• 제목/요약/키워드: 1-OHP

검색결과 81건 처리시간 0.029초

점농어 Lateolabrax maculatus의 성 성숙에 미치는 광주기의 영향 (Effect of Photoperiods on Sexual Maturation in Spotted seabass, Lateolabrax maculatus)

  • 임상구;김영수;백재민;김종현;한형균;조용철;강용진
    • 수산해양교육연구
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    • 제26권5호
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    • pp.935-940
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    • 2014
  • 점농어, Lateolabrax maculatus 암컷의 GSI변화는 실험개시시에 $0.51{\pm}0.05%$였고, 사육 90일 후인 실험종료시에는 대조구(자연광주기)에서 $1.07{\pm}0.09%$인데 비해 9L:15D구에서 $1.93{\pm}0.06%$로 가장 높았으며, 15L:9D에서 $0.32{\pm}0.07%$로 가장 낮은 값을 보였다. 수컷의 GSI변화는 실험개시시에 $0.16{\pm}0.05%$였으며, 실험종료시에는 대조구의 경우 $0.75{\pm}0.05%$인데 비해 9L:15D에서 $1.89{\pm}0.12%$ 가장 높았으며, 15L:9D에서 $0.22{\pm}0.06%$로 가장 낮은 값을 보였다. 암컷의 혈중 E2 변화는 실험개시시에 $125.8{\pm}9.5pg/ml$였으나 실험종료시에 대조구에서 $226.0{\pm}13.62pg/ml$였으며, 9L:15D에서 $296.3{\pm}15.0pg/ml$로 가장 높았고 15L:9D에서 $138.5{\pm}7.9pg/ml$로 가장 낮은 값을 보였다. 혈중 testosterone은 실험개시시에 $172.5{\pm}14.5pg/ml$였으나, 실험종료시에 대조구에서 $194.3{\pm}23.6pg/ml$였으며, 모든 실험구에서 대조구보다 낮은 값을 보였다. 혈중 $17a20{\beta}OHP$ 농도는 실험개시시에 $174.0{\pm}28.5pg/ml$였으나 실험종료시에 대조구에서 $193.5{\pm}13.4pg/ml$였으며, 대조구가 나머지 실험구에 비해 높은 값을 보였다. 혈중 testosterone의 농도는 실험개시시에 $125.0{\pm}5.1pg/ml$였으며 실험종료시에 대조구에서 $259.3{\pm}33.1pg/ml$였으며, 9L:15D에서 $370.5{\pm}27.5pg/ml$로 가장 높았고 15L:9D에서 $112.3{\pm}8.7pg/ml$로 가장 낮은 값을 보였다. 수컷의 혈중 $17a20{\beta}OHP$ 농도는 실험개시시에 $205.3{\pm}15.1pg/ml$였으며, 실험종료시에 대조구에서 $196.3{\pm}17.0pg/ml$였으며, 다른 실험구에 비해 가장 높은 값을 보였다.

충남지역 초등학교의 구강보건관리 실태 (Current Oral Health Care of Elementary School in Chungnam Province, Korea)

  • 배진순;장성실
    • 한국학교보건학회지
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    • 제13권2호
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    • pp.331-340
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    • 2000
  • Primary school is regarded as an important period when many health-related behaviors and life-styles begin to be formed. Acquiring them through school heath education has a strong influence on the health promotion of not only the family but also the community. The objectives of this study were to evaluate current oral health care of elementary schools in Chungnam province and to provide information for further development in elementary school oral health. We performed a questionnaire survey to 280 health teachers and among them, 155 teachers answered. The result of this study were as follows: 1. Sixty five percent of the health teachers had little interest in oral health. Major information sources for teaching oral health were books in 58.1% of the 155 teachers and 83.2% of teachers spent 30 minutes to 1hour per day in oral health care practice for the students. 2. Contents of the oral health education were composed of regular and special curriculums, and an average of education time during a semester was 2.6 hours in 3rd grade, and 1.3 hours in first and second grade. 60.6% of the teachers made the children practice the proper method of tooth brushing during the education time. 3. Major problems in oral health education were insufficient time, lack of equipment and difficulty in teaching method. The educational media were tooth models among 91.0% and OHP among 85.2% of the teachers. The tooth model was usually used in first to fourth grades and OHP in fifth to sixth grades. But 63.9% health teachers need to develop stronger educational methods using multimedia. 4. Meanwhile the most important strategy of oral health in urban schools was health education, that of rural schools was fluoride mouth-rinsing programme. Fluoride mouth-rinsing programmes were performed by 60.0% of the elementary school. Periodic dental examination was performed in all elementary schools. 98.2% of the schools sent the results home through school notification letters, but post-examination management was performed in only 67.1% of them 64.5% of the health teachers do follow-ups on the oral disease of the children after the examination. Only 0.7% of the schools have oral health education plans for the students' parents. Considering these major strategies for elementary school oral health care were health education, practicing proper methods of tooth brushing, periodic dental examinations, and fluoride mouth-rinsing programmes. But health teachers need more time for oral health education, practicing and management, and developing education materials. With regard to the high demand for oral health education and poor follow-up after periodic examination, the oral health education in elementary school should be considered as a formal educational course for more proper management of oral health, including application of major strategies to the children in earlier grades and efforts for increasing recognition and participation of the parents.

