• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.341-346
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• 2013

The risk of cervical cancer development in women infected with HPV varies in relation to the individual host's genetic makeup. Many studies on polymorphisms as genetic factors have been aimed at analyzing associations with cervical cancer. In this study, single nucleotide polymorphisms (SNPs) in 3 genes were investigated in relation to cervical cancer progression in HPV16 infected women with lesions. Two thousand cervical specimens were typed by PCR sequencing methods for TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566). Ninety two HPV16 positive cases and thirty two normal cases were randomly selected. Analysis of TP53 (rs1042522) showed a significantly higher frequency in cancer samples (OR=1.22, 95%CI=1.004-1.481, p-value=0.016) while differences in frequency were not significant within each group (p-value=0.070). The genotype distributions of p16 (rs11515 and rs3088440) and NQO1 (rs1800566) did not show any significantly higher frequency in cancer samples (p-value=0.106, 0.675 and 0.132, respectively) or within each group (p-value=0.347, 0.939 and 0.111, respectively). The results indicated that the polymorphism in TP53 (rs1042522) might be associated with risk of cervical cancer development in HPV16 infected women. Further studies of possible mechanisms of influence on cervical cancer development would be useful to manage HPV infected patients.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.8
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• pp.4149-4154
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• 2016

Background: Cervical carcinoma is one of the main causes of mortality in women worldwide as well as in India. It occurs as a result of various molecular events that develop from the combined influences of an individual's genetic predisposition and external agents such as smoking and menstrual hygiene, for example. However, infection with human papillomavirus (HPV) is the established major risk factor. The aim of the current study was to investigate p16 CpG island methylation and establish any correlation with mRNA expression in north Indian population. Materials and Methods: We analyzed 196 woman volunteer out of which 98 were cases and 98 healthy controls. For the analysis of methylation pattern, DNA extracted from blood samples was modified with a bisulfate kit and used as template for methylation specific PCR (MSP). Quantitative real-time PCR (QRT-PCR) was performed to check mRNA expression. Results: Correlation between methylation status of p16 gene and poor menstrual hygiene was significant (p=0.006), high parity cases showed methylation of p16 gene (p=0.031) with increased risk up to 1.86 times for cervical cancer and smoking was a strong risk factor associated with cervical cancer. We analyzed methylation pattern and found 60.3% methylation in cases with low mRNA expression level (0.014) as compare to controls (1.24). It was also observed that promoter methylation of p16 gene was significantly greater in FIGO stage III. Conclusions: We conclude that p16 methylation plays an important role in cervical cancer in the north Indian population and its methylation decreases mRNA expression. It can be used as an important and consistent blood biomarker in cervical cancer patients.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.48 no.3
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• pp.42-49
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• 2011

In this paper, we propose a fast macroblock mode decision algorithm in H.264/AVC, based on the image sequence statistics. Specically, considering the directional characteristics of image sequences, we eliminate sub$8{\times}4$ or sub$4{\times}8$ mode decision process based on the rate-distortion cost of Inter$16{\times}8$ or Inter$8{\times}16$ mode respectively. Additionally, exploiting the optimal modes of submacroblock in inter$8{\times}8$ mode, we propose an algorithm to eliminate Intra$4{\times}4$ or Intra$16{\times}16$ mode decision process selectively. From the simulation results, the proposed method reduce the encoding time by maximum 70% of total, compared with the other conventional methods.

• Journal of the Korean Society of Radiology
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• v.6 no.4
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• pp.275-279
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• 2012

Methods and results : The suspected patient who have results of CTA and CAG examinations to evaluate coronary stenose to undergo each 16MD CT(n=93) and dual source CT(n=100). As a results of statistic, the highest rank of sensitivity, specificity, PPV, NPV and accuracy in coronary artery with using 16MDCT was displayed in LAD(73.5%), RCA(74.5%), LAD(66.7%), LCX(75%), LCX(67.7%). The mean diagnostic accuracy of dual source CT was more 17% than 16MDCT. Dual source CT was recorded 84% mean of accuracy. In addition to, segments of coronary artery did not show significant differences in all of them. However, distal segment become more and more accurate than proximal site.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.12 no.5
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• pp.123-128
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• 2012

In order to overcome the hardware complexity and performance limit problems, recently the multi-core architecture has been prevalent. For hardware simplicity, usually RISC processor is adopted as the unit core processor. However, if the performance of unit core processor is enhanced, the overall performance of the multi-core processor architecture can be further enhanced. In this paper, in-order superscalar processor is utilized as the core for the multi-core processor architecture. Using SPEC 2000 benchmarks as input, the trace-driven simulation has been performed for the number of superscalar cores between 2 and 16 and the window size of 4 to 16 extensively. As a result, the 16-core superscalar processor for the window size of 16 results in 8.4 times speed up over the single core superscalar processor. When compared with the same number of cores, the multi-core superscalar processor performance doubles that of the multi-core RISC processor.

