• Journal of Biomedical Engineering Research
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• v.41 no.2
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• pp.107-119
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• 2020

The deep neural networks (DNN) that can replicate the behavior of the human expert who recognizes the characteristics of ECG waveform have been developed and studied to analyze ECG. However, although the existing DNNs can not provide the explanations for their decisions, those trials have attempted to determine whether patients have certain diseases or not and those decisions could not be accepted because of the absence of relating theoretical basis. In addition, these DNNs required a lot of training data to obtain sufficient accuracy in spite of the difficulty in the acquisition of relating clinical data. In this study, a small-sized continuous data processing DNN (C-DNN) was suggested to determine the simple characteristics of ECG wave that were not required additional explanations about its decisions and the C-DNN can be easily trained with small training data. Although it can analyze small input data that was selected in narrow region on whole ECG, it can continuously scan all ECG data and find important points such as start and end points of P, QRS and T waves within a short time. The star and end points of ECG waves determined by the C-DNNs were compared with the results performed by human experts to estimate the accuracies of the C-DNNs. The C-DNN has 150 inputs, 51 outputs, two hidden layers and one output layer. To find the start and end points, two C-DNNs were trained through deep learning technology and applied to a parameter acquisition algorithms. 12 lead ECG data measured in four patients and obtained through PhysioNet was processed to make training data by human experts. The accuracy of the C-DNNs were evaluated with extra data that were not used at deep learning by comparing the results between C-DNNs and human experts. The averages of the time differences between the C-DNNs and experts were 0.1 msec and 13.5 msec respectively and those standard deviations were 17.6 msec and 15.7 msec. The final step combining the results of C-DNN through the waveforms of 12 leads was successfully determined all 33 waves without error that the time differences of human experts decision were over 20 msec. The reliable decision of the ECG wave's start and end points benefits the acquisition of accurate ECG parameters such as the wave lengths, amplitudes and intervals of P, QRS and T waves.

• The Korean Journal of Nuclear Medicine Technology
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• v.12 no.3
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• pp.176-180
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• 2008

Department of Nuclear Medicine in Seoul National University Hospital (SNUH) had developed $^{18}F$-Flumazenil as Benzodiazepine receptor imaging agent for PET diagnosis of Epilepsy. But production Activity of $^{18}F$-Flumazenil is decreased owing to this method has difficult synthesis procedures and pretty long synthesis time. In this study, we can modify synthesizing method to have more simple procedure and less spend time and help to increase production Activity. Old method: Radioactivity was produced by cyclotron was captured by QMA cartridge that was activated. Captured radioactivity was eluted into the reaction vial by using kryptofix solution and delivered. After evaporation of eluent, the azeotrophic drying step repeated two times. tosylflumazenil in anhydrous Acetonitrile was added to a reaction vial while bubbling. The reaction mixture was evaporated until the mixture volume was 0.5 mL. Reaction vial washed with 20 % Acetonitrile and that solution went into the reaction vial. The reaction mixture was loaded to the HPLC loop by hand and purified $^{18}F$-Flumazenil by HPLC column. New method: We used $TBAHCO_3$ solution as a eluent. After the eluent was evaporated, tosylflumazenil in anhydrous acetonitrile was added to a reaction vial and the reaction mixture was bubbled for 15 minutes. It was evaporated until the mixture volume became 0.5 mL. It was loaded to the HPLC loop. In old method, $^{18}F$-Flumazenil was synthesized via 6 steps synthesis procedures in 105 minutes with 30~35% synthesizing yield (non-decay correction) and specific activity was about $0.5{\sim}2{\times}10^5$ Ci/mole. In new method, It had 3 steps synthesis procedures in 53 minutes with 40~45% synthesizing yield and specific activity was about $3{\sim}8{\times}10^5$ Ci/mole. This method leads to improve of minimizing synthesis time, increasing synthesis yield and specific activity. While we can load reaction mixture to the HPLC loop, we can expose high radiation field thanks to used by hand.