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특수학교의 보건관리 (Health Management and Services of School-Nurse in Special Schools)

  • 이경희;박재용
    • 한국학교보건학회지
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    • 제4권2호
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    • pp.176-192
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    • 1991
  • 특수학교 보건관리의 방향 설정과 특수학교 양호교사 업무 수행에 있어 질적 향상을 위한 기초 자료를 제시하고자 전국의 102개 특수학교 양호교사를 대상으로 1991년 2월 1일부터 1991년 3월 31일까지 우편 설문 조사를 실시하여 회수된 77개 학교를 대상으로 분석한 결과를 요약하면 다음과 같다. 특수학교의 67.5%가 사립이고, 83.2%가 시 이상 지역에 위치해 있으며, 정신지체학교가 48.1%로 가장 많았다. 특수학교의 평균 학급수는 17.2학급, 평균학생수는 194명, 평균교직원 수는 28명이었다. 양호교사의 평균 연령은 32.7세였고, 97.4%가 전문대학 이상 졸업자였으며, 71.4%가 기혼자였고, 79.2%가 임상이나 보건과 관련된 분야의 과거경력이 있는 것으로 나타났다. 또한 62.3%의 양호교사가 단독 업무를 보고있었으며, 77.9%가 초등에 소속되어 있었다. 대상 특수학교 양호실은 68.9%가 l층에 위치해 있었고, 학교보건 조직은 90.9%가 구성되어 있지 않았으며, 학교보건 인력으로 교의, 치과의, 학교 약사 모두를 위촉하고 있는 곳은 18.2%에 불과했다. 학교보건에 관한 연간 예산은 양호교사의 46.8%가 모르고 있었으며, 학교당 평균 년간지출액은 317,000원으로 그 중 의약품 구입비가 제일 많았다. 학교당 월 평균양호실 이용자수는 71명이었고, 학생 1인당 연간 양호실 이용은 4.4회였으며, 외상으로 인한 이용이 26.6%로 가장 많았다. 양호실 이용자중 1.4%가 의료기관에 의뢰되었는데, 시각장애학교는 고열, 정서장애학교는 골절, 다른 영역학교는 외상으로 가장 많이 의뢰하였다. 특수학교 아동 중 간질 학생수는 956명으로 조사 대상학교 학생수의6.4%를 차지하고 있었다. 신체검사를 2회 이상 실시하고 있는 학교는 22.6% 밖에 되지 않았으며, 98.7%가 보건교육을 실시하고 있고, 성교육은 98.7%가 필요하다고 강조하였다. 보건교육은 개인 위생에 가장 비중을 두고 있었으며, 시각장애 학교는 방송교육, 청각장애 학교는 OHP나 VTR, 다른 영역의 학교는 가정통신문이나 OHP VTR을 가장 많이 사용하는 교육매체였다. 대상 양호교사의 46.8%가 학교보건관리중 보건교육이 가장 어렵다고 하였으며, 중점개선내용으로 49.4%가 특수학교 보건관리에 대한 구체적인 업무 지침이 필요하다고 강조하였다. 사업계획 및 평가, 양호실 관리, 보건교육, 환경관리, 건강관리 등의 양호교사 업무 수행은 비교적 높은 수행율과 자신감을 나타냈으나, 그 중 학교보건 사업의 평가, 체력검사, 보건교육 후 평가, 학교정화구역 관리, 상처 봉합에 대한 수행율과 자신감이 비교적 낮았다. 따라서 특수학교 보건관리의 방향설정과 양호업무의 질적수준 향상을 위하여 학교보건사업에 대한 구체적인 업무지침의 개선과 특수학교 양호교사에 대한 별도교육이 필요한 것으로 생각된다.

