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Supplementation of Laurus nobilis Attenuate Ethanol-induced Psychomotor Alterations in Rats  

dela Pena, Irene Joy I. (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University)
de la Pena, June Bryan (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University)
Yoon, Seo Young (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University)
Kim, Hee Jin (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University)
Lee, Jin Hee (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University)
Paek, Se Hee (Food R & D Center, CJ CHEILJEDANG)
Seo, Yong Ki (Food R & D Center, CJ CHEILJEDANG)
Park, Seok Jun (Food R & D Center, CJ CHEILJEDANG)
Moon, Byoung Seok (Food R & D Center, CJ CHEILJEDANG)
Cheong, Jae Hoon (Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University)
Publication Information
Natural Product Sciences / v.20, no.1, 2014 , pp. 44-50 More about this Journal
Abstract
Laurus nobilis (L. nobilis) is traditionally used as an herbal medicine to treat various diseases. Ethanol (EtOH) consumption entails physiological, mental and psychomotor alterations. The aim of the present study was to assess the effects of L. nobilis in attenuating the EtOH-induced psychomotor alterations. L. nobilis was administered to SD rats, 30 minutes before EtOH administration (4 g/kg), at doses of 25, 50 and 100 mg/kg. Evaluations of psychomotor activity in the open-field, accelerating rota-rod, wire, and swimming ability were done at 1, 2, 4 and 8 hours after EtOH administration. In addition, blood ethanol and acetaldehyde levels were also measured. Pre-treatment of L. nobilis significantly improved EtOH-induced psychomotor alterations and decreased blood ethanol and acetaldehyde levels. These findings suggest that L. nobilis might be an effective substance to attenuate the harmful effects of EtOH, particularly psychomotor alterations, and can potentially be considered as a functional food.
Keywords
Laurus nobilis; Ethanol; Psychomotor alterations; Behavioral alterations; Acetaldehyde;
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