2014
  • Ethanol consumption causes psychomotor alterations. Hovenia Semen seu Fructus (HS), widely distributed in Korea, China, and Japan, has been reported to have beneficial effects on acute alcohol-induced liver injury. The present study sought to assess the effects of HS extract on ethanol-induced psychomotor alterations in rats. Sprague-Dawley rats were orally (p.o.) given ethanol (4 g/kg) (ethanol group) to induce psychomotor alterations. A separate group (HS-treated groups), were treated with different dosages of HS (50, 100, and 200 mg/kg, p.o.), 30 minutes before ethanol treatment. The control group received only the vehicle (saline). Ethanol-induced psychomotor alterations were evaluated in the open-field, rota-rod, hanging wire, and cold swimming test. In addition, blood ethanol and acetaldehyde concentrations were also measured. Behavioral evaluations and blood analysis were carried out 0.5, 1, 2, 4, and 8 hours after ethanol administration. Pre-treatment of HS ameliorated ethanol-induced alterations in the open-field, rota-rod, and cold swimming test, significantly evident in 2 and 4 hours after ethanol treatment. These improvements coincided with decrease in blood ethanol and acetaldehyde concentration. Based on these results, the present study suggests that HS may have ameliorating effects against ethanol-induced psychomotor alterations.

Finite element analysis of maxillary incisor displacement during en-masse retraction according to orthodontic mini-implant position

  • Song, Jae-Won;Lim, Joong-Ki;Lee, Kee-Joon;Sung, Sang-Jin;Chun, Youn-Sic;Mo, Sung-Seo
    • The korean journal of orthodontics
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    • v.46 no.4
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    • pp.242-252
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    • 2016
  • Objective: Orthodontic mini-implants (OMI) generate various horizontal and vertical force vectors and moments according to their insertion positions. This study aimed to help select ideal biomechanics during maxillary incisor retraction by varying the length in the anterior retraction hook (ARH) and OMI position. Methods: Two extraction models were constructed to analyze the three-dimentional finite element: a first premolar extraction model (Model 1, M1) and a residual 1-mm space post-extraction model (Model 2, M2). The OMI position was set at a height of 8 mm from the arch wire between the second maxillary premolar and the first molar (low OMI traction) or at a 12-mm height in the mesial second maxillary premolar (high OMI traction). Retraction force vectors of 200 g from the ARH (-1, +1, +3, and +6 mm) at low or high OMI traction were resolved into X-, Y-, and Z-axis components. Results: In M1 (low and high OMI traction) and M2 (low OMI traction), the maxillary incisor tip was extruded, but the apex was intruded, and the occlusal plane was rotated clockwise. Significant intrusion and counter-clockwise rotation in the occlusal plane were observed under high OMI traction and -1 mm ARH in M2. Conclusions: This study observed orthodontic tooth movement according to the OMI position and ARH height, and M2 under high OMI traction with short ARH showed retraction with maxillary incisor intrusion.

A STUDY OF DETERMINATION OF PHYSIOLOGICAL ROOT APEX BY ELECTRICAL RESISTANCE VALUE (전기저항치에 의한 생리적 근첨(根尖)의 측정에 관한 연구)

