• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.1
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• pp.141-148
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• 1998

This study describes the effects of 1,25-dihydroxyvitamin D3[1,25(OH)2D3, calcitriol] analog, 1,25(OH)2-16ene-23yne-D3 on proliferatin and differentiatin of the human histiocytic lymphoma cell line U937. This paper also describes the effects of 1,25(OH)2-16ene-23yne-D3 on ${\gamma}$-interferon(IFN-${\gamma}$) synthesis by phytohemagglutinin-activated peripheral blood lymphocytes(PBLs). In the present investigation, 1,25(OH2)-16ene-23yne-D3 was compared to the natural metablite of vitamin D3, 1,25(OH)2D3. 1,25(OH)2-16ene-23yne-D3 was more potent than 1,25(OH)2D3 for inhibition of proliferation and induction of differentiation of U937 cells, Its effects on inhibition of proliferation was about 30-fold more potent than 1,25(OH)2D3. On induction of differentiation as measured by nonspecific esterase (NSE) activity and morphologic change, this analog morphologically and functionally differentiated U937 cells to monocyte-macrophage phenotype showing a decrease of N/C ration in Giemsa staining and the increase of adherence ability of surface. After 3 days in culture, a more significant supression of IFN-${\gamma}$ synthesis analog on supression of IFN-${\gamma}$ synthesis was a dose-dependent manner, with peak activity at 10-7M. The strong direct effects of 1,25(OH)2-16ene-23yne-D3 on cell proliferation and cell differentiation, make this compound an interesting candidate for clinical studies for several types of malignancies, and the effects on supression of IFN-${\gamma}$ synthesis provide the further evidence for a role of 1,25(OH)2-16ene-23yne-D3 in immunoregulation.

• The Journal of the Korea institute of electronic communication sciences
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• v.4 no.1
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• pp.53-59
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• 2009

By the use of open source and 16bit Microcomputer, IDB(Integrated Development Board) for embedded technical education was designed and developed. Based on 16bit MCU H8/300H, LED, LED Matrix, motors, sensors and various I/O circuitry, and the connection to a computer via the SCI, and $16{\times}2$ character LCD was designed and implemented on IDB. In addition, the software development environment was build by the assembler and H8 C compiler which is provided to the open-source software. And memory expansion was considered to include TRON(Real time OS) and uClinux. To verify the developed board, IDB was fabricated by PCB machine, and the fuction was confirmed by the basic I/O control program.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.27 no.11
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• pp.1019-1022
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• 2016

In this paper, a 2~16 GHz GaN wideband power amplifier MMIC s designed and fabricated using the nonuniform power amplifier design technique that utilizes drain shunt capacitors to simultaneously provide each transistor with the optimum load impedance and phase balance between input and output transmission lines. The power amplifier MMIC chip that is fabricated using the $0.25{\mu}m$ GaN HEMT foundry process of Win Semiconductors occupies an area of $3.9mm{\times}3.1mm$ and shows a linear gain of larger than 12 dB and an input return loss of greater than 10 dB. Under a continuous-wave mode, it has a saturated output power of 36.2~38.5 dBm and a power-added efficiency of about 8~16 % in 2 to 16 GHz.

• Journal of the Korean Society of Food Science and Nutrition
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• v.21 no.4
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• pp.327-333
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• 1992

This study was performed to investigate effects of ethanol and dietary protein levels on protein metabolism in 15-week-old male rats given a normal diet. Rats were divided into 8 groups : control group (165 protein, 16 PC) and 8%(8PE), 16%(16PE) and 24% protein groups (24PE) to which was given 5% ethanol mixed into their drinking water after 4 weeks and 10 weeks. Body weight gain, organ weight, serum glucose concentration and liver protein concentrations were not affected by either ethanol or dietary protein levels. Serum total protein concentrations after 10 weeks were significantly increased in the 16 PE and 24PE groups compared with that of control group. Serum albumin concentrations after 10 weeks were significantly increased in all the ethanol-administered groups than that of control group. Fecal and urinary nitrogen metabolism wee not affected by ethanol.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.3
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• pp.231-237
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• 2017

This study was performed to cytotoxicity, tyrosinase inhibition activity, intracellular melanin contents to verify the whitening effect of fraction from Glycine soja Siebold et Zucc. (G. soja). Using western blotting, tyrosinase expression in B16F10 melanoma cells and expression levels of tyrosinase related protein-1 (TRP-1) and protein-2 (TRP-2) were examined. As a result, all of the fractions showed a high cell viability over 82% at the concentrations of 0.125, 0.25, 0.5, 2.0 mg/mL. When the whitening effects of fractions from G. soja were tested using B16F10 melanoma cells treated with the ${\alpha}$-melanocyte stimulating hormone (${\alpha}-MSH$), the EtOAc fractions inhibited tyrosinase and melanogenesis effectively. The result of protein expression measurement using western blot showed that TRP-1, TRP-2 and tyrosinase protein expression in B16F10 melanoma cells treated with extracts decreased. Therefore, it is concluded that the fractions from G. soja have whitening effect by inhibiting protein related melanogenesis.

