• Title/Summary/Keyword: 10+2 rule

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Maximum tolerated dose estimation by Biased coin design and stopping rule in Phase I clinical trial (제 1상 임상시험에서 Biased Coin Design과 멈춤규칙을 이용한 MTD 추정법)

  • Jeon, Soyoung;Kim, Dongjae
    • The Korean Journal of Applied Statistics
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    • v.33 no.2
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    • pp.137-145
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    • 2020
  • Phase I clinical trials (Dose Finding Studies) are the first step in administering new drugs developed through animal experiments or in vitro experiments to humans. An important area of interest in designing Phase I clinical trials is determining the dose that provides the greatest efficacy and acceptable safe dose to the patient. In this paper, we propose a method to determine the maximum tolerated dose considering efficacy and safety using Biased coin design and stopping rule. The proposed method is compared with existing methods through simulation.

Backward Migration of an Active Rule Mobile Agent on the Sensor Network (센서네트워크상에서 능동규칙 이동에이전트의 역 방향 이주)

  • Lee, Yonsik
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.17 no.2
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    • pp.488-494
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    • 2013
  • For the activeness and autonomy of a sensor network, the efficient migration method of a mobile agent and the consistent naming services are the required components of a sensor network. Accordingly, this paper presented the implementation of backward migration of an active rule mobile agent applying the naming method based on RMI that used the meta_table including the informations about the components of a sensor network. This study implemented based on the extension of the forward migration[12], and the results of the various experiments present the efficacy of mobile agent middleware system and the possibility of constructing efficient sensor network application environment. And, the results of this study are able to enhance the adaptability on dynamic changes of environment in sensor network application development.

Refractive Error in 7-9 Year-old Korea Children (7세부터 9세 사이의 한국인 어린이의 굴절 이상)

  • Kim, Douk-Hoon;Alberto, Mercedita O.
    • Journal of Korean Clinical Health Science
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    • v.2 no.3
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    • pp.203-208
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    • 2014
  • Purpose. To analysis the refractive error in 7-9 year-old Korea children. Methods. From July 2013 to June 2014, two hundred eighty two subjects were performed in refraction test using the Auto-Refractometry. Results. The refractive error by spherical equivalent among all subjects was myopia 47.58%, emmetropia 42.35%, astigmatism 32.33%, and hyperopia 8.76%. Myopia was more common in female than males although the difference was not statically significant. The axis of astigmatism was with the rule in 65%, against the rule in 31.5%, and oblique in 3.5% There was a statistical significance between 7 year and 9 year of male in the spherical equivalent power(p=0.010). Also there was a statistical significance between 7 years and 9 years of female in the spherical equivalent power(p=0.036). However, there was not a statistical significance between male and female in spherical equivalent power(p>0.5). Conclusions. In this study, myopia was the most common refractive error. On the other hand, The prevalence of the axis of astigmatism was the with- the- rule. The spherical equivalent of refractive error was similar results between male and female. However The refractive error was different style with aging. these data suggested that the analysis of the refractive error at young children can provide the information of useful diagnosis for the correction of visual acuity.

Modeling of Hybrid Railway Vehicles with Hydrogen Fuel-Cell/Battery using a Rule-Based Algorithm (규칙기반 알고리즘을 이용한 수소연료전지/배터리 하이브리드 철도차량 모델링)

  • Oh, Yoon-Gi;Han, Byeol;Oh, Yong-Kuk;Ryu, Joon-Hyoung;Lee, Kyo-Beum
    • Journal of IKEEE
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    • v.24 no.2
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    • pp.610-618
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    • 2020
  • This paper presents the modeling of hybrid railway vehicles with hydrogen Fuel-Cells (FCs)/battery using a rule-based algorithm. The driving power of traction system is determined with the speed-torque curve by operation area of the electric machine and the electrical systems are modeled. The demanded power of electrical systems is set with the energy management system (EMS). The consumption of hydrogen is effectively managed with the subdivided operation region depending on the state of charge (SOC). The validity of the modeling is verified using MATLAB/Simulink.

A study on Unifying Hanja Variant Groups of Korea and China for LGR (Label Generation Rule) of Internet Top-Level Hangeul Hanja Domain

  • Kim, Kyongsok
    • International journal of advanced smart convergence
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    • v.7 no.2
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    • pp.7-21
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    • 2018
  • The author studied the process of unifying Hanja variant groups of Korea and China for LGR (Label Generation Rule) of Internet Top-Level Hangeul Hanja Domain and possible confusion between Hangeul syllable and Hanja character. Among 3518 Chinese variant groups, Korea and China need not review variant groups which include no or just one Korean Hanja character. Korea and China reviewed 304 Chinese variant groups (9% of the 3518 Chinese variant groups) which include two or more Korean Hanja characters. By doing so, Korea and China succeeded in efficiently unifying variant groups. Unification process of variant groups which is the main core of Korea-China coordination and almost final unification result is summarized in this paper. In addition, the author analyzed systematically whether some Hanja character could be confused with a Hangeul syllable and obtained a good result which was not expected at the beginning. Probably this kind of systematic analysis has not been performed in the past and seems the first attempt, which is one of the contributions of this paper. The author also reviewed how to express K-LGR in XML for submission to ICANN.

