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이온토포레시스에 의한 극성약물의 경피흡수 촉진

  • 심창구;김종국
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1992.05a
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    • pp.62-62
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    • 1992
  • 1.이온토포레시스에 의한 ISP의 경피촙수증가는 단순투과의 약 13배로서 그 증가정도는 전류세기와 약물농도에 비례하였다. 2. 가해주는 $Na^{+}$ 농도가 커질수록 ISP의 flux는 감소하였다. 3. ion-pairing agent률 가하면 ISP의 flux는 감소하는데, 그 감소정도는 TU>SAL>BEN 로서 이는 이 물질들이 ISP와 ion-pair를 형성하는 능력순서와 같았다. 4. ISP용액의 pH증가시 ISP의 flux는 대체적으로 증가하며 그 pattern은 피부의 pKa를 3.5로 가정할 때의 피부해리곡선과 유사하였다. ISP가 광범위한 pH에서 완벽하게 해리된다고 가정할 때 pH증가시 flux증가는 피부해리 증가에 따른 permselectivity 증가에 기인한 것으로 생각되었다.

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AE Count Rate and Crack Growth Rate under Low Cycle Fatigue Fracture Loading (저주기 피로 파괴 하중하에서 AE수 변화율과 균열성장율에 관한 연구)

  • 이강용
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.13 no.2
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    • pp.252-256
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    • 1989
  • In the low cycle fatigue fracture testing with KS(or JIS) SS41, crack growth rate, AE count rate and J-integral range are measured to get empirical relations between crack growth rate and J-integral range, AE count rate and J-integral range as well as AE count rate and crack growth rate. All the relations are shown to be linear on the log-log graphs. It is also shown that the linear relations can be formulated by using Dunegan's assumption and elastic-plastic fracture mechanics along with the well-known relation of crack growth rate and J-integral range. It is concluded that the differences between experimental and theoretical values are due to Dunegan's assumption.

Prospects of future changes of hydrological characteristics in South-North Korea river basin according to climate change scenarios (기후변화시나리오를 반영한 남북공유하천유역의 미래 수문특성 변화 전망)

  • Yeom, Woongsun;Park, Dong-Hyeok;Ahn, Jaehyun
    • Proceedings of the Korea Water Resources Association Conference
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    • 2020.06a
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    • pp.266-266
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    • 2020
  • 본 연구에서는 기후변화로 인한 남북공유하천유역의 미래 수문특성 변화를 전망하기 위해 ArcGIS 프로그램을 통해 산정된 격자형 수문특성 매개변수를 분포형 모형인 GRM에 적용하여 임진강유역의 미래 유출수문특성 변화를 분석하였다. 분포형 모형에 사용되는 강우량 자료는 기상관측소 단위로 상세화된 13개 전지구 기후 모델 중 RCP4.5, 8.5 시나리오의 공유하천유역 인접 11개 관측소별 빈도해석 결과를 시·공간적으로 분포하여 사용하였다. 또한 미래기간별 유출특성 변화추이를 분석하기 위하여 참조기간(1981-2005), 21세기 전반기(F1, 2011-2040), 중반기(F2, 2041-2070), 후반기(F3, 2071-2100)로 구분하여 분석을 실시하였다. 분석 결과 본 연구의 대상지점인 임진강유역은 기후변화로 인해 확률강우량이 증가하여 유역의 유출수문특성에 직접적인 영향이 있을 것으로 예측되었다. RCP 4.5 시나리오에서는 21세기 후반기인 F3에 확률강우량 및 유출량의 증가추세가 줄어들 것으로 전망되나, 참조기간 대비 F1에서 20.4%, F2에서 35.7%, F3에서 34.6%의 평균 유출량 증가율을 보였으며, RCP 8.5 시나리오에서는 F1에서 19.9%, F2에서 38.3%, F3에서 67.8%로 지속적인 증가가 전망되었다. 또한 첨두홍수량 발생시각은 참조기간 대비 약 4.6~13.3% 감소가 예상되었다. 기후변화로 인한 홍수량의 변화는 재해위험을 증가시킬 수 있으며, 이러한 상황에서 남한과 북한의 협력을 통한 유역통합관리의 필요성은 점차 커질 것으로 보인다. 이를 위해서는 정확한 수문학적 분석을 선행하여야 하며, 본 연구가 남북공유하천유역의 재해위험을 평가하는 기초자료로 활용될 수 있을 것으로 판단된다.