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성장중인 양서류 여포의 스테로이드 생성능력 획득에 관한 연구 (Development of Steroidogenic Capacity during Follicle Growth in Amphibian Ovarian Follicles)

  • 안련섭;소재목;임욱빈;나철호;권혁방
    • 한국동물학회지
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    • 제39권3호
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    • pp.257-265
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    • 1996
  • 참개구리를 사용하여 난소내 여포들이 성장시기에 획즉하게 되는 스테로이드들의 생성능력을 조사하였다. 개구리로부터 중간(0.7-1.11mm) 크기 이하의 여포들을 분리한 다음 전구스테로이들이나 뇌하수체추출물(FPH)을 포함한 배양액에서 6시간 배양 후 이들에 의해 산물스테로이드로 전환된 양을 방사면역 측정법으로 조사하였다. FPH의 처리는 중간 크기의 여포만 스테로이드들의 생성을 현저히 촉진하고 작은 여포들(0.35-0.7mm)에서는 촉진효과가 매우 미약하였다. Progenenolone의 첨가는 가장 작은 여포 (0.22-0.4mm)들에 의해서도 progesterone(P$_4$)으로 전환되었다. 그러나 가장 작은 여포에서는 P$_4$를 첨가했을 때에도 역시 같은 현상이 나타났다. 작은 여포와 중간 여포들에 의한 전환된 스테로이드들의 양을 단위표면적의 전환량으로 계산 비교해 본 결과 전환된 양은 거의 같았다. 이는 작은 여포의 여포세포들 (granulosa cells)이 이미 E$_2$에 이르는 모든 중간 산물들을 생성할 능력을 가졌다는 것을 의미한다. 그러나 이들이 FPH에 의해서는 스테로이드를 조금밖에 생성하지 못하는 것으로 보아 아직 부족한 또다른 요인들이 있는것으로 추정된다.

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Interpretation of androgen and anti-Mullerian hormone profiles in a Hispanic cohort of 5- to 8-year-old girls with premature adrenarche

  • Brar, Preneet Cheema;Dingle, Elena;Ovadia, Daniela;Pivo, Sarah;Prasad, Veeramac;David, Raphael
    • Annals of Pediatric Endocrinology and Metabolism
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    • 제23권4호
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    • pp.210-214
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    • 2018
  • Purpose: Premature adrenarche (PA) often leads to polycystic ovary syndrome (PCOS). Higher anti-mullerian hormone (AMH) levels are reported in PCOS. We studied the androgen profile and AMH profiles in Hispanic girls with PA (aged 5-8 years) and age and body mass index (BMI) matched controls. Methods: Retrospective review of electronic medical records of girls who met the inclusion criteria for premature adrenarche were done. Results: PA girls (n=76) were matched to control girls (n=12) for age (mean${\pm}$standard deviation) ($6.7{\pm}1years$ vs. $6.2{\pm}1.3years$) and BMI ($20{\pm}10kg/m^2$ vs. $17.8{\pm}2.7kg/m^2$). Dehydroepiandrostenedione sulfate ($63.3{\pm}51.3{\mu}g/dL$ vs. $29.8{\pm}17.3{\mu}g/dL$, P<0.001) and testosterone levels ($11.4{\pm}4.8ng/dL$ vs. $8.2{\pm}2.9ng/dL$, P=0.001) were significantly higher in the PA group than controls. AMH values (<14 years: reference range, 0.49-3.15 ng/mL) were $3.2{\pm}2.2ng/mL$ vs. $4.6{\pm}3.2ng/mL$ respectively in the PA and control groups and were not different (P=0.4). AMH did not show a correlation with bone age (P=0.1), and testosterone (P=0.9) in the PA group. 17-hydroxyprogesterone levels (17-OHP ng/dL) were $39.5{\pm}30.5ng/dL$ vs. $36.8{\pm}19.8ng/dL$ in PA versus control girls. The concentration of 17-OHP was not statistically different between the control and PA groups. Conclusion: Higher AMH was not observed in PA girls and no correlation with BA and androgen levels was observed.

