• 인터넷정보학회논문지
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• 제15권1호
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• pp.179-191
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• 2014

이 논문에서는 WiFi 트래픽으로 인해 IEEE 802.15.4 노드에서 프레임 전송에 장애가 발생할 때, IEEE 802.15.4 네트워크의 노드들을 새로운 채널에서 동작시키기 위한 프레임 전송방법과 특성에 연구되었다. WiFi 트래픽의 간섭에 대한 평가, 간섭이 적거나 없는 새로운 채널의 탐색 및 동작채널을 변경하기 위한 연구들에 대해 분석하였다. IEEE 802.11 네트워크와 중첩된 무선채널에서 IEEE 802.15.4 프레임의 전송지연과 CSMA-CA 알고리즘을 적용하지 않은 IEEE 802.15.4 프레임 전송시 프레임들의 충돌 및 IEEE 802.11 노드들의 동작에 대해 설명하였다. 충돌된 IEEE 802.15.4 프레임의 잔여부분을 사용하기 위해 프레임형식코드블럭들을 포함한 프레임의 전송방법이 제안되었다. 제안된 방법의 실험을 통해, 충돌시 프레임형식코드블럭들이 수신기에서 동기화되어 수신되는 현상을 관찰하고, IEEE 802.15.4 프레임에서 충돌을 겪는 위치, 프레임수신율에 대한 특성이 분석되었다. WiFi 트래픽의 간섭을 피하기 위해 IEEE 802.15.4 네트워크의 채널변경명령을 전송하고 응답을 얻기까지 걸리는 시간을 측정한 실험결과는 제안된 방법이 기존의 방법보다 개선된 성능을 나타낸다.

• 한국농공학회지
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• 제30권2호
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• pp.82-94
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• 1988

The purpose of this study is to introduce the Double Punch test method which is an indirect testing method of tensile strength of concrete, and to compare with the tensile strength of concrete as determined by the split-cylinder test, a practical method for performing the Double Punch test to obtain the tensile strength of concrete is proposed and recommended for general use. In this study, the dimensions of cylindrical specimens used in the Double-Punch test were 15X30cm, 15X15cm, 10${\times}$(20cm, and 5${\times}$l0cm, and in the split-cylinder test were 15${\times}$(30cm, 15${\times}$(15cm, and 10${\times}$(20cm. And the diameters of loading punches used in the Double-Punch test were 1.5cm, 2.5cm, and 3.5 cm. The results obtained from tests are summarized as follows ; 1. In the split-cylinder test, the tensile strength of concrete by the linear elasticity theory is similar to that of plasticity theory. 2. Both split-cylinder test and Double-Punch test, tensile strength of concrete is increased with decreasing specimen size. This tendency is identical when the ratio of specimen diameter to height is 1: 2, but that tendency is quite different when the ratio is 1: 3. In the Double-Punch test, if specimen size is constant, by increasing the punch size, tensile strength of concrete is increased, too. 4. Using a 15 ${\times}$( 15 cm cylinder specimen and 3.5 cm diameter punch in the Double Punch test would give the most uniform and consistent result in tensile strength, and the result showed a gQod correlation with splitting tensile strength from 15 x 30cm specimen. 5. In order to obtain satisfactory results and to nuninuze variability, it is proposed that specimens of 15 cm in diameter and 15 cm in height with two 3.5 cm diameter punches should be used. It seems, therefore, reasonable tt) take f't=0.0024 P(kg / cm$^2$) as a working formula for computing the tensile strength in the Double Punch test for concrete.

• Molecules and Cells
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• 제38권5호
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• pp.457-465
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• 2015

The 15-kDa selenoprotein (Sep15) is a selenoprotein residing in the lumen of the endoplasmic reticulum (ER) and implicated in quality control of protein folding. Herein, we established an inducible RNAi cell line that targets Sep15 mRNA in Chang liver cells. RNAi-induced Sep15 deficiency led to inhibition of cell proliferation, whereas cell growth was resumed after removal of the knockdown inducer. Sep15-deficient cells were arrested at the G1 phase by upregulating p21 and p27, and these cells were also characterized by ER stress. In addition, Sep15 deficiency led to the relocation of focal adhesions to the periphery of the cell basement and to the decrease of the migratory and invasive ability. All these changes were reversible depending on Sep15 status. Rescuing the knockdown state by expressing a silent mutant Sep15 mRNA that is resistant to siRNA also reversed the phenotypic changes. Our results suggest that SEP15 plays important roles in the regulation of the G1 phase during the cell cycle as well as in cell motility in Chang liver cells, and that this selenoprotein offers a novel functional link between the cell cycle and cell motility.