A Study on the Historical Research on the Costume of Memorial Service Officials at Yeongwol King Danjong Cultural Festival (단종 제향 복원을 위한 재관(齋官) 복식 고증)

  • Lee, Eun-Joo
    • Journal of the Korean Society of Costume
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    • v.62 no.8
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    • pp.118-133
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    • 2012
  • A historical research on the costume of memorial service officials during the period of late 18th century, King Jeongjo period, is performed for an accurate reconstruction of the memorial service for King Danjong, which is a part of King Danjong Cultural Festival held at Yeongwol. This paper summarizes the results of the research as follows: 1. Jangneung memorial service is held only on Hansik day and the procedure follows the rule based on Gukjooryeui(國朝五禮儀). The service was first held in 1791 for King Danjong and his royal followers. 2. The rule based on Chunkwantonggo(春官通考), defines the king's tomb memorial services and attendees. King Danjong's memorial service follows the rule regarding its attendees and the attendees include high-ranking local government officials, local confucian scholars, and service men. 3. The costume of attendees for the King Danjong's memorial service is as follows: 1)Dangsangkwan(堂上官) and Danghakwan(堂下官) wear Sangbok(常服), which consisted of Samo(紗帽), Heukdanllyeong(黑團領), Pumdae(品帶), and black boots(黑靴). 2)Local confucian scholars wear their uniform consisting of Yukeon(儒巾), Dopo(道袍), Sejodae, and black boots. 3)Service men wear their uniform consisting of Jeonjakeon(典字巾), red-robe with rounded collar called Hongui(紅衣), Kwangdaw hoe(廣多繪), and Uuhae(雲鞋).

A Multiagent System for Workflow-Based Bioinformatics Tool Integration

  • Sohn, Bong-Ki;Lee, Keon-Myung;Kim, Hak-Joon
    • International Journal of Fuzzy Logic and Intelligent Systems
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    • v.3 no.2
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    • pp.133-137
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    • 2003
  • Various bioinformatics tools for biological data processing have been developed and most of them are available in public. Most bioinformatics works are carried out by a composite application of those tools. Several integration approaches have been proposed for easy use of the tools. This paper proposes a new multi agent system to integrate bioinformatics tools in the perspective of workflow since the composite applications of tools can be regarded as workflows. For the easy integration, the proposed system employs wrapper agents for existing tools, uses XML-based messages in the inter-agent communication, and agents are supposed to extract necessary information from the received messages. This allows new tools to be easily added on the integration framework. The proposed method allows various control structures in workflow definition and provides the progress monitoring capability of the on-going workflows. In particular, agents in this system have the rule-based architecture which allows the defined rule set to be a special role agent. This feature provides fast and flexible agent development to aid in managing the complexity of bioinformatics application. This system has been partially implemented and has been proven to be a viable implementation for workflow-based bioinformatics tool integration.

Public Satisfaction Analysis of Weather Forecast Service by Using Twitter (Twitter를 활용한 기상예보서비스에 대한 사용자들의 만족도 분석)

  • Lee, Ki-Kwang
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.41 no.2
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    • pp.9-15
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    • 2018
  • This study is intended to investigate that it is possible to analyze the public awareness and satisfaction of the weather forecast service provided by the Korea Meteorological Administration (KMA) through social media data as a way to overcome limitations of the questionnaire-based survey in the previous research. Sentiment analysis and association rule mining were used for Twitter data containing opinions about the weather forecast service. As a result of sentiment analysis, the frequency of negative opinions was very high, about 75%, relative to positive opinions because of the nature of public services. The detailed analysis shows that a large portion of users are dissatisfied with precipitation forecast and that it is needed to analyze the two kinds of error types of the precipitation forecast, namely, 'False alarm' and 'Miss' in more detail. Therefore, association rule mining was performed on negative tweets for each of these error types. As a result, it was found that a considerable number of complaints occurred when preventive actions were useless because the forecast predicting rain had a 'False alarm' error. In addition, this study found that people's dissatisfaction increased when they experienced inconveniences due to either unpredictable high winds and heavy rains in summer or severe cold in winter, which were missed by weather forecast. This study suggests that the analysis of social media data can provide detailed information about forecast users' opinion in almost real time, which is impossible through survey or interview.

Analysis of Game Character Using Emotion Rule (감정규칙을 사용한 게임 캐릭터 분석)

  • Park, Jun-Hyoung;Ko, Il-Ju
    • Journal of Korea Game Society
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    • v.14 no.2
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    • pp.7-18
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    • 2014
  • Emotion is one of the elements of the game that will help the user interaction. The way to express the emotions and personality of the character was taken into account severity of reaction to action or a specific graphics in the game so far. However recently structured for the interest in the study of emotion increases and to utilize a variety of feelings in the game is needed. In the field of autonomous agents, studies of the possibility of the use of emotion, defined 12 different emotion rules. In this paper, we dilate by defining the terms used in the game rules of emotion made the rules of the emotion of the game. And, we analyzed emotions in actual game character used Game Emotions Rule. As a result, it was possible to see the rules of the game feeling separate from that being used for game genre similar.

Efficient Storage Structures for a Stock Investment Recommendation System (주식 투자 추천 시스템을 위한 효율적인 저장 구조)

  • Ha, You-Min;Kim, Sang-Wook;Park, Sang-Hyun;Lim, Seung-Hwan
    • The KIPS Transactions:PartD
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    • v.16D no.2
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    • pp.169-176
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    • 2009
  • Rule discovery is an operation that discovers patterns frequently occurring in a given database. Rule discovery makes it possible to find useful rules from a stock database, thereby recommending buying or selling times to stock investors. In this paper, we discuss storage structures for efficient processing of queries in a system that recommends stock investments. First, we propose five storage structures for efficient recommending of stock investments. Next, we discuss their characteristics, advantages, and disadvantages. Then, we verify their performances by extensive experiments with real-life stock data. The results show that the histogram-based structure improves the query performance of the previous one up to about 170 times.