• Journal of Ginseng Research
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• v.46 no.5
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• pp.675-682
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• 2022

Background: Korean Red Ginseng (KRG) was reported to play an anti-inflammatory role, however, previous studies largely focused on the effects of KRG on priming step, the inflammation-preparing step, and the anti-inflammatory effect of KRG on triggering, the inflammation-activating step has been poorly understood. This study demonstrated anti-inflammatory role of KRG in caspase-11 non-canonical inflammasome activation in macrophages during triggering of inflammatory responses. Methods: Caspase-11 non-canonical inflammasome-activated J774A.1 macrophages were established by priming with Pam3CSK4 and triggering with lipopolysaccharide (LPS). Cell viability and pyroptosis were examined by MTT and lactate dehydrogenase (LDH) assays. Nitric oxide (NO)-inhibitory effect of KRG was assessed using a NO production assay. Expression and proteolytic cleavage of proteins were examined by Western blotting analysis. In vivo anti-inflammatory action of KRG was evaluated with the LPS-injected sepsis model in mice. Results: KRG reduced LPS-stimulated NO production in J774A.1 cells and suppressed pyroptosis and IL-1β secretion in caspase-11 non-canonical inflammasome-activated J774A.1 cells. Mechanistic studies demonstrated that KRG suppressed the direct interaction between LPS and caspase-11 and inhibited proteolytic processing of both caspase-11 and gasdermin D in caspase-11 non-canonical inflammasome-activated J774A.1 cells. Furthermore, KRG significantly ameliorated LPS-mediated lethal septic shock in mice. Conclusion: The results demonstrate a novel mechanism of KRG-mediated anti-inflammatory action that operates through targeting the caspase-11 non-canonical inflammasome at triggering step of macrophage-mediated inflammatory response.

• Kyungpook Mathematical Journal
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• v.50 no.1
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• pp.101-107
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• 2010

A module M is said to satisfy the $EC_{11}$ condition if every ec-submodule of M has a complement which is a direct summand. We show that for a multiplication module over a commutative ring the $EC_{11}$ and P-extending conditions are equivalent. It is shown that the $EC_{11}$ property is not inherited by direct summands. Moreover, we prove that if M is an $EC_{11}$-module where SocM is an ec-submodule, then it is a direct sum of a module with essential socle and a module with zero socle. An example is given to show that the reverse of the last result does not hold.

• Journal of Life Science
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• v.31 no.2
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• pp.115-125
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• 2021

Calcium-dependent protein kinases (CDPKs) are known to be involved in regulating plant responses to abiotic stresses such as salinity, cold temperature and dehydration,. Although CDPKs constitute a large multigene family consisting of 31 genes in rice, only a few rice CDPKs' functions have been identified. Therefore, in order to elucidate the functions of OsCPK11 in rice, this study was intended to focus on the expression pattern analysis of OsCPK11 in wild type and ND0001 oscpk11 mutant plants under these abiotic stresses. For the salt, cold and drought stress treatment, seedlings were exposed to 200 mM NaCl, 4℃ and 20% PEG 6,000, respectively. RT-PCR and quantitative real-time PCR were performed to determine the expression patterns of OsCPK11 in wild type and ND0001 mutant plants. RT-PCR results showed that OsCPK11 transcripts in the wild type and heterozygous mutant were detected, but not in the homozygous mutant. Real-time PCR results showed that relative expression of OsCPK11 of wild type plants was increased and reached to the highest level at 24 hr, at 6 hr and at 24 hr under salt, cold and drought stress conditions, respectively. Relative expression of OsCPK11 of ND0001 homozygous plant was significantly reduced compared to that of wild type. These results suggested that oscpk11 homozygous mutant knocks out OsCPK11 and OsCPK11 might be involved in salt, cold and drought stress signaling by regulating its gene expression.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.5
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• pp.1702-1707
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• 2010

As quantities of the data that transmitting by the wireless are more increased, the interest and application are extending about 802.11n that uses by combination two existing 20MHz wireless LAN Channel. 802.11n use dual band of 2.4GHz band and 5.8GHz. So this is expected in mass wireless transmission method because of interference evasion effect in compliance with the radio communication of existing 2GHz neighborhood band. Like this 802.11n uses the radio as well and transmits information there is not only a possibility of undergoing an influence in radio wave environment of circumference. Specially the interior environment and outdoor environment is a possibility of saying that will be defined with each other different modeling as affects in radio communication is different. In this paper, we'll compare the influence to RF feature (802.11n) by (Indoor/Outdoor) environment difference through compared with 802.11n RF feature and Network feature in (Indoor/Outdoor) environment and also examine the correlation between RF feature and Network feature.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2009.10a
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• pp.108-111
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• 2009

