• 치과방사선
• /
• 제25권1호
• /
• pp.141-150
• /
• 1995

종양유발성 골연화증은 종양에 의하여 생성된 활동성 펩티드호르몬과 유사한 물질이 골이나 위장관에 작용하여 칼슘대사와 인대사의 변화를 일으키거나, 정상적인 비타민 D대사에 장애를 일으킴으로써 2차적으로 발생되는 대사성 질환으로 알려져 있다. 이의 발생빈도는 매우 낮으며, 임상적으로는 체중과 신장의 감소, 전신적인 골격의 동통 및 근무력증과 병적 골절이 동반되어 나타난다. 방사선사진에서는 골소주의 전반적인 소실, 피질골의 비박, 위골절, 치조백선의 소실 등을 보이고, 실험실 소견에서는 혈청인의 농도와 신세뇨관에서 인의 재흡수율의 감소 및 혈청 알칼리성 인산화효소 농도의 상승이 관찰된다. 본질환은 종양이 제거되면 별도의 부가적인 치료 없이도 임상적, 방사선학적 소견 및 실험실 소견의 뚜렷한 개선을 보이므로 이의 치료에 있어서 정확한 진단이 매우 중요하다. 저자들은 전신적인 동통과 근무력증을 주소로 내원한 환자들에게서 발생된 종양유발성 골연화증 3예를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다.

• 한국수정란이식학회지
• /
• 제16권1호
• /
• pp.7-14
• /
• 2001

The aims of these study were to diagnose early pregnancy and reproductive disorders by using progesterone concentration and ultrasonography. The measurement of blood progesterone (P$_4$) concentration was conducted to diagnose pregnancy and to detect corpus luteum (CL) or evaluate disorder of CLs. As a result, the incidence rates of reproductive disorders were as follows : SH and EED (41.9%), inacitve ovaries (32.6%), follicullar cyst (9.3%), PCL (7.0%), endometritis (4.7%), pyometra (2.3%) and luteal cyst (2.3%). 61 Cows having P$_4$concentration 1.0 ng/ml(at the insemination) were increased to 1.0 ng/ml $\geq$ 6day after insemination. 50 cows among 61 cows were diagnosed pregnant. 8 cows among 13 HanWoos having P$_4$concentration 1.0 ng/ml at the insemination and 1.0 ng/mnl 6 day after insemination had non-ovulatory estrus and the others had P$_4$concentration 1.0 ng/ml at the insemination and 1.0 ng/ml $\geq$ 6 day after insemination, which was the error of estrus detection. All 13 cows were diagnosed non-pregnant. 47 cows diagnosed pregnant after insemination of P$_4$concentration 3.0 ng/ml were examined by ultrasonography at 30 day post-insemination. As a result, 41 cows were diagnosed pregnant (87.2%) but 14 cows having P$_4$concentration 3.0 ng/ml at 21 day after insemination was diagnosed to non-pregnancy. Calving intervals by surveying 100 cows were as follows 11~12 months (20%), 12~13 months (36%), 13~14 months (19%), 14 months $\geq$ (25%), respectively. In conclusion, hormone and ultrasonography help to detect reproductive disorders exactly and diagnose early pregnancy. This study suggest that diagnosis of early pregnancy and reproductive disorder by blood P$_4$concentration and ultrasonography improve reproduction management of HanWoo.