• Environmental and Resource Economics Review
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• v.12 no.4
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• pp.611-635
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• 2003

This study deals with the "Dissemination Stage", the final step in the R&D process consisting of R&DDD($R&D^3$ : Research & Development, Demonstration, Dissemination). At the "Dissemination Stage", the newly configured technical design is compared with other alternatives to come up with the most desirable selection. The assessment conducted at this stage is not a simple procedure. It goes through the complex evaluation process in which various elements including economic effects and technical characteristics are considered. The reason for taking such a complex procedure is that the assessment, selection and application of the desirable technical alternative is critical for the company's competitive edge in every field of industrial sectors, thus influencing its survival and continuous growth. This study reviews the AHP method for assessing technical alternatives of the heat supply system design. And, to show the practical validity of the AHP method, it is applied to the evaluation of waste heat system alternatives in the field of energy supply system technology.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.12
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• pp.1691-1695
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• 2005

The bovine lymphocyte antigen (BoLA)-DRB3 gene encodes cell surface glycoproteins that initiate immune responses by presenting processed antigenic peptides to CD4 T helper cells. DRB3 is the most polymorphic bovine MHC class II gene which encodes the peptide-binding groove. Since different alleles favour the binding of different peptides, DRB3 has been extensively evaluated as a candidate marker for associations with various bovine diseases and immunological traits. For that reason, the genetic diversity of the bovine class II DRB3 locus was investigated by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). This study describes genetic variability in the BoLA-DRB3 in Iranian Golpayegani Cattle. Iranian Golpayegani Cows (n = 50) were genotyped for bovine lymphocyte antigen (BoLA)-DRB3.2 allele by polymerase chain reaction and restriction fragment length polymorphism method. Bovine DNA was isolated from aliquots of whole blood. A two-step polymerase chain reaction followed by digestion with restriction endonucleases RsaI, HaeIII and BstYI was conducted on the DNA from Iranian Golpayegani Cattle. In the Iranian Golpayegani herd studied, we identified 19 alleles.DRB3.2${\times}$16 had the highest allelic frequency (14%), followed by DRB3.2${\times}$7 (11%). Six alleles (DRB3.2${\times}$25, ${\times}$24, ${\times}$22, ${\times}$20, ${\times}$15, ${\times}$3) had frequencies = 2%. Although additional studies are required to confirm the present findings, our results indicate that exon 2 of the BoLA-DRB3 gene is highly polymorphic in Iranian Golpayegani Cattle.

• Journal of Advanced Navigation Technology
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• v.12 no.1
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• pp.61-67
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• 2008

Each organization installing and operating multimedia system, to achieve the goal of organization, should decide security level, implement security countermeasure, and manage these countermeasures to keep the effects. To decide and manage security level of multimedia system, the first, organizations must be able to decide security level, and then, organizations must establish procedures for building security countermeasures according to security level. For the next step, organizations must be able to select areas where security countermeasures should be applied, and the last, organizations must be able to evaluate and improve the effect of security countermeasures. In this paper, based on the analysis of threat to multimedia system and the consideration for multimedia assets, we propose a method for deciding security level of multimedia system.

• Nuclear Engineering and Technology
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• v.52 no.7
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• pp.1443-1451
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• 2020

The objective of this study is to design a robust power control system for a small pressurized water reactor (PWR) to achieve stable power operations under conditions of external disturbances and internal model uncertainties. For this purpose, the multiple-input multiple-output transfer function models of the reactor core at five power levels are derived from point reactor kinetics equations and the Mann's thermodynamic model. Using the transfer function models, five local reactor power controllers are designed using an H infinity (H_∞) mixed sensitivity method to minimize the core power disturbance under various uncertainties at the five power levels, respectively. Then a multimodel approach with triangular membership functions is employed to integrate the five local controllers into a multimodel robust control system that is applicable for the entire power range. The performance of the robust power system is assessed against 10% of full power (FP) step load increase transients with coolant inlet temperature disturbances at different power levels and large-scope, rapid ramp load change transient. The simulation results show that the robust control system could maintain satisfactory control performance and good robustness of the reactor under external disturbances and internal model uncertainties, demonstrating the effective of the robust power control design.

• Journal of Advanced Marine Engineering and Technology
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• v.12 no.2
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• pp.21-34
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• 1988

Machinery enclosures are widely adopted to reduce the noise emission in various fields of application. Emitted noise, which is due to the vibration of enclosure's outer surface, is composed of two kinds of sound with different path of propagation. One is the "structure-borne sound", while the other is "air-borne sound". In order to get a most efficient machinery enclouser a prudent consideration upon the above structure-borne and air-borne sound is required, as the guiding principle of contermeasure for each noise is quite different. The controlling of input vibration and its isolation are major subjects for the structure-borne sound, and the specifications of absorbing members and damping panels are the major related matters for the air-borne sound. Hence, it seems very efficient to separate the total sounds into two categories with a great accuracy when one think of further reduction of noise from the existing enclosure, although its separating methods have not been made clear for many years. Author proposes an application method of experimental modal analysis to extract the structure-borne sound from the measured total radiation sound, as the air-borne sound is deduced by the vectorial difference between the measured total radiation sound and the calculated structure-borne sound. In order to calculate the correct structure-borne sound by the excitation at an arbitrary point on the enclosure structure, it is important to decide 1) how to estimate the enclosure's surface vibration velocity and 2) how to compute the radiation sound which is considered as the effect of vibration modes of enclosure surface. The former can be solved with total frequency response function calculated by the application of experimental modal analysis. The latter is to be solved by the author's new approaches for radiation sound computation by means of the Rayleigh's integral equation and the boundary-element method applied complex surface vibration velocity. As a first step, structure-borne sound by the excitation at an arbitry point on the rectangular plate with fixed edges, has been calculated to verified the reliability of the developed computation methods. The results of calculation show good agreements with those of the actual measurements.actual measurements.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.12 no.2
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• pp.52-65
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• 2006