In this paper, the development of unmanned vehicle systems to analysis applicable communications and alternative IEEE 802.11a. IEEE 802.11b/g uses the 2.4GHz. So, using the 5GHz OFDM in IEEE 802.11a interference phenomenon better. IEEE 802.11a has a maximum speed of 54Mbps. Indoors and apartment parking on experiment to soft roaming, hard roaming. Test equipments are AP four units(RSU), reliable results for the AP one unit Bridge, Switch one unit, one server notebook, one notebook(OBU), one car. Use Softwares are Wireshark, Jperf, Ping and million second transfer was used to develop the program. So the actual car was similar to the environment. With the results of the experiment for the unmanned vehicle systems will provide the best method.

• Proceedings of the IEEK Conference
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• 2003.11a
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• pp.545-548
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• 2003

MIMO-OFDM 시스템은 다중 안테나 송신을 통하여 시스템의 capacity를 극대화 하지만, 이를 위해서는 정확한 채널계수 값의 추정을 필요로 한다. 본 논문에서는 MIMO-OFDM시스템을 위한 채널계수 추정기법으로서 Space-Time Coding(STC)에 기반을 둔 방식을 제안한다. 제안된 채널 계수 추정 기법을 위해 필요한 심볼 구조, frame 구조를 IEEE 802.11a 시스템에 적용하였다. VBLAST 기법이 적용된 IEEE 802.11a 기반의 4 by 4 MIMO-OFDM 시스템에 대한 모의 실험을 통하여 제안된 방법의 성능과 기존의 방법의 성능을 coded BER를 통해 비교 분석해 보았다.

• Proceedings of the IEEK Conference
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• 2003.07a
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• pp.198-201
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• 2003

In this paper, we analyze high-rate orthogonal frequency division multiplexing(OFDM) system using time switched time diversity(TSTD) method based on IEEE 802.11a. First, we modeled the transmitter and receiver of OFDM system based on IEEE 802.11a. Then, we applied the TSTD to OFDM system. Finally we analyzed the performance of OFDM system using TSTD method by simulation over the 5GHz realistic channel model, where channel coding and channel equalizer over multipath environment are also applied.

• Proceedings of the IEEK Conference
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• 2003.11c
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• pp.204-207
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• 2003

MIMO-OFDM 시스템은 다중 안테나 송신을 통하여 시스템의 capacity를 극대화하지만, 이를 위해서는 정확한 채널 계수 값의 추정을 필요로 한다. 본 논문에서 는 MIMO-OFDM 시스템을 위한 채널계수 추정기법으로서 Space-Time Coding(STC)에 기반을 둔 방식을 제안한다. 제안된 채널계수 추정기법을 위해 필요한 심볼구조, frame 구조를 IEEE 802.11a 시스템에 적용하였다. VBLAST 기법이 적용된 IEEE 802.11a 기반의 4 by 4 MIMO-OFDM 시스템에 대한 모의실험을 통하여 제안된 방법의 성능과 기존의 방법의 성능을 coded BER를 통해 비교 분석해 보았다.

• Bulletin of the Korean Chemical Society
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• v.22 no.11
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• pp.1273-1276
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• 2001

• BMB Reports
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• v.52 no.2
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• pp.157-162
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• 2019

Our previous study found that two novel cancer-related genes, PRR11 and SKA2, constituted a classic gene pair that was regulated by p53 and NF-Y in lung cancer. However, their role and regulatory mechanism in breast cancer remain elusive. In this study, we found that the expression levels of PRR11 and SKA2 were upregulated and have a negative prognotic value in breast cancer. Loss-of-function experiments showed that RNAi-mediated knockdown of PRR11 and/or SKA2 inhibited proliferation, migration, and invasion of breast cancer cells. Mechanistic experiments revealed that knockdown of PRR11 and/or SKA2 caused dysregulation of several downstream genes, including CDK6, TPM3, and USP12, etc. Luciferase reporter assays demonstrated that wild type p53 significantly repressed the PRR11-SKA2 bidirectional promoter activity, but not NF-Y. Interestingly, NF-Y was only essential for and correlated with the expression of PRR11, but not SKA2. Consistently, adriamycin-induced (ADR) activation of endogenous p53 also caused significant repression of the PRR11 and SKA2 gene pair expression. Notably, breast cancer patients with lower expression levels of either PRR11 or SKA2, along with wild type p53, exhibited better disease-free survival compared to others with p53 mutations and/or higher expression levels of either PRR11 or SKA2. Collectively, our study indicates that the PRR11 and SKA2 transcription unit might be an oncogenic contributor and might serve as a novel diagnostic and therapeutic target in breast cancer.