클로르헥시딘 바니쉬와 클로르헥시딘 양치액 사용시 치면 착색면적의 비교 (A COMPARISON OF STAIN RATIO INDUCED BY CHLORHEXIDINE AND CHLORHEXIDINE VARNISH APPLICATION)

  • 황정환;최영철;이긍호
    • 대한소아치과학회지
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    • 제25권3호
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    • pp.513-524
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    • 1998
  • The purpose of this study was to compare the staining ratio on the enamel surface following the use of chlorhexidine mouthwash and the chlorhexidine varnish application. Labial and lingual surfaces of maxillary and mandibular incisors of adults were selected to evaluate the staining ratio. The control group was consisted of 8 individuals, the experimental group 1 and 2 were consisted of 50 each. Prophylaxis with pumice was performed to remove the stain already established on the enamel surface of all groups. The group 1 was asked to use chlorhexidine mouthwash(Hexadent, chlorhexidine gluconate 1ml/100ml) for a minute twice a day. The chlorhexidine $varnish^{(R)}$($Chlorzoin^{(R)}$, consisted of solution 1(10% chlorhexidine acetate) and solution 2(polyurethane sealant)) was applied on the enamel surfaces of the group 2. After 4 weeks of experiment, intraoral photogragh of tooth surfaces were taken in order to record the stained area on the enamel of the control and the experimental groups. Outline of teeth and the stained area in the photographs was traced on the OHP film. Scanner and computer processor were used to calculate stained surface ratio.

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동자개(Pseudobagrus fulvidraco)의 생식소 퇴화에 미치는 수온과 광주기의 영향 (Effect of Water Temperatures and Photoperiods on Gondal Degeneracy in Banded Catfish Pseudobagrus fulvidraco)

  • 임상구;김영수;한창희
    • 수산해양교육연구
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    • 제24권6호
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    • pp.845-853
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    • 2012
  • To investigate the role of temperatures and photoperiods as environmental cues regulating reproductive rhythm in Pseudobagrus fulvidraco, rearing experiments were conducted using sveral rearing regimes conbined with photoperiods and water temperatures during gonadal degeneration periods. Gonadosomatic index (GSI) in control was $8.16{\pm}1.50%$, while in other experiment GSI levels in female were lower than that in the control. In case of experimental precinct of 9 light (L) and 15 L, GSI levels were decreased. But GSI level with $20^{\circ}C$ was no diffrence after 40 and 60 days. GSI level in male of control was $0.35{\pm}0.05%$. GSI under 9 L and $25^{\circ}C$ was similar to that in control, whereas its level in other experiments was lower than that in control. Testosterone (T) of female was $3.68{\pm}0.22$ ng/mL at experimental precinct. In case of 9 L and 15 L, concentration of T were lower than experimental precinct in all of water temperature. Estradiol-$17{\beta}$ ($E_2$) and $7{\alpha}$, $20{\beta}$-dihydroxy-4-pregnen-3-one ($17{\alpha}20{\beta}OHP$) levels of female were $0.42{\pm}0.02$ and $0.83{\pm}0.01$ ng/mL at experimental precinct. $E_2$ levels of 9 and 15 L were higher than experimental precinct and $17{\alpha}20{\beta}OHP$ levels of 9 and 15 L were higher than experimental precinct. In case of T and 11-ketotestosterone levels were $0.69{\pm}0.11$ and $.62{\pm}0.03$ ng/mL in male. During the period of gonadal degeneration, gonadal maturation did not occur in any of the experimental regimes. However, comparatively high levels of $E_2$ observed at low temperature regimes ($20^{\circ}C$) regardless of photoperiods.

잉크젯 프린팅 기술을 이용한 플렉서블 온·습도센서 개발 (Fabrication of Flexible Temperature & Humidity Sensor Using Inkjet-printing Technology)

  • 계지원;한동철;신한재;김헌곤;이왕훈
    • 센서학회지
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    • 제24권2호
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    • pp.119-123
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    • 2015
  • This paper presents the inkjet-printed flexible temperature and humidity sensor(F-TH sensor) using PEDOT:PSS. The series, mesh and parallel type sensing element using PEDOT:PSS ink was printed on the overhead projector(OHP) film. The fabricated sensor of each structure has the temperature sensitivity of $140{\Omega}/^{\circ}C$, $29{\Omega}/^{\circ}C$ and $1.4{\Omega}/^{\circ}C$ with linearity, respectively. Also the fabricated sensor was not only possible to measure a temperature, but also to detect humidity. The humidity sensitivity of $400{\Omega}/%RH$, $3.4{\Omega}/%RH$ and $3{\Omega}/%RH$ with linearity, respectively. The fabricated F-TH sensor is expected for the various applications such as electronic devices, bio-healthcare, industrial field.