• Korean Journal of Radiology
• /
• 제25권3호
• /
• pp.257-266
• /
• 2024

Objective: To investigate molecular and functional consequences of additional exposures to iodine- or gadolinium-based contrast agents within 24 hours from the initial intravenous administration of iodine-based contrast agents through an animal study. Materials and Methods: Fifty-six Sprague-Dawley male rats were equally divided into eight groups: negative control, positive control (PC) with single-dose administration of CT contrast agent, and additional administration of either CT or MR contrast agents 2, 4, or 24 hours from initial CT contrast agent injection. A 12 µL/g of iodinated contrast agent or a 0.47 µL/g of gadolinium-based contrast agent were injected into the tail vein. Serum levels of blood urea nitrogen, creatinine, cystatin C (Cys C), and malondialdehyde (MDA) were measured. mRNA and protein levels of kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were evaluated. Results: Levels of serum creatinine (SCr) were significantly higher in repeated CT contrast agent injection groups than in PC (0.21 ± 0.02 mg/dL for PC; 0.40 ± 0.02, 0.34 ± 0.03, and 0.41 ± 0.10 mg/dL for 2-, 4-, and 24-hour interval groups, respectively; P < 0.001). There was no significant difference in the average Cys C and MDA levels between PC and repeated CT contrast agent injection groups (Cys C, P = 0.256-0.362; MDA, P > 0.99). Additional doses of MR contrast agent did not make significant changes compared to PC in SCr (P > 0.99), Cys C (P = 0.262), and MDA (P = 0.139-0.771) levels. mRNA and protein levels of KIM-1 and NGAL were not significantly different among additional CT or MR contrast agent groups (P > 0.05). Conclusion: A sufficient time interval, probably more than 24 hours, between repeated contrast-enhanced CT examinations may be necessary to avoid deterioration in renal function. However, conducting contrast-enhanced MRI on the same day as contrast-enhanced CT may not induce clinically significant kidney injury.

• 한국전자파학회논문지
• /
• 제29권1호
• /
• pp.36-41
• /
• 2018

본 논문에서는 밀리미터파(W 대역) 다중개구각 혼안테나를 제안하였다. 제안된 안테나는 전계면 및 자계면 빔폭이 동일한 다중모드 이중편파 정사각형 혼으로서 다중모드 생성부, 4개의 정사각형 도파관 여기부, 합패턴 형성을 위한 직교모드 변환기와 전력결합기로 구성된다. 제작이 용이하도록 안테나 구조를 설계하고, 층별 기계가공과 확산접합 기법을 적용하여 ${\pm}0.02mm$ 오차 이내로 제작하였다. 회로망분석기와 원전계 측정시설을 이용하여 제작된 안테나의 입력 반사계수와 방사패턴을 측정하였다. 측정 결과, 제안한 안테나는 중심 주파수를 기준으로 1 GHz 이내에서 17.7~18.3 dBi의 이득, $25.2{\sim}28.5^{\circ}$의 빔폭, 1.02~1.75의 입력 VSWR 특성을 가짐을 확인하였다.

• 대한의생명과학회지
• /
• 제10권1호
• /
• pp.55-63
• /
• 2004

Bovine leukemia virus (BLV) is a causative agent for lymphoma disease in cattle including cows worldwide. BLV shares similar virion structure and characteristics with other retroviruses. The pol gene of the BLV genome produced reverse transcriptase (RT) and integrase (IN) for important roles for BLV genome integration into host cell chromosomes that is known to be coded in the 3' side of the BLV pol gene (one third portion). In this study, we have sequenced 978 bp in the 3' side of the BLV pol gene from BLV 10C3 in order to determine the BLV IN region of it. And we compared it to the nucleotide sequences of an Australian BLV isolate. As a result, nucleotide sequences of the IN region of the Korean-type BLV pol gene were mutated at a rate of 3.7%. We can confirm that the typical mutations are such as Arg (AGG) $\rightarrow$ Lys (AAG), Thr (ACG) $\rightarrow$ Met (ATG), Ile (ATT) $\rightarrow$ Val (GTT), Asn (ACC) $\rightarrow$ His (CAC), Phe (TTT) $\rightarrow$ Leu (TTG) and Asn (ACC) $\rightarrow$ Asp (GAC). From the analysis of the sequencing data, we were able to determine the zinc-finger-like "HHCC" motif in the amino terminus of BLV IN, that was H-$X_3$-H-$X_{25}-C-X_2$-C. It was also found the DD35E motif in the IN catalytic domain as D-$X_{56}$-D-$X_{35}$-E. It fits very well to the consensus sequences of retroviral IN as well as HHCC motif.

