Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Case Report of Asbestosis

  • Lee, Yong-Hwan (Department of Preventive Medicine, College of Medicine, Kosin University) ;
  • Chang, Hee-Kyung (Department of Pathology, College of Medicine, Kosin University) ;
  • Kiyoshi Sakai (Nagoya City Public Health Research Institute) ;
  • Naomi Hisanaga (National Institute of Industrial Health) ;
  • Chung, Yong-Hyun (Center for Occupational Toxicology, Occupational Safety & Health Research Institute) ;
  • Han, Jeong-Hee (Center for Occupational Toxicology, Occupational Safety & Health Research Institute) ;
  • Yu, Il-Je (Center for Occupational Toxicology, Occupational Safety & Health Research Institute)
  • Published : 2001.10.01
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Abstract

A patient,58 years of age, with suspected 0/l pneumoconiosis since 1993, complained of a dry cough and exertioning dyspnea for 6 months. He had worked in an asbestos company for more than 20 years from 1974. He was subsequently diagnosed with an interstitial lung disease during an annual special health check-up for asbestos workers. h chest X-ray showed an interstitial lung disease and high-resolution computed tomography (HRCT) showed a round opaque asbestosis with chronic hypersensitivity pneumonitis. A pulmonary function test indicated that the patient had a mild restrictive lung disease with FEV1 1.67 litters and 82% FEVl/FVC. The bronchoalveloar larvage fluid included many asbestos bodies, indicating previous exposure to asbestos. Transmission electron microscopy (TEM) using an energy dispersive X-ray analyzer (EDX) revealed many asbestos bodies consisting of mainly crocidolite fibers (6,071$\times$$10^6$fibers/g of dry lung). The patient had an unusually high asbestos content of 6,112$\times$$10^6$ asbestos fibers/9 of dry lung.

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References

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