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Glucose Tolerance and Insulin Response to Intravenous Glucose Load in Sheep Fed on Germinated Sorghum Grain

  • Achmadi, Joelal;Pangestu, Eko;Wahyono, Fajar
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.10
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    • pp.1575-1579
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    • 2007
  • The glucose tolerance and pancreatic insulin secretion response to glucose in sheep fed on germinated sorghum grain were determined using an intravenous glucose load. Twelve male Thin Tail sheep (an Indonesian native sheep, 12 months old and 14.8 kg average body weight) were divided randomly into sorghum grain-based (S), germinated sorghum grain-based (G) and maize grain-based (C) diets. Sheep were maintained at the same daily intake levels of metabolizable energy and crude protein in the diets throughout the experimental period. After two months of the experimental conditions, each diet group was subjected to an intravenous glucose load experiment in which five doses of glucose (0, 10, 20, 40 and 80 mg/kg BW) were injected to estimate the rate of glucose removal from blood and the pancreatic insulin secretion response. For each sheep and each glucose load dose, the incremental blood serum glucose and insulin concentrations above pre-injection concentration were calculated as serum glucose and insulin response areas. At all glucose doses, sheep fed on S diet had a greater (p<0.05) glucose response area compared to those of sheep fed on G and C diets. Likewise at all glucose doses, the insulin response area was smaller (p<0.05) in sheep fed on S diet than in sheep fed on G and C diets. The glucose and insulin response areas in sheep fed on G and C diets differed slightly. It was concluded that the portion of maize grain in the ruminant ration could be substituted by germinated sorghum grain.

Influence of Age and Fasting on the Anti-hyperglycemic Effect of Onion in Normal and Diabetic rat (정상 및 당뇨 흰쥐에서 주령과 절식에 의한 양파의 혈당조절작용 변화)

  • 문창현;정이숙;김민화;이수환;백은주;박세원
    • Biomolecules & Therapeutics
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    • v.5 no.4
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    • pp.364-368
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    • 1997
  • Onion (Allium cepa Linn) has been reported to have hypoglycemic activity in human and several animal models. In the present study, we performed intraperitoneal glucose tolerance test (IPGTT) in young (1.5mo) and aged (5 mo) rats treated with onion in order to determine whether aging can influence on the anti-hy-perglycemic effect of onion. In addition, we investigated the hypoglycemic effect of onion in streptozotocin- induced diabetic rats treated with aqueous extracts of onion (500 mg/kg, i.p., daily) for 4 weeks. Blood glucose level was determined in fasted and fed rats by using a glucometer (Johnson & Johnson). In glucose tolerance test, blood glucose level was maximally increased 15 min after glucose load (2 g/kg, i.p.), and recovered to the basal level 3 hr after glucose challenge in young and old rats. The maximum blood glucose levels of young and aged rat were 184$\pm$7.49 and 225.2$\pm$ 12.55 mg/dl, respectively. A single i.p. injection of aqueous extract of onion (1 g/kg) 30 min before glucose challenge significantly decreased blood glucose levels at 15, 30, 60, 90 min after glucose load in aged rats, while the administration of onion did not show any significant effect in young rats. In onion-treated diabetic rats, significant hypoglycemic effect (p<0.05) was observed, and the effect was greater in fasted rats than in fed. In conclusion, these results suggest that anti-hyperlycemic effect of onion can be changed by age and fasting.

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Experimental study on hysteretic properties of SRC columns with high steel ratio

  • Lu, Xilin;Yin, Xiaowei;Jiang, Huanjun
    • Steel and Composite Structures
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    • v.17 no.3
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    • pp.287-303
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    • 2014
  • 8 steel reinforced concrete (SRC) columns with the encased steel ratio of 13.12% and 15.04% respectively were tested under the test axial load ratio of 0.33-0.80 and the low-frequency cyclic lateral loading. The cross sectional area of composite columns was $500mm{\times}500mm$. The mechanical properties, failure modes and deformabilities were studied. All the specimens produced flexure failure subject to combined axial force, bending moment and shear. Force-displacement hysteretic curves, strain curves of encased steels and rebars were obtained. The interaction behavior of encased steel and concrete were verified. The hysteretic curves of columns were plump in shapes. Hysteresis loops were almost coincident under the same levels of lateral loading, and bearing capacities did not change much, which indicated that the columns had good energy-dissipation performance and seismic capacity. Based on the equilibrium equation, the suggested practical calculation method could accurately predict the flexural strength of SRC columns with cross-shaped section encased steel. The obtained M-N curves of SRC columns can be used as references for further studies.