• 대한본초학회지
• /
• 제28권2호
• /
• pp.45-53
• /
• 2013

Objectives : The purpose of the study is to determine the neuroprotective effects of the water and 80% EtOH extract of some herbal medicine plant on ischemia reperfusion-induced cell death in SK-N-SH human brain neuronal cells. Methods : SK-N-SH cells were treated with 3mM sodium azide and 10 mM 2-deoxy-D-glucose for 45 min, ptior to the addition of different concentrations of herbal medicine plant extract (0, 10, 25, 50, 100, 250, 500, 1000 ${\mu}g/ml$) for 2 hr and then reperfused with growth medium, incubated for 24 h. Cell viability was determined by WST-1 assay, and ATP/ADP levels were measured by ADP/ATP ratio assay kit. Results : Herbal medicine plant extract significantly inhibited decreasing the cell viability in ischemia-induced SK-N-SH cells. Also increased the ratio of ADP/ATP in ischemia-induced neuronal cells. Conclusions : Our results suggest that herbal medicine plant extract has a neuroprotective property via increasing the energy levels in neuronal cells, suggesting that extract may has a therapeutic potential in the treatment of ischemic brain injury. The exact component and mechanism remains for the future study.

• 한국수산과학회지
• /
• 제54권5호
• /
• pp.703-713
• /
• 2021

Mackerel Scomber japonicus is an excellent source of vitamins (A, D and B₁₂), omega-3 fatty acids, dietary protein and minerals. This study was conducted to prepare mackerel-based processed seafood products such as grilled product with super-heated (GM), tang (TM) and salad with sweet potato (SSM) using mackerel as senior-friendly seafoods and to examine their quality characteristics. The hardness of GM, TM and SSM were 240.3×1.0³, 21.7×1.0³ and 7.4×1.0³ N/m², respectively. The viscosity of SSM was 25,450 m·Pas. The nutritional content of mackerel-processed products was within the senior-friendly standard specifications for protein, vitamin C, vitamin B₂ (riboflavin) and vitamin B₃ (niacin) ing GM, protein, vitamin B₃ and calcium for TM, and protein, vitamin D, vitamin B₂ and vitamin B₃ in SSM. All the mackerel-processed products were safe as senior-friendly seafoods, since digestibility rates were 81.5% for GM, 87.9% for TM and 93.5% for SSM. The physical, nutritional and the sanitation results indicated that senior-friendly seafoods classified of the mackerel-processed products was step 1 for GM, step 2 for TM and step 3 for SSM according to the Korean Food Code and Korean Indusrty Standards.

• 한국잡초학회지
• /
• 제15권1호
• /
• pp.39-45
• /
• 1995

벼 직파재배답(直播栽培畓)에서의 효과적인 잡초방제체계를 확립하기 위하여 잡초발생 생태 및 적미(赤米)발생에 관한 기초자료를 얻고자 1992년부터 시험포장과 농가답을 대상으로 수행한 시험결과를 요약하면 다음과 같다. 1. 직파재배답(直播栽培畓)은 이앙답(移秧畓)에 비하여 피, 적미(赤米), 드렁새, 바랭이, 강아지풀 등의 1년생(年生) 화본과 잡초 발생이 많았다. 2. 파종사기별로 피와 벼의 출아소요기간(出芽所要期間)에 차이가 있었는데, 피의 출아기간(出芽期間)은 4월 5일 파종(播種)에서는 14일, 5월 15일 파종(播種)은 8일, 6월 25일 파종(播種)에는 4일이 소요되었으며, 각 시기별로 벼는 피에 비하여 4~6일 출아(出芽)가 늦었다. 3. 재배양식별(栽培樣式別) 잡초발생량 및 수량감소정도는 직파재배(直播栽培)>기계이앙(機械移秧)>손이앙 순이었으며, 직파재배(直播栽培)는 손이앙에 비해 잡초발생량은 2~3배 많고, 수량감소는 담수직파(湛水直播)에서 40~60%, 건답직파(乾畓直播)에서는 70~100%로 특히 피의 발생이 많았다. 4. 보리를 앞작물로 하는 미맥2모작(米麥2毛作) 작부체계재배(作付體系栽培)가 벼 단작(單作)의 1모작(毛作) 재배(栽培)에 비하여 피를 비롯한 대부분의 잡초가 발생이 억제되었으며, 전체적으로 약(約) 30% 정도의 발생경감 효과가 있었고, 수량(收量)도 다소 증수되었다. 5. 적미(赤米)의 발생은 파종시기와 밀접한 관계가 있었는데, 2월에서 6월까지의 파종시기에서 0.4~3.6% 정도 발생되었으며, 파종시기가 빠를수록 발생량이 많았다. 6. 경운방법(耕耘方法)에 따라서도 적미(赤米)의 발생양상이 달라졌는데, 무경운(無耕耘)>로타리>경운(耕耘)+로타리 순이었으며, 무경운재배(無耕耘栽培)에서는 경운(耕耘)+로타리 재배(栽培)에 비해 6배 이상 발생량이 증가하였다. 7. 직파재배(直播栽培) 경과 연수에 따른 적미(赤米)발생량은 지역에 따라 상당한 차이가 있었으며, 재배년수(栽培年數)와는 일정한 경향이 없었다.