GPX1 및 hOGG1 유전자다형성에 따른 유전자의 산화적 손상 및 폐암 발생 위험도 평가 (Effects of Oxidative DNA Damage and Genetic Polymorphism of the Glutathione Peroxidase 1 (GPX1) and 8-Oxoguanine Glycosylase 1 (hOGG1) on Lung Cancer)

  • 이철호;이계영;최강현;홍윤철;노성일;엄상용;고영준;장연위;임동혁;강종원;김헌;김용대
    • Journal of Preventive Medicine and Public Health
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    • 제39권2호
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    • pp.130-134
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    • 2006
  • Objectives : Oxidative DNA damage is a known risk factor of lung cancer. The glutathione peroxidase (GPX) antioxidant enzyme that reduces hydrogen peroxide and lipid peroxides plays a significant role in protecting cells from the oxidative stress induced by reactive oxygen species. The aim of this case-control study was to investigate effects of oxidative stress and genetic polymorphisms of the GPX1 genes and the interaction between them in the carcinogenesis of lung cancer. Methods : Two hundreds patients with lung cancer and 200 age- and sex-matched controls were enrolled in this study. Every subject was asked to complete a questionnaire concerning their smoking habits and their environmental exposure to PAHs. The genotypes of the GPX1 and 8-oxoguanine glycosylase 1 (hOGG1) genes were examined and the concentrations of urinary hydroxypyrene (1-OHP), 2-naphthol and 8-hydroxydeoxyguanosine (8-OH-dG) were measured. Results : Cigarette smoking was a significant risk factor for lung cancer. The levels of urinary 8-OH-dG were higher in the patients (p<0.001), whereas the urinary 1-OHP and 2-naphthol levels were higher in the controls. The GPX1 codon 198 polymorphism was associated with an increased risk of lung cancer. Individuals carrying the Pro/Leu or Leu/Leu genotype of GPX1 were at a higher risk for lung cancer (adjusted OR=2.29). In addition, these individuals were shown to have high urinary 8-OH-dG concentrations compared to the individuals with the GPX1 Pro/Pro genotype. On the other hand, the polymorphism of the hOGG1 gene did not affect the lung cancer risk and the oxidative DNA damage. Conclusions : These results lead to a conclusion that individuals with the GPX1 Pro/Leu or Leu/Leu genotype would be more susceptible to the lung cancer induced by oxidative stress than those individuals with the Pro/Pro genotype.

한국 신생아 집단검사의 과거, 현재, 미래 (The Past, Present, Future of Newborn Screening in Korea)

  • 이동환
    • 대한유전성대사질환학회지
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    • 제14권1호
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    • pp.1-9
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    • 2014
  • Many inborn errors of metabolism can be completely cured with early detection and early treatment. This is why neonatal screening on inborn errors of metabolism is implemented worldwide. In 1991, the Ministry of Health & Social affairs adopted a nationwide service program for neonatal screening of phenylketonuria, galactosemia, maple syrup urine disease, homocystinuria, histidinemia and congenital hypothyroidism for newborns delivered from low class pregnant women registered in health centers. Government decreased the test items from six to two, PKU and congenital hypothyroidism to increase test numbers with same budget from 1995. 78 laboratories wanted to participate for neonatal screening test in 1999. Government decided to screen six items of PKU, congenital hypothyroidism, maple syrup urine disease, homocystinuria, galactosemia and congenital adrenal hyperplasia from 2006. In 2014, thirteen laboratories are participating. Inter laboratory quality control was started 6 times a year from 1994. In case a patient with an inherited metabolic disease is diagnosed by screening of government program, special milk is provided at government's expense. According to the government project, from 1997 to 2013, 7,080,569 newborns were screened. 144 PKU, 2.451 congenital hypothyroidism were detected. So incidence of PKU is 1/49,170 and congenital hypothyroidism is 1/2,888. The cost benefit of performing screening procedures coupled with treatment has been estimated to be as high as 1.77 times in PKU, 11.11 times in congenital hypothyroidism than cost without screening. By January 2007, many European countries had expanded of their newborn screening programs by inclusion of Tandem mass spectrometry. We are trying to increase the budget to test all newborns for Tandem mass spectrometry from 2016. We are considering four to five central laboratories which cover all newborns and are equipped with tandem mass spectrometer & enzyme immunoassay for TSH, 17OHP & enzyme colorimetric assay for galactose. And I hope to expand test including Wilson disease screening test and lysosomal storage diseases.