Sling exercises therapy can speak as appliable comprehensive exercises therapy technique efficiently in general exercise field for injured worker's rehabilitation process and health improvement patient or athlete, injury or disease that have pain or dysfunction to neuromuscular system using that shake. At 1990 an early stage, because physical therapist and doctors of medical treatment developed country norway of north europe cooperate sling exercises therapy's concept trend spreading worldwide establishing theory newly based on scientific basic be. Musculoskeletal system, old man and young child's nervous system injurer's treatment and exercise and industry worker's rehabilitation process, athlete's rehabilitation etc. several fields introduced in early 2000s to Korea apply. Sling exercises therapy neuromuscular system disease continuous abatement as general concept of active exercise and treatment that use sling exercises equipment by purpose know can. This review article wishes to introduce about neuromuscular activation, "Neurac" technique that can speak as step developed more concept based on application principle etc, of basic sling exercises effort's change by suspension point's change that is concept, stability exercises principle, open kinetic chain exercises and closed kinetic chain exercises. Arranged about Plateau potential's characteristic and working mechanism and Neurac technique's application method that can say as Neurac technique's neuro-physiologic base, and presented treatment method of lumbar part disease and cervical part, shoulder joint part disease to application example. Because plateau potential forward player that induce using Neurac technique in part muscles that act role that keep spine surrounding stability in this article keeps muscle's contraction continuously, between global and local muscles, presented several study findings that can cause affirmative change in insufficient muscle adjustment state such as imbalance of muscles' action order. Expect that case studies that use this Neurac technique here after consist continuously.

• Journal of Korean Society of Forest Science
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• v.18 no.1
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• pp.9-12
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• 1973

Volume increment and estimation of future growth of pitch pine stand at age of 16 were analyzed based on the stand table method. The diameter growth survey was made by the Meyer's Increment Borer method which was based on the volume formular made on the single tree volume. The formular is V=0.000058D $^{1.6}{\times}H^{1.1}$ This survey was made based on the 95% reliability surveyed on the 339 trees in the 0.33ha of sample plot espicially set up. (1) Linear regression over annual diameter growth for the diameter is as follows; y=0.1618+0.0298x (2) Ninety percent of the total trees, in the diameter distribution of 2cm round off, each increased one step in diameter. (3) Stand volume increment percentage shows 16%. (4) The increment of stand volume for 5 years shows 46% of increment rate.

• Journal of Microbiology and Biotechnology
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• v.7 no.2
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• pp.144-150
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• 1997

We developed a simple and efficient method to prepare a Pseudomonas vaccine of outer membrane (OM) proteins free from lipopolysaccharide (LPS). A three step purification process including extraction, ultrafiltration and ultracentrifugation effectively removed LPS from the OM protein fraction. Approximately 2 mg of the OM proteins was obtained from 1 g of wet cell. LPS contaminant in the vaccine preparation was less than 0.003% (w/w) of protein and protease activity was not detectable. To achieve a wide range of protection, OM proteins prepared from four attenuated P. aeruginosa strains were mixed in equal amounts and used as a vaccine, which elicited in rabbits a high titer of antibody reactive to all of the seven Fisher types. The antisera from the immunized rabbit had a strong reactivity to vaccine proteins larger than 25 kDa. In a burned mouse infection model, immunization with the vaccine significantly enhanced bacterial clearance in the Pseudomonas infected skin. The vaccination also provided mice an excellent protection against Pseudomonas infection (11, 16). Data on antigenicity, mutagenicity, acute, subacute toxicity and pharmacological tests confirmed the safety of the vaccine (1, 3, 10, 12, 17). These data demonstrate that this method can be applied to manufacture a bacterial vaccine of OM proteins with safety and prophylactic efficacy at a practical low cost.