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Hypofractionated Radiation Therapy for Early Glottic Cancer - Preliminary Results - (초기 성문암 환자에서의 소분할 조사법을 이용한 방사선치료 - 예비적 결과 -)

  • Wu Hong-Gyun;Hong Semie;Shin Seong Soo;Park Charn Il
    • Radiation Oncology Journal
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    • v.19 no.4
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    • pp.301-305
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    • 2001
  • Purpose : This study was peformed for the evaluation of the feasibility and toxicity of hypofractionated radiation therapy for early glottic cancer Methods and Materials : From February 1999 to February 2000, 20 patients with Histologically confirmed Stage I, II glottic cancer were enrolled into this study. There were 18 males and 2 females, the median age of the patients was 59 years. The distribution of stage distribution was as fellows; T1aN0-16 patients, T1bN0-1 patient, T2N0-3 patients. Eighteen patients underwent laryngomicroscopic biopsy only, and two patients underwent laser cordectomy. All patients received radical radiation therapy (2.5 Gy per fraction, 24 fractions, total 60 Gy). Median duration of treatment was 36 days (range $31\~45\;days$). Results : Radiation therapy were well tolerated. Most common acute reactions were odynophagia and hoarseness, and these reactions resolved after radiation therapy. There were one case of RTOG grade 3 odynophagia $(5\%)$, six cases of grade 3 hoarseness $(30\%)$. Response of radiation therapy was evaluated one month after completion of treatment. All patients revealed complete response. During follow up, total three cases of treatment failure were detected. two cases were local recurrence in 10 and 13 months of radiation therapy and one case was local recurrence and distant metastasis in 2 months of radiation therapy. Conclusion : This hypofractionated radiation therapy schedule was feasible and effective for control of early glottic cancer But longer follow up time would be required to assess the long-term disease control and the late complication by shortening radiation therapy duration.

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A Study on Goryo Celadons of intaglio '○' pattern and '⊙'pattern (고려 음각 '○'문과 '⊙'문청자의 연구)

  • Han, Seong-Uk
    • KOMUNHWA
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    • no.70
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    • pp.133-161
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    • 2007
  • It is judged that celadons with '○' pattern and '⊙' pattern have the indication of manufacturer by engraving mark at the internal center of the bottom. These celadons were produced at No.8.23.27 kiln sites located at Sadang-ri(사당리), Daegu-myon(대구면), Gangjin-gun(강진군), Jeollanamdo(전라남도), Korea and '⊙’ patterned celadon porcelain was found only at No. 23 and 27 kiln sites, so it is assumed that its production sites were limited. Kinds of celadons included bowl, dish, cup, bottle, case and vessel for emptied wine and there were a lot of dishes with a variety of patterns. These celadons were engraved by molded design technique using the same ceramic design as the pattern of celadons in the period of their prosperity and it was appropriate method to produce celadons of a good quality with production method to keep decorative design like pattern or size uniformly. It was also found that inlay method was not universalized in this period and similar celadons were produced with molded design in large quantities. These celadons had partially fire clay temper, but most of them were burnt by supporting the inner bottom of U-type base with quartzite after whole glazing. It was known through relics excavated at Seokreung(석릉) royal tomb of King Heejong(희종) at Ganghwa(강화) and Hyeeumwon(혜음원) temple site at Paju(파주) and military house at Wakamiyaoji(약궁대로) avenue Kamakura(겸창)-city, Japan(일본) that these celadons were manufactured at two quarters of the 13th century centering around 1230s. Therefore, these celadons will be significant materials to fill the gap of the celadons in the 13th century resulted from the record chronologically that green celadons were manufactured in the 12th century. And this period was invaded by Mongolia(몽고), but central control was achieved and green celadons were continuously produced. It was also considered that these celadons were excavated at Gabgot-ri(갑곶리) and Gwanchung-ri(관청리), Ganghwa(강화), Hyeeumwon temple, Paju which played the role of temporary palace, Bu1guksa(불국사) temple at Gyeongju(경주), Silsangsa(실상사) temple at Namwon(남원) and relics of Jangheung(장흥) adjacent to Daeguso(대구소) and these were produced for high class.

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Luminescence Properties of $BaNb2O6:RE^{3+}$(RE=Eu, Dy) Phosphor Powders