Extreme Multi-Level Percutaneous Vertebroplasty for Newly Developed Multiple Adjacent Compression Fractures

  • Kim, Han-Woong;Song, Jae-Wook;Kwon, Austin;Kim, In-Hwan
    • Journal of Korean Neurosurgical Society
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    • v.45 no.6
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    • pp.378-380
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    • 2009
  • Osteoporotic patients who undergo percutaneous vertebroplasty (PVP) have the risk of a repeated collapse of their adjacent vertebral body due to alteration of load transfer into the adjacent vertebral body. The authors have experienced a rare case of repeated osteoporotic vertebral compression fractures (VCF) resulting in extreme multi-level PVP. A 74-year-old female developed severe back pain after slipping down one month ago. Her X-ray and MR images indicated a T11 VCF. She underwent successful PVP with polymethylmethacrylate (PMMA). Two weeks later, she returned to our hospital due to a similar back pain. Repeated X-ray and MR images showed an adjacent VCF on T12. A retrial of PVP was performed on T12, which provided immediate pain relief. Since then, repeated collapses of the vertebral body occurred 12 times in 13 levels within a 24-month period. Each time the woman was admitted to our hospital, she was diagnosed of newly developed VCFs and underwent repeated PVPs with PMMA, which finally eased back pain. Based on our experience with this patient, repeated multiple PVP is not dangerous because its few and minor complications. Therefore, repeated PVP can serve as an effective treatment modality for extreme-multi level VCFs.

Clinical Significance of Quantitative Analysis of Plasma Epstein-Barr Virus DNA in Patients of Xinjiang Uygur Nationality with Hodgkin's Lymphoma

  • Li, Xun;Yang, Shun-E.;Guo, Yun-Quan;Shen, Ming-Xia;Gu, Li;Gulikezi, Gulikezi;Zhao, Bing;Liu, Wei;Tuerxun, Tuerxun;Bai, Jing-Ping
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.12
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    • pp.6379-6384
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    • 2012
  • Objective: To investigate the relationship between plasma EBV-DNA concentration and clinicopathologic features of Hodgkin's lymphoma cases. Methods: At first, the positive rate of plasma EBV-DNA was determined with a nested-PCR method using 45 specimens from Uygur HL patients, as well as 110 healthy people sampled as normal controls. Secondly, using fluorescent quantitative nested-PCR, EBV viral load was assessed in the EBV-DNA positive plasma samples. Then, relationships between plasma EBV viral load and clinicopathologic features of HL patients were analyzed. Results: The positive rate of plasma EBV-DNA of HL patients was significantly higher than that of normal controls (53.3% vs 26.4%, P=0.001). There was no significant difference about plasma EBV viral load between EBV-associated HL and EBV-DNA positive normal people (P=0.490). Looking at patients' characteristics, plasma EBV viral load in 10-20 years EBV-associated HL was higher than in EBV cases which were less than 10 years or more than 35 years (P=0.025). Furthermore, in EBV-associated HL, concentration of plasma EBV-DNA was significantly higher in advanced stage disease (stages III-IV; P=0.013), and with B-symptoms (P=0.020). Conclusion: EBV-DNA levels were associated with part of clinicopathologic features of cases. It was of practical use to screen HL. Further etiological studies appear warranted.

External retrofit of beam-column joints in old fashioned RC structures

  • Adibi, Mahdi;Marefat, Mohammad S.;Arani, Kamyar Karbasi;Zare, Hamid
    • Earthquakes and Structures
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    • v.12 no.2
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    • pp.237-250
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    • 2017
  • There has been increasing attention in many countries on seismic retrofit of old fashioned RC structures in recent years. In such buildings, the joints lack transverse reinforcement and suffer inadequate seismic dimensional requirements and the reinforcement is plain bar. The behavior of the joints is governed by sliding of steel bars and diagonal shear failure is less influential. Different methods to retrofit beam-column joints have been proposed in the literature such as wrapping the joint by FRP sheets, enlargement of the beam-column joint, and strengthening the joint by steel sheets. In this study, an enlargement technique that uses external prestressed cross ties with steel angles is examined. The technique has already been used for substructures reinforced by deformed bars and has advantages such as efficient enhancement of seismic capacity and lack of damage to the joint. Three reference specimens and two retrofitted units are tested under increasing lateral cyclic load in combination with two levels of axial load. The reference specimens showed relatively low shear strength of 0.150${\surd}$($f_c$) and 0.30${\surd}$($f_c$) for the exterior and interior joints, respectively. In addition, relatively brittle behavior was observed and large deformations extended into the panel zone of the joints. The retrofit method has increased ductility ratio of the interior beam-column joints by 63%, and energy dissipation capacity by 77%, relative to the control specimen; For external joints, these values were 11%, and 94%. The retrofit method has successfully relocated the plastic joints far from the column face. The retrofit method has improved shear strength of the joints by less than 10%.

A Research of Optimum Supply Reserve Levels for Stability of Power System (전력계통 안전을 위한 공급예비력 적정수준에 대한 연구)

  • Ahn, Dae-Hoon;Kwon, Seok-Kee;Joo, Haeng-Ro;Choi, Eun-Jae
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.22 no.9
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    • pp.55-61
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    • 2008
  • Because of the high increasing rate of load demand these days the necessity of deciding what optimum reserve level is appropriate to most stably supply electricity is being emphasized. This research studies the downward tendency of reserve ratio by analyzing the trend of change of the network scale, reserve, and reserve ratio while optimum reserve has been increased as the network system scale grow up. This means, at this moment 6,000[MW] is optimum level for short term prospect of power supply and demand. And also, it has been analyzed that, as the annual peak load exceeded 50,000[MW], confirming the amount of optimum reserve level is more stable than keeping 10 to 12[%] reserve ratio.

