• Toxicological Research
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• 제17권3호
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• pp.163-165
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• 2001

A patient,58 years of age, with suspected 0/l pneumoconiosis since 1993, complained of a dry cough and exertioning dyspnea for 6 months. He had worked in an asbestos company for more than 20 years from 1974. He was subsequently diagnosed with an interstitial lung disease during an annual special health check-up for asbestos workers. h chest X-ray showed an interstitial lung disease and high-resolution computed tomography (HRCT) showed a round opaque asbestosis with chronic hypersensitivity pneumonitis. A pulmonary function test indicated that the patient had a mild restrictive lung disease with FEV1 1.67 litters and 82% FEVl/FVC. The bronchoalveloar larvage fluid included many asbestos bodies, indicating previous exposure to asbestos. Transmission electron microscopy (TEM) using an energy dispersive X-ray analyzer (EDX) revealed many asbestos bodies consisting of mainly crocidolite fibers (6,071$\times$$10^6$fibers/g of dry lung). The patient had an unusually high asbestos content of 6,112$\times$$10^6$ asbestos fibers/9 of dry lung.

• 한국환경보건학회지
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• 제44권1호
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• pp.15-23
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• 2018

Objectives: The purpose of this study was to investigate the changes in hazardous pollutant emissions in Korea over the period of 2006-2015. Methods: A survey of hazardous pollutant emissions was conducted through the homepage for 2006-2015. The emission of hazardous chemicals and the health effect was examined using the Annual Report of Air Quality in Korea (2016) and National Health Statistics (2015) as references. Results: Hazardous pollutant emissions increased by 1.1 times over the past decade, and the circulation amount of chemicals was 15% compared to the previous year. $PM_{10}$ concentrations showed a tendency to decrease, but emissions have not declined. In addition, asthma and atopic dermatitis correlated with similar emissions, but allergic disease showed no connection. Conclusion: These results on hazardous pollutant emissions indicate that they have increased. However, no association between emissions and health effects was shown, so more research is needed.

• 한국농공학회논문집
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• 제60권6호
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• pp.33-42
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• 2018

This study evaluated the vulnerability of irrigation water supplied to the crops. The target areas were selected as Dangjin-si, Yesan-gun, and Cheongyang-gun. The survey items of the climate exposure were annual precipitation and rainless days. The sensitivity survey items were cultivation area, groundwater level, evapotranspiration and groundwater consumption. The survey items of the adaptability were Number of groundwater well and Water supply ratio. The survey methods for these items were investigated in a variety of ways, including "National Climate Data Service System", "Korean Statistical Information Service", "National ground water monitoring network in korea annual report" and "Chungcheongnam-do Statistical Yearbook", "HOMWRS". Vulnerability assessment results were rated within the range of 0~100 points. The first grade was rated 0-25, the second grade 26-50, the third grade 51-75, and the fourth grade 76-100. And the lower the score, the lower the vulnerability. As a result, Cheongyang-gun showed a high vulnerability of over 50 points, Dangjin-si showed a low vulnerability rating of 31.20 points and a Yesan-gun of 36.00 points.

• 한국식품조리과학회지
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• 제20권6호
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• pp.708-711
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• 2004

Swedish research in 2002 indicated that acrylamide formation was particularly associated with traditional high temperature cooking processes of certain carbohydrate-rich foods. Since the Swedish report, similar findings have been reported by researchers in numerous other countries. In 2003, three hundred and twenty seven domestic food products, selected on the basis of annual sales in Korea, were analyzed. The results were similar to those from other countries. In this study, the monitoring of acrylamide was expanded to include Korean traditional food products. Samples were purchased from local markets, prepared and then analyzed using LC/MS/MS methods. The categorized food products analyzed included cooked rices and porridges, soup products, fried products, boiled down products, seasoned products, roasted products and coffee. The acrylamide concentrations of the samples were $ND\~18ppb$ in cooked rices and porridges, $ND\~28ppb$ in soup products, $ND\~22ppb$ in fried products, $ND\~218ppb$ in boiled down products, <10ppb in seasoned and roasted products, and <10\~11ppb in brewed coffee and coffee drinks.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8529-8538
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• 2014

According to the China tumor registry 2013 annual report, breast cancer, lung cancer, and ovarian cancer are three common cancers in China nowadays, with high mortality due to the absence of early diagnosis technology. However, proteomics has been widespreadly implanted into every field of life science and medicine as an important part of post-genomics era research. The development of theory and technology in proteomics has provided new ideas and research fields for cancer research. Proteomics can be used not only for elucidating the mechanisms of carcinogenesis focussing on whole proteins of the tissue or cell, but also seeking the biomarkers for diagnosis and therapy of cancer. In this review, we introduce proteomics principles, covering current technology used in exploring early diagnosis biomarkers of breast cancer, lung cancer and ovarian cancer.

• Journal of Gastric Cancer
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• 제14권3호
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• pp.207-210
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• 2014

The peritoneum is the most frequent site of recurrence for gastric cancer after gastrectomy, followed by the liver and lymph nodes. In contrast, metastasis to the thymus is rare. Annual surveillance with computed tomography was performed on a 67-year-old man who previously underwent a distal gastrectomy and D2 lymph node dissection for gastric cancer at Tottori University. Five years after the initial operation, an anterior mediastinal tumor was detected by computed tomography. The patient underwent video-assisted thoracic surgery to remove the tumor. Histopathology revealed adenocarcinoma cells similar to those of the gastric cancer resected 5 years previously. Thymic metastasis was considered likely based on the location of the tumor. The recognition that gastric cancer can metastasize to unusual anatomic locations, such as the thymus, can facilitate an accurate, prompt diagnosis and appropriate treatment.