  • Yun, Ki-Bock
    • Restorative Dentistry and Endodontics
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    • v.7 no.1
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    • pp.25-31
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    • 1981
  • One of the most important factors for successful endodontic therapy is an accurate length determination of physiological root apex. Some methods suggested for the measurement of root canal length, include digital-tactile sense and roentgenographic technique with measuring wire, scale and grid. But these methods do not derermine an accurate working length to physiological root apex. Recently electronic measuring devices are used to locate the physiological root apex in root canal length determination and these devices are accepted as an effective apparatus. The 89 patients (116 teeth, 144 canals) among the out-patients of Yonsei University Dental Infirmary, who had had an endodontic treatment in the Department of Operative Dentistry, were measured by the Root-Canal Meter$^{(R)}$ as an electronic device, and radiographs to determine the distribution and location of physiological root apex, then the following results were made: (1) Range of ${\pm}$1mm from the radiographic root apex were present in 88.88% (128 canals) of the subjects. (2) Physiological root apex and radiographic root apex were coincided in 31.94% (46 canals) of the subjects. (3) The actual length of the physiological root apex of the teeth were as follow; A : in the maxillary central incisor : 0.46mm B : in the maxillary lateral incisor : 0.44mm C : in the maxillary canine : 0.44mm D : in the maxillary 1st premolar : a) Buccal : 0.59mm b) Lingual : 0.34mm E : in the maxillary 2nd premolar : 0.54mm F : in the maxillary 1st molar : a) Mesio-buccal : 0.50mm b) Disto-buccal : 0.42mm c) Lingual : 0.56mm G : in the mandibular central incisor : 0.62mm H : in the mandibular lateral incisor : 0.45mm in the mandibular canine : 0.54mm J : in the mandibular 1st premolar : 0.47mm K : in the mandibular 2nd premolar : 0.34mm L : in the mandibular 1st molar : a) Mesio-buccal : 0.54mm b) Mesio-lingual : 0.31mm c) Distal : 0.37mm.

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Fabrication of $MgB_2$ Sheet by Powder Rolling Method (분말압연 공정에 의한 $MgB_2$ 판재 제조)

  • Chung, K.C.;Jeong, T.J.;Kim, T.H.;Ahn, S.T.;Park, Y.S.;Kim, D.H.;Wang, X.L.;Dou, S.X.
    • Progress in Superconductivity
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    • v.12 no.2
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    • pp.88-92
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    • 2011
  • [ $MgB_2$ ]superconducting sheets have been fabricated using powder roll compaction method. Sheet-type $MgB_2$ bulk samples were successfully fabricated using the pre-reacted $MgB_2$ powders. In this work, $MgB_2$ powders were compacted by two rotating rolls and squeezed out as a form of $MgB_2$ sheets of ~1 mm thickness. The rolling speed of 0.3-0.7 rpm and the gap distance of 0.3-0.8 mm between the two rollers were carefully controlled to get a full compaction of the powders into bulk $MgB_2$ sheets. The densities of $MgB_2$ sheets were 1.98-2.05 g/$cm^3$, which is 75.44-77.99 % of the theoretical value of 2.63 g/$cm^3$. And the density comparison was made compared to those of typical $MgB_2$ bulks from uni-axial pressing and $MgB_2$ wires from Powder-In-Tube processing.

Simulation of Signal Amplitudes and Signal-to-noise Ratios of $1^{st}$ order and $2^{nd}$ order Gradiometers with Various Baselines (다양한 기저선을 갖는 1차 및 2차 미분계의 신호크기 및 신호 대 잡음비 조사)

  • Kang, C.S.;Yu, K.K.;Lee, Y.H.;Kwon, H.;Kim, J.M.;Park, Y.K.;Lee, S.G.
    • Progress in Superconductivity
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    • v.9 no.1
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    • pp.40-44
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    • 2007
  • We investigated signal-to-noise ratios (SNRs) of magnetocardiography (MCG) signals using the first-order and the second-order gradiometers of different baselines. The MCG signals were recorded using a measurement system with 61 magnetometers which measured the normal magnetic component to the chest surface. The distance between the chest surface and the bottom of the dewar was changed from 0 cm to 15 cm, and the MCGs were measured for each distance. By subtracting the other signals (distance = 1 to 15 cm) from the reference signal (distance =0 cm), we could simulate the first-order and the second-order gradiometer signals with various baselines. In addition, to evaluate the reproducibility of the simulation, we fabricated the wire wound first-order and second-order gradiometers which measured a normal magnetic component to the chest surface. The baselines of the first-order gradiometers were, respectively, 50 mm, 70 mm and 100 mm and the baseline of the second-order gradiometer was 50 mm. Using these gradiometers, we recorded the MCG signal and compared the SNR between the simulation and the measurement.