• 한국수산과학회지
• /
• 제28권4호
• /
• pp.487-491
• /
• 1995

수용성 chitin 유도체인 CM-chitin의 식품분야 또는 기타 산업적 이용을 위한 기초자료를 제시할 목적으로 희박용액중에서 CM-chitin의 고유점도에 미치는 pH 및 분자량의 영향을 조사한 결과를 요약하면 다음과 같다. Chitin으로부터 조제한 CM-chitin을 0.1M NaCl 용액에 녹여 $30^{\circ}C$에서 측정한 CM-chitin의 고유점도는 1.23dl/g이었고, 분자량은 15,500이었으며, CM-chitin과 반응한 NaOH의 당량으로부터 계산한 치환도는 0.62이었다. CM-chitin의 고유점도에 대한 pH의 영향은 pH 7.0이하에서는 pH가 낮을수록 고유점도는 급격히 감소하였으며, pH 7.0이 상에서는 pH가 증가하여도 고유점도의 변화는 거의 나타나지 않았다. 초음파 처리 시간에 따른 고유점도와 분자량의 변화는 처리시간 20분까지는 고유점도와 분자량은 각각 3.1dl/g에서 2.55dl/g, 15,500에서 12,600으로 감소하여 감소속도가 빨랐으나 20분 이후부터는 거의 일정하여 1시간 처리 후의 고유점 도와 분자량은 각각 2.5dㅣ/g, 12,370이었다. 용매를 물로 사용하였을 때 CM-chitin의 고유점도와 분자량과의 관계에 있어서 K는 $3.48\times10^{-4}이었고, v는 0.94이었다.

• 치과방사선
• /
• 제25권2호
• /
• pp.363-373
• /
• 1995

The aim of this study was to evaluate and compare observer performance between conventional radiographs and their digitized images for the detection of bone loss in the bifurcation of mandiblar first molar. One dried human mandible with minimal periodontal bone loss around the first molar was selected and serially enlarged 17 step defects were prepared in the bifurcation area. The mandible was radiographed with exposure time of 0.12, 0.20, 0.25, 0.32, 0.40, 0.64 seconds, after each successive step in the preperation and all radiographs were digitized with IBM-PC/32 bit-Dx compatible, video camera (VM-S8200, Hitachi Co., Japan), and color monitor(Multisync 3D, NEC, Japan). Sylvia Image Capture Board for the ADC(analog to digital converter) was used. The obtained results were as follows: 1. In the conventional radiographs, the mean score of the readability was higher at the condition of exposure time with 0.32 second. Also, as the size of artificial lesion was increased, the readability of radiographs was elevated (P<0.05). 2. In the digital images, the mean score of the readability was higher at the condition of exposure time with 0.40 second. Also, as the size of artificial lesion was increased, the readability of digital images was elevated(P<0.05). 3. At the same exposure time, the mean scores of readibility were mostly higher in the digitized images. As the exposure time was increased, the digital images were superior to radiographs in readability. 4. As the size of lesion was changed, the digital images were superior to radiographs in detecting small lesion. 5. The coefficient of variation of mean score has no significant difference between digital images and radiographs.