Effect of nutrient composition in a mixed meal on the postprandial glycemic response in healthy people: a preliminary study

  • Kim, Jiyoung S.;Nam, Kisun;Chung, Sang-Jin
    • Nutrition Research and Practice
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    • v.13 no.2
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    • pp.126-133
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    • 2019
  • BACKGROUND/OBJECTIVES: The glycemic index (GI) is a measure of the postprandial glucose response (PPGR) to food items, and glycemic load (GL) is a measure of the PPGR to the diet. For those who need to maintain a healthy diet, it is beneficial to regulate appropriate levels of blood glucose. In reality, what influences the meal GI or GL depends on the macronutrient composition and the physical chemistry reactions in vivo. Thus, we investigated whether different macronutrients in a meal significantly affect the PPGR and the validity of calculated GI and GL values for mixed meals. SUBJECTS/METHODS: 12 healthy subjects (6 male, 6 female) were recruited at a campus setting, and subjects consumed a total of 6 test meals one by one, each morning between 8:00 and 8:30 am after 12 h of fasting. PPGR was measured after each consumed meal and serial finger pricks were performed at indicated times. Test meals included 1) 68 g oral glucose, 2) 210 g rice, 3) rice plus 170 g egg white (RE), 4) rice plus 200 g bean sprouts (RS), 5) rice plus 10 g oil (RO), and 6) rice plus, egg white, bean sprouts, and oil (RESO). The incremental area under the curve (iAUC) was calculated to assess the PPGR. Mixed meal GI and GL values were calculated based on the nutrients the subjects consumed in each of the test meals. RESULTS: The iAUC for all meals containing two macronutrients (RS, RO, or RE) were not significantly different from the rice iAUC, whereas, the RESO iAUC ($2,237.5{\pm}264.9$) was significantly lower (P < 0.05). The RESO meal's calculated GI and GL values were different from the actual GI and GL values measured from the study subjects (P < 0.05). CONCLUSIONS: The mixed meal containing three macronutrients (RESO) decreased the PPGR in healthy individuals, leading to significantly lower actual GI and GL values than those derived by nutrient-based calculations. Thus, consuming various macronutrient containing meals is beneficial in regulating PPGR.

Inelatic Behaviors of A 3-Story Reinforced Concrete Frame with Nonseismic Details (비내진 상세를 가진 3층 철근콘크리트 골조의 비탄성 거동)

  • 이한선;우성우;허윤섭
    • Proceedings of the Korea Concrete Institute Conference
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    • 1998.04b
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    • pp.427-432
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    • 1998
  • The objective of this research is to observe the actual response of low-rise nonseismic moment-resisting reinforced frame subjected to varied levels of earthquake ground motions. First of all, the reduction scale for the model was determined as 1 : 5 considering the capacity of the shaking table to be used. This model was, then, subjected to the shaking table motions simulating Taft N21E component earthquake ground motions, whose peak ground accelerations(PGA's) were modified to 0.12g, 0.2g, 0.3g, and 0.4g. The global behavior and failure mode were observed. The lateral accelerations and displacements at each story and local deformations at the critical portions of structure were measured. The base shear was measured by using specially made load cells. Before and after each earthquake simulation test, free vibration tests were performed to find the changes in the natural period and damping ratio of the model.

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The Experimental Study on Seismic Performance of RC Bridge Columns with Longitudinal Steel Lap Splice (겹침이음 상세에 따른 철근콘크리트 교각의 내진성능에 관한 실험적 연구)

  • 석상근;손혁수;정철호;이재훈
    • Proceedings of the Korea Concrete Institute Conference
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    • 2001.05a
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    • pp.553-558
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    • 2001
  • Recent destructive seismic events demonstrated the importance of mitigating human casualties and serious property damages in design and construction of structures. The Korean Bridge Design Specifications (1992) adopted seismic design requirements based on the AASHTO specification, and minor modification was made in 2000. The longitudinal steel connection of reinforced concrete bridge column is sometimes practically unavoidable. The longitudinal reinforcement details affect seismic performance such as flexural failure and shear failure. This research aims to develop longitudinal steel connection details with confinement steel by experimental study for seismic performance of reinforced concrete bridge columns. Quasi-static test under three different axial load levels was conducted for 12 spiral column specimens. All the column specimens had the same aspect ratio of 3.5. The column specimens were transversely reinforced with spiral and with five different longitudinal steel connection. The final objective of this study is to suggest appropriate longitudinal reinforcement connection details for the limited ductility design concept and improve construction quality.

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