• Biomedical Science Letters
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• v.29 no.4
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• pp.355-362
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• 2023

This study aimed to determine whether smoking affects the metabolic syndrome and its components through long-term follow-up. Of the 10,030 cohort subjects in the community-based Korean Genome and Epidemiology Study (KoGES) from 2001 to 2018, 2,848 people with metabolic syndrome and 4,854 people with insufficient data for analysis were excluded for this study. The study population comprised 2,328 individuals (1,123 men, 1,205 women) who were eligible for inclusion. The mean age of the participants was 49.2±7.5 years, and 21.9% were current smoker. In log rank test, current smoker had a significantly higher cumulative incidence of metabolic syndrome compared with non smoker (P<0.001). In the Cox proportional hazards model adjusted for key variables, metabolic syndrome (hazard ratio [HR] 1.57, P<0.001), high fasting glucose (HR 1.40, P<0.01), hypertriglyceridemia (HR 1.60, P<0.001), low HDL-cholesterol (HR, 1.30, P<0.01), and abdominal obesity (HR 1.32, P<0.01) in current smoker compared with non smoker were statistically significant, respectively, but not hypertension (HR 1.00, P>0.05). After adjustment for confounders, the time (P-time<0.001) and group (P-group<0.001) effects on metabolic syndrome score change were statistically significant. Furthermore, the interaction analysis of time and smoking group on the change in metabolic syndrome score was statistically significant (P-interaction<0.001). In long-term follow-up, smoking worsens metabolic syndrome.

• Journal of the Korea Society of Computer and Information
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• v.21 no.8
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• pp.117-126
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• 2016

The purpose of this study was to explain the influence of depression on the life satisfaction of the elderly with hypertension. Also, we were focusing whether there is a mediating effect of subjective health status between depression and life satisfaction of the elderly with hypertension. 2,198 persons with hypertension over 65 years of age were selected from the data of KLoSA(Korean Longitudinal Study of Ageing), administered by The Korea Employment Information Service in 2014. Life satisfaction was measured by 10-Likert. The depression measured by CES-D10. The mediating variable is subjective health status measured by 5-Likert. As the method of analysis, the multiple regressions were used with SPSS 19.0. The result of the study shows that depression has a negative influence on life satisfaction and a negative influence on subjective health status. It was also verified that the subjective health status variable has a mediating effect between depression and life satisfaction. These results present the importance of psychological approach for the health promotion experts intervening with the elderly with hypertension.

• Tuberculosis and Respiratory Diseases
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• v.76 no.4
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• pp.169-174
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• 2014

Background: The Korean Obstructive Lung Disease (KOLD) Cohort Study is a prospective longitudinal study of patients with chronic obstructive pulmonary disease (COPD), asthma, or other unclassified obstructive lung diseases. It was designed to develop new classification models and biomarkers that predict clinically relevant outcomes for patients with obstructive lung diseases. Methods: Patients over 18 years old who have chronic respiratory symptoms and airflow limitations or bronchial hyper-responsiveness were enrolled at 17 centers in South Korea. After a baseline visit, the subjects were followed up every 3 months for various assessments. Results: From June 2005 to October 2013, a total of 477 subjects (433 [91%] males; 381 [80%] diagnosed with COPD) were enrolled. Analyses of the KOLD Cohort Study identified distinct phenotypes in patients with COPD, and predictors of therapeutic responses and exacerbations as well as the factors related to pulmonary hypertension in COPD. In addition, several genotypes were associated with radiological phenotypes and therapeutic responses among Korean COPD patients. Conclusion: The KOLD Cohort Study is one of the leading long-term prospective longitudinal studies investigating heterogeneity of the COPD and is expected to provide new insights for pathogenesis and the long-term progression of COPD.

• Korean Journal of Clinical Pharmacy
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• v.29 no.4
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• pp.238-246
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• 2019

Background: In South Korea, as an aged society, an understanding of dementia and its risk factors is important from clinical and healthcare policy perspectives. Relationship between cognitive impairment and body weight or weight changes have been reported, but these were contradictory. We have evaluated the association between weight changes and cognitive decline using national level longitudinal data. Methods: Data from the Korean Longitudinal Study of Ageing from 2006 to 2012 were used. Association between weight changes and decline in cognitive function as measured by K-MMSE (the Korean version of the Mini-mental state examination) score was assessed by multivariate logistic regression. Weight changes were calculated from 1st wave and 3rd wave survey data, and classified into five groups as stable, increases, decreases of >10%, or 5%-10%. Results: About 37% of the total participants (n=4,512) were 65 years or older. These participants made up the largest proportion of the groups with weight change exceeding 10%. Multivariate logistic regression analyses revealed that weight changes exceeding 10% (10% increase vs stable, adjusted OR [aOR] 1.47, 95% confidence interval (CI) 1.11-1.95; 10% decrease vs stable, aOR 1.44, 95% CI 1.11-1.88) were significant predictive factors for decline in cognitive function. In subgroup analyses, the association between weight changes and cognitive decline was significant in males aged over 65 years and in normal BMI groups. Conclusion: Weight changes, both increases and decreases exceeding 10% of baseline, were significantly associated with declines in cognitive function among older adults in South Korea.

