Browse > Article
http://dx.doi.org/10.5713/ajas.2007.1575

Glucose Tolerance and Insulin Response to Intravenous Glucose Load in Sheep Fed on Germinated Sorghum Grain  

Achmadi, Joelal (Laboratory of Nutritional Biochemistry Faculty of Animal Agriculture, Diponegoro University)
Pangestu, Eko (Laboratory of Nutritional Biochemistry Faculty of Animal Agriculture, Diponegoro University)
Wahyono, Fajar (Laboratory of Nutritional Biochemistry Faculty of Animal Agriculture, Diponegoro University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.20, no.10, 2007 , pp. 1575-1579 More about this Journal
Abstract
The glucose tolerance and pancreatic insulin secretion response to glucose in sheep fed on germinated sorghum grain were determined using an intravenous glucose load. Twelve male Thin Tail sheep (an Indonesian native sheep, 12 months old and 14.8 kg average body weight) were divided randomly into sorghum grain-based (S), germinated sorghum grain-based (G) and maize grain-based (C) diets. Sheep were maintained at the same daily intake levels of metabolizable energy and crude protein in the diets throughout the experimental period. After two months of the experimental conditions, each diet group was subjected to an intravenous glucose load experiment in which five doses of glucose (0, 10, 20, 40 and 80 mg/kg BW) were injected to estimate the rate of glucose removal from blood and the pancreatic insulin secretion response. For each sheep and each glucose load dose, the incremental blood serum glucose and insulin concentrations above pre-injection concentration were calculated as serum glucose and insulin response areas. At all glucose doses, sheep fed on S diet had a greater (p<0.05) glucose response area compared to those of sheep fed on G and C diets. Likewise at all glucose doses, the insulin response area was smaller (p<0.05) in sheep fed on S diet than in sheep fed on G and C diets. The glucose and insulin response areas in sheep fed on G and C diets differed slightly. It was concluded that the portion of maize grain in the ruminant ration could be substituted by germinated sorghum grain.
Keywords
Glucose; Insulin; Sorghum; Sheep;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
연도 인용수 순위
1 Waghorn, G. C., D. S. Flux and M. J. Ulyatt. 1987. Effects of dietary protein and energy intakes on growth hormone, insulin, glucose tolerance and fatty acid synthesis in young whether sheep. Anim. Prod. 44:143-152.   DOI
2 Fujita, T., M. Kajita, H. Sano and A. Shiga. 2006. Effects of nonprotein energy on the concentrations of plasma metabolites and insulin, and tissue responsiveness and sensitivity to insulin in goats. Asian-Aust. J. Anim. Sci. 19:1010-1018.   과학기술학회마을   DOI
3 Achmadi, J., T. Yanagisawa, H. Sano and Y. Terashima. 1993. Pancreatic insulin secretory response and insulin action in heat-exposed sheep given a concentrate or roughage diet. Domest. Anim. Endocrinol. 10(4):279-297.   DOI   ScienceOn
4 Janes, A. N., T. E. C. Weekes and D. G. Armstrong. 1985. Absorption and metabolism of glucose by the mesentricdrained viscera of sheep fed on dried-grass, maize-based diets. Br. J. Nutr. 54:449-446.   DOI   ScienceOn
5 Sasaki, Y., H. Takahashi, H. Aso, H. Hikosaka, A. Agino and S. Oda. 1984. Insulin response and glucose tolerance following feeding in sheep. Br. J. Nutr. 52:351-358.   DOI   ScienceOn
6 Sasaki, Y. and H. Takahashi. 1980. Insulin secretion response in sheep exposed to cold. J. Physiol. (London) 306:323-335.   DOI
7 Mitaru, B. N., R. D. Reichert and R. Blair. 1985. Protein and amino acid digestibilities for chickens of reconstituted and boiled sorghum grains varying in tannin contents. Poult. Sci. 64:101-106.   DOI
8 NRC. 1985. Nutrient Requirement of Sheep. 6th Rev. Ed. National Academy of Science, Washington DC.
9 Sasaki, S. and Y. Watanabe. 1990. Insulin sensitivity and responsiveness to isolated ovine adipocytes. Jpn. J. Zootech. Sci. 61:549-556.
10 Sumiati and D. M. Suci. 1996. An effort to improve the nutritive value of sorghum by high moisture storage treatment on broiler performance. Indon. J. Nutr. Feed Sci. 1(1):9-12.
11 Weekes, T. E. C., Y. Sasaki and T. Tsuda. 1983. Enhanced responsiveness to insulin in sheep exposed to cold. Am. J. Physiol. 224(7):E335-E345.
12 Weekes, T. E. C. 1991. Hormonal control of glucose Metabolism. In: Physiological Aspects of Digestion and Metabolism in Ruminants (Ed. T. Tsuda, Y. Sasaki and R. Kawashima). Proceeding of the 7th International Symposium on Ruminant Physiology. Academic Press, San Diego. pp. 183-200.
13 Trenkle, A. 1978. Relation of hormonal variations to nutritional studies and metabolism of ruminants. J. Dairy Sci. 61:281-293.   DOI   ScienceOn
14 McCann, J. P., M. B. Ullmann, M. R. Temple, T. J. Reimers and E. N. Bergman. 1986. Insulin and glucose response to glucose injection in fed and fasted obese and lean sheep. J. Nutr. 116:1287-1297.   DOI
15 Cole, N. A., D. M. Hallford and R. Gallavan. 1993. Influence of a glucose load in fed or unfed lambs on blood metabolites and hormone patterns. J. Anim. Sci. 71:765-773.
16 Hartadi, H., S. Reksohadiprodjo, S. Lebdosukojo and A. D. Tillman. 1994. Table of Feed Composition for Indonesia. Gadjah Mada University Press, Yogyakarta.
17 Bassett, J. M. 1975. Dietary and gastrointestinal control of hormones regulating carbohydrate metabolism in ruminants. In : (Ed. I. W. McDonald and Proc. of The IV International Symposium on Ruminants PhysiologyA. C. I. Warner). The University of New England Publishing Unit, Armidale, NSW. Australia. pp. 383-398.
18 Bassett, J. M. 1978. Endocrine factors in the control of nutrient utilization: ruminants. Proc. Soc. 37:273-280.
19 Fujita, T., M. Kajita and H. Sano. 2007. Effects of dietary starch and sucrose on tissue responsiveness and sensitivity to insulin in goats fed a high-concentrate diet. Asian-Aust. J. Anim. Sci. 20:385-392.   과학기술학회마을   DOI
20 Reichert, R. D., S. E. Fleming and D. J. Schwab. 1980. Tannin and nutritional improvement of sorghum by aerob storage on $H_2O$ or NaOH treated grain. J. Agric. Food Chem. 28:824-829.   DOI