• 한국통신학회논문지
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• 제35권4C호
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• pp.358-363
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• 2010

IEEE 802.15.4a에 제안된 IR-UWB (Impulse Radio Ultra Wideband) 시스템의 경우 패킷 방식으로 동작하며 하나의 패킷은 SYNC 심볼 (symbol)과 SFD (Start of Frame Delimiter) 심볼로 이루어진 프리앰블, 헤더 및 데이터부로 구성된다. 성공적인 패킷 수신을 위해서는 프리앰블을 이용한 초기 동기 획득과 SFD 검출이 필수적이다. IEEE 802.15.4a IR-UWB 시스템의 경우 SFD 패턴은 8개의 심볼로 구성되어 있으며 SYNC 패턴의 길이에 비하여 매우 짧아 정상적으로 초기 동기를 획득한 경우에도 SFD 패턴 검출에 실패하여 해당 패킷에 대한 복조를 수행하지 못하는 경우가 발생한다. 본 논문에서는 초기 동기 획득 이후 잉여 SYNC 심볼들 중 일부를 활용하여 IEEE 802.15.4a에 제안된 IR-UWB 시스템의 SFD 검출 성능을 개선하는 방안을 제안한다.

• 한국재료학회지
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• 제20권5호
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• pp.252-256
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• 2010

The study was done to change the morphology and pore size of SBA-15 silica, and the characteristics of SBA-15 silica were investigated with TG-DSC, XRD, SEM, TEM and N2 adsorption-desorption under changing aging conditions. SBA-15 silica having a 2D-hexagonal structure was synthesized and confirmed by SEM and TEM. The structure of mesoporus silica SBA-15 showed a pore having regularly formed hexagonal structure and a passage having a cylindrical shape. This result is in good agreement with the pore forming in XRD and cylindrical shape of the structure in $N_2$ adsorption-desorption isotherm. SBA-15 silica showed a large BET surface area of $603-698\;m^2/g$, a pore volume of $0.673-0.926\;cm^3/g$, a large pore diameter of 5.62-7.42 nm, and a thick pore wall of 3.31-4.37 nm. This result shows that as the aging temperature increases, the BET surface area, pore volume, and pore diameter increase but the pore wall thickness decreases. The BET surface areas in SM-2 and SM-3 are as large as $698\;m^2/g$. However, SM-2 has a large surface area and forms a thick pore wall, when the aging temperature is $100^{\circ}C$ and is synthesized into stable mesoporous SBA-15 silica.

• Biomolecules & Therapeutics
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• 제27권4호
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• pp.414-422
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• 2019

There is accumulating evidence that microRNAs are emerging as pivotal regulators in the development and progression of neuropathic pain. MicroRNA-15a/16 (miR-15a/16) have been reported to play an important role in various diseases and inflammation response processes. However, whether miR-15a/16 participates in the regulation of neuroinflammation and neuropathic pain development remains unknown. In this study, we established a mouse model of neuropathic pain by chronic constriction injury (CCI) of the sciatic nerves. Our results showed that both miR-15a and miR-16 expression was significantly upregulated in the spinal cord of CCI rats. Downregulation of the expression of miR-15a and miR-16 by intrathecal injection of a specific inhibitor significantly attenuated the mechanical allodynia and thermal hyperalgesia of CCI rats. Furthermore, inhibition of miR-15a and miR-16 downregulated the expression of interleukin-$1{\beta}$ and tumor-necrosis factor-${\alpha}$ in the spinal cord of CCI rats. Bioinformatic analysis predicted that G protein-coupled receptor kinase 2 (GRK2), an important regulator in neuropathic pain and inflammation, was a potential target gene of miR-15a and miR-16. Inhibition of miR-15a and miR-16 markedly increased the expression of GRK2 while downregulating the activation of p38 mitogen-activated protein kinase and $NF-{\kappa}B$ in CCI rats. Notably, the silencing of GRK2 significantly reversed the inhibitory effects of miR-15a/16 inhibition in neuropathic pain. In conclusion, our results suggest that inhibition of miR-15a/16 expression alleviates neuropathic pain development by targeting GRK2. These findings provide novel insights into the molecular pathogenesis of neuropathic pain and suggest potential therapeutic targets for preventing neuropathic pain development.

• 한국산업융합학회 논문집
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• 제20권3호
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• pp.205-212
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• 2017

This paper focuses on worst-case delay analysis of the time-triggered IEEE 802.15.4 protocol to satisfy the industrial quality-of-service (QoS) performance. The IEEE 802.15.4 protocol is considered to be unsuitable for industrial networks because its medium access control method is contention-based CSMA/CA, which exhibits unstable performance with an unbounded delay distribution under heavy traffic. To avoid these limitations, this paper presents a time-triggered version of the nonbeacon-enabled network of IEEE 802.15.4 that relies on a time division multiplexing access (TDMA) method implemented in the application layer without any modification of specification. The timing analysis of this time-triggered IEEE 802.15.4 was executed, and the worst-case transmission delay was calculated. Based on this analysis, the time-triggered IEEE 802.15.4 is a promising alternative for wireless industrial networking.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2083-2087
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• 2014