• Journal of the Institute of Electronics Engineers of Korea TE
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• v.37 no.3
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• pp.6-15
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• 2000

In this paper, we propose a high speed parallel multiplier with a hierarchical architecture using a fast 4-2 compressor and 6-2 compressor. Generally, the performance of parallel multiplier depends on the processing speed of partial products summation tree with CSA adder. In this paper we propose a new circuit of 4-2 compressor and 6-2 compressor which reduces the propagation delay time, compared with conventional one. We Propose a hierarchical multiplier architecture in order to improve the execution speed of 16$\times$16 parallel multiplier using proposed compressors in this paper and make layout design easily by regular structure. The propagation delay time of the proposed 4-2 compressor circuit was 14% reduced as a result of SPICE simulation, compared with the conventional 4-2 compressor. The total propagation delay time of proposed 16$\times$16 parallel multiplier was 12% reduced using proposed 4-2 compressor and 6-2 compressor.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.5675-5679
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• 2015

Background: Low-risk human papillomavirus (LR-HPV) infection is the main cause of genital warts. LRHPV genotypes 6 and 11 are associated with genital warts, but there have only been a few published studies about the genotype-specific prevalence of HPV in genital warts in China. The objective of our study was to assess the prevalence of HPV genotypes for clinical cases involving both men and women and to evaluate the potential benefit of a quadrivalent (genotypes 6, 11, 16, and 18) HPV vaccine in eastern Guangdong province of China. Materials and Methods: A total of 696 eligible patients with genital warts were enrolled during the period Aug 2009 through Oct 2014. Specimens were collected from genital warts, the HPV GenoArray test was used for HPV detection and genotyping, which could detect 21 HPV genotypes, including genotypes 6, 11, 16, and 18. Results: Among the 696 cases, 675 samples were successfully genotyped. The median age of patients was 32.1 years (range, 16-67 years). The most prevalent genotypes were HPV-6 (285/675, 42.2%), HPV-11 (265/675, 39.3%), HPV-52 (52/675, 7.7%), HPV-16 (51/675, 7.56%), HPV-81 (50/675, 7.40%) and HPV-58 (37/675, 5.48%). Low-risk genotypes predominated, with a prevalence of 96.59%. The cumulative prevalence of genotypes 6 and 11 was 78.7% (531/675), the cumulative prevalence of genotypes 16 and 18 was 11.6% (78/675), and the cumulative prevalence of genotypes 6, 11, 16, and 18 was 82.5% (557/675). Conclusions: Our results provide strong evidence that, in eastern Guangdong, different from Western countries, the most prevalent low risk HPV genotypes in patients with genital warts are 6, 11 and 81. The quadrivalent HPV vaccine could prevent 82.5% of genital warts in eastern Guangdong.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.10
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• pp.1558-1564
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• 2018

Objective: We report monitoring conservation effect for a Chinese indigenous chicken (Langshan) breed using major histocompatibility complex (MHC) and DNA barcords. Methods: The full length of MHC B-G gene and mitochondrial cytochrome oxidase I (COI) gene in generations 0, 5, 10, 15, 16, and 17 was measured using re-sequencing and sequencing procedures, respectively. Results: There were 292 single nucleotide polymorphisms of MHC B-G gene identified in six generations. Heterozygosity (He) and polymorphic information content (PIC) of MHC B-G gene in generations 10, 15, 16, and 17 remained stable. He and PIC of MHC B-G gene were different in six generations, with G10, G15, G16, G17 >G5>G0 (p<0.05). For the COI gene, there were five haplotypes in generations 0, 5, 10, 15, 16, and 17. Where Hap2 and Hap4 were the shared haplotypes, 164 individuals shared Hap2 haplotypes, while Hap1 and Hap3 were the shared haplotypes in generations 0 and 5 and Hap5 was a shared haplotype in generations 10, 15, 16, and 17. The sequence of COI gene in 6 generations was tested by Tajima's and D value, and the results were not significant, which were consistent with neutral mutation. There were no differences in generations 10, 15, 16, and 17for measured phenotypic traits. In other generations, for annual egg production, with G5, G10, G15, G16, G17>G0 (p<0.05). For age at the first egg and age at sexual maturity, with G10, G15, G16, G17>G5>G0 (p<0.05). Conclusion: Combined with the results of COI gene DNA barcodes, MHC B-G gene, and phenotypic traits we can see that genetic diversity remained stable from generations 10 to 17 and the equimultiple random matching pedigrees conservation population conservation effect of Langshan chicken was effective as measured by these criteria.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3139-3142
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• 2013

Associations of P16, MGMT, hMLH1 and hMLH2 with gastric cancer and their relation with MTHFR status in gastric patients who were confirmed with pathological diagnosis were assessed. Aberrant DNA methylation of P16, MGMT, hMLH1 and hMLH2 and polymorphisms of MTHFR C677T were assayed. The proportional DNA hypermethylation in P16, MGMT, hMLH1 and hMLH2 in cancer tissues was significantly higher than in remote normal-appearing tissues. DNA hypermethylation of P16 and MGMT was correlated with the T and N stages. Individuals with homozygotes (TT) of MTHFR C677T had significant risk of hypermethylation of MGMT in cancer tissues [OR (95% CI)= 3.47(1.41-7.93)]. However, we did not find association between polymorphism in MTHFR C677T and risk of hypermethylation in P16, MGMT, hMLH1 and hMLH2 genes either in cancer or remote normal-appearing tissues. Aberrant hypermethylation of P16, MGMT, hMLH1 and hMLH2 could be predictive of gastric cancer.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.4
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• pp.953-958
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• 2013

In this paper, an efficient hardware architecture is proposed for $32{\times}32$ inverse transform HEVC decoder. HEVC is a new image compression standard to deal with much larger image sizes compared with conventional image codecs, such as 4k, 8k images. To process huge image data effectively, it adopts various new block structures. Theses blocks consists of $4{\times}4$, $8{\times}8$, $16{\times}16$, and $32{\times}32$ block. This paper suggests an effective structures to process $32{\times}32$ inverse transform. This structure of inverse transform adopts the decomposed $16{\times}16$ matrixes of $32{\times}32$ matrix, and simplified the operations by implementing multiplying with shifters and adders. Additionally the operations frequency is downed by using multicycle paths. Also this structure can be easily adopted to a multi-size transform or a forward transform block in HEVC codec.