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STATUS OF THE ASTRID CORE AT THE END OF THE PRE-CONCEPTUAL DESIGN PHASE 1

  • Chenaud, Ms.;Devictor, N.;Mignot, G.;Varaine, F.;Venard, C.;Martin, L.;Phelip, M.;Lorenzo, D.;Serre, F.;Bertrand, F.;Alpy, N.;Le Flem, M.;Gavoille, P.;Lavastre, R.;Richard, P.;Verrier, D.;Schmitt, D.
    • Nuclear Engineering and Technology
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    • v.45 no.6
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    • pp.721-730
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    • 2013
  • Within the framework of the ASTRID project, core design studies are being conducted by the CEA with support from AREVA and EDF. The pre-conceptual design studies are being conducted in accordance with the GEN IV reactor objectives, particularly in terms of improving safety. This involves limiting the consequences of 1) a hypothetical control rod withdrawal accident (by minimizing the core reactivity loss during the irradiation cycle), and 2) an hypothetical loss-of-flow accident (by reducing the sodium void worth). Two types of cores are being studied for the ASTRID project. The first is based on a 'large pin/small spacing wire' concept derived from the SFR V2b, while the other is based on an innovative CFV design. A distinctive feature of the CFV core is its negative sodium void worth. In 2011, the evaluation of a preliminary version (v1) of this CFV core for ASTRID underlined its potential capacity to improve the prevention of severe accidents. An improved version of the ASTRID CFV core (v2) was proposed in 2012 to comply with all the control rod withdrawal criteria, while increasing safety margins for all unprotected-loss-of-flow (ULOF) transients and improving the general design. This paper describes the CFV v2 design options and reports on the progress of the studies at the end of pre-conceptual design phase 1 concerning: - Core performance, - Intrinsic behavior during unprotected transients, - Simulation of severe accident scenarios, - Qualification requirements. The paper also specifies the open options for the materials, sub-assemblies, absorbers, and core monitoring that will continue to be studied during the conceptual design phase.

Development of the Pushing Type Cutting Device to Dismantle Concrete Structure for Decommissioning of Nuclear Power Plant (원전해체 시 콘크리트 구조물 절단을 위한 밀기형 절단장치 개발)

  • Lee, Bong-Jae;Kwon, Yong-Kyu;Hong, Chang-Dong;Lee, Dong-Won;Min, Kyong-Nam
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.18 no.1
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    • pp.103-111
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    • 2020
  • Pulling-type cutting devices, which use a diamond wire saw, have been used generally for cutting concrete structures. In this study, a pushing-type cutting device with a collection cover was developed by overcoming the disadvantages of pulling-type devices. In this device, dry or liquid methods can be selected to cool frictional heat. Operation and leakage tests of the dust generated during the dismantling of a concrete structure were carried out, confirming the suitable operation of the fabricated cutting device; the leakage rate was approximately 1.7%. For a conservative evaluation, the internal dose of workers was estimated in dismantling the core center part of biological shield concrete with a specific activity of 99.5 Bq·g-1. The committed effective dose per worker was 0.25 mSv. The developed cutting device contributed to reducing radioactive concrete waste and minimizing worker exposure due to its easy installation. Therefore, it can be utilized as a cutting apparatus for dismantling not only reinforced concrete structures but also radioactive biological shield concrete in nuclear power plant decommissioning efforts.