• Journal of Pharmaceutical Investigation
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• 제34권3호
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• pp.229-254
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• 2004

The objective of this study was to scrutinize the rationale of SUPAC-MR and its application in processing postapproval changes to modified release solid oral dosage forms. The types of postapproval changes that were primarily covered with SUPAC-MR included variations in the components and composition, the site of manufacturing, batch size, manufacturing equipment, and manufacturing process. SUPAC-MR defined levels of postapproval changes that the industry might make. Classification of such categories was based on the likelihood of risk occurrence and potential impact of changes upon the safety and efficacy of approved drug products. In most cases, the changes could be classified into 3 levels. It described what chemistry, manufacturing, and control tests should be conducted for each change level. The important tests specified in SUPAC-MR were batch release, stability, in vitro dissolution, and in vivo bioequivalence tests. It then suggested what type of a filing report should be submitted to the FDA for each change level. In general, level 1 changes could be reported in an annual report, whereas level 2 and/or 3 changes could be submitted in changes-being-effected or prior approval supplements. It could be understood that the purpose of SUPAC-MR was to maintain the safety and quality of approved modified release solid oral dosage forms undergoing certain changes. At the same time, it contributed to providing a less burdensome regulatory process with the manufacturers when they wanted to make postapproval changes. European regulatory agencies also implemented SUPAC-like regulations in handling such changes to drug products. Therefore, in this study a recommendation was made for KFDA and the Korean industry to evaluate thoroughly the usefulness of these guidances and regulations in dealing with postapproval changes to modified release solid oral dosage forms.

• Tuberculosis and Respiratory Diseases
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• 제74권3호
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• pp.104-110
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• 2013

Background: Notified tuberculosis (TB) cases in Korea have not decreased over the last decade (2001-2010). Methods: To clarify the reasons, we analyzed an annual report on notified tuberculosis patients and age-specific population drift in Korea. Results: Compared to the age-specific notified TB cases between 2001 and 2010, distinctive features in notified TB cases and new cases increased markedly in people aged 45-54 years and in patients over 65 years old, whereas those between 15-34 years in 2010 decreased drastically. In particular, notified TB individuals over 65 years old occupied 29.6% of the cases in 2010, which was 1.5 times higher than that in 2001. The main reason not to decrease in notified TB patients for the last decade (2001-2010) was due to the increasing elderly population as well as the aging of baby boomers, which have a higher risk of TB development. Conclusion: Korea needs to pay attention to the older population in order to successfully decrease the burden of TB in the future.

• Journal of Yeungnam Medical Science
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• 제2권1호
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• pp.281-286
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• 1985

소장 평활근육종은 매우 드물고 특이증상이 없으므로 원인 모를 위장관 출혈, 장폐쇄, 종물촉지, 빈혈, 복통 및 오한 등이 동반될 때 한 번은 고려하여 조기진단으로 환자의 사망율을 줄여야 할 것으로 사료된다. 최근들어 우리 나라에서도 그 증례보고가 늘어나고 본원에서도 2예를 경험한 바 이를 요약하면 1) 2예 모두 33세 남자였다 2) 발생부위는 공장 1예, 회장 1예였다 3) 주소는 1예에서는 복부통증을 동반한 종물촉지였고 다른 l 예에서는 천공에 의한 급성복막염 증상이었다. 4) 실험치상 CEA가 1예에서는 3.37에서 11.65ng/ml로 증가하였고, 다른 1예에서는 1.83 ng/ml였다. 혈색소는 술전 8.1gm%, 9.5gm%로 나타났다. Benzidine 잠혈반응은 둘 다 양성(++)였다. 5) 수술은 1예에서는 광범위 절제술 실시후 약 13개월만에 재발하여 재 수술하여 조직 검사를 다시 시행한 후 화학요법(VAC) 치료후 현재까지 외래에서 정기검진을 하고 있으며, 나머지 l예에서는 광범위 절제술후 15일만에 자진 퇴원하여 결과관철이 되지 못하고 있다.

• 농촌의학ㆍ지역보건
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• 제30권3호
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• pp.293-303
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• 2005

정부가 주관하는 여러 가지 암관리 사업들이 지방 자치 단체에 의해 시행되면서 지방마다의 암환자 발생에 대한 연구와 자료의 부족으로 사업의 효율성이 떨어지고 있다고 생각한다. 따라서, 국립 암센터에 등록된 자료를 가지고 각 지방 자치 단체의 연구 및 활용이 절실히 필요하다고 생각된다. 울릉군의 암종의 발생이 우리 나라 전체 비율보다 높은 양상을 보이므로 그에 대한 자치단체의 주민 교육 및 예방에 대한 노력이 필요하며, 울릉군의 여성의 유방암 환자의 등록 건수가 적은것은 추가적인 조사와 연구로 원인을 밝혀야 할 것으로 생각된다.