Colorectal cancers remain to be a common cause of cancer-related death. Early-onset cases as well as those of various ethnic origins have aggressive clinical features, the basis of which requires further exploration. The aim of this work was to examine the expression patterns of $p15^{INK4b}$ and SMAD4 in colorectal carcinoma of different ethnic origins. Fifty-five sporadic colorectal carcinoma of Egyptian origin, 25 of which were early onset, and 54 cancers of Finnish origin were immunohistochemically stained with antibodies against $p15^{INK4b}$ and SMAD4 proteins. Data were compared to the methylation status of the $p15^{INK4b}$ gene promotor. $p15^{INK4b}$ was totally lost or deficient (lost in ${\geq}50%$ of tumor cell) in 47/55 (85%) tumors of Egyptian origin as compared to 6/50 (12%) tumors of Finnish origin (p=7e-15). In the Egyptian cases with $p15^{INK4b}$ loss and available $p15^{INK4b}$ promotor methylation status, 89% of cases which lost $p15^{INK4b}$ expression were associated with $p15^{INK4b}$ gene promotor hypermethylation. SMAD4 was lost or deficient in 25/54 (46%) tumors of Egyptian origin and 28/48 (58%) tumors of Finnish origin. 22/54 (41%) Egyptian tumors showed combined loss/deficiency of both $p15^{INK4b}$ and SMAD4, while $p15^{INK4b}$ was selectively lost/deficient with positive SMAD4 expression in 24/54 (44%) tumors. Loss of $p15^{INK4b}$ was associated with older age at presentation (>50 years) in the Egyptian tumors (p=0.04). These data show for the first time that $p15^{INK4b}$ loss of expression marks a subset of colorectal cancers and ethnic origin may play a role in this selection. In a substantial number of cases, the loss was independent of SMAD4 but rather associated with $p15^{INK4b}$ gene promotor hypermethylation and old age which could be related to different environmental exposures.

• 한국임상수의학회지
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• 제19권4호
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• pp.391-396
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• 2002

젖소에서 우유생산량의 증가시키기 위한 방안을 제시하기 위하여, 고능력우와 저능력우의 혈액화학치를 조사 연구하였다. 젖소 30두(3산에서 5산 사이)를 분만후 15, 30, 60, 90일의 착유량을 기준으로 두 군으로 나누었다. 착유량이 27 kg/day 이하인 군을 A(group A)군으로 하고, 30 kg/day 이상인 군을 B(group B)군으로 하였다. 혈액 샘플은 경정맥을 통하여, 분만전 15일, 분만후 12시간 이내(0 days), 분만후 15, 30, 60, 90일에 채혈하였다. 혈액 광물질 중 Mg과 Cg 농도는 B군이 A군보다 지속적으로 높았다. 무기인 농도는 두 군간에 분만전후에 변동이 있었으나, 분만후 15일과 30일에는 B군이 A군보다 유의성있게 높았다 (p<0.05). 혈액화학치 중에 cholesterol 농도는 분만당일을 제외하고는 B군이 지속적으로 높았고, BUN 농도와 glucose 농도는 두 군간에 차이가 없었다. 비타민 A 농도는 분만전 15일과 분만후 15일에 B군이 A군보다 유의성있게 높았고 (p<0.01), 비타민 E 농도는 실험기간동안에 두 군 사이에 차이가 없었다. 결과적으로 우유 생산량을 증가시키기 위해서 저능력우에 분만 전후에 사료 중에 Mg, Ca, Pi 과 비타민 A를 첨가하여주는 것이 효과가 있을 것이다.

• International Journal of Industrial Entomology and Biomaterials
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• 제10권1호
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• pp.11-17
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• 2005

In our research to identify gene involved in the cuticle protein, we cloned a novel cuticle protein gene, ApCP15.5, from the Chinese oak silkmoth, Antheraea pernyi, larvae cDNA library. The gene encodes a 149 amino acid polypeptide with a predicted molecular mass of 15.5 kDa and a pI of 9.54. The ApCP15.5 contained a type-specific consensus sequence identifiable in other insect cuticle proteins and the deduced amino acid sequence of the ApCP15.5 cDNA is most homologous to Tenebrio molitor-C1B ($43\%$ protein sequence identity), followed by Locusta migratoria-76 ($42\%$ protein sequence identity). Northern blot and Western blot analyses revealed that the ApCP15.5 showed the epidermis-specific expression. The expression profile of ApCP15.5 indicated that the ApCP15.5 mRNA expression was detected in the early stages after larval ecdysis and larval-pupal metamorphosis, and its expression level was most significant on the first day of larval ecdysis and pupal stage. The ApCP15.5 was expressed as a 15.5 kDa polypeptide in baculovirus-infected insect cells.