  • Gang, Dae-Min;Jo, Sin-Ho
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.08a
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    • pp.172-172
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    • 2013
  • 최근에 디스프로슘 이온이 도핑된 형광체의 백색 발광 현상 때문에 백색 발광 소재의 제조에 관한 연구가 상당한 관심을 끌고 있다. 본 연구에서는 $Eu^{3+}$$Dy^{3+}$ 이온의 몰 비를 변화시키면서 $BaNb_2O_6:RE^{3+}$ (RE=Eu, Dy) 형광체 분말을 합성한 결과를 보고한다. 특히 활성제 이온인 $Eu^{3+}$$Dy^{3+}$ 이온의 몰 비에 따른 $BaNb_2O_6$ 형광체 분말의 결정 구조, 입자의 모양과 크기, 흡광과 발광 스펙트럼의 변화를 관측하였고, 최적의 합성 조건을 제시하고자 한다. 파장 393 nm로 여기 시킨 $Dy^{3+}$ 이온의 몰 비에 따른 $BaNb_2O_6$ 형광체 분말의 발광 스펙트럼은 580 nm에 주 피크를 갖는 황색 스펙트럼이 관측되었다. 이 발광 신호는 $^4F_{9/2}-^6H_{13/2}$ 전이 신호이다. $Dy^{3+}$ 이온의 몰 비가 0 mol인 경우에는 발광 신호가 검출되지 않았다. $Dy^{3+}$ 이온의 몰 비가 0.10 mol일 때 발광 피크의 세기는 최대이었으며, $Dy^{3+}$ 이온의 몰 비가 더욱 증가함에 따라 발광 스펙트럼의 세기는 계속 증가하지 않고 갑자기 감소하기 시작하였다. 이것은 $Dy^{3+}$ 이온의 몰 비가 임계값을 초과하여 더욱 증가하면 모체 격자들 사이에 치환 고용되어 있는 $Dy^{3+}$ 이온들 사이의 거리가 더욱 가까워져서 $Dy^{3+}$ 이온들이 서로 용이하게 결합함으로써 내부 산란에 의하여 발광의 세기가 감소함을 의미한다. 흡광 스펙트럼의 경우에, $Dy^{3+}$ 이온의 몰 비가 0.01 mol일때 형광체 분말은 두 종류의 흡광 스펙트럼을 나타내었다. 첫째는 $Dy^{3+}$ 양이온과 $O^{2-}$ 음이온들 사이에 발생한 전하 전달 밴드에 의해 발생하는 310 nm를 정점으로 하여 280~340 nm 영역에 걸쳐서 광범위하게 분포하는 흡광 신호가 관측되었으며, 둘째는 $Dy^{3+}$ 이온의 $4f^9$ 전자 배열 내에서 발생하는 4f-4f 전이 신호로서, 이것은 350~500 nm 영역에 걸쳐서 비교적 밴드폭이 좁은 다수의 흡광 신호가 나타났다. 본 실험에서는 다섯 개의 피크를 갖는 흡광 신호가 검출되었는데, 이중에서 제일 강한 주 피크인 393 nm의 흡수 파장은 모체 격자 내에 있는 $Dy^{3+}$ 이온의 바닥 상태인 $^6H_{15/2}$ 준위에서 여기 상태인 $^4F_{7/2}$ 인 에너지 준위로 전이하면서 발생한 신호이며, 이에 비하여 상대적으로 흡광 세기가 약한 370, 432, 458, 370 nm의 흡수 파장이 관측되었다.

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A Study on History and Archetype Technology of Goli-su in Korea (한국 고리수의 역사와 원형기술의 복원 연구)

  • Kim, Young-ran
    • Korean Journal of Heritage: History & Science
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    • v.46 no.2
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    • pp.4-25
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    • 2013
  • Goli-su is the innovative special kind of the embroidery technique, which combines twining and interlacing skill with metal technology and makes the loops woven to each other with a strand. The loops floating on the space of the ground look like floating veins of sculpture and give people the feeling of the openwork. This kind of characteristic has some similarities with the lacework craft of Western Europe in texture and technique style, but it has its own features different from that of Western Europe. It mainly represents the splendid gloss with metallic materials in the Embroidered cloth, such as gold foil or wire. In the 10th century, early days of Goryo, we can see the basic Goli-su structure form of its initial period in the boy motif embroidery purse unearthed from the first level of Octagonal Nine-storied Pagoda of Woljeong-sa. In the Middle period of Joseon, there are several pieces of Goli-su embroidered relic called "Battle Flag of Goryo", which was taken by the Japanese in 1592 and is now in the Japanese temple. This piece is now converted into altar-table covers. In 18~19th century, two pairs of embroidered pillows in Joseon palace were kept intact, whose time and source are very accurate. The frame of the pillows was embroidered with Goli-su veins, and some gold foil papers were inserted into the inside. The triangle motif with silk was embroidered on the pillow. The stitch in the Needle-Looped embroidery is divided into three kinds according to comprehensive classification: 1. Goli-su ; 2. Goli-Kamgi-su ; 3. Goli-Saegim-su. From the 10th century newly establishing stage to the 13th century, Goli-su has appeared variational stitches and employed 2~3 dimensional color schemes gradually. According to the research of this thesis, we can still see this stitch in the embroidery pillow, which proves that Goli-suwas still kept in Korea in the 19th century. And in terms of the research achievement of this thesis, Archetype technology of Goli-su was restored. Han Sang-soo, Important Intangible Cultural Heritage No. 80 and Master of Embroidery already recreated the Korean relics of Goli-su in Joseon Dynasty. The Needle-Looped embriodery is the overall technological result of ancestral outstanding Metal craft, Twining and Interlacing craft, and Embroidery art. We should inherit, create, and seek the new direction in modern multi-dimensional and international industry societyon the basis of these research results. We can inherit the long history of embroidering, weaving, fiber processing, and expand the applications of other craft industries, and develop new advanced additional values of new dress material, fashion technology, ornament craft and artistic design. Thus, other crafts assist each other and broaden the expressive field to pursue more diversified formative beauty and beautify our life abundantly together.