• Journal of Sasang Constitutional Medicine
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• v.34 no.2
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• pp.1-14
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• 2022

Objectives The aim of this study was to investigate the change in Sasang constitution prediction value in 2 years and find the factors associated with it. Methods Cohort data from Korean medicine data center was used. Using Korean Sasang Constitutional Diagnostic Questionnaire (KS-15) which consist of questions related to body shape, temperament, and symptoms, participants were categorized into Tae-Yang (TY), Tae-Eum (TE), So-Yang (SY), and So-Eum (SE). Sasang constitution was assessed on the baseline and after two years. Result Total 5,784 participants were analyzed. (TE 3, 341; SE 911; SY 1,532). Among them, 1,402 participants (24.2%) showed different prediction value in KS-15 after two years. The proportion of participants showing different prediction value in two years was the highest in SY, and the lowest in TE group. The factors associated with the change in Sasang constitution prediction value were different by constitution type. The change in feeling after sweating was significantly associated with the change in prediction value in TE and SY groups, not in SE group. Although temperament was not significantly associated with the change in prediction value from TE to SE, it was significantly associated with that in the change from TE to SY. The change in BMI and appetite were associated with the change in constitution prediction value in all three constitution types. Conclusion Although the factors associated with the change in prediction value of Sasang constitution were different by each constitution type, BMI and appetite were significant in all three types. These factors could be useful for developing Sasang constitution questionnaire and deciding re-prediction needs of Sasang constitution. Further research about the factors related to Sasang constitution diagnosis need to be conducted.

• 한국노년학
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• v.41 no.3
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• pp.421-444
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• 2021

The purpose of this research is to examine the reciprocal relationships between depression and marital satisfaction among older couples. For longitudinal dyadic analysis, this study sets up a research model based on the Actor-Partner Interdependence Model, the Common Fate Model, and Autoregressive Cross-Lagged Model. Data came from four annual waves from the 10th year (2015) to the 13th year (2018) of the Korean Welfare Panel Survey and the final sample comprised a total of 1,383 married couples over 60 years of age in 2015. Structural Equation Modeling identified the reciprocal relationship between depression and marital satisfaction among older couples, with higher marital satisfaction of older couples leading to lower depression of husbands' and wives', and with higher depression of husbands' and wives' inducing lower marital satisfaction of the couples. Thus, this study suggested that longitudinal interplay between depression and marital satisfaction can lead to a vicious cycle. Based on these findings, the need to intervene at both the individual level and the couple level was discussed in order to reduce depression and improve marital satisfaction.

• Journal of the Korea Convergence Society
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• v.8 no.9
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• pp.277-283
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• 2017

This paper deals with a longitudinal time series study on the viewing behavior of digital media service. After holdback of terrestrial broadcasting VOD service was extended in 2013, viewers' terrestrial broadcasting VOD viewing went down sharply. Researcher assumed that there was driven by watching alternative products such as movies, kids, etc. as the cause of the decline of the terrestrial broadcasting VOD viewing. In addition, researcher assumed that the decline of terrestrial broadcasting VOD viewing had an influence on the viewing rate of the terrestrial real-time broadcasting, and confirmed the cause of the decreasing of the terrestrial real-time broadcasting viewing rate. In order for terrestrial broadcasters to retrieve real-time broadcasting and VOD viewing, it is necessary to shorten the VOD holdback and reacquire viewers away from terrestrial broadcasting.

• Journal of the Korea institute for structural maintenance and inspection
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• v.14 no.2
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• pp.176-183
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• 2010

In the steel deck box girder bridges, the deck is composed of deck plate, longitudinal and lateral direction ribs. The bridge, that is considered in this study, has been used for about 40 years and, recently, several cracks were found in the connection area of U-ribs. Further, additional cracks were occurred after some lateral rib plates and longitudinal frames were attached for the purpose of reinforcement. Therefore, the connection method in the U-ribs reinforcement was changed from the bolting to the weldment to get rid of stress concentration and further cracking. In this study, the stress in the U-ribs connection was analysed numerically and variable amplitude stress for the real traffic loads was measured experimentally before and after the frame reinforcement. Finally, the effects of reinforcement method were investigated and discussed.

• The Journal of the Korea Contents Association
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• v.20 no.10
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• pp.458-469
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• 2020

Geriatric depression is associated with pathological changes in the brain and increases the risk of cognitive impairment or dementia. However, high cognitive reserve, such as high education, can delay or minimize clinical manifestations of pathologies involving the brain, so the effect of geriatric depression on cognitive impairment or dementia may vary depending on the education level. In this study, the author analyzed data from the Korean Longitudinal Study of Aging (KLoSA) to examine whether the effect of geriatric depression on cognitive function differed depending on education level. Among the 10,254 subjects registered in the KLoSA, the 4,905 subjects who met the inclusion criteria were analyzed by stepwise regression analysis. The results were as follows: first, depressive symptoms predicted low cognitive function after 12 years; second, the negative effect of depressive symptoms on cognitive function after 12 years was higher in the old adult group than in the young adult group; and third, the effect of age was significant only in the low-educated group. These results suggest that depressive symptoms in low-educated old adults may increase the risk of development of dementia in the long term.

• Journal of the Korea Convergence Society
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• v.10 no.9
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• pp.229-236
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• 2019

This is an exploratory study examining factors associated with awareness of the National Long Term Care Insurance in Korea. The researchers also examined the differences in factors based on their age, between the middle-aged group(45-64 years of age) and the elderly group(65 years and older). The 6th wave of Korean Longitudinal Study of Ageing(KLoSA) was used for secondary data analysis. Results indicated that for the middle-aged, gender, volunteer participation, ADL, IADL, and depression were related to their awareness of the long term care insurance. However, for the elderly, social capital factors were significantly related to their awareness of the insurance. Age and depression were also significant factors associated with the awareness level of the long term care insurance among the elderly. Based on the findings, implications for social welfare policy are discussed.