Supplementation of Laurus nobilis Attenuate Ethanol-induced Psychomotor Alterations in Rats

  • dela Pena, Irene Joy I.;de la Pena, June Bryan;Yoon, Seo Young;Kim, Hee Jin;Lee, Jin Hee;Paek, Se Hee;Seo, Yong Ki;Park, Seok Jun;Moon, Byoung Seok;Cheong, Jae Hoon
    • Natural Product Sciences
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    • v.20 no.1
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    • pp.44-50
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    • 2014
  • Laurus nobilis (L. nobilis) is traditionally used as an herbal medicine to treat various diseases. Ethanol (EtOH) consumption entails physiological, mental and psychomotor alterations. The aim of the present study was to assess the effects of L. nobilis in attenuating the EtOH-induced psychomotor alterations. L. nobilis was administered to SD rats, 30 minutes before EtOH administration (4 g/kg), at doses of 25, 50 and 100 mg/kg. Evaluations of psychomotor activity in the open-field, accelerating rota-rod, wire, and swimming ability were done at 1, 2, 4 and 8 hours after EtOH administration. In addition, blood ethanol and acetaldehyde levels were also measured. Pre-treatment of L. nobilis significantly improved EtOH-induced psychomotor alterations and decreased blood ethanol and acetaldehyde levels. These findings suggest that L. nobilis might be an effective substance to attenuate the harmful effects of EtOH, particularly psychomotor alterations, and can potentially be considered as a functional food.

Purification of Si using Catalytic CVD

  • Jo, Chul-Gi;Lee, Kyeong-Seop;Song, Min-Wu;Kim, Young-Soon;Shin, Hyung-Shik
    • 한국신재생에너지학회:학술대회논문집
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    • 2009.11a
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    • pp.383-383
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    • 2009
  • Silicon is commercially prepared by the reaction of high-purity silica with wood, charcoal, and coal, in an electric arc furnace using carbon electrodes, so called the metallurgical refining process, which produces ~98% pure Si (MG-Si). This can be further purified to solar grade silicon (SoG-Si) by various techniques. The most problematic impurity elements are B and P because of their high segregation coefficients. In this study, we explored the possibility of the using Cat-CVD for Si purification. The existing hot-wire CVD was modified to accommodate the catalyzer and the heating source. Mo boat (1.5 cm ${\times}$ 1 cm ${\times}$ 0.2 cm) was used as a heating source. Commercially available Si was purchased from Nilaco corporation (~99% pure). This powder was kept in the Mo-boat and heated to the purification temperature. In addition to the purification by cat-CVD technique, other methods such as thermal CVD, plasma enhanced CVD, vacuum annealing was also tried. It is found that the impurities are reduced to a great extent when treated with cat-CVD method.

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Torque control during lingual anterior retraction without posterior appliances

  • Mo, Sung-Seo;Kim, Seong-Hun;Sung, Sang-Jin;Chung, Kyu-Rhim;Chun, Yun-Sic;Kook, Yoon-Ah;Nelson, Gerald
    • The korean journal of orthodontics
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    • v.43 no.1
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    • pp.3-14
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    • 2013
  • Objective: To evaluate the factors that affect torque control during anterior retraction when utilizing the C-retractor with a palatal miniplate as an exclusive source of anchorage without posterior appliances. Methods: The C-retractor was modeled using a 3-dimensional beam element (0.9-mm-diameter stainless-steel wire) attached to mesh bonding pads. Various vertical heights and 2 attachment positions for the lingual anterior retraction hooks (LARHs) were evaluated. A force of 200 g was applied from each side hook of the miniplate to the splinted segment of 6 or 8 anterior teeth. Results: During anterior retraction, an increase in the LARH vertical height increased the amount of lingual root torque and intrusion of the incisors. In particular, with increasing vertical height, the tooth displacement pattern changed from controlled tipping to bodily displacement and then to lingual root displacement. The effects were enhanced when the LARH was located between the central and lateral incisors, as compared to when the LARH was located between the lateral incisors and canines. Conclusions: Three-dimensional lingual anterior retraction of the 6 or 8 anterior teeth can be accomplished using the palatal miniplate as the only anchorage source. Using LARHs at different heights or positions affects the quality of torque and intrusion.