Phototaxis of Fish 6. Responce of Sea-bass to the White Lights (어류의 주광성에 관한 연구 6. 백색광에 대한 능성어의 반응)

  • Yang, Yong Rhim
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.23 no.3
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    • pp.27-27
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    • 1987
  • The purpose of this study is to find the light intensity which induced maximum gathering rate and to observe the variation of the gathering rate both at daytime and night by using Sea-bass, Epinephelus septemfasciatus (Thunberg). An experimental tank (360 L×50 W×55H cm) was set up in a dark room. An illumination system was attached to the end of one side of the tank to control horizontal light intensity. Eight artificial light sources were prepared by combination of three with white light bulbs (10W, 60W, 100W) and eight filters. During the experiment water depth was maintained 50cm level in the tank. The tank was marked into six longitudinal sections each being 60cm long to observe the distribution of fish. The fish were acclimatized in dark condition for 50 minutes before the main experiment. Upon turning on the light, the number of fish in each section was counted 60 times every 30 seconds, and the gathering rate was obtained from the average number of fish in each section. The light intensity inducing maximum gathering rate was 24.13 lux (15.25~35.93 lux) at daytime and 0.41 lux (0.25~0.63 lux) at night. The variation of the gathering rate of fish in illumination time was great and did not show any definite pattern but fluctuated irregularly. Its different between daytime and night is remarkable.

Phototaxis of Fish 6. Responce of Sea-bass to the White Lights (어류의 주광성에 관한 연구 6. 백색광에 대한 능성어의 반응)

  • 양용림
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.23 no.3
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    • pp.137-143
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    • 1987
  • The purpose of this study is to find the light intensity which induced maximum gathering rate and to observe the variation of the gathering rate both at daytime and night by using Sea-bass, Epinephelus septemfasciatus (Thunberg). An experimental tank (360 L$\times$50 W$\times$55H cm) was set up in a dark room. An illumination system was attached to the end of one side of the tank to control horizontal light intensity. Eight artificial light sources were prepared by combination of three with white light bulbs (10W, 60W, 100W) and eight filters. During the experiment water depth was maintained 50cm level in the tank. The tank was marked into six longitudinal sections each being 60cm long to observe the distribution of fish. The fish were acclimatized in dark condition for 50 minutes before the main experiment. Upon turning on the light, the number of fish in each section was counted 60 times every 30 seconds, and the gathering rate was obtained from the average number of fish in each section. The light intensity inducing maximum gathering rate was 24.13 lux (15.25~35.93 lux) at daytime and 0.41 lux (0.25~0.63 lux) at night. The variation of the gathering rate of fish in illumination time was great and did not show any definite pattern but fluctuated irregularly. Its different between daytime and night is remarkable.

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Study of Traditional Plants of Jeju Island (Five literatures in Joseon Dynasty period) (조선시대 문헌에 기록된 제주도 전통식물의 통시적 연구-세종실록지리지, 신증동국여지승람, 탐라지, 남환박물, 제주계록을 중심으로-)

  • Lee, Chang Shook;Yeau, Sung Hee;Chung, So Yeon
    • Korean Journal of Plant Resources
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    • v.29 no.2
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    • pp.225-234
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    • 2016
  • To understand the traditional knowledge of botanical taxa in Jeju Island, a diachronic study was carried out by comparing the archaic and modern names of the native plants in Jeju Island. To identify the archaic names of the plants, five old documents (Sejongshillokchiriji, Shinjŭngdonggukyŏjisŭngnam, T'amnaji, Namhwanbangmul and Jejugyerok) that were written during the Joseon Dynasty between the 15th and 19th centuries were closely examined. A total of 131 taxa (65 families, 112 genera, 118 species and 13 varieties), 7.3% of the native plants known to be currently present in Jeju Island, was identified. Out of these, 21.4% was the plants found in the southern area. Among the five old documents analyzed for this study, Namhwanbangmul recorded the largest number of plants, 89 taxa. We closely examined the consistency between the modern and archaic names of each plant, and discussed the problems in matching the names of some plants analyzed in this study.