• Journal of Sasang Constitutional Medicine
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• v.5 no.1
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• pp.87-104
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• 1993

This study was performed to analize the possibility of validation about Questionaire of Sasang constitution Classification which has been made through several stages for the purpose of promoting the objectivity of Sasang constitutional classification. The results of statistical research about the responses data of Sasang Questionaire are as follow: 1. In the case of mutual relation between the items of the QSCC(Questionaire of Sasang Constitution Classification) and 16PF, every item displaced singnificant result.(in male group) 2. In the investigation to classify the score distribution of Sasang items three groups and analize the gap of mean value in each of 16PF, the characters of each Sasang group were turn out as follows: (1) The Taee-Yang group has extrovert and narcissistic inclination. (2) The So-Yang group shows remarkable extrovert inclination. (3) The Tae-Eum group has hidden fear and introvert inclination. (4) The So-Eum group has revealed physical unstability and introvert inclination. 3. The statistical research of female group didn't display any significant result. It will be necessary to analize the respondent shape of female group and introduce new items to coincident with faminine psychology. 4. In the research using 16PF accompany with QSCC in order to classify the Sasang constitution, the accuracy rate of diagnosis showed inspiring elevation. For that reason, it seems to be desirable to introduce some items of 16PF into QSCC. According to above results, although QSCC contains several problems to be solved, its validity was proved, and the analysis of statistics suggests the possibility to step forward by introducing 16PF in some problems of promoting the accuracy of Sasang Constitutional diagnosis, assuring the objectibity of Sasang constitution classification and so on.

• Tuberculosis and Respiratory Diseases
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• v.73 no.1
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• pp.11-21
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• 2012

Background: While qualitative analysis of methylation has been reviewed, the quantitative analysis of methylation has rarely been studied. We evaluated the methylation status of CDKN2A, $RAR{\beta}$, and RASSF1A promoter regions in non-small cell lung carcinomas (NSCLCs) by using pyrosequencing. Then, we evaluated the association between methylation at the promoter regions of these tumor suppressor genes and the clinicopathological parameters of the NSCLCs. Methods: We collected tumor tissues from a total of 53 patients with NSCLCs and analyzed the methylation level of the CDKN2A, $RAR{\beta}$, and RASSF1A promoter regions by using pyrosequencing. In addition, we investigated the correlation between the hypermethylation of CDKN2A and the loss of $p16^{INK4A}$ immunoexpression. Results: Hypermethylation of CDKN2A, $RAR{\beta}$, and RASSF1A promoter regions were 16 (30.2%), 22 (41.5%), and 21 tumors (39.6%), respectively. The incidence of hypermethylation at the CDKN2A promoter in the tumors was higher in undifferentiated large cell carcinomas than in other subtypes (p=0.002). Hyperrmethylation of CDKN2A was significantly associated with $p16^{INK4A}$ immunoexpression loss (p=0.045). With regard to the clinicopathological characteristics of NSCLC, certain histopathological subtypes were found to be strongly associated with the loss of $p16^{INK4A}$ immunoexpression (p=0.016). Squamous cell carcinoma and undifferentiated large cell carcinoma showed $p16^{INK4A}$ immunoexpression loss more frequently. The Kaplan-Meier survival curves analysis showed that methylation level and patient survival were barely related to one another. Conclusion: We quantitatively analyzed the promoter methylation status by using pyrosequencing. We showed a significant correlation between CDKN2A hypermethylation and $p16^{INK4A}$ immunoexpression loss.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.6A
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• pp.537-543
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• 2007

In this paper, we propose a new stopping criterion for the turbo processing (Turbo-BLAST) of MIMO-OFDM system. To reduce the high computational complexity of turbo-BLAST, it is desirable to lessen the outer-loop iteration number. In a system such as IEEE 802.16e Mobile WiMax, no CRC bits are available except the last encoding packet of a transmitted burst, so early stopping criteria without the help of CRC bits are needed. The proposed criterion counts the sign differences between received parity bits and the re-encoded parity bits from received information bits. With the tail-biting code which is accepted for IEEE 802.16e, a method that the re-encoder operates at half complexity is also proposed. Computer simulations show that the proposed stopping criterion approaches the performance of GENIE aided criterion with less average number of iterations than the other early stopping criteria.

• Journal of Life Science
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• v.23 no.11
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• pp.1305-1310
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• 2013

Dill (Anethum graveolens L.) is an annual herb with a long history and it is mainly used as a spice and as a medicine that is effective as a digestive aid, a sedative, and a narcotic, and that helps remove bad breath. Dill grows wild in the districts along the shores of the Mediterranean Sea, West Asia, China, and Korea. An estimate of the phylogenetic relationships within dill accessions in 20 countries was inferred using data from the rps16-trnK3-intergenic spacer. The aligned data sets for dill ranged from 747 to 779 nucleotides (bp) as a result of the differences in the insert/delete nucleotides. The sequence variation within the dill accessions was mostly due to nucleotide substitutions, although several small insertions and deletions can be found. Among 100 accessions from 20 countries, the Eastern Asia accessions were more closely related to the North American accessions than to the Central Asia and European accessions. Although some accessions were not congruent completely with geographical locations, the dill accessions with rps16-trnK analysis resulted in plants with better-resolved clades.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.10
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• pp.1875-1882
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• 2008

Nowadays, usage of mobile unit which has a characteristic of low cost and high efficiency is being generalized because of frequent use of internet-based variable service and application in IEEE 802.16 WiMAX. A study for handling a security problem of high speed internet service is rising while the use of a mobile is being generalized. This paper suggests a security mechanism which provides safety from certification load of SS and a security attack as well as a basic function which is provided from IEEE 802.16e standard to satisfy security demand of IEEE802.16 WiMAX. The proposed mechanism exchangeskey material information for TEK and data code by using 난수(?) and secret value created by SS and BS, also reduces capacity load of BS not to perform an additional certificate procedure of BS by using the early certification information and certificate of SS.